Details of the Target

General Information of Target

Target ID LDTP02540
Target Name Microtubule-associated protein 2 (MAP2)
Gene Name MAP2
Gene ID 4133
Synonyms
Microtubule-associated protein 2; MAP-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADERKDEAKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGE
HGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQT
AALPLAAEETANLPPSPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEK
ESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHTLVASLEDMKQK
TEPSLVVPGIDLPKEPPTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPMREKDVFDD
IPKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFLQPDDKKSLQQTSGPA
TAKDSFKIEEPHEAKPDKMAEAPPSEAMTLPKDAHIPVVEEHVMGKVLEEEKEAINQETV
QQRDTFTPSGQEPILTEKETELKLEEKTTISDKEAVPKESKPPKPADEEIGIIQTSTEHT
FSEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEPSALIEKSSIQELFEMR
VDDKDKIEGVGAATSAELDMPFYEDKSGMSKYFETSALKEEATKSIEPGSDYYELSDTRE
SVHESIDTMSPMHKNGDKEFQTGKESQPSPPAQEAGYSTLAQSYPSDLPEEPSSPQERMF
TIDPKVYGEKRDLHSKNKDDLTLSRSLGLGGRSAIEQRSMSINLPMSCLDSIALGFNFGR
GHDLSPLASDILTNTSGSMDEGDDYLPATTPALEKAPCFPVESKEEEQIEKVKATGEEST
QAEISCESPFLAKDFYKNGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSVPSETVV
EDSRTGLPPVTDENHVIVKTDSQLEDLGYCVFNKYTVPLPSPVQDSENLSGESGTFYEGT
DDKVRRDLATDLSLIEVKLAAAGRVKDEFSVDKEASAHISGDKSGLSKEFDQEKKANDRL
DTVLEKSEEHADSKEHAKKTEEAGDEIETFGLGVTYEQALAKDLSIPTDASSEKAEKGLS
SVPEIAEVEPSKKVEQGLDFAVQGQLDVKISDFGQMASGLNIDDRRATELKLEATQDMTP
SSKAPQEADAFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHESL
TMESLKADEGKKETSPESSLIQDEIAVKLSVEIPCPPAVSEADLATDERADVQMEFIQGP
KEESKETPDISITPSDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLLFRSDTLQITDL
GVSGAREEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEVE
RRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPASPEREEVALSEYKTETYDDYKDETTIDD
SIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKPFKTGRGRIST
PERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTRPTHLS
CVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDE
NSFSLNSSISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTP
SYPRTPHTPGTPKSAILVPSEKKVAIIRTPPKSPATPKQLRLINQPLPDLKNVKSKIGST
DNIKYQPKGGQVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKV
GSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGAEIITQSPGRSSVASPRRLSNVSSS
GSINLLESPQLATLAEDVTAALAKQGL
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton
Function The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
Uniprot ID
P11137
Ensemble ID
ENST00000199940.10
HGNC ID
HGNC:6839
ChEMBL ID
CHEMBL2390810

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.S1608R .
CCLP1 SNV: p.E1449K DBIA    Probe Info 
COLO320 SNV: p.D1380E .
DETROIT562 SNV: p.P49A .
HCT15 SNV: p.Q633H .
HDMYZ SNV: p.A1337V .
HEC1 SNV: p.L1249F .
HT115 SNV: p.T1705A
Substitution: p.A829F		 .
ICC106 SNV: p.Y1685Ter .
ICC9 SNV: p.P1666T .
IGR1 Substitution: p.K530I DBIA    Probe Info 
KATOIII SNV: p.S862G .
LN18 SNV: p.Y897Ter; p.K903N .
MCC13 SNV: p.P208S; p.P1623L .
MCC26 SNV: p.D349N .
MEWO SNV: p.S785L; p.L1140F; p.R1426K DBIA    Probe Info 
MOLT4 SNV: p.P138L; p.P880S .
NCIH1793 Insertion: p.I1601HfsTer21 .
NCIH1993 SNV: p.R720L .
NCIH2286 SNV: p.P1354L; p.Q1665Ter DBIA    Probe Info 
P31FUJ Insertion: p.T1474NfsTer22 .
PANC0403 SNV: p.L1119V DBIA    Probe Info 
RKO SNV: p.I1210T .
SJSA1 Substitution: p.G846I .
SKMEL28 SNV: p.T800S DBIA    Probe Info 
SNGM Insertion: p.T1474NfsTer22 .
SNU1 SNV: p.A526V .
SW1990 SNV: p.T216M .
SW403 SNV: p.K1633R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DAyne
 Probe Info  		2.79  LDD0261  [1]
DBIA
 Probe Info  		C758(1.50)  LDD3311  [2]
Acrolein
 Probe Info  		H395(0.00); H402(0.00)  LDD0233  [3]
IA-alkyne
 Probe Info  		C870(0.00); C1273(0.00)  LDD0162  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 42-MG-BA C758(1.71)  LDD2244  [2]
 LDCM0023  KB03 A204 C1175(0.71); C708(1.47)  LDD2669  [2]
 LDCM0024  KB05 G361 C758(1.50)  LDD3311  [2]
 LDCM0109  NEM HeLa H395(0.00); H402(0.00)  LDD0233  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein E (APOE) Apolipoprotein A1/A4/E family P02649
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Core-binding factor subunit beta (CBFB) CBF-beta family Q13951

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Docetaxel Small molecular drug DB01248
Estramustine Small molecular drug DB01196
Paclitaxel Small molecular drug DB01229

References

1 Proteome-Wide Profiling of Cellular Targets Modified by Dopamine Metabolites Using a Bio-Orthogonally Functionalized Catecholamine. ACS Chem Biol. 2021 Nov 19;16(11):2581-2594. doi: 10.1021/acschembio.1c00629. Epub 2021 Nov 2.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060