Details of the Target

General Information of Target

Target ID LDTP13657
Target Name Melanoma-associated antigen D2 (MAGED2)
Gene Name MAGED2
Gene ID 10916
Synonyms
BCG1; Melanoma-associated antigen D2; 11B6; Breast cancer-associated gene 1 protein; BCG-1; Hepatocellular carcinoma-associated protein JCL-1; MAGE-D2 antigen
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSVTYDDSVGVEVSSDSFWEVGNYKRTVKRIDDGHRLCSDLMNCLHERARIEKAYAQQLT
EWARRWRQLVEKGPQYGTVEKAWMAFMSEAERVSELHLEVKASLMNDDFEKIKNWQKEAF
HKQMMGGFKETKEAEDGFRKAQKPWAKKLKEVEAAKKAHHAACKEEKLAISREANSKADP
SLNPEQLKKLQDKIEKCKQDVLKTKEKYEKSLKELDQGTPQYMENMEQVFEQCQQFEEKR
LRFFREVLLEVQKHLDLSNVAGYKAIYHDLEQSIRAADAVEDLRWFRANHGPGMAMNWPQ
FEEWSADLNRTLSRREKKKATDGVTLTGINQTGDQSLPSKPSSTLNVPSNPAQSAQSQSS
YNPFEDEDDTGSTVSEKDDTKAKNVSSYEKTQSYPTDWSDDESNNPFSSTDANGDSNPFD
DDATSGTEVRVRALYDYEGQEHDELSFKAGDELTKMEDEDEQGWCKGRLDNGQVGLYPAN
YVEAIQ
Target Bioclass
Other
Function
Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule.
Uniprot ID
Q9UNF1
Ensemble ID
ENST00000218439.8
HGNC ID
HGNC:16353

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.S377N DBIA    Probe Info 
HS578T SNV: p.K458Q DBIA    Probe Info 
IGROV1 SNV: p.A158T DBIA    Probe Info 
MCC13 SNV: p.R323Q; p.T451I .
MELJUSO SNV: p.R76P DBIA    Probe Info 
OVK18 SNV: p.E68D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
TH211
 Probe Info  		Y346(13.21); Y326(8.41)  LDD0257  [3]
TH216
 Probe Info  		Y317(18.36)  LDD0259  [3]
STPyne
 Probe Info  		K107(6.25); K125(8.40); K133(8.79); K293(7.14)  LDD0277  [4]
ONAyne
 Probe Info  		N.A.  LDD0273  [4]
Probe 1
 Probe Info  		Y313(20.78); Y317(23.97); Y428(17.29)  LDD3495  [5]
Alkylaryl probe 1
 Probe Info  		6.00  LDD0388  [6]
Jackson_1
 Probe Info  		4.34  LDD0121  [7]
DA-P3
 Probe Info  		4.12  LDD0181  [8]
AHL-Pu-1
 Probe Info  		C516(2.90)  LDD0168  [9]
Alkyne-RA190
 Probe Info  		2.98  LDD0299  [10]
EA-probe
 Probe Info  		N.A.  LDD0440  [11]
HHS-482
 Probe Info  		Y317(2.79)  LDD0288  [12]
HHS-475
 Probe Info  		Y439(0.60); Y449(0.83); Y317(1.17); Y448(1.63)  LDD0264  [13]
HHS-465
 Probe Info  		Y317(6.90)  LDD2237  [14]
DBIA
 Probe Info  		C516(1.49)  LDD0080  [15]
ATP probe
 Probe Info  		K494(0.00); K59(0.00); K133(0.00)  LDD0199  [16]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [17]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [18]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [17]
NAIA_4
 Probe Info  		N.A.  LDD2226  [19]
IPM
 Probe Info  		N.A.  LDD2156  [20]
NHS
 Probe Info  		N.A.  LDD0010  [21]
SF
 Probe Info  		N.A.  LDD0028  [22]
1c-yne
 Probe Info  		K484(0.00); K311(0.00)  LDD0228  [23]
Acrolein
 Probe Info  		N.A.  LDD0217  [24]
AOyne
 Probe Info  		11.40  LDD0443  [25]
NAIA_5
 Probe Info  		N.A.  LDD2223  [19]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C191
 Probe Info  		11.00  LDD1868  [26]
C193
 Probe Info  		5.50  LDD1869  [26]
FFF probe11
 Probe Info  		9.05  LDD0472  [27]
FFF probe13
 Probe Info  		20.00  LDD0475  [27]
FFF probe14
 Probe Info  		20.00  LDD0477  [27]
FFF probe2
 Probe Info  		12.47  LDD0463  [27]
FFF probe3
 Probe Info  		12.38  LDD0464  [27]
STS-2
 Probe Info  		N.A.  LDD0138  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C516(2.90)  LDD0168  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C516(3.01)  LDD0169  [9]
 LDCM0214  AC1 HCT 116 C516(0.94)  LDD0531  [15]
 LDCM0215  AC10 HCT 116 C516(1.20)  LDD0532  [15]
 LDCM0216  AC100 HCT 116 C516(0.90)  LDD0533  [15]
 LDCM0217  AC101 HCT 116 C516(0.95)  LDD0534  [15]
 LDCM0218  AC102 HCT 116 C516(0.86)  LDD0535  [15]
 LDCM0219  AC103 HCT 116 C516(1.12)  LDD0536  [15]
 LDCM0220  AC104 HCT 116 C516(0.93)  LDD0537  [15]
 LDCM0221  AC105 HCT 116 C516(0.95)  LDD0538  [15]
 LDCM0222  AC106 HCT 116 C516(0.98)  LDD0539  [15]
 LDCM0223  AC107 HCT 116 C516(0.94)  LDD0540  [15]
 LDCM0224  AC108 HCT 116 C516(0.96)  LDD0541  [15]
 LDCM0225  AC109 HCT 116 C516(0.92)  LDD0542  [15]
 LDCM0226  AC11 HCT 116 C516(1.11)  LDD0543  [15]
 LDCM0227  AC110 HCT 116 C516(0.92)  LDD0544  [15]
 LDCM0228  AC111 HCT 116 C516(0.99)  LDD0545  [15]
 LDCM0229  AC112 HCT 116 C516(0.97)  LDD0546  [15]
 LDCM0230  AC113 HCT 116 C516(1.02)  LDD0547  [15]
 LDCM0231  AC114 HCT 116 C516(1.08)  LDD0548  [15]
 LDCM0232  AC115 HCT 116 C516(1.14)  LDD0549  [15]
 LDCM0233  AC116 HCT 116 C516(1.21)  LDD0550  [15]
 LDCM0234  AC117 HCT 116 C516(1.07)  LDD0551  [15]
 LDCM0235  AC118 HCT 116 C516(1.01)  LDD0552  [15]
 LDCM0236  AC119 HCT 116 C516(1.00)  LDD0553  [15]
 LDCM0237  AC12 HCT 116 C516(1.05)  LDD0554  [15]
 LDCM0238  AC120 HCT 116 C516(1.23)  LDD0555  [15]
 LDCM0239  AC121 HCT 116 C516(0.96)  LDD0556  [15]
 LDCM0240  AC122 HCT 116 C516(1.00)  LDD0557  [15]
 LDCM0241  AC123 HCT 116 C516(1.04)  LDD0558  [15]
 LDCM0242  AC124 HCT 116 C516(1.17)  LDD0559  [15]
 LDCM0243  AC125 HCT 116 C516(1.12)  LDD0560  [15]
 LDCM0244  AC126 HCT 116 C516(1.30)  LDD0561  [15]
 LDCM0245  AC127 HCT 116 C516(1.21)  LDD0562  [15]
 LDCM0246  AC128 HCT 116 C516(1.31)  LDD0563  [15]
 LDCM0247  AC129 HCT 116 C516(0.95)  LDD0564  [15]
 LDCM0249  AC130 HCT 116 C516(1.17)  LDD0566  [15]
 LDCM0250  AC131 HCT 116 C516(1.09)  LDD0567  [15]
 LDCM0251  AC132 HCT 116 C516(0.86)  LDD0568  [15]
 LDCM0252  AC133 HCT 116 C516(0.98)  LDD0569  [15]
 LDCM0253  AC134 HCT 116 C516(1.07)  LDD0570  [15]
 LDCM0254  AC135 HCT 116 C516(1.06)  LDD0571  [15]
 LDCM0255  AC136 HCT 116 C516(0.93)  LDD0572  [15]
 LDCM0256  AC137 HCT 116 C516(0.84)  LDD0573  [15]
 LDCM0257  AC138 HCT 116 C516(0.98)  LDD0574  [15]
 LDCM0258  AC139 HCT 116 C516(1.06)  LDD0575  [15]
 LDCM0259  AC14 HCT 116 C516(0.93)  LDD0576  [15]
 LDCM0260  AC140 HCT 116 C516(1.05)  LDD0577  [15]
 LDCM0261  AC141 HCT 116 C516(1.13)  LDD0578  [15]
 LDCM0262  AC142 HCT 116 C516(0.84)  LDD0579  [15]
 LDCM0263  AC143 HCT 116 C516(1.19)  LDD0580  [15]
 LDCM0264  AC144 HCT 116 C516(1.19)  LDD0581  [15]
 LDCM0265  AC145 HCT 116 C516(0.84)  LDD0582  [15]
 LDCM0266  AC146 HCT 116 C516(0.97)  LDD0583  [15]
 LDCM0267  AC147 HCT 116 C516(1.25)  LDD0584  [15]
 LDCM0268  AC148 HCT 116 C516(1.49)  LDD0585  [15]
 LDCM0269  AC149 HCT 116 C516(1.28)  LDD0586  [15]
 LDCM0270  AC15 HCT 116 C516(1.31)  LDD0587  [15]
 LDCM0271  AC150 HCT 116 C516(1.11)  LDD0588  [15]
 LDCM0272  AC151 HCT 116 C516(1.04)  LDD0589  [15]
 LDCM0273  AC152 HCT 116 C516(1.46)  LDD0590  [15]
 LDCM0274  AC153 HCT 116 C516(1.99)  LDD0591  [15]
 LDCM0621  AC154 HCT 116 C516(1.21)  LDD2158  [15]
 LDCM0622  AC155 HCT 116 C516(1.27)  LDD2159  [15]
 LDCM0623  AC156 HCT 116 C516(1.04)  LDD2160  [15]
 LDCM0624  AC157 HCT 116 C516(1.14)  LDD2161  [15]
 LDCM0276  AC17 HEK-293T C516(0.76)  LDD0874  [15]
 LDCM0277  AC18 HEK-293T C516(0.84)  LDD0875  [15]
 LDCM0278  AC19 HEK-293T C516(0.88)  LDD0876  [15]
 LDCM0279  AC2 HCT 116 C516(0.95)  LDD0596  [15]
 LDCM0280  AC20 HEK-293T C516(0.87)  LDD0878  [15]
 LDCM0281  AC21 HEK-293T C516(0.93)  LDD0879  [15]
 LDCM0282  AC22 HEK-293T C516(0.76)  LDD0880  [15]
 LDCM0283  AC23 HEK-293T C516(0.78)  LDD0881  [15]
 LDCM0284  AC24 HEK-293T C516(0.88)  LDD0882  [15]
 LDCM0285  AC25 PaTu 8988t C516(0.97)  LDD1164  [15]
 LDCM0286  AC26 PaTu 8988t C516(1.00)  LDD1165  [15]
 LDCM0287  AC27 PaTu 8988t C516(1.09)  LDD1166  [15]
 LDCM0288  AC28 PaTu 8988t C516(1.16)  LDD1167  [15]
 LDCM0289  AC29 PaTu 8988t C516(1.02)  LDD1168  [15]
 LDCM0290  AC3 HCT 116 C516(0.93)  LDD0607  [15]
 LDCM0291  AC30 PaTu 8988t C516(0.96)  LDD1170  [15]
 LDCM0292  AC31 PaTu 8988t C516(1.03)  LDD1171  [15]
 LDCM0293  AC32 PaTu 8988t C516(1.09)  LDD1172  [15]
 LDCM0294  AC33 PaTu 8988t C516(1.20)  LDD1173  [15]
 LDCM0295  AC34 PaTu 8988t C516(1.12)  LDD1174  [15]
 LDCM0296  AC35 HEK-293T C516(0.93)  LDD0894  [15]
 LDCM0297  AC36 HEK-293T C516(0.92)  LDD0895  [15]
 LDCM0298  AC37 HEK-293T C516(0.78)  LDD0896  [15]
 LDCM0299  AC38 HEK-293T C516(1.24)  LDD0897  [15]
 LDCM0300  AC39 HEK-293T C516(1.09)  LDD0898  [15]
 LDCM0301  AC4 HCT 116 C516(0.98)  LDD0618  [15]
 LDCM0302  AC40 HEK-293T C516(1.07)  LDD0900  [15]
 LDCM0303  AC41 HEK-293T C516(0.97)  LDD0901  [15]
 LDCM0304  AC42 HEK-293T C516(1.04)  LDD0902  [15]
 LDCM0305  AC43 HEK-293T C516(1.04)  LDD0903  [15]
 LDCM0306  AC44 HEK-293T C516(0.90)  LDD0904  [15]
 LDCM0307  AC45 HEK-293T C516(1.13)  LDD0905  [15]
 LDCM0308  AC46 HEK-293T C516(0.84)  LDD0906  [15]
 LDCM0309  AC47 HEK-293T C516(0.82)  LDD0907  [15]
 LDCM0310  AC48 HEK-293T C516(0.85)  LDD0908  [15]
 LDCM0311  AC49 HEK-293T C516(0.81)  LDD0909  [15]
 LDCM0312  AC5 HCT 116 C516(0.94)  LDD0629  [15]
 LDCM0313  AC50 HEK-293T C516(0.83)  LDD0911  [15]
 LDCM0314  AC51 HEK-293T C516(0.80)  LDD0912  [15]
 LDCM0315  AC52 HEK-293T C516(0.89)  LDD0913  [15]
 LDCM0316  AC53 HEK-293T C516(1.06)  LDD0914  [15]
 LDCM0317  AC54 HEK-293T C516(0.90)  LDD0915  [15]
 LDCM0318  AC55 HEK-293T C516(0.88)  LDD0916  [15]
 LDCM0319  AC56 HEK-293T C516(0.87)  LDD0917  [15]
 LDCM0320  AC57 HEK-293T C516(1.11)  LDD0918  [15]
 LDCM0321  AC58 HEK-293T C516(1.11)  LDD0919  [15]
 LDCM0322  AC59 HEK-293T C516(1.10)  LDD0920  [15]
 LDCM0323  AC6 HCT 116 C516(1.09)  LDD0640  [15]
 LDCM0324  AC60 HEK-293T C516(0.91)  LDD0922  [15]
 LDCM0325  AC61 HEK-293T C516(0.75)  LDD0923  [15]
 LDCM0326  AC62 HEK-293T C516(0.95)  LDD0924  [15]
 LDCM0327  AC63 HEK-293T C516(0.91)  LDD0925  [15]
 LDCM0328  AC64 HEK-293T C516(0.95)  LDD0926  [15]
 LDCM0329  AC65 HEK-293T C516(0.84)  LDD0927  [15]
 LDCM0330  AC66 HEK-293T C516(1.04)  LDD0928  [15]
 LDCM0331  AC67 HEK-293T C516(0.87)  LDD0929  [15]
 LDCM0332  AC68 HEK-293T C516(0.98)  LDD0930  [15]
 LDCM0333  AC69 HEK-293T C516(1.01)  LDD0931  [15]
 LDCM0334  AC7 HCT 116 C516(0.98)  LDD0651  [15]
 LDCM0335  AC70 HEK-293T C516(0.96)  LDD0933  [15]
 LDCM0336  AC71 HEK-293T C516(1.04)  LDD0934  [15]
 LDCM0337  AC72 HEK-293T C516(1.03)  LDD0935  [15]
 LDCM0338  AC73 HEK-293T C516(1.01)  LDD0936  [15]
 LDCM0339  AC74 HEK-293T C516(1.06)  LDD0937  [15]
 LDCM0340  AC75 HEK-293T C516(1.13)  LDD0938  [15]
 LDCM0341  AC76 HEK-293T C516(1.10)  LDD0939  [15]
 LDCM0342  AC77 HEK-293T C516(1.03)  LDD0940  [15]
 LDCM0343  AC78 HEK-293T C516(0.97)  LDD0941  [15]
 LDCM0344  AC79 HEK-293T C516(1.24)  LDD0942  [15]
 LDCM0345  AC8 HCT 116 C516(1.07)  LDD0662  [15]
 LDCM0346  AC80 HEK-293T C516(0.93)  LDD0944  [15]
 LDCM0347  AC81 HEK-293T C516(1.09)  LDD0945  [15]
 LDCM0348  AC82 HEK-293T C516(1.01)  LDD0946  [15]
 LDCM0349  AC83 HCT 116 C516(1.33)  LDD0666  [15]
 LDCM0350  AC84 HCT 116 C516(1.22)  LDD0667  [15]
 LDCM0351  AC85 HCT 116 C516(1.15)  LDD0668  [15]
 LDCM0352  AC86 HCT 116 C516(1.22)  LDD0669  [15]
 LDCM0353  AC87 HCT 116 C516(1.17)  LDD0670  [15]
 LDCM0354  AC88 HCT 116 C516(1.22)  LDD0671  [15]
 LDCM0355  AC89 HCT 116 C516(1.16)  LDD0672  [15]
 LDCM0357  AC90 HCT 116 C516(1.47)  LDD0674  [15]
 LDCM0358  AC91 HCT 116 C516(1.26)  LDD0675  [15]
 LDCM0359  AC92 HCT 116 C516(1.40)  LDD0676  [15]
 LDCM0360  AC93 HCT 116 C516(1.12)  LDD0677  [15]
 LDCM0361  AC94 HCT 116 C516(1.09)  LDD0678  [15]
 LDCM0362  AC95 HCT 116 C516(1.15)  LDD0679  [15]
 LDCM0363  AC96 HCT 116 C516(1.30)  LDD0680  [15]
 LDCM0364  AC97 HCT 116 C516(1.42)  LDD0681  [15]
 LDCM0365  AC98 HCT 116 C516(0.99)  LDD0682  [15]
 LDCM0366  AC99 HCT 116 C516(0.88)  LDD0683  [15]
 LDCM0248  AKOS034007472 HCT 116 C516(1.01)  LDD0565  [15]
 LDCM0356  AKOS034007680 HCT 116 C516(1.12)  LDD0673  [15]
 LDCM0275  AKOS034007705 HCT 116 C516(1.46)  LDD0592  [15]
 LDCM0156  Aniline NCI-H1299 12.09  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [24]
 LDCM0071  Cisar_cp14 MDA-MB-231 4.34  LDD0121  [7]
 LDCM0367  CL1 HEK-293T C516(0.93)  LDD0965  [15]
 LDCM0368  CL10 HEK-293T C516(0.73)  LDD0966  [15]
 LDCM0369  CL100 HCT 116 C516(0.96)  LDD0686  [15]
 LDCM0370  CL101 HCT 116 C516(1.12)  LDD0687  [15]
 LDCM0371  CL102 HCT 116 C516(1.06)  LDD0688  [15]
 LDCM0372  CL103 HCT 116 C516(0.96)  LDD0689  [15]
 LDCM0373  CL104 HCT 116 C516(1.02)  LDD0690  [15]
 LDCM0374  CL105 HEK-293T C516(0.84)  LDD0972  [15]
 LDCM0375  CL106 HEK-293T C516(0.81)  LDD0973  [15]
 LDCM0376  CL107 HEK-293T C516(0.95)  LDD0974  [15]
 LDCM0377  CL108 HEK-293T C516(0.84)  LDD0975  [15]
 LDCM0378  CL109 HEK-293T C516(0.88)  LDD0976  [15]
 LDCM0379  CL11 HEK-293T C516(0.75)  LDD0977  [15]
 LDCM0380  CL110 HEK-293T C516(0.75)  LDD0978  [15]
 LDCM0381  CL111 HEK-293T C516(1.00)  LDD0979  [15]
 LDCM0382  CL112 PaTu 8988t C516(0.99)  LDD1261  [15]
 LDCM0383  CL113 PaTu 8988t C516(0.97)  LDD1262  [15]
 LDCM0384  CL114 PaTu 8988t C516(1.08)  LDD1263  [15]
 LDCM0385  CL115 PaTu 8988t C516(1.01)  LDD1264  [15]
 LDCM0386  CL116 PaTu 8988t C516(1.10)  LDD1265  [15]
 LDCM0387  CL117 HEK-293T C516(0.99)  LDD0985  [15]
 LDCM0388  CL118 HEK-293T C516(1.06)  LDD0986  [15]
 LDCM0389  CL119 HEK-293T C516(1.08)  LDD0987  [15]
 LDCM0390  CL12 HEK-293T C516(1.03)  LDD0988  [15]
 LDCM0391  CL120 HEK-293T C516(1.01)  LDD0989  [15]
 LDCM0392  CL121 HEK-293T C516(0.78)  LDD0990  [15]
 LDCM0393  CL122 HEK-293T C516(1.05)  LDD0991  [15]
 LDCM0394  CL123 HEK-293T C516(0.76)  LDD0992  [15]
 LDCM0395  CL124 HEK-293T C516(0.89)  LDD0993  [15]
 LDCM0396  CL125 HEK-293T C516(1.01)  LDD0994  [15]
 LDCM0397  CL126 HEK-293T C516(1.10)  LDD0995  [15]
 LDCM0398  CL127 HEK-293T C516(1.06)  LDD0996  [15]
 LDCM0399  CL128 HEK-293T C516(1.05)  LDD0997  [15]
 LDCM0400  CL13 HEK-293T C516(0.96)  LDD0998  [15]
 LDCM0401  CL14 HEK-293T C516(0.92)  LDD0999  [15]
 LDCM0402  CL15 HEK-293T C516(0.87)  LDD1000  [15]
 LDCM0403  CL16 HCT 116 C516(1.46)  LDD0720  [15]
 LDCM0404  CL17 HCT 116 C516(0.72)  LDD0721  [15]
 LDCM0405  CL18 HCT 116 C516(0.80)  LDD0722  [15]
 LDCM0406  CL19 HCT 116 C516(0.88)  LDD0723  [15]
 LDCM0407  CL2 HEK-293T C516(0.95)  LDD1005  [15]
 LDCM0408  CL20 HCT 116 C516(0.91)  LDD0725  [15]
 LDCM0409  CL21 HCT 116 C516(0.78)  LDD0726  [15]
 LDCM0410  CL22 HCT 116 C516(1.23)  LDD0727  [15]
 LDCM0411  CL23 HCT 116 C516(1.48)  LDD0728  [15]
 LDCM0412  CL24 HCT 116 C516(1.65)  LDD0729  [15]
 LDCM0413  CL25 HCT 116 C516(2.41)  LDD0730  [15]
 LDCM0414  CL26 HCT 116 C516(0.98)  LDD0731  [15]
 LDCM0415  CL27 HCT 116 C516(0.81)  LDD0732  [15]
 LDCM0416  CL28 HCT 116 C516(0.85)  LDD0733  [15]
 LDCM0417  CL29 HCT 116 C516(1.14)  LDD0734  [15]
 LDCM0418  CL3 HEK-293T C516(1.06)  LDD1016  [15]
 LDCM0419  CL30 HCT 116 C516(1.37)  LDD0736  [15]
 LDCM0420  CL31 HCT 116 C516(0.98)  LDD0737  [15]
 LDCM0421  CL32 HCT 116 C516(1.15)  LDD0738  [15]
 LDCM0422  CL33 HCT 116 C516(0.91)  LDD0739  [15]
 LDCM0423  CL34 HCT 116 C516(1.17)  LDD0740  [15]
 LDCM0424  CL35 HCT 116 C516(1.04)  LDD0741  [15]
 LDCM0425  CL36 HCT 116 C516(1.20)  LDD0742  [15]
 LDCM0426  CL37 HCT 116 C516(1.15)  LDD0743  [15]
 LDCM0428  CL39 HCT 116 C516(1.09)  LDD0745  [15]
 LDCM0429  CL4 HEK-293T C516(1.37)  LDD1027  [15]
 LDCM0430  CL40 HCT 116 C516(1.04)  LDD0747  [15]
 LDCM0431  CL41 HCT 116 C516(1.14)  LDD0748  [15]
 LDCM0432  CL42 HCT 116 C516(1.30)  LDD0749  [15]
 LDCM0433  CL43 HCT 116 C516(1.55)  LDD0750  [15]
 LDCM0434  CL44 HCT 116 C516(1.33)  LDD0751  [15]
 LDCM0435  CL45 HCT 116 C516(1.28)  LDD0752  [15]
 LDCM0436  CL46 HEK-293T C516(1.25)  LDD1034  [15]
 LDCM0437  CL47 HEK-293T C516(0.84)  LDD1035  [15]
 LDCM0438  CL48 HEK-293T C516(1.14)  LDD1036  [15]
 LDCM0439  CL49 HEK-293T C516(0.79)  LDD1037  [15]
 LDCM0440  CL5 HEK-293T C516(1.11)  LDD1038  [15]
 LDCM0441  CL50 HEK-293T C516(1.02)  LDD1039  [15]
 LDCM0442  CL51 HEK-293T C516(1.07)  LDD1040  [15]
 LDCM0443  CL52 HEK-293T C516(0.88)  LDD1041  [15]
 LDCM0444  CL53 HEK-293T C516(0.73)  LDD1042  [15]
 LDCM0445  CL54 HEK-293T C516(1.02)  LDD1043  [15]
 LDCM0446  CL55 HEK-293T C516(1.16)  LDD1044  [15]
 LDCM0447  CL56 HEK-293T C516(0.95)  LDD1045  [15]
 LDCM0448  CL57 HEK-293T C516(1.43)  LDD1046  [15]
 LDCM0449  CL58 HEK-293T C516(1.26)  LDD1047  [15]
 LDCM0450  CL59 HEK-293T C516(0.98)  LDD1048  [15]
 LDCM0451  CL6 HEK-293T C516(1.07)  LDD1049  [15]
 LDCM0452  CL60 HEK-293T C516(1.01)  LDD1050  [15]
 LDCM0453  CL61 HEK-293T C516(0.95)  LDD1051  [15]
 LDCM0454  CL62 HEK-293T C516(0.89)  LDD1052  [15]
 LDCM0455  CL63 HEK-293T C516(0.80)  LDD1053  [15]
 LDCM0456  CL64 HEK-293T C516(0.96)  LDD1054  [15]
 LDCM0457  CL65 HEK-293T C516(1.01)  LDD1055  [15]
 LDCM0458  CL66 HEK-293T C516(0.93)  LDD1056  [15]
 LDCM0459  CL67 HEK-293T C516(1.16)  LDD1057  [15]
 LDCM0460  CL68 HEK-293T C516(1.01)  LDD1058  [15]
 LDCM0461  CL69 HEK-293T C516(1.06)  LDD1059  [15]
 LDCM0462  CL7 HEK-293T C516(0.98)  LDD1060  [15]
 LDCM0463  CL70 HEK-293T C516(1.11)  LDD1061  [15]
 LDCM0464  CL71 HEK-293T C516(1.15)  LDD1062  [15]
 LDCM0465  CL72 HEK-293T C516(1.01)  LDD1063  [15]
 LDCM0466  CL73 HEK-293T C516(0.96)  LDD1064  [15]
 LDCM0467  CL74 HEK-293T C516(0.75)  LDD1065  [15]
 LDCM0469  CL76 HCT 116 C516(1.51)  LDD0786  [15]
 LDCM0470  CL77 HCT 116 C516(1.53)  LDD0787  [15]
 LDCM0471  CL78 HCT 116 C516(1.51)  LDD0788  [15]
 LDCM0472  CL79 HCT 116 C516(1.98)  LDD0789  [15]
 LDCM0473  CL8 HEK-293T C516(0.88)  LDD1071  [15]
 LDCM0474  CL80 HCT 116 C516(1.26)  LDD0791  [15]
 LDCM0475  CL81 HCT 116 C516(1.53)  LDD0792  [15]
 LDCM0476  CL82 HCT 116 C516(1.70)  LDD0793  [15]
 LDCM0477  CL83 HCT 116 C516(1.76)  LDD0794  [15]
 LDCM0478  CL84 HCT 116 C516(1.27)  LDD0795  [15]
 LDCM0479  CL85 HCT 116 C516(1.61)  LDD0796  [15]
 LDCM0480  CL86 HCT 116 C516(1.12)  LDD0797  [15]
 LDCM0481  CL87 HCT 116 C516(1.35)  LDD0798  [15]
 LDCM0482  CL88 HCT 116 C516(1.79)  LDD0799  [15]
 LDCM0483  CL89 HCT 116 C516(2.25)  LDD0800  [15]
 LDCM0484  CL9 HEK-293T C516(0.99)  LDD1082  [15]
 LDCM0485  CL90 HCT 116 C516(1.15)  LDD0802  [15]
 LDCM0486  CL91 HCT 116 C516(1.00)  LDD0803  [15]
 LDCM0487  CL92 HCT 116 C516(0.98)  LDD0804  [15]
 LDCM0488  CL93 HCT 116 C516(0.87)  LDD0805  [15]
 LDCM0489  CL94 HCT 116 C516(0.91)  LDD0806  [15]
 LDCM0490  CL95 HCT 116 C516(0.98)  LDD0807  [15]
 LDCM0491  CL96 HCT 116 C516(0.91)  LDD0808  [15]
 LDCM0492  CL97 HCT 116 C516(0.84)  LDD0809  [15]
 LDCM0493  CL98 HCT 116 C516(0.94)  LDD0810  [15]
 LDCM0494  CL99 HCT 116 C516(0.84)  LDD0811  [15]
 LDCM0495  E2913 HEK-293T C516(1.08)  LDD1698  [29]
 LDCM0031  Epigallocatechin gallate HEK-293T 34.48  LDD0183  [8]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [11]
 LDCM0625  F8 Ramos C516(1.98)  LDD2187  [30]
 LDCM0576  Fragment14 Ramos C516(0.92)  LDD2193  [30]
 LDCM0586  Fragment28 Ramos C516(0.46)  LDD2198  [30]
 LDCM0468  Fragment33 HEK-293T C516(0.69)  LDD1066  [15]
 LDCM0566  Fragment4 Ramos C516(0.63)  LDD2184  [30]
 LDCM0427  Fragment51 HCT 116 C516(1.36)  LDD0744  [15]
 LDCM0569  Fragment7 Ramos C516(2.47)  LDD2186  [30]
 LDCM0116  HHS-0101 DM93 Y439(0.60); Y449(0.83); Y317(1.17); Y448(1.63)  LDD0264  [13]
 LDCM0117  HHS-0201 DM93 Y317(0.70); Y439(0.71); Y449(0.80); Y448(1.32)  LDD0265  [13]
 LDCM0118  HHS-0301 DM93 Y448(0.62); Y439(0.82); Y449(0.87); Y317(0.88)  LDD0266  [13]
 LDCM0119  HHS-0401 DM93 Y439(0.75); Y448(0.77); Y449(0.83); Y317(0.85)  LDD0267  [13]
 LDCM0120  HHS-0701 DM93 Y449(0.88); Y439(0.99); Y317(1.30); Y448(1.37)  LDD0268  [13]
 LDCM0107  IAA HeLa N.A.  LDD0221  [24]
 LDCM0126  JWB150 DM93 Y317(2.79)  LDD0288  [12]
 LDCM0022  KB02 HCT 116 C516(1.49)  LDD0080  [15]
 LDCM0023  KB03 HCT 116 C516(1.68)  LDD0081  [15]
 LDCM0024  KB05 HCT 116 C516(1.73)  LDD0082  [15]
 LDCM0030  Luteolin HEK-293T 8.84  LDD0182  [8]
 LDCM0109  NEM HeLa N.A.  LDD0223  [24]
 LDCM0032  Oleacein HEK-293T 5.57  LDD0184  [8]
 LDCM0099  Phenelzine MDA-MB-231 6.00  LDD0388  [6]
 LDCM0029  Quercetin HEK-293T 4.12  LDD0181  [8]
 LDCM0131  RA190 MM1.R 2.98  LDD0299  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tyrosine-protein kinase JAK3 (JAK3) Tyr protein kinase family P52333

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
7 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
8 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
11 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
12 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
13 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
14 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
15 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
16 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
17 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
18 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
21 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
22 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
23 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
25 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
26 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
27 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
28 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
29 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
30 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578