Details of the Target

General Information of Target

Target ID LDTP13916
Target Name Calcium-regulated heat-stable protein 1 (CARHSP1)
Gene Name CARHSP1
Gene ID 23589
Synonyms
Calcium-regulated heat-stable protein 1; Calcium-regulated heat-stable protein of 24 kDa; CRHSP-24
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MILTKAQYDEIAQCLVSVPPTRQSLRKLKQRFPSQSQATLLSIFSQEYQKHIKRTHAKHH
TSEAIESYYQRYLNGVVKNGAAPVLLDLANEVDYAPSLMARLILERFLQEHEETPPSKSI
INSMLRDPSQIPDGVLANQVYQCIVNDCCYGPLVDCIKHAIGHEHEVLLRDLLLEKNLSF
LDEDQLRAKGYDKTPDFILQVPVAVEGHIIHWIESKASFGDECSHHAYLHDQFWSYWNRF
GPGLVIYWYGFIQELDCNRERGILLKACFPTNIVTLCHSIA
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro).
Uniprot ID
Q9Y2V2
Ensemble ID
ENST00000311052.10
HGNC ID
HGNC:17150

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DAyne
 Probe Info  		3.35  LDD0261  [2]
DA-P2
 Probe Info  		4.84  LDD0348  [3]
TG42
 Probe Info  		4.61  LDD0043  [4]
TH211
 Probe Info  		Y99(14.12)  LDD0257  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
STPyne
 Probe Info  		K74(0.68)  LDD2217  [7]
DBIA
 Probe Info  		C112(1.25)  LDD3314  [8]
DA-P3
 Probe Info  		5.61  LDD0180  [3]
IPM
 Probe Info  		C112(1.03)  LDD1702  [9]
5E-2FA
 Probe Info  		H143(0.00); H130(0.00); H14(0.00)  LDD2235  [10]
ATP probe
 Probe Info  		N.A.  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [12]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [12]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [12]
NAIA_4
 Probe Info  		C67(0.00); C112(0.00)  LDD2226  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [14]
Acrolein
 Probe Info  		N.A.  LDD0217  [15]
AOyne
 Probe Info  		15.00  LDD0443  [16]
NAIA_5
 Probe Info  		C67(0.00); C112(0.00)  LDD2223  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C112(1.00)  LDD1507  [17]
 LDCM0215  AC10 HEK-293T C112(0.94)  LDD1508  [17]
 LDCM0226  AC11 HEK-293T C112(1.01)  LDD1509  [17]
 LDCM0237  AC12 HEK-293T C112(1.12)  LDD1510  [17]
 LDCM0259  AC14 HEK-293T C112(1.01)  LDD1512  [17]
 LDCM0270  AC15 HEK-293T C112(1.11)  LDD1513  [17]
 LDCM0276  AC17 HEK-293T C112(0.97)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C112(1.05)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C112(0.90)  LDD1517  [17]
 LDCM0279  AC2 HEK-293T C112(1.03)  LDD1518  [17]
 LDCM0280  AC20 HEK-293T C112(1.11)  LDD1519  [17]
 LDCM0281  AC21 HEK-293T C112(1.06)  LDD1520  [17]
 LDCM0282  AC22 HEK-293T C112(0.97)  LDD1521  [17]
 LDCM0283  AC23 HEK-293T C112(1.07)  LDD1522  [17]
 LDCM0284  AC24 HEK-293T C112(1.11)  LDD1523  [17]
 LDCM0285  AC25 HEK-293T C112(0.99)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C112(1.02)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C112(0.96)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C112(1.04)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C112(1.02)  LDD1528  [17]
 LDCM0290  AC3 HEK-293T C112(0.97)  LDD1529  [17]
 LDCM0291  AC30 HEK-293T C112(1.04)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C112(1.01)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C112(1.04)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C112(1.08)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C112(1.05)  LDD1534  [17]
 LDCM0296  AC35 HEK-293T C112(1.03)  LDD1535  [17]
 LDCM0297  AC36 HEK-293T C112(1.08)  LDD1536  [17]
 LDCM0298  AC37 HEK-293T C112(1.10)  LDD1537  [17]
 LDCM0299  AC38 HEK-293T C112(1.04)  LDD1538  [17]
 LDCM0300  AC39 HEK-293T C112(1.06)  LDD1539  [17]
 LDCM0301  AC4 HEK-293T C112(1.02)  LDD1540  [17]
 LDCM0302  AC40 HEK-293T C112(1.10)  LDD1541  [17]
 LDCM0303  AC41 HEK-293T C112(1.09)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C112(1.01)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C112(1.03)  LDD1544  [17]
 LDCM0306  AC44 HEK-293T C112(1.13)  LDD1545  [17]
 LDCM0307  AC45 HEK-293T C112(1.06)  LDD1546  [17]
 LDCM0308  AC46 HEK-293T C112(1.05)  LDD1547  [17]
 LDCM0309  AC47 HEK-293T C112(1.01)  LDD1548  [17]
 LDCM0310  AC48 HEK-293T C112(1.10)  LDD1549  [17]
 LDCM0311  AC49 HEK-293T C112(0.99)  LDD1550  [17]
 LDCM0312  AC5 HEK-293T C112(1.05)  LDD1551  [17]
 LDCM0313  AC50 HEK-293T C112(0.98)  LDD1552  [17]
 LDCM0314  AC51 HEK-293T C112(1.00)  LDD1553  [17]
 LDCM0315  AC52 HEK-293T C112(1.02)  LDD1554  [17]
 LDCM0316  AC53 HEK-293T C112(1.06)  LDD1555  [17]
 LDCM0317  AC54 HEK-293T C112(1.03)  LDD1556  [17]
 LDCM0318  AC55 HEK-293T C112(1.04)  LDD1557  [17]
 LDCM0319  AC56 HEK-293T C112(1.05)  LDD1558  [17]
 LDCM0320  AC57 HEK-293T C112(0.98)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C112(0.98)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C112(1.00)  LDD1561  [17]
 LDCM0323  AC6 HEK-293T C112(1.03)  LDD1562  [17]
 LDCM0324  AC60 HEK-293T C112(1.06)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C112(0.98)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C112(1.03)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C112(1.04)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C112(1.05)  LDD1567  [17]
 LDCM0334  AC7 HEK-293T C112(1.03)  LDD1568  [17]
 LDCM0345  AC8 HEK-293T C112(1.09)  LDD1569  [17]
 LDCM0248  AKOS034007472 HEK-293T C112(1.04)  LDD1511  [17]
 LDCM0356  AKOS034007680 HEK-293T C112(1.03)  LDD1570  [17]
 LDCM0275  AKOS034007705 HEK-293T C112(1.08)  LDD1514  [17]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [15]
 LDCM0367  CL1 HEK-293T C112(1.25)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C112(0.88)  LDD1572  [17]
 LDCM0369  CL100 HEK-293T C112(0.97)  LDD1573  [17]
 LDCM0370  CL101 HEK-293T C112(1.04)  LDD1574  [17]
 LDCM0371  CL102 HEK-293T C112(0.95)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C112(1.07)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C112(1.05)  LDD1577  [17]
 LDCM0374  CL105 HEK-293T C112(1.12)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C112(0.95)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C112(1.08)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C112(0.98)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C112(1.09)  LDD1582  [17]
 LDCM0379  CL11 HEK-293T C112(1.11)  LDD1583  [17]
 LDCM0380  CL110 HEK-293T C112(0.96)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C112(1.01)  LDD1585  [17]
 LDCM0382  CL112 HEK-293T C112(0.91)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C112(1.09)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C112(0.92)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C112(1.00)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C112(0.99)  LDD1590  [17]
 LDCM0387  CL117 HEK-293T C112(1.17)  LDD1591  [17]
 LDCM0388  CL118 HEK-293T C112(0.97)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C112(1.07)  LDD1593  [17]
 LDCM0390  CL12 HEK-293T C112(1.00)  LDD1594  [17]
 LDCM0391  CL120 HEK-293T C112(1.13)  LDD1595  [17]
 LDCM0392  CL121 HEK-293T C112(1.15)  LDD1596  [17]
 LDCM0393  CL122 HEK-293T C112(0.99)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C112(0.95)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C112(1.05)  LDD1599  [17]
 LDCM0396  CL125 HEK-293T C112(1.09)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C112(0.95)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C112(0.99)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C112(1.01)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C112(1.20)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C112(0.99)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C112(1.00)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C112(1.09)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C112(0.95)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C112(1.05)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C112(1.13)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C112(0.98)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C112(1.07)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C112(1.02)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C112(1.06)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C112(1.10)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C112(1.03)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C112(1.13)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C112(1.02)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C112(1.04)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C112(1.04)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C112(1.13)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C112(1.15)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C112(1.11)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C112(1.05)  LDD1624  [17]
 LDCM0421  CL32 HEK-293T C112(1.07)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C112(0.97)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C112(1.02)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C112(1.04)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C112(1.03)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C112(1.09)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C112(1.06)  LDD1632  [17]
 LDCM0429  CL4 HEK-293T C112(1.02)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C112(1.06)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C112(0.91)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C112(1.04)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C112(1.06)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C112(1.10)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C112(1.02)  LDD1639  [17]
 LDCM0436  CL46 HEK-293T C112(1.09)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C112(1.10)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C112(1.07)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C112(1.30)  LDD1643  [17]
 LDCM0440  CL5 HEK-293T C112(1.02)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C112(1.06)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C112(0.99)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C112(0.96)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C112(0.98)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C112(1.04)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C112(1.20)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C112(0.99)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C112(1.04)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C112(1.07)  LDD1653  [17]
 LDCM0451  CL6 HEK-293T C112(0.90)  LDD1654  [17]
 LDCM0452  CL60 HEK-293T C112(1.13)  LDD1655  [17]
 LDCM0453  CL61 HEK-293T C112(1.16)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C112(1.04)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C112(0.96)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C112(1.02)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C112(1.04)  LDD1660  [17]
 LDCM0458  CL66 HEK-293T C112(1.13)  LDD1661  [17]
 LDCM0459  CL67 HEK-293T C112(0.98)  LDD1662  [17]
 LDCM0460  CL68 HEK-293T C112(1.05)  LDD1663  [17]
 LDCM0461  CL69 HEK-293T C112(1.05)  LDD1664  [17]
 LDCM0462  CL7 HEK-293T C112(0.95)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C112(1.05)  LDD1666  [17]
 LDCM0464  CL71 HEK-293T C112(1.17)  LDD1667  [17]
 LDCM0465  CL72 HEK-293T C112(1.09)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C112(1.08)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C112(0.97)  LDD1670  [17]
 LDCM0469  CL76 HEK-293T C112(1.05)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C112(0.99)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C112(1.03)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C112(1.09)  LDD1675  [17]
 LDCM0473  CL8 HEK-293T C112(0.83)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C112(1.10)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C112(1.10)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C112(1.08)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C112(1.13)  LDD1680  [17]
 LDCM0478  CL84 HEK-293T C112(1.04)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C112(1.46)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C112(1.03)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C112(1.15)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C112(1.05)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C112(1.05)  LDD1686  [17]
 LDCM0484  CL9 HEK-293T C112(1.08)  LDD1687  [17]
 LDCM0485  CL90 HEK-293T C112(0.88)  LDD1688  [17]
 LDCM0486  CL91 HEK-293T C112(1.01)  LDD1689  [17]
 LDCM0487  CL92 HEK-293T C112(1.06)  LDD1690  [17]
 LDCM0488  CL93 HEK-293T C112(0.96)  LDD1691  [17]
 LDCM0489  CL94 HEK-293T C112(1.10)  LDD1692  [17]
 LDCM0490  CL95 HEK-293T C112(1.06)  LDD1693  [17]
 LDCM0491  CL96 HEK-293T C112(1.04)  LDD1694  [17]
 LDCM0492  CL97 HEK-293T C112(1.01)  LDD1695  [17]
 LDCM0493  CL98 HEK-293T C112(0.98)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C112(1.05)  LDD1697  [17]
 LDCM0028  Dobutamine HEK-293T 5.61  LDD0180  [3]
 LDCM0495  E2913 HEK-293T C112(1.14)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C112(1.03)  LDD1702  [9]
 LDCM0572  Fragment10 Ramos C112(2.78)  LDD2189  [18]
 LDCM0574  Fragment12 Ramos C112(0.46)  LDD2191  [18]
 LDCM0579  Fragment20 Ramos C112(2.12)  LDD2194  [18]
 LDCM0580  Fragment21 Ramos C112(0.53)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C112(3.36)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C112(0.55)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C112(0.65)  LDD2198  [18]
 LDCM0589  Fragment31 Ramos C112(0.59)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C112(3.76)  LDD2201  [18]
 LDCM0468  Fragment33 HEK-293T C112(1.12)  LDD1671  [17]
 LDCM0596  Fragment38 Ramos C112(0.70)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C112(0.49)  LDD2184  [18]
 LDCM0427  Fragment51 HEK-293T C112(1.11)  LDD1631  [17]
 LDCM0610  Fragment52 Ramos C112(0.86)  LDD2204  [18]
 LDCM0569  Fragment7 Ramos C112(0.70)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C112(1.92)  LDD2188  [18]
 LDCM0107  IAA HeLa N.A.  LDD0221  [15]
 LDCM0022  KB02 HEK-293T C112(1.13)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C112(1.10)  LDD1497  [17]
 LDCM0024  KB05 IGR37 C112(1.25)  LDD3314  [8]
 LDCM0109  NEM HeLa N.A.  LDD0223  [15]
 LDCM0032  Oleacein HEK-293T 7.01  LDD0184  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) Phosphatase 2A regulatory subunit A family P30153
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
A-kinase anchor protein 8-like (AKAP8L) AKAP95 family Q9ULX6
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Dedicator of cytokinesis protein 8 (DOCK8) DOCK family Q8NF50
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
TNF receptor-associated factor 1 (TRAF1) . Q13077

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
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Mass spectrometry data entry: PXD043348
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Mass spectrometry data entry: PXD010277
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Mass spectrometry data entry: PXD047840
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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD042377
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD033004
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578