Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name DA-P3  Probe Info 
Probe concentration 15 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
LFQ
Competitor Name Oleacein  Competitor Info 
Competitor Concentration 150 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 67 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03540  Heme oxygenase 2 (HMOX2) 15.1
 LDTP00751  Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) 14.8
 LDTP09412  Serine/threonine-protein kinase Nek9 (NEK9) 13.4
 LDTP03003  Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2) 12.2
 LDTP08615  Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 (RPAP2) 12.1
 LDTP08023  Elongation factor-like GTPase 1 (EFL1) 11.9
 LDTP13112  Phosphatidylinositol 4-kinase beta (PI4KB) 11.6
 LDTP00999  GDP-mannose 4,6 dehydratase (GMDS) 11.4
 LDTP02770  Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) 11.3
 LDTP01435  Phospholipase DDHD2 (DDHD2) 10.8
 LDTP14064  TNF receptor-associated factor 6 (TRAF6) 10.7
 LDTP04435  Interleukin-1 receptor-associated kinase 1 (IRAK1) 10.4
 LDTP11571  Uridine-cytidine kinase 2 (UCK2) 10.3
 LDTP10500  Lymphokine-activated killer T-cell-originated protein kinase (PBK) 10.3
 LDTP12599  Ubiquitin-like-conjugating enzyme ATG3 (ATG3) 10.1
 LDTP00544  Sphingolipid delta(4)-desaturase DES1 (DEGS1) 9.9
 LDTP13682  Transcription termination factor 2 (TTF2) 9.4
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) 9.4
 LDTP07515  tRNA N(3)-methylcytidine methyltransferase METTL2B (METTL2B) 9.3
 LDTP02984  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) 9.3
 LDTP12364  Inositol-3-phosphate synthase 1 (ISYNA1) 9.1
 LDTP14159  Ubiquitin carboxyl-terminal hydrolase 16 (USP16) 9.1
 LDTP00497  Cyclin-G-associated kinase (GAK) 8.0
 LDTP08231  E3 ubiquitin-protein ligase ZNF598 (ZNF598) 7.5
 LDTP02696  Glycogen [starch] synthase, muscle (GYS1) 7.4
 LDTP04185  Glutamate--cysteine ligase catalytic subunit (GCLC) 7.3
 LDTP00837  Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1) 7.0
 LDTP06190  Ubiquitin carboxyl-terminal hydrolase 10 (USP10) 6.9
 LDTP14415  GTP-binding protein 1 (GTPBP1) 6.8
 LDTP14535  6-phosphogluconolactonase (PGLS) 6.8
 LDTP00758  Thioredoxin-like protein 1 (TXNL1) 6.8
 LDTP19838  Immunity-related GTPase family Q protein (IRGQ) 6.7
 LDTP00747  Mitogen-activated protein kinase kinase kinase 7 (MAP3K7) 6.3
 LDTP02000  3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) 6.0
 LDTP11601  (E3-independent) E2 ubiquitin-conjugating enzyme (UBE2O) 6.0
 LDTP02922  CTP synthase 1 (CTPS1) 6.0
 LDTP03084  Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) 5.8
 LDTP09792  Inositol hexakisphosphate kinase 1 (IP6K1) 5.8
 LDTP07171  Terminal uridylyltransferase 4 (TUT4) 5.6
 LDTP04519  Kinesin-like protein KIF11 (KIF11) 5.4
 LDTP02602  Histidine--tRNA ligase, cytoplasmic (HARS1) 5.4
 LDTP12312  Ras-related protein Rab-18 (RAB18) 5.3
 LDTP13733  Endoribonuclease Dicer (DICER1) 5.3
 LDTP11909  Serine/threonine-protein kinase WNK1 (WNK1) 5.2
 LDTP07118  E3 ubiquitin-protein ligase UBR4 (UBR4) 5.2
 LDTP05475  Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) 5.0
 LDTP11819  STE20-like serine/threonine-protein kinase (SLK) 4.9
 LDTP00013  Ubiquitin-like modifier-activating enzyme 6 (UBA6) 4.9
 LDTP11299  Serine/threonine-protein kinase RIO2 (RIOK2) 4.9
 LDTP06270  Signal peptidase complex subunit 2 (SPCS2) 4.8
 LDTP10809  SRSF protein kinase 1 (SRPK1) 4.7
 LDTP05481  Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (GFPT1) 4.6
 LDTP18530  Protein NDRG3 (NDRG3) 4.5
 LDTP11266  tRNA (guanine(6)-N2)-methyltransferase THUMP3 (THUMPD3) 4.4
 LDTP03938  N-alpha-acetyltransferase 10 (NAA10) 4.3
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) 4.3
 LDTP09487  tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 (NSUN6) 4.2
 LDTP06199  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) 4.2
 LDTP14065  Mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5) 4.2
 LDTP00225  26S proteasome non-ATPase regulatory subunit 9 (PSMD9) 4.2
 LDTP06142  Squalene monooxygenase (SQLE) 4.1
 LDTP03259  Ribonucleoside-diphosphate reductase large subunit (RRM1) 4.1
 LDTP02264  Asparagine synthetase [glutamine-hydrolyzing] (ASNS) 4.1
 LDTP00694  E3 ubiquitin-protein ligase Praja-2 (PJA2) 4.1
 LDTP07502  Putative ATP-dependent RNA helicase DHX57 (DHX57) 4.0
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 4.0
 LDTP03420  Glutathione S-transferase Mu 2 (GSTM2) 4.0
Transporter and channel
Click to Show/Hide to Show 15 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00958  TBC1 domain family member 4 (TBC1D4) 18.5
 LDTP04770  Syntaxin-17 (STX17) 13.7
 LDTP08040  Zinc finger FYVE domain-containing protein 16 (ZFYVE16) 13.6
 LDTP02330  Signal recognition particle 19 kDa protein (SRP19) 11.6
 LDTP09352  DnaJ homolog subfamily B member 14 (DNAJB14) 10.1
 LDTP12281  Golgi-associated PDZ and coiled-coil motif-containing protein (GOPC) 8.7
 LDTP05938  Sorting nexin-1 (SNX1) 6.2
 LDTP12292  Junctophilin-1 (JPH1) 6.1
 LDTP11161  Extended synaptotagmin-1 (ESYT1) 5.3
 LDTP04597  Methylosome subunit pICln (CLNS1A) 4.7
 LDTP06633  Reticulon-1 (RTN1) 4.7
 LDTP13415  ADP-ribosylation factor-binding protein GGA1 (GGA1) 4.5
 LDTP02009  Cystatin-B (CSTB) 4.3
 LDTP01380  Wolframin (WFS1) 4.3
 LDTP01475  WD repeat-containing protein 47 (WDR47) 4.3
Transcription factor
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05254  Nuclear factor NF-kappa-B p100 subunit (NFKB2) 19.7
 LDTP03903  Signal transducer and activator of transcription 3 (STAT3) 12.5
 LDTP10039  Myocardin-related transcription factor A (MRTFA) 8.4
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09680  Palladin (PALLD) 16.6
Other
Click to Show/Hide to Show 92 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01177  Hyaluronan mediated motility receptor (HMMR) 39.6
 LDTP06515  Coiled-coil domain-containing protein 6 (CCDC6) 32.0
 LDTP04112  Microtubule-associated protein 1B (MAP1B) 29.9
 LDTP07476  RAD50-interacting protein 1 (RINT1) 28.6
 LDTP11367  Oxysterol-binding protein-related protein 11 (OSBPL11) 28.4
 LDTP03719  Serpin B6 (SERPINB6) 15.6
 LDTP19787  RING finger protein 214 (RNF214) 15.5
 LDTP08069  HAUS augmin-like complex subunit 6 (HAUS6) 15.3
 LDTP15057  TBC1 domain family member 9B (TBC1D9B) 14.8
 LDTP09049  NHL repeat-containing protein 2 (NHLRC2) 14.7
 LDTP00039  SH3 and PX domain-containing protein 2B (SH3PXD2B) 13.5
 LDTP13710  Trinucleotide repeat-containing gene 6B protein (TNRC6B) 12.5
 LDTP01684  BAG family molecular chaperone regulator 3 (BAG3) 11.9
 LDTP16155  Opioid growth factor receptor (OGFR) 11.3
 LDTP08950  ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1) 11.2
 LDTP15727  Protein LTV1 homolog (LTV1) 11.1
 LDTP03151  Oxysterol-binding protein 1 (OSBP) 10.6
 LDTP07297  Microtubule-associated protein 1S (MAP1S) 10.5
 LDTP08535  MAP7 domain-containing protein 3 (MAP7D3) 10.4
 LDTP12077  Jupiter microtubule associated homolog 2 (JPT2) 10.3
 LDTP10656  Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP3) 10.3
 LDTP01151  Serine/threonine-protein phosphatase 6 regulatory subunit 2 (PPP6R2) 10.2
 LDTP09828  Ankyrin repeat and SAM domain-containing protein 1A (ANKS1A) 9.9
 LDTP07061  Synaptosomal-associated protein 47 (SNAP47) 9.8
 LDTP13525  Muskelin (MKLN1) 8.9
 LDTP00737  Centriolar coiled-coil protein of 110 kDa (CCP110) 8.5
 LDTP12443  Anillin (ANLN) 8.4
 LDTP00019  Shootin-1 (SHTN1) 8.4
 LDTP18272  Transmembrane protein 209 (TMEM209) 8.3
 LDTP07124  Rho GTPase-activating protein 21 (ARHGAP21) 8.3
 LDTP06268  Condensin complex subunit 2 (NCAPH) 8.1
 LDTP12000  RNA polymerase II-associated protein 3 (RPAP3) 7.8
 LDTP17214  Protein odr-4 homolog (ODR4) 7.6
 LDTP08095  Coiled-coil domain-containing protein R3HCC1L (R3HCC1L) 7.3
 LDTP07132  Ubiquitin-associated protein 2 (UBAP2) 7.3
 LDTP16116  BSD domain-containing protein 1 (BSDC1) 7.2
 LDTP13916  Calcium-regulated heat-stable protein 1 (CARHSP1) 7.0
 LDTP15705  BTB/POZ domain-containing protein KCTD12 (KCTD12) 7.0
 LDTP07348  Cytospin-A (SPECC1L) 6.9
 LDTP08888  Oxidation resistance protein 1 (OXR1) 6.8
 LDTP10753  Sperm-associated antigen 5 (SPAG5) 6.6
 LDTP01677  Double-stranded RNA-binding protein Staufen homolog 1 (STAU1) 6.5
 LDTP12448  Gephyrin (GPHN) 6.4
 LDTP15947  Mitochondrial fission regulator 1-like (MTFR1L) 6.3
 LDTP04560  Cytosolic Fe-S cluster assembly factor NUBP1 (NUBP1) 6.3
 LDTP07598  BRCA1-associated ATM activator 1 (BRAT1) 6.2
 LDTP14978  Protein PRRC2B (PRRC2B) 6.2
 LDTP06527  Alpha-internexin (INA) 6.2
 LDTP11870  BolA-like protein 2 (BOLA2; BOLA2B) 6.1
 LDTP06383  Calponin-3 (CNN3) 6.1
 LDTP12640  Gamma-taxilin (TXLNG) 6.0
 LDTP19626  Glucocorticoid-induced transcript 1 protein (GLCCI1) 5.9
 LDTP09118  SLAIN motif-containing protein 1 (SLAIN1) 5.9
 LDTP12865  G2 and S phase-expressed protein 1 (GTSE1) 5.9
 LDTP08325  Zinc finger C3HC-type protein 1 (ZC3HC1) 5.8
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) 5.8
 LDTP13241  LIM domain-containing protein 1 (LIMD1) 5.8
 LDTP11327  RNA polymerase II-associated protein 1 (RPAP1) 5.7
 LDTP01129  CLIP-associating protein 2 (CLASP2) 5.7
 LDTP13657  Melanoma-associated antigen D2 (MAGED2) 5.6
 LDTP13402  Dynactin subunit 4 (DCTN4) 5.6
 LDTP03404  Microtubule-associated protein 4 (MAP4) 5.5
 LDTP06255  GTPase-activating protein and VPS9 domain-containing protein 1 (GAPVD1) 5.4
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) 5.4
 LDTP12025  UPF0488 protein C8orf33 (C8orf33) 5.3
 LDTP00755  WD repeat-containing protein 62 (WDR62) 5.3
 LDTP13007  Calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1) 5.2
 LDTP08795  GH3 domain-containing protein (GHDC) 5.2
 LDTP01210  Transforming acidic coiled-coil-containing protein 1 (TACC1) 5.2
 LDTP01285  TIP41-like protein (TIPRL) 5.1
 LDTP06439  Thyroid receptor-interacting protein 6 (TRIP6) 5.1
 LDTP09512  Partitioning defective 3 homolog (PARD3) 5.1
 LDTP01511  Elongator complex protein 1 (ELP1) 5.0
 LDTP04935  Prefoldin subunit 3 (VBP1) 5.0
 LDTP09363  TBC1 domain family member 15 (TBC1D15) 4.9
 LDTP10435  PRKC apoptosis WT1 regulator protein (PAWR) 4.9
 LDTP03426  Protein ITPRID2 (ITPRID2) 4.8
 LDTP06983  Serine/threonine-protein phosphatase 6 regulatory subunit 3 (PPP6R3) 4.6
 LDTP06094  Src substrate cortactin (CTTN) 4.6
 LDTP09504  Gem-associated protein 5 (GEMIN5) 4.6
 LDTP19976  Leucine-rich repeat-containing protein 40 (LRRC40) 4.5
 LDTP06886  Centrosomal protein of 55 kDa (CEP55) 4.3
 LDTP09655  Ataxin-2-like protein (ATXN2L) 4.3
 LDTP11695  Kinesin light chain 2 (KLC2) 4.2
 LDTP18337  Guanine nucleotide-binding protein subunit beta-like protein 1 (GNB1L) 4.2
 LDTP09008  Probable RNA-binding protein EIF1AD (EIF1AD) 4.2
 LDTP10417  DISP complex protein LRCH3 (LRCH3) 4.1
 LDTP04199  Protein PRRC2A (PRRC2A) 4.1
 LDTP08523  Centrosomal protein of 97 kDa (CEP97) 4.1
 LDTP01678  Tetratricopeptide repeat protein 4 (TTC4) 4.1
 LDTP13913  Inner nuclear membrane protein Man1 (LEMD3) 4.1
 LDTP10361  BLOC-1-related complex subunit 6 (BORCS6) 4.0

References

1 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348