Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name DAyne  Probe Info 
Probe concentration 10 uM
Criteria Quantification: Probe vs DMSO
Quantitative Method
LFQ
In Vivo Experiment Model Model Type Living cell
Derived Tissue Adrenal
Disease Model Bone marrow neuroblastoma [ICD11: 2A00]
Model Name Human neuroblastoma cells (SH-SY5Y)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 14 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06078  Dihydropyrimidinase-related protein 1 (CRMP1) 4.4
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) 4.1
 LDTP02222  Bifunctional glutamate/proline--tRNA ligase (EPRS1) 3.5
 LDTP02733  Pyruvate kinase PKM (PKM) 3.5
 LDTP02770  Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) 3.4
 LDTP02331  Dopamine beta-hydroxylase (DBH) 3.2
 LDTP08135  E3 ubiquitin-protein ligase HUWE1 (HUWE1) 3.1
 LDTP04310  E3 SUMO-protein ligase RanBP2 (RANBP2) 3.1
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) 3.0
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) 2.9
 LDTP06190  Ubiquitin carboxyl-terminal hydrolase 10 (USP10) 2.7
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 2.5
 LDTP02188  Protein disulfide-isomerase (P4HB) 2.2
 LDTP19838  Immunity-related GTPase family Q protein (IRGQ) 2.1
Transporter and channel
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03107  Filamin-A (FLNA) 2.6
 LDTP02915  Neuromodulin (GAP43) 2.3
 LDTP05252  Clathrin heavy chain 1 (CLTC) 2.3
Other
Click to Show/Hide to Show 19 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) 5.1
 LDTP03404  Microtubule-associated protein 4 (MAP4) 5.0
 LDTP03244  Cofilin-1 (CFL1) 4.7
 LDTP04112  Microtubule-associated protein 1B (MAP1B) 4.2
 LDTP04206  Nestin (NES) 3.4
 LDTP13916  Calcium-regulated heat-stable protein 1 (CARHSP1) 3.4
 LDTP05280  Serine/arginine-rich splicing factor 2 (SRSF2) 3.1
 LDTP06094  Src substrate cortactin (CTTN) 3.0
 LDTP02540  Microtubule-associated protein 2 (MAP2) 2.8
 LDTP14085  Protein PRRC2C (PRRC2C) 2.7
 LDTP16652  Retrotransposon-like protein 1 (RTL1) 2.7
 LDTP06383  Calponin-3 (CNN3) 2.6
 LDTP03982  Epidermal growth factor receptor substrate 15 (EPS15) 2.4
 LDTP08058  Mitochondrial antiviral-signaling protein (MAVS) 2.4
 LDTP19610  Uncharacterized protein C11orf96 (C11orf96) 2.3
 LDTP04935  Prefoldin subunit 3 (VBP1) 2.3
 LDTP07605  La-related protein 1 (LARP1) 2.1
 LDTP06527  Alpha-internexin (INA) 2.1
 LDTP12214  Echinoderm microtubule-associated protein-like 4 (EML4) 2.0

References

1 Proteome-Wide Profiling of Cellular Targets Modified by Dopamine Metabolites Using a Bio-Orthogonally Functionalized Catecholamine. ACS Chem Biol. 2021 Nov 19;16(11):2581-2594. doi: 10.1021/acschembio.1c00629. Epub 2021 Nov 2.