Details of the Target

General Information of Target

Target ID LDTP05252
Target Name Clathrin heavy chain 1 (CLTC)
Gene Name CLTC
Gene ID 1213
Synonyms
CLH17; CLTCL2; KIAA0034; Clathrin heavy chain 1; Clathrin heavy chain on chromosome 17; CLH-17
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSN
PIRRPISADSAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTMTDDVTFWKWISLNTVA
LVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGN
QPFPKKAVDVFFPPEAQNDFPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISG
ETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGA
EELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGI
LLDQGQLNKYESLELCRPVLQQGRKQLLEKWLKEDKLECSEELGDLVKSVDPTLALSVYL
RANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDE
EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAIL
GNQMFTHYDRAHIAQLCEKAGLLQRALEHFTDLYDIKRAVVHTHLLNPEWLVNYFGSLSV
EDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVN
FSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDR
FDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQF
STDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYY
DSRVVGKYCEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWGSVL
LESNPYRRPLIDQVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSE
HRNLQNLLILTAIKADRTRVMEYINRLDNYDAPDIANIAISNELFEEAFAIFRKFDVNTS
AVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSSYMEV
VQAANTSGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAELEEFINGPNNAHIQQ
VGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVDGARKANSTRTWKEVCFAC
VDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTEL
AILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAIITMMN
HPTDAWKEGQFKDIITKVANVELYYRAIQFYLEFKPLLLNDLLMVLSPRLDHTRAVNYFS
KVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLE
KHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQE
EKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVDKLDASESLR
KEEEQATETQPIVYGQPQLMLTAGPSVAVPPQAPFGYGYTAPPYGQPQPGFGYSM
Target Bioclass
Transporter and channel
Family
Clathrin heavy chain family
Subcellular location
Cytoplasmic vesicle membrane
Function
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Plays a role in early autophagosome formation. Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating.
Uniprot ID
Q00610
Ensemble ID
ENST00000269122.8
HGNC ID
HGNC:2092
ChEMBL ID
CHEMBL3108634

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BICR22 SNV: p.I1174M DBIA    Probe Info 
BT549 SNV: p.C748F; p.D1580N DBIA    Probe Info 
CCK81 Deletion: p.P413del DBIA    Probe Info 
DU145 SNV: p.A1095V DBIA    Probe Info 
HCT15 SNV: p.T1079A DBIA    Probe Info 
HEC1 SNV: p.V959M DBIA    Probe Info 
HT115 SNV: p.R892K DBIA    Probe Info 
KMS27 SNV: p.A406T DBIA    Probe Info 
KYSE410 SNV: p.Q1083H DBIA    Probe Info 
MCC13 SNV: p.E1622K DBIA    Probe Info 
MFE319 SNV: p.Y156H; p.Y510F DBIA    Probe Info 
NCIH1048 SNV: p.S1016Y DBIA    Probe Info 
OVK18 SNV: p.A1568S DBIA    Probe Info 
SW1573 SNV: p.D913H DBIA    Probe Info 
SW620 SNV: p.P1667S DBIA    Probe Info 
YSCCC SNV: p.E42Q; p.A1112S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 59 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		6.31  LDD0402  [1]
P1
 Probe Info  		10.00  LDD0452  [2]
P2
 Probe Info  		1.85  LDD0449  [2]
P3
 Probe Info  		1.77  LDD0450  [2]
P8
 Probe Info  		6.35  LDD0455  [2]
A-EBA
 Probe Info  		3.93  LDD0215  [3]
DAyne
 Probe Info  		2.26  LDD0261  [4]
CY4
 Probe Info  		2.44  LDD0244  [5]
N1
 Probe Info  		3.12  LDD0242  [5]
TH211
 Probe Info  		Y1237(20.00); Y966(20.00); Y1477(18.01); Y1451(17.68)  LDD0257  [6]
TH214
 Probe Info  		Y1451(20.00); Y634(20.00)  LDD0258  [6]
TH216
 Probe Info  		Y1451(20.00); Y1513(20.00); Y731(12.83); Y1211(5.25)  LDD0259  [6]
YN-4
 Probe Info  		100.00  LDD0445  [7]
ONAyne
 Probe Info  		K367(0.00); K1501(0.00); K637(0.00)  LDD0273  [8]
OPA-S-S-alkyne
 Probe Info  		K1516(1.45); K1264(1.58); K637(2.63); K619(2.75)  LDD3494  [9]
Probe 1
 Probe Info  		Y377(6.98); Y430(36.84); Y754(21.88); Y883(85.77)  LDD3495  [10]
JZ128-DTB
 Probe Info  		C491(0.00); C926(0.00); C328(0.00); C1205(0.00)  LDD0462  [11]
THZ1-DTB
 Probe Info  		C1205(1.21); C753(1.05); C934(1.05); C328(1.00)  LDD0460  [11]
AHL-Pu-1
 Probe Info  		C459(3.81); C491(2.18)  LDD0168  [12]
HHS-482
 Probe Info  		Y1438(0.57); Y634(0.74)  LDD0285  [13]
HHS-475
 Probe Info  		Y883(0.51); Y377(0.52); Y430(0.81); Y279(0.81)  LDD0264  [14]
HHS-465
 Probe Info  		Y279(4.82); Y430(4.12); Y634(9.21); Y799(2.61)  LDD2237  [15]
DBIA
 Probe Info  		C870(1.15); C926(1.02); C934(1.02)  LDD0078  [16]
5E-2FA
 Probe Info  		H12(0.00); H1233(0.00); H1502(0.00); H197(0.00)  LDD2235  [17]
AMP probe
 Probe Info  		K245(0.00); K246(0.00)  LDD0200  [18]
ATP probe
 Probe Info  		K245(0.00); K246(0.00); K189(0.00); K1441(0.00)  LDD0199  [18]
4-Iodoacetamidophenylacetylene
 Probe Info  		C617(0.00); C666(0.00); C1102(0.00); C918(0.00)  LDD0038  [19]
IA-alkyne
 Probe Info  		C1205(0.00); C753(0.00); C736(0.00); C918(0.00)  LDD0032  [20]
IPIAA_H
 Probe Info  		C666(0.00); C491(0.00); C824(0.00); C870(0.00)  LDD0030  [21]
IPIAA_L
 Probe Info  		C151(0.00); C918(0.00); C753(0.00); C39(0.00)  LDD0031  [21]
Lodoacetamide azide
 Probe Info  		C617(0.00); C666(0.00); C1102(0.00); C918(0.00)  LDD0037  [19]
ATP probe
 Probe Info  		K830(0.00); K1441(0.00); K1034(0.00); K951(0.00)  LDD0035  [22]
BTD
 Probe Info  		N.A.  LDD0004  [23]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [24]
NAIA_4
 Probe Info  		C328(0.00); C617(0.00); C870(0.00); C1205(0.00)  LDD2226  [25]
TFBX
 Probe Info  		C736(0.00); C753(0.00); C748(0.00); C491(0.00)  LDD0027  [24]
WYneC
 Probe Info  		N.A.  LDD0014  [23]
WYneN
 Probe Info  		C736(0.00); C824(0.00); C778(0.00); C491(0.00)  LDD0021  [23]
WYneO
 Probe Info  		C491(0.00); C1257(0.00); C1528(0.00); C736(0.00)  LDD0022  [23]
aHNE
 Probe Info  		N.A.  LDD0001  [23]
Compound 10
 Probe Info  		C1205(0.00); C151(0.00); C491(0.00); C617(0.00)  LDD2216  [26]
ENE
 Probe Info  		C870(0.00); C753(0.00); C491(0.00)  LDD0006  [23]
IPM
 Probe Info  		N.A.  LDD0005  [23]
NHS
 Probe Info  		K637(0.00); K246(0.00); K1441(0.00); K96(0.00)  LDD0010  [23]
PF-06672131
 Probe Info  		C436(0.00); C491(0.00); C753(0.00); C870(0.00)  LDD0017  [27]
PPMS
 Probe Info  		C491(0.00); C870(0.00)  LDD0008  [23]
SF
 Probe Info  		K1441(0.00); K78(0.00); K246(0.00); K1501(0.00)  LDD0028  [28]
STPyne
 Probe Info  		K367(0.00); K246(0.00); K767(0.00); K96(0.00)  LDD0009  [23]
VSF
 Probe Info  		C736(0.00); C1102(0.00); C926(0.00); C934(0.00)  LDD0007  [23]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [29]
Ox-W18
 Probe Info  		W451(0.00); W514(0.00); W861(0.00); W1340(0.00)  LDD2175  [30]
1c-yne
 Probe Info  		K1609(0.00); K367(0.00); K382(0.00); K453(0.00)  LDD0228  [31]
1d-yne
 Probe Info  		N.A.  LDD0357  [31]
Acrolein
 Probe Info  		H1197(0.00); H1233(0.00); C459(0.00); C870(0.00)  LDD0217  [32]
Cinnamaldehyde
 Probe Info  		C491(0.00); C870(0.00); C617(0.00); C151(0.00)  LDD0220  [32]
Crotonaldehyde
 Probe Info  		C870(0.00); C151(0.00); C491(0.00); C617(0.00)  LDD0219  [32]
Methacrolein
 Probe Info  		C151(0.00); C870(0.00); C459(0.00); C491(0.00)  LDD0218  [32]
W1
 Probe Info  		C870(0.00); C753(0.00); C459(0.00); C617(0.00)  LDD0236  [33]
NAIA_5
 Probe Info  		C491(0.00); C1102(0.00); C1205(0.00); C753(0.00)  LDD2223  [25]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [34]
DA-2
 Probe Info  		N.A.  LDD0073  [35]
STS-1
 Probe Info  		N.A.  LDD0068  [36]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C870(0.78); C617(0.42); C736(0.76); C491(0.41)  LDD2142  [37]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C870(1.01); C617(0.38); C736(0.69); C753(0.68)  LDD2112  [37]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C870(0.79); C617(0.71); C736(0.70); C1528(0.64)  LDD2095  [37]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C870(0.95); C617(0.90); C736(0.83); C1528(1.11)  LDD2130  [37]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C870(1.16); C617(1.03); C736(1.13); C436(1.24)  LDD2117  [37]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C870(1.45); C617(1.50); C736(1.38); C1528(1.54)  LDD2152  [37]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C870(0.94); C617(1.04); C736(1.03); C682(0.88)  LDD2103  [37]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C870(0.60); C617(0.58); C736(0.74); C1528(0.93)  LDD2132  [37]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C870(0.74); C617(0.66); C736(0.65); C1528(0.98)  LDD2131  [37]
 LDCM0025  4SU-RNA HEK-293T C459(3.81); C491(2.18)  LDD0168  [12]
 LDCM0026  4SU-RNA+native RNA HEK-293T C824(4.87); C459(2.69); C491(2.22); C436(2.69)  LDD0169  [12]
 LDCM0561  Abegg_cp(-)-10 HeLa C1102(2.27)  LDD0312  [24]
 LDCM0214  AC1 HCT 116 C1565(0.76); C1573(0.76); C1569(0.76); C1102(0.92)  LDD0531  [16]
 LDCM0215  AC10 HCT 116 C1102(0.61); C1257(0.97); C1260(0.90); C1528(1.30)  LDD0532  [16]
 LDCM0216  AC100 HCT 116 C1102(0.59); C1257(0.57); C1260(0.58); C1528(1.62)  LDD0533  [16]
 LDCM0217  AC101 HCT 116 C1102(0.66); C1257(0.59); C1260(0.55); C1528(0.92)  LDD0534  [16]
 LDCM0218  AC102 HCT 116 C1102(0.65); C1257(0.60); C1260(0.60); C1528(1.17)  LDD0535  [16]
 LDCM0219  AC103 HCT 116 C1102(0.42); C1257(0.51); C1260(0.53); C1528(0.98)  LDD0536  [16]
 LDCM0220  AC104 HCT 116 C1102(0.45); C1257(0.63); C1260(0.62); C1528(1.23)  LDD0537  [16]
 LDCM0221  AC105 HCT 116 C1102(0.53); C1257(0.56); C1260(0.53); C1528(1.10)  LDD0538  [16]
 LDCM0222  AC106 HCT 116 C1102(0.49); C1257(0.52); C1260(0.52); C1528(1.21)  LDD0539  [16]
 LDCM0223  AC107 HCT 116 C1102(0.76); C1257(0.56); C1260(0.66); C1528(1.55)  LDD0540  [16]
 LDCM0224  AC108 HCT 116 C1102(0.88); C1257(0.59); C1260(0.76); C1528(1.32)  LDD0541  [16]
 LDCM0225  AC109 HCT 116 C1102(0.75); C1257(0.68); C1260(0.76); C1528(1.22)  LDD0542  [16]
 LDCM0226  AC11 HCT 116 C1102(0.58); C1257(0.94); C1260(0.88); C1528(1.24)  LDD0543  [16]
 LDCM0227  AC110 HCT 116 C1102(0.68); C1257(0.62); C1260(0.69); C1528(1.11)  LDD0544  [16]
 LDCM0228  AC111 HCT 116 C1102(0.70); C1257(0.54); C1260(0.62); C1528(0.99)  LDD0545  [16]
 LDCM0229  AC112 HCT 116 C1102(0.57); C1257(0.49); C1260(0.56); C1528(0.77)  LDD0546  [16]
 LDCM0230  AC113 HCT 116 C1565(0.53); C1573(0.53); C1102(1.07); C1257(0.94)  LDD0547  [16]
 LDCM0231  AC114 HCT 116 C1565(0.45); C1573(0.45); C1102(0.76); C1257(0.83)  LDD0548  [16]
 LDCM0232  AC115 HCT 116 C1565(0.42); C1573(0.42); C1102(0.58); C1257(0.89)  LDD0549  [16]
 LDCM0233  AC116 HCT 116 C1565(0.41); C1573(0.41); C1102(0.58); C1257(0.83)  LDD0550  [16]
 LDCM0234  AC117 HCT 116 C1565(0.74); C1573(0.74); C1102(0.74); C1257(0.76)  LDD0551  [16]
 LDCM0235  AC118 HCT 116 C1565(0.30); C1573(0.30); C1102(0.88); C1257(0.90)  LDD0552  [16]
 LDCM0236  AC119 HCT 116 C1565(0.34); C1573(0.34); C1102(0.74); C1257(0.78)  LDD0553  [16]
 LDCM0237  AC12 HCT 116 C1102(0.82); C1257(1.01); C1260(0.98); C1528(1.35)  LDD0554  [16]
 LDCM0238  AC120 HCT 116 C1565(0.43); C1573(0.43); C1102(0.63); C1257(0.79)  LDD0555  [16]
 LDCM0239  AC121 HCT 116 C1565(0.28); C1573(0.28); C1102(1.05); C1257(0.98)  LDD0556  [16]
 LDCM0240  AC122 HCT 116 C1565(0.39); C1573(0.39); C1102(0.93); C1257(1.16)  LDD0557  [16]
 LDCM0241  AC123 HCT 116 C1565(0.63); C1573(0.63); C1102(1.24); C1257(1.14)  LDD0558  [16]
 LDCM0242  AC124 HCT 116 C1565(0.47); C1573(0.47); C1102(0.98); C1257(0.96)  LDD0559  [16]
 LDCM0243  AC125 HCT 116 C1565(1.40); C1573(1.40); C1102(0.81); C1257(0.87)  LDD0560  [16]
 LDCM0244  AC126 HCT 116 C1565(0.42); C1573(0.42); C1102(0.62); C1257(0.90)  LDD0561  [16]
 LDCM0245  AC127 HCT 116 C1565(0.62); C1573(0.62); C1102(0.71); C1257(0.93)  LDD0562  [16]
 LDCM0246  AC128 HCT 116 C1565(1.64); C1573(1.64); C1102(1.10); C1257(1.49)  LDD0563  [16]
 LDCM0247  AC129 HCT 116 C1565(1.27); C1573(1.27); C1102(1.79); C1257(1.18)  LDD0564  [16]
 LDCM0249  AC130 HCT 116 C1565(1.25); C1573(1.25); C1102(1.24); C1257(1.16)  LDD0566  [16]
 LDCM0250  AC131 HCT 116 C1565(4.68); C1573(4.68); C1102(1.27); C1257(1.03)  LDD0567  [16]
 LDCM0251  AC132 HCT 116 C1565(1.07); C1573(1.07); C1102(1.14); C1257(1.07)  LDD0568  [16]
 LDCM0252  AC133 HCT 116 C1565(1.17); C1573(1.17); C1102(1.05); C1257(1.18)  LDD0569  [16]
 LDCM0253  AC134 HCT 116 C1565(1.39); C1573(1.39); C1102(0.93); C1257(0.89)  LDD0570  [16]
 LDCM0254  AC135 HCT 116 C1565(2.17); C1573(2.17); C1102(1.01); C1257(0.96)  LDD0571  [16]
 LDCM0255  AC136 HCT 116 C1565(0.96); C1573(0.96); C1102(0.93); C1257(0.94)  LDD0572  [16]
 LDCM0256  AC137 HCT 116 C1565(0.90); C1573(0.90); C1102(1.01); C1257(1.02)  LDD0573  [16]
 LDCM0257  AC138 HCT 116 C1565(0.82); C1573(0.82); C1102(0.95); C1257(0.97)  LDD0574  [16]
 LDCM0258  AC139 HCT 116 C1565(1.38); C1573(1.38); C1102(0.88); C1257(0.77)  LDD0575  [16]
 LDCM0259  AC14 HCT 116 C1102(0.94); C1257(1.10); C1260(1.04); C1528(1.33)  LDD0576  [16]
 LDCM0260  AC140 HCT 116 C1565(1.03); C1573(1.03); C1102(0.78); C1257(0.87)  LDD0577  [16]
 LDCM0261  AC141 HCT 116 C1565(1.09); C1573(1.09); C1102(0.92); C1257(0.81)  LDD0578  [16]
 LDCM0262  AC142 HCT 116 C1565(0.84); C1573(0.84); C1102(1.94); C1257(1.33)  LDD0579  [16]
 LDCM0263  AC143 HCT 116 C1102(0.75); C1257(0.69); C1260(0.82); C1528(0.80)  LDD0580  [16]
 LDCM0264  AC144 HCT 116 C1102(0.46); C459(0.46); C491(0.47); C934(0.49)  LDD0581  [16]
 LDCM0265  AC145 HCT 116 C934(0.57); C1102(0.59); C926(0.61); C491(0.62)  LDD0582  [16]
 LDCM0266  AC146 HCT 116 C926(0.52); C934(0.54); C491(0.55); C459(0.58)  LDD0583  [16]
 LDCM0267  AC147 HCT 116 C459(0.44); C491(0.46); C1102(0.48); C926(0.50)  LDD0584  [16]
 LDCM0268  AC148 HCT 116 C459(0.38); C491(0.43); C1102(0.46); C934(0.57)  LDD0585  [16]
 LDCM0269  AC149 HCT 116 C459(0.46); C491(0.48); C1102(0.50); C926(0.51)  LDD0586  [16]
 LDCM0270  AC15 HCT 116 C1102(0.69); C824(0.70); C934(0.70); C778(0.72)  LDD0587  [16]
 LDCM0271  AC150 HCT 116 C217(0.54); C934(0.57); C926(0.59); C1102(0.61)  LDD0588  [16]
 LDCM0272  AC151 HCT 116 C934(0.63); C459(0.65); C491(0.68); C1102(0.69)  LDD0589  [16]
 LDCM0273  AC152 HCT 116 C459(0.39); C934(0.46); C491(0.47); C926(0.49)  LDD0590  [16]
 LDCM0274  AC153 HCT 116 C459(0.36); C491(0.47); C1102(0.57); C934(0.60)  LDD0591  [16]
 LDCM0621  AC154 HCT 116 C1102(0.52); C1257(0.71); C1260(0.72); C1528(0.82)  LDD2158  [16]
 LDCM0622  AC155 HCT 116 C1102(0.56); C1257(0.79); C1260(0.80); C1528(0.87)  LDD2159  [16]
 LDCM0623  AC156 HCT 116 C1102(0.87); C1257(1.07); C1260(0.97); C1528(1.00)  LDD2160  [16]
 LDCM0624  AC157 HCT 116 C1102(0.94); C1257(0.95); C1260(0.84); C1528(0.77)  LDD2161  [16]
 LDCM0276  AC17 HCT 116 C459(0.70); C491(0.71); C1102(0.73); C1257(0.73)  LDD0593  [16]
 LDCM0277  AC18 HCT 116 C459(0.47); C1102(0.61); C491(0.65); C934(0.71)  LDD0594  [16]
 LDCM0278  AC19 HCT 116 C491(0.64); C1102(0.66); C459(0.67); C934(0.76)  LDD0595  [16]
 LDCM0279  AC2 HCT 116 C1565(0.66); C1573(0.66); C1569(0.66); C918(0.67)  LDD0596  [16]
 LDCM0280  AC20 HCT 116 C491(0.69); C459(0.72); C1102(0.74); C934(0.77)  LDD0597  [16]
 LDCM0281  AC21 HCT 116 C491(0.62); C459(0.63); C1102(0.64); C934(0.80)  LDD0598  [16]
 LDCM0282  AC22 HCT 116 C491(0.76); C459(0.78); C1102(0.83); C1257(0.83)  LDD0599  [16]
 LDCM0283  AC23 HCT 116 C491(0.64); C934(0.71); C459(0.71); C1102(0.72)  LDD0600  [16]
 LDCM0284  AC24 HCT 116 C491(0.74); C934(0.79); C926(0.83); C1102(0.86)  LDD0601  [16]
 LDCM0285  AC25 HCT 116 C926(0.73); C918(0.81); C617(0.83); C753(0.84)  LDD0602  [16]
 LDCM0286  AC26 HCT 116 C918(0.57); C1102(0.58); C926(0.60); C617(0.65)  LDD0603  [16]
 LDCM0287  AC27 HCT 116 C926(0.47); C1102(0.57); C491(0.60); C918(0.63)  LDD0604  [16]
 LDCM0288  AC28 HCT 116 C926(0.49); C1102(0.53); C491(0.63); C918(0.64)  LDD0605  [16]
 LDCM0289  AC29 HCT 116 C1102(0.51); C926(0.55); C918(0.57); C617(0.60)  LDD0606  [16]
 LDCM0290  AC3 HCT 116 C217(0.60); C918(0.73); C1565(0.73); C1573(0.73)  LDD0607  [16]
 LDCM0291  AC30 HCT 116 C1102(0.48); C926(0.49); C918(0.54); C617(0.57)  LDD0608  [16]
 LDCM0292  AC31 HCT 116 C926(0.53); C491(0.65); C918(0.67); C682(0.68)  LDD0609  [16]
 LDCM0293  AC32 HCT 116 C926(0.41); C918(0.48); C1102(0.50); C491(0.51)  LDD0610  [16]
 LDCM0294  AC33 HCT 116 C926(0.41); C1102(0.50); C491(0.59); C617(0.60)  LDD0611  [16]
 LDCM0295  AC34 HCT 116 C926(0.42); C1102(0.44); C459(0.57); C491(0.59)  LDD0612  [16]
 LDCM0296  AC35 HCT 116 C870(0.85); C778(0.88); C217(0.91); C1528(1.02)  LDD0613  [16]
 LDCM0297  AC36 HCT 116 C1528(0.90); C217(0.90); C778(0.91); C1260(0.91)  LDD0614  [16]
 LDCM0298  AC37 HCT 116 C870(1.01); C617(1.06); C1260(1.12); C753(1.12)  LDD0615  [16]
 LDCM0299  AC38 HCT 116 C778(0.83); C1528(0.89); C1260(0.90); C682(0.91)  LDD0616  [16]
 LDCM0300  AC39 HCT 116 C217(0.60); C778(0.92); C1102(0.93); C918(0.93)  LDD0617  [16]
 LDCM0301  AC4 HCT 116 C217(0.66); C1102(0.67); C918(0.69); C1565(0.70)  LDD0618  [16]
 LDCM0302  AC40 HCT 116 C1102(0.85); C918(0.99); C736(1.00); C753(1.00)  LDD0619  [16]
 LDCM0303  AC41 HCT 116 C217(0.66); C1257(0.88); C918(0.89); C617(0.94)  LDD0620  [16]
 LDCM0304  AC42 HCT 116 C217(0.75); C778(0.76); C1102(0.82); C436(0.83)  LDD0621  [16]
 LDCM0305  AC43 HCT 116 C436(0.72); C918(0.79); C1257(0.89); C617(0.90)  LDD0622  [16]
 LDCM0306  AC44 HCT 116 C217(0.82); C1102(1.00); C1260(1.04); C436(1.05)  LDD0623  [16]
 LDCM0307  AC45 HCT 116 C217(0.96); C1102(0.97); C617(0.98); C436(0.99)  LDD0624  [16]
 LDCM0308  AC46 HCT 116 C918(0.71); C436(0.75); C1528(0.88); C617(0.88)  LDD0625  [16]
 LDCM0309  AC47 HCT 116 C918(0.76); C436(0.76); C217(0.78); C459(0.91)  LDD0626  [16]
 LDCM0310  AC48 HCT 116 C918(0.62); C436(0.70); C1528(1.01); C1257(1.03)  LDD0627  [16]
 LDCM0311  AC49 HCT 116 C1102(0.67); C918(0.67); C682(0.71); C436(0.71)  LDD0628  [16]
 LDCM0312  AC5 HCT 116 C1565(0.56); C1573(0.56); C1569(0.56); C918(0.61)  LDD0629  [16]
 LDCM0313  AC50 HCT 116 C1102(0.65); C918(0.67); C459(0.69); C436(0.70)  LDD0630  [16]
 LDCM0314  AC51 HCT 116 C682(0.60); C436(0.62); C918(0.76); C753(0.92)  LDD0631  [16]
 LDCM0315  AC52 HCT 116 C918(0.65); C436(0.68); C682(0.83); C1102(0.84)  LDD0632  [16]
 LDCM0316  AC53 HCT 116 C918(0.73); C459(0.78); C436(0.84); C1102(0.86)  LDD0633  [16]
 LDCM0317  AC54 HCT 116 C1102(0.71); C436(0.71); C918(0.72); C459(0.77)  LDD0634  [16]
 LDCM0318  AC55 HCT 116 C459(0.80); C491(0.87); C1102(0.91); C918(0.93)  LDD0635  [16]
 LDCM0319  AC56 HCT 116 C459(0.67); C436(0.73); C918(0.79); C491(0.80)  LDD0636  [16]
 LDCM0320  AC57 HCT 116 C1102(0.47); C918(0.66); C934(0.76); C926(0.77)  LDD0637  [16]
 LDCM0321  AC58 HCT 116 C918(0.52); C1102(0.53); C934(0.55); C926(0.56)  LDD0638  [16]
 LDCM0322  AC59 HCT 116 C1102(0.39); C918(0.63); C617(0.71); C934(0.74)  LDD0639  [16]
 LDCM0323  AC6 HCT 116 C1102(0.57); C918(0.61); C491(0.70); C934(0.70)  LDD0640  [16]
 LDCM0324  AC60 HCT 116 C1102(0.40); C918(0.73); C1257(0.78); C1260(0.78)  LDD0641  [16]
 LDCM0325  AC61 HCT 116 C918(0.58); C1102(0.72); C682(0.76); C934(0.76)  LDD0642  [16]
 LDCM0326  AC62 HCT 116 C1102(0.39); C918(0.69); C934(0.77); C491(0.77)  LDD0643  [16]
 LDCM0327  AC63 HCT 116 C1102(0.43); C918(0.81); C1257(0.84); C682(0.86)  LDD0644  [16]
 LDCM0328  AC64 HCT 116 C1102(0.33); C918(0.80); C617(0.85); C491(0.95)  LDD0645  [16]
 LDCM0329  AC65 HCT 116 C1102(0.41); C918(0.42); C934(0.63); C926(0.65)  LDD0646  [16]
 LDCM0330  AC66 HCT 116 C918(0.50); C1102(0.55); C934(0.67); C926(0.68)  LDD0647  [16]
 LDCM0331  AC67 HCT 116 C1102(0.41); C918(0.62); C682(0.71); C934(0.74)  LDD0648  [16]
 LDCM0332  AC68 HCT 116 C682(0.65); C824(0.70); C778(0.76); C1102(0.78)  LDD0649  [16]
 LDCM0333  AC69 HCT 116 C682(0.62); C824(0.78); C1102(0.80); C778(0.84)  LDD0650  [16]
 LDCM0334  AC7 HCT 116 C459(0.72); C1102(0.74); C934(0.76); C918(0.76)  LDD0651  [16]
 LDCM0335  AC70 HCT 116 C1102(0.62); C1569(0.68); C1565(0.70); C682(0.70)  LDD0652  [16]
 LDCM0336  AC71 HCT 116 C1573(0.71); C1569(0.73); C1565(0.74); C870(0.93)  LDD0653  [16]
 LDCM0337  AC72 HCT 116 C1102(0.71); C778(0.72); C491(0.76); C926(0.76)  LDD0654  [16]
 LDCM0338  AC73 HCT 116 C1102(0.68); C682(0.70); C491(0.76); C436(0.79)  LDD0655  [16]
 LDCM0339  AC74 HCT 116 C1102(0.83); C824(0.91); C491(0.94); C436(0.95)  LDD0656  [16]
 LDCM0340  AC75 HCT 116 C682(0.66); C1102(0.69); C491(0.72); C217(0.80)  LDD0657  [16]
 LDCM0341  AC76 HCT 116 C824(0.72); C1102(0.78); C682(0.81); C778(0.91)  LDD0658  [16]
 LDCM0342  AC77 HCT 116 C682(0.42); C1102(0.64); C436(0.65); C778(0.72)  LDD0659  [16]
 LDCM0343  AC78 HCT 116 C824(0.62); C682(0.74); C1573(0.78); C1569(0.79)  LDD0660  [16]
 LDCM0344  AC79 HCT 116 C682(0.66); C1102(0.71); C1569(0.74); C1573(0.75)  LDD0661  [16]
 LDCM0345  AC8 HCT 116 C1102(0.57); C934(0.61); C926(0.65); C824(0.71)  LDD0662  [16]
 LDCM0346  AC80 HCT 116 C682(0.76); C1102(0.83); C1569(0.86); C1573(0.89)  LDD0663  [16]
 LDCM0347  AC81 HCT 116 C824(0.15); C682(0.57); C1569(0.58); C1565(0.66)  LDD0664  [16]
 LDCM0348  AC82 HCT 116 C217(0.70); C682(0.73); C1102(0.82); C436(0.85)  LDD0665  [16]
 LDCM0349  AC83 HCT 116 C459(0.31); C1102(0.43); C926(0.54); C934(0.58)  LDD0666  [16]
 LDCM0350  AC84 HCT 116 C459(0.34); C1102(0.39); C926(0.52); C934(0.55)  LDD0667  [16]
 LDCM0351  AC85 HCT 116 C1102(0.44); C459(0.45); C682(0.55); C926(0.61)  LDD0668  [16]
 LDCM0352  AC86 HCT 116 C459(0.43); C926(0.51); C1102(0.51); C934(0.55)  LDD0669  [16]
 LDCM0353  AC87 HCT 116 C617(0.77); C824(0.79); C491(0.81); C918(0.87)  LDD0670  [16]
 LDCM0354  AC88 HCT 116 C459(0.50); C1102(0.53); C926(0.55); C934(0.58)  LDD0671  [16]
 LDCM0355  AC89 HCT 116 C459(0.43); C1102(0.49); C926(0.50); C934(0.50)  LDD0672  [16]
 LDCM0357  AC90 HCT 116 C918(0.70); C1260(0.81); C824(0.83); C753(0.84)  LDD0674  [16]
 LDCM0358  AC91 HCT 116 C459(0.30); C1102(0.46); C926(0.51); C934(0.56)  LDD0675  [16]
 LDCM0359  AC92 HCT 116 C459(0.33); C1102(0.41); C926(0.50); C934(0.52)  LDD0676  [16]
 LDCM0360  AC93 HCT 116 C459(0.48); C1102(0.52); C934(0.54); C926(0.54)  LDD0677  [16]
 LDCM0361  AC94 HCT 116 C1102(0.49); C459(0.54); C926(0.55); C934(0.59)  LDD0678  [16]
 LDCM0362  AC95 HCT 116 C824(0.87); C436(0.96); C753(0.97); C1528(0.98)  LDD0679  [16]
 LDCM0363  AC96 HCT 116 C459(0.42); C1102(0.42); C934(0.54); C926(0.54)  LDD0680  [16]
 LDCM0364  AC97 HCT 116 C459(0.33); C1102(0.44); C926(0.45); C934(0.49)  LDD0681  [16]
 LDCM0365  AC98 HCT 116 C459(0.22); C682(0.32); C934(0.41); C1102(0.42)  LDD0682  [16]
 LDCM0366  AC99 HCT 116 C682(0.47); C934(0.51); C926(0.52); C1102(0.53)  LDD0683  [16]
 LDCM0545  Acetamide MDA-MB-231 C870(0.52); C617(0.41); C736(0.42); C436(1.00)  LDD2138  [37]
 LDCM0520  AKOS000195272 MDA-MB-231 C870(0.81); C736(0.73); C1528(1.07); C436(0.63)  LDD2113  [37]
 LDCM0248  AKOS034007472 HCT 116 C1102(1.02); C1257(1.00); C1260(0.97); C1528(1.14)  LDD0565  [16]
 LDCM0356  AKOS034007680 HCT 116 C459(0.67); C824(0.72); C217(0.72); C1102(0.74)  LDD0673  [16]
 LDCM0275  AKOS034007705 HCT 116 C459(0.47); C1102(0.52); C918(0.59); C824(0.67)  LDD0592  [16]
 LDCM0156  Aniline NCI-H1299 C491(0.00); C870(0.00)  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C870(1.15); C926(1.02); C934(1.02)  LDD0078  [16]
 LDCM0200  BPK-25 T cell C870(7.66)  LDD0516  [38]
 LDCM0498  BS-3668 MDA-MB-231 C870(0.74); C617(0.51); C736(0.56); C1528(0.55)  LDD2091  [37]
 LDCM0630  CCW28-3 231MFP C870(1.36)  LDD2214  [39]
 LDCM0108  Chloroacetamide HeLa C459(0.00); H1088(0.00); C870(0.00); C151(0.00)  LDD0222  [32]
 LDCM0632  CL-Sc Hep-G2 C778(20.00); C617(2.40); C736(2.09); C1528(1.12)  LDD2227  [25]
 LDCM0367  CL1 HCT 116 C682(0.93); C870(0.94); C753(0.95); C617(0.99)  LDD0684  [16]
 LDCM0368  CL10 HCT 116 C918(0.81); C824(0.84); C491(0.86); C1102(0.87)  LDD0685  [16]
 LDCM0369  CL100 HCT 116 C1565(0.61); C1573(0.61); C1569(0.61); C1102(0.63)  LDD0686  [16]
 LDCM0370  CL101 HCT 116 C824(0.61); C459(0.62); C1102(0.62); C918(0.65)  LDD0687  [16]
 LDCM0371  CL102 HCT 116 C918(0.73); C778(0.75); C1102(0.83); C824(0.84)  LDD0688  [16]
 LDCM0372  CL103 HCT 116 C824(0.74); C778(0.82); C918(0.84); C926(0.87)  LDD0689  [16]
 LDCM0373  CL104 HCT 116 C778(0.75); C824(0.81); C459(0.82); C918(0.85)  LDD0690  [16]
 LDCM0374  CL105 HCT 116 C459(0.56); C1102(0.61); C491(0.62); C934(0.66)  LDD0691  [16]
 LDCM0375  CL106 HCT 116 C459(0.50); C491(0.59); C1102(0.62); C934(0.68)  LDD0692  [16]
 LDCM0376  CL107 HCT 116 C459(0.49); C1102(0.57); C934(0.59); C491(0.62)  LDD0693  [16]
 LDCM0377  CL108 HCT 116 C459(0.46); C1102(0.56); C491(0.62); C1257(0.77)  LDD0694  [16]
 LDCM0378  CL109 HCT 116 C1102(0.51); C934(0.59); C459(0.59); C926(0.65)  LDD0695  [16]
 LDCM0379  CL11 HCT 116 C682(0.73); C918(0.85); C1102(0.91); C824(0.93)  LDD0696  [16]
 LDCM0380  CL110 HCT 116 C1102(0.48); C459(0.51); C934(0.58); C491(0.60)  LDD0697  [16]
 LDCM0381  CL111 HCT 116 C1102(0.53); C459(0.59); C934(0.60); C491(0.61)  LDD0698  [16]
 LDCM0382  CL112 HCT 116 C753(0.77); C926(0.78); C1102(0.84); C682(0.84)  LDD0699  [16]
 LDCM0383  CL113 HCT 116 C926(0.44); C1102(0.54); C682(0.54); C491(0.56)  LDD0700  [16]
 LDCM0384  CL114 HCT 116 C1257(0.59); C926(0.61); C918(0.62); C1528(0.63)  LDD0701  [16]
 LDCM0385  CL115 HCT 116 C926(0.48); C1102(0.55); C682(0.59); C491(0.60)  LDD0702  [16]
 LDCM0386  CL116 HCT 116 C926(0.51); C1102(0.61); C918(0.64); C1257(0.66)  LDD0703  [16]
 LDCM0387  CL117 HCT 116 C1102(0.80); C217(0.88); C491(0.96); C682(0.99)  LDD0704  [16]
 LDCM0388  CL118 HCT 116 C217(0.74); C778(0.83); C918(0.86); C682(0.93)  LDD0705  [16]
 LDCM0389  CL119 HCT 116 C918(0.86); C1102(0.86); C617(0.87); C934(0.92)  LDD0706  [16]
 LDCM0390  CL12 HCT 116 C682(0.86); C1102(0.87); C918(0.89); C491(0.91)  LDD0707  [16]
 LDCM0391  CL120 HCT 116 C217(0.58); C778(0.75); C918(0.77); C1257(0.87)  LDD0708  [16]
 LDCM0392  CL121 HCT 116 C918(0.69); C436(0.74); C736(0.84); C617(0.84)  LDD0709  [16]
 LDCM0393  CL122 HCT 116 C918(0.82); C436(0.86); C491(0.88); C682(0.88)  LDD0710  [16]
 LDCM0394  CL123 HCT 116 C918(0.70); C459(0.78); C1102(0.79); C617(0.84)  LDD0711  [16]
 LDCM0395  CL124 HCT 116 C918(0.62); C1102(0.72); C459(0.79); C617(0.81)  LDD0712  [16]
 LDCM0396  CL125 HCT 116 C918(0.63); C1102(0.71); C1257(0.74); C1260(0.77)  LDD0713  [16]
 LDCM0397  CL126 HCT 116 C918(0.51); C1102(0.60); C682(0.65); C926(0.68)  LDD0714  [16]
 LDCM0398  CL127 HCT 116 C1102(0.61); C918(0.66); C926(0.76); C934(0.77)  LDD0715  [16]
 LDCM0399  CL128 HCT 116 C1102(0.46); C918(0.50); C934(0.68); C926(0.69)  LDD0716  [16]
 LDCM0400  CL13 HCT 116 C918(0.91); C682(0.91); C1102(1.01); C491(1.01)  LDD0717  [16]
 LDCM0401  CL14 HCT 116 C682(0.55); C753(0.80); C824(0.85); C918(0.87)  LDD0718  [16]
 LDCM0402  CL15 HCT 116 C682(0.81); C918(0.88); C778(0.94); C491(0.98)  LDD0719  [16]
 LDCM0403  CL16 HCT 116 C682(0.59); C1102(0.60); C934(0.67); C824(0.67)  LDD0720  [16]
 LDCM0404  CL17 HCT 116 C682(0.47); C491(0.76); C824(0.81); C934(0.83)  LDD0721  [16]
 LDCM0405  CL18 HCT 116 C682(0.82); C824(0.89); C436(0.92); C918(0.92)  LDD0722  [16]
 LDCM0406  CL19 HCT 116 C682(0.42); C1102(0.72); C491(0.74); C934(0.75)  LDD0723  [16]
 LDCM0407  CL2 HCT 116 C682(0.88); C753(0.94); C1528(0.94); C824(0.99)  LDD0724  [16]
 LDCM0408  CL20 HCT 116 C1102(0.52); C682(0.54); C491(0.60); C824(0.63)  LDD0725  [16]
 LDCM0409  CL21 HCT 116 C1102(0.52); C682(0.53); C934(0.59); C926(0.62)  LDD0726  [16]
 LDCM0410  CL22 HCT 116 C1102(0.56); C491(0.66); C682(0.68); C436(0.73)  LDD0727  [16]
 LDCM0411  CL23 HCT 116 C682(0.50); C1102(0.51); C934(0.61); C926(0.61)  LDD0728  [16]
 LDCM0412  CL24 HCT 116 C1102(0.46); C682(0.52); C824(0.59); C934(0.65)  LDD0729  [16]
 LDCM0413  CL25 HCT 116 C1102(0.43); C1257(1.03); C1260(0.92); C1528(1.38)  LDD0730  [16]
 LDCM0414  CL26 HCT 116 C1102(0.41); C1257(0.90); C1260(0.85); C1528(0.95)  LDD0731  [16]
 LDCM0415  CL27 HCT 116 C1102(0.60); C1257(0.94); C1260(0.87); C1528(1.45)  LDD0732  [16]
 LDCM0416  CL28 HCT 116 C1102(0.51); C1257(1.04); C1260(0.94); C1528(1.02)  LDD0733  [16]
 LDCM0417  CL29 HCT 116 C1102(0.54); C1257(1.02); C1260(0.96); C1528(1.06)  LDD0734  [16]
 LDCM0418  CL3 HCT 116 C1102(1.30); C1257(1.08); C1260(1.13); C1528(0.90)  LDD0735  [16]
 LDCM0419  CL30 HCT 116 C1102(0.62); C1257(0.93); C1260(0.89); C1528(1.06)  LDD0736  [16]
 LDCM0420  CL31 HCT 116 C1565(1.57); C1573(1.57); C1569(1.57); C1102(0.69)  LDD0737  [16]
 LDCM0421  CL32 HCT 116 C1565(1.55); C1573(1.55); C1569(1.55); C1102(0.94)  LDD0738  [16]
 LDCM0422  CL33 HCT 116 C1565(1.55); C1573(1.55); C1569(1.55); C1102(0.69)  LDD0739  [16]
 LDCM0423  CL34 HCT 116 C1565(2.39); C1573(2.39); C1569(2.39); C1102(0.53)  LDD0740  [16]
 LDCM0424  CL35 HCT 116 C1565(5.56); C1573(5.56); C1569(5.56); C1102(0.51)  LDD0741  [16]
 LDCM0425  CL36 HCT 116 C1565(2.54); C1573(2.54); C1569(2.54); C1102(0.56)  LDD0742  [16]
 LDCM0426  CL37 HCT 116 C1565(3.40); C1573(3.40); C1569(3.40); C1102(0.55)  LDD0743  [16]
 LDCM0428  CL39 HCT 116 C1565(2.22); C1573(2.22); C1569(2.22); C1102(0.50)  LDD0745  [16]
 LDCM0429  CL4 HCT 116 C1102(1.02); C1257(0.95); C1260(0.96); C1528(1.05)  LDD0746  [16]
 LDCM0430  CL40 HCT 116 C1565(1.97); C1573(1.97); C1569(1.97); C1102(0.53)  LDD0747  [16]
 LDCM0431  CL41 HCT 116 C1565(1.50); C1573(1.50); C1569(1.50); C1102(0.58)  LDD0748  [16]
 LDCM0432  CL42 HCT 116 C1565(2.32); C1573(2.32); C1569(2.32); C1102(0.53)  LDD0749  [16]
 LDCM0433  CL43 HCT 116 C1565(3.59); C1573(3.59); C1569(3.59); C1102(0.53)  LDD0750  [16]
 LDCM0434  CL44 HCT 116 C1565(2.94); C1573(2.94); C1569(2.94); C1102(0.67)  LDD0751  [16]
 LDCM0435  CL45 HCT 116 C1565(3.52); C1573(3.52); C1569(3.52); C1102(0.60)  LDD0752  [16]
 LDCM0436  CL46 HCT 116 C1102(1.97); C1257(1.18); C1260(1.17); C151(1.05)  LDD0753  [16]
 LDCM0437  CL47 HCT 116 C1102(1.73); C1257(1.06); C1260(1.08); C151(0.98)  LDD0754  [16]
 LDCM0438  CL48 HCT 116 C1102(1.67); C1257(1.06); C1260(1.05); C151(0.85)  LDD0755  [16]
 LDCM0439  CL49 HCT 116 C1102(1.19); C1257(1.19); C1260(1.12); C151(0.95)  LDD0756  [16]
 LDCM0440  CL5 HCT 116 C1102(1.19); C1257(1.02); C1260(1.05); C1528(1.09)  LDD0757  [16]
 LDCM0441  CL50 HCT 116 C1102(1.37); C1257(1.09); C1260(1.10); C151(0.88)  LDD0758  [16]
 LDCM0442  CL51 HCT 116 C1102(1.42); C1257(1.10); C1260(1.06); C151(0.88)  LDD0759  [16]
 LDCM0443  CL52 HCT 116 C1102(1.33); C1257(0.93); C1260(0.91); C151(0.85)  LDD0760  [16]
 LDCM0444  CL53 HCT 116 C1102(1.30); C1257(1.03); C1260(1.01); C151(0.95)  LDD0761  [16]
 LDCM0445  CL54 HCT 116 C1102(1.69); C1257(1.32); C1260(1.21); C151(1.00)  LDD0762  [16]
 LDCM0446  CL55 HCT 116 C1102(1.58); C1257(1.24); C1260(1.17); C151(0.83)  LDD0763  [16]
 LDCM0447  CL56 HCT 116 C1102(1.03); C1257(1.10); C1260(1.05); C151(1.01)  LDD0764  [16]
 LDCM0448  CL57 HCT 116 C1102(1.43); C1257(1.13); C1260(1.11); C151(0.76)  LDD0765  [16]
 LDCM0449  CL58 HCT 116 C1102(1.69); C1257(1.12); C1260(1.10); C151(0.91)  LDD0766  [16]
 LDCM0450  CL59 HCT 116 C1102(1.08); C1257(1.10); C1260(1.10); C151(0.94)  LDD0767  [16]
 LDCM0451  CL6 HCT 116 C1102(1.26); C1257(1.04); C1260(1.07); C1528(0.95)  LDD0768  [16]
 LDCM0452  CL60 HCT 116 C1102(1.17); C1257(1.02); C1260(1.03); C151(0.89)  LDD0769  [16]
 LDCM0453  CL61 HCT 116 C1102(0.73); C1257(0.90); C1260(0.85); C151(0.77)  LDD0770  [16]
 LDCM0454  CL62 HCT 116 C1102(0.76); C1257(0.87); C1260(0.81); C151(0.77)  LDD0771  [16]
 LDCM0455  CL63 HCT 116 C1102(0.60); C1257(0.85); C1260(0.81); C151(0.70)  LDD0772  [16]
 LDCM0456  CL64 HCT 116 C1102(0.49); C1257(0.93); C1260(0.83); C151(0.77)  LDD0773  [16]
 LDCM0457  CL65 HCT 116 C1102(0.68); C1257(0.96); C1260(0.89); C151(0.86)  LDD0774  [16]
 LDCM0458  CL66 HCT 116 C1102(0.49); C1257(1.01); C1260(0.92); C151(0.78)  LDD0775  [16]
 LDCM0459  CL67 HCT 116 C1102(0.57); C1257(0.94); C1260(0.91); C151(0.72)  LDD0776  [16]
 LDCM0460  CL68 HCT 116 C1102(0.60); C1257(1.03); C1260(0.82); C151(0.91)  LDD0777  [16]
 LDCM0461  CL69 HCT 116 C1102(1.40); C1257(1.21); C1260(1.10); C151(1.11)  LDD0778  [16]
 LDCM0462  CL7 HCT 116 C1102(0.88); C1257(1.18); C1260(1.17); C1528(1.25)  LDD0779  [16]
 LDCM0463  CL70 HCT 116 C1102(0.70); C1257(0.98); C1260(0.87); C151(0.83)  LDD0780  [16]
 LDCM0464  CL71 HCT 116 C1102(0.52); C1257(0.85); C1260(0.79); C151(0.79)  LDD0781  [16]
 LDCM0465  CL72 HCT 116 C1102(0.72); C1257(0.96); C1260(0.75); C151(0.73)  LDD0782  [16]
 LDCM0466  CL73 HCT 116 C1102(0.56); C1257(0.85); C1260(0.76); C151(0.68)  LDD0783  [16]
 LDCM0467  CL74 HCT 116 C1102(0.51); C1257(0.83); C1260(0.75); C151(0.73)  LDD0784  [16]
 LDCM0469  CL76 HCT 116 C1565(1.61); C1573(1.61); C1569(2.03); C1102(0.78)  LDD0786  [16]
 LDCM0470  CL77 HCT 116 C1565(1.93); C1573(1.93); C1569(1.96); C1102(0.73)  LDD0787  [16]
 LDCM0471  CL78 HCT 116 C1565(1.22); C1573(1.22); C1569(1.51); C1102(0.49)  LDD0788  [16]
 LDCM0472  CL79 HCT 116 C1565(1.67); C1573(1.67); C1569(1.96); C1102(0.32)  LDD0789  [16]
 LDCM0473  CL8 HCT 116 C1102(0.72); C1257(1.07); C1260(1.04); C1528(1.02)  LDD0790  [16]
 LDCM0474  CL80 HCT 116 C1565(1.98); C1573(1.98); C1569(1.93); C1102(1.23)  LDD0791  [16]
 LDCM0475  CL81 HCT 116 C1565(1.09); C1573(1.09); C1569(1.13); C1102(0.39)  LDD0792  [16]
 LDCM0476  CL82 HCT 116 C1565(1.57); C1573(1.57); C1569(1.80); C1102(0.32)  LDD0793  [16]
 LDCM0477  CL83 HCT 116 C1565(1.87); C1573(1.87); C1569(2.01); C1102(0.32)  LDD0794  [16]
 LDCM0478  CL84 HCT 116 C1565(1.72); C1573(1.72); C1569(1.73); C1102(0.35)  LDD0795  [16]
 LDCM0479  CL85 HCT 116 C1565(1.39); C1573(1.39); C1569(2.03); C1102(0.45)  LDD0796  [16]
 LDCM0480  CL86 HCT 116 C1565(1.11); C1573(1.11); C1569(1.15); C1102(0.65)  LDD0797  [16]
 LDCM0481  CL87 HCT 116 C1565(1.20); C1573(1.20); C1569(1.37); C1102(0.37)  LDD0798  [16]
 LDCM0482  CL88 HCT 116 C1565(1.54); C1573(1.54); C1569(1.99); C1102(0.33)  LDD0799  [16]
 LDCM0483  CL89 HCT 116 C1565(1.57); C1573(1.57); C1569(2.11); C1102(0.33)  LDD0800  [16]
 LDCM0484  CL9 HCT 116 C1102(0.92); C1257(0.99); C1260(0.98); C1528(1.11)  LDD0801  [16]
 LDCM0485  CL90 HCT 116 C1565(1.00); C1573(1.00); C1569(0.87); C1102(1.18)  LDD0802  [16]
 LDCM0486  CL91 HCT 116 C1565(0.57); C1573(0.57); C1569(0.57); C1102(0.68)  LDD0803  [16]
 LDCM0487  CL92 HCT 116 C1565(0.52); C1573(0.52); C1569(0.52); C1102(0.74)  LDD0804  [16]
 LDCM0488  CL93 HCT 116 C1565(1.23); C1573(1.23); C1569(1.23); C1102(0.86)  LDD0805  [16]
 LDCM0489  CL94 HCT 116 C1565(0.78); C1573(0.78); C1569(0.78); C1102(0.74)  LDD0806  [16]
 LDCM0490  CL95 HCT 116 C1565(0.59); C1573(0.59); C1569(0.59); C1102(0.61)  LDD0807  [16]
 LDCM0491  CL96 HCT 116 C1565(0.58); C1573(0.58); C1569(0.58); C1102(0.65)  LDD0808  [16]
 LDCM0492  CL97 HCT 116 C1565(0.85); C1573(0.85); C1569(0.85); C1102(0.64)  LDD0809  [16]
 LDCM0493  CL98 HCT 116 C1565(0.61); C1573(0.61); C1569(0.61); C1102(0.56)  LDD0810  [16]
 LDCM0494  CL99 HCT 116 C1565(0.67); C1573(0.67); C1569(0.67); C1102(0.57)  LDD0811  [16]
 LDCM0495  E2913 HEK-293T C753(0.98); C870(0.86); C617(1.01); C736(0.94)  LDD1698  [40]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C870(4.44); C1260(2.40); C1528(1.83); C778(1.52)  LDD1702  [37]
 LDCM0625  F8 Ramos C736(1.29); C617(1.18); C753(1.21); C1102(1.03)  LDD2187  [41]
 LDCM0572  Fragment10 Ramos C736(1.08); C617(0.77); C753(1.01); C1102(0.76)  LDD2189  [41]
 LDCM0573  Fragment11 MDA-MB-231 C870(0.88)  LDD1467  [42]
 LDCM0574  Fragment12 MDA-MB-231 C870(1.66)  LDD1468  [42]
 LDCM0575  Fragment13 Ramos C736(1.26); C617(0.98); C753(1.19); C1102(1.11)  LDD2192  [41]
 LDCM0576  Fragment14 MDA-MB-231 C870(20.00)  LDD1471  [42]
 LDCM0579  Fragment20 Ramos C736(1.32); C617(0.72); C753(0.91); C1102(0.95)  LDD2194  [41]
 LDCM0580  Fragment21 Ramos C736(0.79); C617(0.80); C753(0.90); C1102(1.06)  LDD2195  [41]
 LDCM0582  Fragment23 Ramos C736(0.88); C617(0.87); C753(0.73); C1102(0.98)  LDD2196  [41]
 LDCM0578  Fragment27 Ramos C736(1.03); C617(0.89); C753(1.26); C1102(1.07)  LDD2197  [41]
 LDCM0586  Fragment28 Ramos C736(0.75); C617(0.72); C753(0.66); C1102(0.68)  LDD2198  [41]
 LDCM0588  Fragment30 Ramos C736(1.43); C617(1.39); C753(1.63); C1102(1.26)  LDD2199  [41]
 LDCM0589  Fragment31 Ramos C736(1.38); C617(1.18); C753(1.25); C1102(1.11)  LDD2200  [41]
 LDCM0590  Fragment32 Ramos C736(1.32); C617(0.89); C753(1.24); C1102(0.71)  LDD2201  [41]
 LDCM0468  Fragment33 HCT 116 C1102(0.59); C1257(0.95); C1260(0.82); C151(0.92)  LDD0785  [16]
 LDCM0596  Fragment38 MDA-MB-231 C870(20.00)  LDD1480  [42]
 LDCM0566  Fragment4 MDA-MB-231 C870(2.14)  LDD1461  [42]
 LDCM0427  Fragment51 HCT 116 C1565(2.57); C1573(2.57); C1569(2.57); C1102(0.52)  LDD0744  [16]
 LDCM0610  Fragment52 Ramos C736(1.72); C617(1.66); C753(1.48); C1102(1.08)  LDD2204  [41]
 LDCM0614  Fragment56 Ramos C736(1.91); C617(1.27); C753(1.58); C1102(1.17)  LDD2205  [41]
 LDCM0569  Fragment7 Ramos C736(1.84); C617(0.99); C753(0.97); C1102(0.80)  LDD2186  [41]
 LDCM0571  Fragment9 MDA-MB-231 C870(2.79)  LDD1463  [42]
 LDCM0116  HHS-0101 DM93 Y883(0.51); Y377(0.52); Y430(0.81); Y279(0.81)  LDD0264  [14]
 LDCM0117  HHS-0201 DM93 Y883(0.59); Y377(0.61); Y634(0.75); Y799(0.76)  LDD0265  [14]
 LDCM0118  HHS-0301 DM93 Y883(0.21); Y634(0.64); Y799(0.74); Y430(0.76)  LDD0266  [14]
 LDCM0119  HHS-0401 DM93 Y883(0.49); Y966(0.67); Y634(0.79); Y430(0.88)  LDD0267  [14]
 LDCM0120  HHS-0701 DM93 Y883(0.12); Y1477(0.89); Y430(0.91); Y510(0.95)  LDD0268  [14]
 LDCM0107  IAA HeLa H1197(0.00); H229(0.00); H309(0.00); H1233(0.00)  LDD0221  [32]
 LDCM0123  JWB131 DM93 Y1438(0.57); Y634(0.74)  LDD0285  [13]
 LDCM0124  JWB142 DM93 Y1438(0.82); Y634(0.91)  LDD0286  [13]
 LDCM0125  JWB146 DM93 Y1438(0.45); Y634(1.06)  LDD0287  [13]
 LDCM0126  JWB150 DM93 Y1438(1.12); Y634(1.53)  LDD0288  [13]
 LDCM0127  JWB152 DM93 Y1438(1.16); Y634(2.04)  LDD0289  [13]
 LDCM0128  JWB198 DM93 Y1438(0.18); Y634(0.53)  LDD0290  [13]
 LDCM0129  JWB202 DM93 Y1438(0.54); Y634(0.90)  LDD0291  [13]
 LDCM0130  JWB211 DM93 Y1438(0.31); Y634(1.16)  LDD0292  [13]
 LDCM0179  JZ128 PC-3 C491(0.00); C926(0.00); C328(0.00); C1205(0.00)  LDD0462  [11]
 LDCM0022  KB02 HCT 116 C870(1.35); C1257(4.84); C926(5.85); C934(5.85)  LDD0080  [16]
 LDCM0023  KB03 HCT 116 C870(1.21); C1257(12.11); C926(11.25); C934(11.25)  LDD0081  [16]
 LDCM0024  KB05 HCT 116 C870(20.00); C1257(9.58); C926(7.12); C934(7.12)  LDD0082  [16]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C870(0.94); C617(1.26); C736(0.94); C1528(1.44)  LDD2102  [37]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C870(0.87); C617(0.78); C736(0.50); C1528(0.60)  LDD2121  [37]
 LDCM0109  NEM HeLa H309(0.00); H1233(0.00); H229(0.00); H1197(0.00)  LDD0223  [32]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C870(0.87); C617(0.63); C736(0.66); C1528(0.70)  LDD2089  [37]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C870(1.11); C736(1.00); C1528(1.43); C436(0.90)  LDD2090  [37]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C870(0.97); C617(1.11); C736(1.05); C436(1.47)  LDD2092  [37]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C870(1.14); C617(1.14); C736(1.30); C753(1.12)  LDD2093  [37]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C870(1.26); C617(2.11)  LDD2094  [37]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C870(0.60); C617(0.12); C736(0.10); C1528(0.12)  LDD2096  [37]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C617(0.78); C736(0.91); C1528(0.74); C436(0.78)  LDD2097  [37]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C870(0.79); C617(0.43); C736(0.79); C436(0.86)  LDD2098  [37]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C870(1.05); C617(1.17); C736(1.16); C753(1.64)  LDD2099  [37]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C870(0.90); C617(0.32); C736(0.64); C753(0.50)  LDD2100  [37]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C870(0.80); C617(1.22); C736(0.86); C1528(1.58)  LDD2101  [37]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C870(0.76); C617(0.52); C736(0.55); C436(0.37)  LDD2104  [37]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C870(1.26); C617(1.90); C736(1.14); C459(1.26)  LDD2105  [37]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C870(0.81); C617(0.59); C736(0.55); C436(0.32)  LDD2106  [37]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C870(1.04); C617(1.05); C736(1.10); C1528(1.19)  LDD2107  [37]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C870(0.82); C617(0.15); C736(0.48); C459(0.56)  LDD2108  [37]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C870(0.95); C617(0.52); C736(0.57); C1528(0.57)  LDD2109  [37]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C870(1.70); C736(1.13); C436(0.47); C459(0.48)  LDD2110  [37]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C870(1.20); C617(1.14); C736(1.30); C1528(1.28)  LDD2111  [37]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C870(0.67); C617(0.93); C736(0.84); C436(0.45)  LDD2114  [37]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C870(0.52); C617(0.69); C736(0.54); C1528(0.79)  LDD2115  [37]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C870(0.89); C617(0.33); C736(0.19); C436(0.05)  LDD2116  [37]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C870(0.91); C617(0.31); C736(0.19); C1528(0.24)  LDD2118  [37]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C870(2.73); C617(1.98); C736(2.45); C1528(1.89)  LDD2119  [37]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C870(0.63); C617(0.84); C736(1.03); C1528(0.96)  LDD2120  [37]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C870(1.01); C617(0.16); C736(0.12); C436(0.18)  LDD2122  [37]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C870(1.05); C617(0.83); C736(1.04); C1528(0.90)  LDD2123  [37]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C870(1.08); C617(0.18); C736(0.11); C1528(0.13)  LDD2124  [37]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C870(0.90); C617(0.79); C736(0.90); C1528(0.92)  LDD2125  [37]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C870(1.00); C617(0.19); C736(0.11); C1528(0.10)  LDD2126  [37]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C870(1.12); C617(1.12); C736(1.26); C1528(1.38)  LDD2127  [37]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C870(0.66); C617(0.70); C736(0.90); C1528(1.12)  LDD2128  [37]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C870(0.96); C617(1.21); C736(1.28); C1528(1.23)  LDD2129  [37]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C870(0.63); C617(0.70); C736(0.55); C436(0.45)  LDD2133  [37]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C870(0.55); C617(0.46); C736(0.57); C753(0.39)  LDD2134  [37]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C870(0.97); C617(1.52); C736(2.01); C1528(1.48)  LDD2135  [37]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C870(1.22); C617(1.49); C736(1.73); C1528(1.69)  LDD2136  [37]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C870(1.07); C617(0.96); C736(1.15); C1528(1.10)  LDD2137  [37]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C436(3.40); C491(2.93); C459(2.84); C736(2.68)  LDD1700  [37]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C870(0.97); C617(0.89); C736(0.94); C1528(0.91)  LDD2140  [37]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C870(0.77); C617(0.13); C736(0.39); C753(0.81)  LDD2141  [37]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C870(0.71); C617(0.85); C736(0.99); C1528(0.99)  LDD2143  [37]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C870(2.89); C617(1.81); C736(2.27); C1528(1.77)  LDD2144  [37]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C870(11.24); C436(6.01); C491(2.75)  LDD2145  [37]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C870(1.13); C617(0.88); C736(1.11); C1528(0.99)  LDD2146  [37]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C870(1.38); C617(2.14); C736(2.22); C1528(2.99)  LDD2147  [37]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C870(0.49); C617(0.52); C436(0.47); C459(0.53)  LDD2148  [37]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C870(0.99); C617(0.21); C736(0.13); C1528(0.19)  LDD2149  [37]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C870(0.55); C617(0.44); C736(0.49); C1528(0.45)  LDD2150  [37]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C870(1.01); C617(0.17); C459(2.15); C682(0.81)  LDD2151  [37]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C870(1.94); C617(1.36); C736(1.75); C753(1.42)  LDD2153  [37]
 LDCM0628  OTUB2-COV-1 HEK-293T C1528(0.84); C870(0.81); C753(0.72); C753(0.64)  LDD2207  [43]
 LDCM0131  RA190 MM1.R C926(2.39); C934(2.39); C491(2.20); C870(1.64)  LDD0304  [44]
 LDCM0021  THZ1 HeLa S3 C1205(1.21); C753(1.05); C934(1.05); C328(1.00)  LDD0460  [11]
 LDCM0110  W12 Hep-G2 C870(22.63)  LDD0237  [33]
 LDCM0111  W14 Hep-G2 C870(23.05)  LDD0238  [33]
 LDCM0112  W16 Hep-G2 C870(0.53)  LDD0239  [33]
 LDCM0113  W17 Hep-G2 C870(12.81); H867(13.63)  LDD0240  [33]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Inositol polyphosphate 5-phosphatase OCRL (OCRL) Inositol 1,4,5-trisphosphate 5-phosphatase type II family Q01968
Activated CDC42 kinase 1 (TNK2) Tyr protein kinase family Q07912
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Clathrin light chain A (CLTA) Clathrin light chain family P09496
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Microphthalmia-associated transcription factor (MITF) MiT/TFE family O75030
Transcriptional activator Myb (MYB) . P10242
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TOM1-like protein 1 (TOM1L1) TOM1 family O75674
G2 and S phase-expressed protein 1 (GTSE1) . Q9NYZ3

References

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3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Proteome-Wide Profiling of Cellular Targets Modified by Dopamine Metabolites Using a Bio-Orthogonally Functionalized Catecholamine. ACS Chem Biol. 2021 Nov 19;16(11):2581-2594. doi: 10.1021/acschembio.1c00629. Epub 2021 Nov 2.
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Mass spectrometry data entry: PXD028270
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Mass spectrometry data entry: PXD042888
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Mass spectrometry data entry: PXD044625
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17 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
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Mass spectrometry data entry: PXD028853
20 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
21 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
22 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
24 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
25 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
26 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
27 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
28 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
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Mass spectrometry data entry: PXD033004
30 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
31 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
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37 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
38 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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