Details of the Probe

General Information of Probe

Probe ID
LDPC0164
Probe Name
DAyne
Synonyms
SCHEMBL21708855
Probe Type
ABPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 191.23
Lipid-water partition coefficient (xlogp) -0.4
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C11H13NO2
IUPAC Name
4-[2-(prop-2-ynylamino)ethyl]benzene-1,2-diol
Canonical SMILES
C#CCNCCC1=CC(=C(C=C1)O)O
InChI
InChI=1S/C11H13NO2/c1-2-6-12-7-5-9-3-4-10(13)11(14)8-9/h1,3-4,8,12-14H,5-7H2
InChIKey
OIMZHWRJAOKZIX-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

28 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Bifunctional glutamate/proline--tRNA ligase (EPRS1) LDTP02222 3.54  LDD0261 
Bifunctional glutamate/proline--tRNA ligase (EPRS1) LDTP02222 3.54  LDD0261 
Dihydropyrimidinase-related protein 1 (CRMP1) LDTP06078 4.44  LDD0261 
Dihydropyrimidinase-related protein 1 (CRMP1) LDTP06078 4.44  LDD0261 
Dopamine beta-hydroxylase (DBH) LDTP02331 3.20  LDD0261 
Dopamine beta-hydroxylase (DBH) LDTP02331 3.20  LDD0261 
E3 SUMO-protein ligase RanBP2 (RANBP2) LDTP04310 3.14  LDD0261 
E3 SUMO-protein ligase RanBP2 (RANBP2) LDTP04310 3.14  LDD0261 
E3 ubiquitin-protein ligase HUWE1 (HUWE1) LDTP08135 3.15  LDD0261 
E3 ubiquitin-protein ligase HUWE1 (HUWE1) LDTP08135 3.15  LDD0261 
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) LDTP02770 3.42  LDD0261 
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) LDTP02770 3.42  LDD0261 
Immunity-related GTPase family Q protein (IRGQ) LDTP19838 2.09  LDD0261 
Immunity-related GTPase family Q protein (IRGQ) LDTP19838 2.09  LDD0261 
Protein disulfide-isomerase (P4HB) LDTP02188 2.24  LDD0261 
Protein disulfide-isomerase (P4HB) LDTP02188 2.24  LDD0261 
Protein disulfide-isomerase A3 (PDIA3) LDTP03521 4.15  LDD0261 
Protein disulfide-isomerase A3 (PDIA3) LDTP03521 4.15  LDD0261 
Protein disulfide-isomerase A6 (PDIA6) LDTP06314 3.03  LDD0261 
Protein disulfide-isomerase A6 (PDIA6) LDTP06314 3.03  LDD0261 
Pyruvate kinase PKM (PKM) LDTP02733 3.49  LDD0261 
Pyruvate kinase PKM (PKM) LDTP02733 3.49  LDD0261 
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) LDTP02860 2.55  LDD0261 
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) LDTP02860 2.55  LDD0261 
Tubulin alpha-1A chain (TUBA1A) LDTP07907 2.86  LDD0261 
Tubulin alpha-1A chain (TUBA1A) LDTP07907 2.86  LDD0261 
Ubiquitin carboxyl-terminal hydrolase 10 (USP10) LDTP06190 2.73  LDD0261 
Ubiquitin carboxyl-terminal hydrolase 10 (USP10) LDTP06190 2.73  LDD0261 
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⏷ Show the Full List of 28 Enzyme
6 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Clathrin heavy chain 1 (CLTC) LDTP05252 2.26  LDD0261 
Clathrin heavy chain 1 (CLTC) LDTP05252 2.26  LDD0261 
Filamin-A (FLNA) LDTP03107 2.61  LDD0261 
Filamin-A (FLNA) LDTP03107 2.61  LDD0261 
Neuromodulin (GAP43) LDTP02915 2.29  LDD0261 
Neuromodulin (GAP43) LDTP02915 2.29  LDD0261 
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⏷ Show the Full List of 6 Transporter and channel
38 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Alpha-internexin (INA) LDTP06527 2.10  LDD0261 
Alpha-internexin (INA) LDTP06527 2.10  LDD0261 
Calcium-regulated heat-stable protein 1 (CARHSP1) LDTP13916 3.35  LDD0261 
Calcium-regulated heat-stable protein 1 (CARHSP1) LDTP13916 3.35  LDD0261 
Calponin-3 (CNN3) LDTP06383 2.60  LDD0261 
Calponin-3 (CNN3) LDTP06383 2.60  LDD0261 
Cofilin-1 (CFL1) LDTP03244 4.74  LDD0261 
Cofilin-1 (CFL1) LDTP03244 4.74  LDD0261 
Echinoderm microtubule-associated protein-like 4 (EML4) LDTP12214 2.02  LDD0261 
Echinoderm microtubule-associated protein-like 4 (EML4) LDTP12214 2.02  LDD0261 
Epidermal growth factor receptor substrate 15 (EPS15) LDTP03982 2.39  LDD0261 
Epidermal growth factor receptor substrate 15 (EPS15) LDTP03982 2.39  LDD0261 
La-related protein 1 (LARP1) LDTP07605 2.12  LDD0261 
La-related protein 1 (LARP1) LDTP07605 2.12  LDD0261 
Microtubule-associated protein 1B (MAP1B) LDTP04112 4.20  LDD0261 
Microtubule-associated protein 1B (MAP1B) LDTP04112 4.20  LDD0261 
Microtubule-associated protein 2 (MAP2) LDTP02540 2.79  LDD0261 
Microtubule-associated protein 2 (MAP2) LDTP02540 2.79  LDD0261 
Microtubule-associated protein 4 (MAP4) LDTP03404 5.00  LDD0261 
Microtubule-associated protein 4 (MAP4) LDTP03404 5.00  LDD0261 
Mitochondrial antiviral-signaling protein (MAVS) LDTP08058 2.39  LDD0261 
Mitochondrial antiviral-signaling protein (MAVS) LDTP08058 2.39  LDD0261 
Nestin (NES) LDTP04206 3.43  LDD0261 
Nestin (NES) LDTP04206 3.43  LDD0261 
Poly(rC)-binding protein 1 (PCBP1) LDTP06366 5.10  LDD0261 
Poly(rC)-binding protein 1 (PCBP1) LDTP06366 5.10  LDD0261 
Prefoldin subunit 3 (VBP1) LDTP04935 2.28  LDD0261 
Prefoldin subunit 3 (VBP1) LDTP04935 2.28  LDD0261 
Protein PRRC2C (PRRC2C) LDTP14085 2.73  LDD0261 
Protein PRRC2C (PRRC2C) LDTP14085 2.73  LDD0261 
Retrotransposon-like protein 1 (RTL1) LDTP16652 2.66  LDD0261 
Retrotransposon-like protein 1 (RTL1) LDTP16652 2.66  LDD0261 
Serine/arginine-rich splicing factor 2 (SRSF2) LDTP05280 3.15  LDD0261 
Serine/arginine-rich splicing factor 2 (SRSF2) LDTP05280 3.15  LDD0261 
Src substrate cortactin (CTTN) LDTP06094 3.00  LDD0261 
Src substrate cortactin (CTTN) LDTP06094 3.00  LDD0261 
Uncharacterized protein C11orf96 (C11orf96) LDTP19610 2.33  LDD0261 
Uncharacterized protein C11orf96 (C11orf96) LDTP19610 2.33  LDD0261 
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⏷ Show the Full List of 38 Other

Full Information of The Labelling Profiles of This Probe

Quantification: Probe vs DMSO
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
10 uM
Quantitative Method
LFQ
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Adrenal
Disease Model
Bone marrow neuroblastoma [ICD11: 2A00]
Model Name
Human neuroblastoma cells (SH-SY5Y)
Interaction Atlas ID
 LDD0261 
Download The Altas

References

1 Proteome-Wide Profiling of Cellular Targets Modified by Dopamine Metabolites Using a Bio-Orthogonally Functionalized Catecholamine. ACS Chem Biol. 2021 Nov 19;16(11):2581-2594. doi: 10.1021/acschembio.1c00629. Epub 2021 Nov 2.