Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment4  Competitor Info 
Competitor Concentration 100 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cells (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 97 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP02074  Aldehyde dehydrogenase, mitochondrial (ALDH2) C319 20.0
 LDTP08401  All trans-polyprenyl-diphosphate synthase PDSS2 (PDSS2) C71 20.0
 LDTP06211  Caspase-8 (CASP8) C360 20.0
 LDTP12539  DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) C130 20.0
 LDTP03786  Glutaredoxin-1 (GLRX) C23 20.0
 LDTP16025  Ketosamine-3-kinase (FN3KRP) C24 20.0
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) C267 20.0
 LDTP10177  Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) C64 20.0
 LDTP13980  Methionine-R-sulfoxide reductase B2, mitochondrial (MSRB2) C105 20.0
 LDTP09598  Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) C207 20.0
 LDTP12837  Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) C22 20.0
 LDTP09126  Probable aminopeptidase NPEPL1 (NPEPL1) C81 20.0
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C57 20.0
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C190 20.0
 LDTP12313  Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 (ALG13) C86 20.0
 LDTP12784  Pyroglutamyl-peptidase 1 (PGPEP1) C149 20.0
 LDTP14155  Serine/threonine-protein kinase MRCK beta (CDC42BPB) C1517 20.0
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) C54 20.0
 LDTP03163  Sterol carrier protein 2 (SCP2) C307 20.0
 LDTP03163  Sterol carrier protein 2 (SCP2) C94 20.0
 LDTP02055  Thymidylate synthase (TYMS) C199 20.0
 LDTP11111  Tudor-interacting repair regulator protein (NUDT16L1) C88 20.0
 LDTP14159  Ubiquitin carboxyl-terminal hydrolase 16 (USP16) C205 20.0
 LDTP10785  Ubiquitin carboxyl-terminal hydrolase 28 (USP28) C171 20.0
 LDTP00013  Ubiquitin-like modifier-activating enzyme 6 (UBA6) C347 20.0
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C620 20.0
 LDTP03859  V-type proton ATPase catalytic subunit A (ATP6V1A) C138 20.0
 LDTP06320  [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (PDK1) C71 20.0
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 19.9
 LDTP05346  Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (ALDH6A1) C317 14.4
 LDTP14888  Pre-rRNA-processing protein TSR1 homolog (TSR1) C126 13.8
 LDTP04076  Mitogen-activated protein kinase 9 (MAPK9) C177 12.0
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 9.0
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 9.0
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 6.8
 LDTP09962  Ubiquitin carboxyl-terminal hydrolase 7 (USP7) C223 6.8
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C758 6.4
 LDTP12227  Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2) C216 5.9
 LDTP10386  ERO1-like protein alpha (ERO1A) C37 5.4
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 4.9
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 4.6
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 4.5
 LDTP03770  Alpha-adducin (ADD1) C68 4.3
 LDTP03316  DNA replication licensing factor MCM3 (MCM3) C119 4.3
 LDTP10801  ATPase WRNIP1 (WRNIP1) C272 3.7
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 3.7
 LDTP10973  Thioredoxin, mitochondrial (TXN2) C90 3.6
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 3.5
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 3.5
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 3.4
 LDTP02502  Thioredoxin (TXN) C32 3.3
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 3.0
 LDTP00481  Ubiquitin/ISG15-conjugating enzyme E2 L6 (UBE2L6) C98 3.0
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 3.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 2.8
 LDTP03152  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) C102 2.8
 LDTP03163  Sterol carrier protein 2 (SCP2) C71 2.7
 LDTP10320  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (TRMT61A) C209 2.4
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 2.4
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 2.3
 LDTP05289  AMP deaminase 2 (AMPD2) C107 2.3
 LDTP02223  Cathepsin B (CTSB) C211 2.3
 LDTP18330  Haloacid dehalogenase-like hydrolase domain-containing 5 (HDHD5) C392 2.2
 LDTP04374  Dynamin-2 (DNM2) C27 2.2
 LDTP11059  ADP-ribose glycohydrolase MACROD1 (MACROD1) C186 1.8
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) C326 1.7
 LDTP05480  Amidophosphoribosyltransferase (PPAT) C100 1.7
 LDTP16095  Ethylmalonyl-CoA decarboxylase (ECHDC1) C133 1.7
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 1.6
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.6
 LDTP07110  Putative transferase CAF17, mitochondrial (IBA57) C170 1.5
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 1.4
 LDTP03400  Deoxycytidine kinase (DCK) C9 1.4
 LDTP04262  Alanine--tRNA ligase, cytoplasmic (AARS1) C773 1.3
 LDTP05773  Peroxiredoxin-4 (PRDX4) C51 1.2
 LDTP04572  Dipeptidyl peptidase 1 (CTSC) C258 1.2
 LDTP14092  Protein phosphatase methylesterase 1 (PPME1) C381 1.1
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C312 1.0
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 1.0
 LDTP04438  Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1) C340 1.0
 LDTP06643  Uridine phosphorylase 1 (UPP1) C162 1.0
 LDTP10774  Elongation factor G, mitochondrial (GFM1) C153 1.0
 LDTP10982  Aconitate hydratase, mitochondrial (ACO2) C385 1.0
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 1.0
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 0.9
 LDTP15311  Deaminated glutathione amidase (NIT1) C165 0.9
 LDTP18123  Isochorismatase domain-containing protein 2 (ISOC2) C114 0.8
 LDTP05859  Integrin-linked protein kinase (ILK) C346 0.8
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C54 0.8
 LDTP13663  Dual specificity protein phosphatase 12 (DUSP12) C265 0.8
 LDTP02022  Thymidine kinase, cytosolic (TK1) C230 0.8
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 0.7
 LDTP15311  Deaminated glutathione amidase (NIT1) C203 0.7
 LDTP06603  Cyclin-dependent kinase inhibitor 3 (CDKN3) C39 0.6
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 0.6
 LDTP03146  Protein-glutamine gamma-glutamyltransferase 2 (TGM2) C277 0.5
 LDTP03258  Thymidylate kinase (DTYMK) C163 0.4
Transporter and channel
Click to Show/Hide to Show 11 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 20.0
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 20.0
 LDTP10642  Chloride intracellular channel protein 6 (CLIC6) C487 20.0
 LDTP04801  Gasdermin-D (GSDMD) C268 20.0
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) C65 4.7
 LDTP09204  Nucleoporin NUP35 (NUP35) C255 3.9
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 3.5
 LDTP05252  Clathrin heavy chain 1 (CLTC) C870 2.1
 LDTP00501  Exportin-1 (XPO1) C528 1.9
 LDTP05591  Nuclear cap-binding protein subunit 1 (NCBP1) C44 1.8
 LDTP03777  Nuclear pore complex protein Nup214 (NUP214) C728 1.7
Transcription factor
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) C55 20.0
 LDTP03280  COUP transcription factor 2 (NR2F2) C326 20.0
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 3.1
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 1.6
Other
Click to Show/Hide to Show 64 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 20.0
 LDTP06268  Condensin complex subunit 2 (NCAPH) C418 20.0
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) C93 20.0
 LDTP10252  Elongator complex protein 4 (ELP4) C218 20.0
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 20.0
 LDTP07088  Formin-binding protein 1-like (FNBP1L) C69 20.0
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 20.0
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 20.0
 LDTP14217  Lipid droplet-regulating VLDL assembly factor AUP1 (AUP1) C391 20.0
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 20.0
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 20.0
 LDTP13088  Protein IMPACT (IMPACT) C195 20.0
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) C18 20.0
 LDTP12412  Reticulon-4 (RTN4) C1101 20.0
 LDTP12800  Serine/threonine-protein phosphatase 4 regulatory subunit 2 (PPP4R2) C22 20.0
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) C532 20.0
 LDTP13583  Targeting protein for Xklp2 (TPX2) C536 20.0
 LDTP07205  Telomere-associated protein RIF1 (RIF1) C2298 20.0
 LDTP11191  WW domain-containing adapter protein with coiled-coil (WAC) C553 17.8
 LDTP06276  MAD2L1-binding protein (MAD2L1BP) C124 13.0
 LDTP01532  ZW10 interactor (ZWINT) C54 12.4
 LDTP12963  Ankycorbin (RAI14) C973 8.7
 LDTP00463  Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) C343 6.6
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) C267 6.0
 LDTP05867  Treacle protein (TCOF1) C1298 5.6
 LDTP15701  EF-hand domain-containing protein D2 (EFHD2) C172 5.3
 LDTP04487  Cyclin-H (CCNH) C244 5.3
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C618 4.5
 LDTP13622  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (NFU1) C213 4.4
 LDTP08018  Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1) C645 4.4
 LDTP06330  Plectin (PLEC) C4574 4.2
 LDTP12443  Anillin (ANLN) C712 4.1
 LDTP10613  Dedicator of cytokinesis protein 7 (DOCK7) C2125 4.1
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) C132 3.8
 LDTP14250  Cytoplasmic dynein 1 light intermediate chain 1 (DYNC1LI1) C51 3.5
 LDTP16117  Mediator of RNA polymerase II transcription subunit 9 (MED9) C139 3.4
 LDTP15896  Ashwin (C2orf49) C10 3.3
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) C242 3.0
 LDTP12753  Succinate dehydrogenase assembly factor 2, mitochondrial (SDHAF2) C83 3.0
 LDTP14351  RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1) C179 3.0
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 2.8
 LDTP05867  Treacle protein (TCOF1) C38 2.8
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 2.7
 LDTP14215  Small ribosomal subunit protein mS40 (MRPS18B) C128 2.3
 LDTP06281  Condensin complex subunit 1 (NCAPD2) C439 2.2
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 2.1
 LDTP07037  WD repeat domain phosphoinositide-interacting protein 3 (WDR45B) C63 2.0
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) C124 1.7
 LDTP10284  Multivesicular body subunit 12A (MVB12A) C231 1.7
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 1.7
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 1.6
 LDTP12571  LanC-like protein 2 (LANCL2) C187 1.6
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) C1227 1.6
 LDTP10864  Calponin-2 (CNN2) C164 1.5
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.4
 LDTP13580  Coronin-1C (CORO1C) C420 1.3
 LDTP07755  Dynamin-binding protein (DNMBP) C691 1.2
 LDTP06046  Ribosome biogenesis protein BOP1 (BOP1) C404 1.2
 LDTP11235  Protein PAXX (PAXX) C180 1.2
 LDTP13964  MOB-like protein phocein (MOB4) C134 1.2
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 0.8
 LDTP18494  Tropomodulin-3 (TMOD3) C132 0.8
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 0.7
 LDTP04560  Cytosolic Fe-S cluster assembly factor NUBP1 (NUBP1) C235 0.6

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.