Details of the Target

General Information of Target

Target ID LDTP12313
Target Name Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 (ALG13)
Gene Name ALG13
Gene ID 79868
Synonyms
CXorf45; GLT28D1; Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13; EC 2.4.1.141; EC 3.4.19.12; Asparagine-linked glycosylation 13 homolog; Glycosyltransferase 28 domain-containing protein 1; UDP-N-acetylglucosamine transferase subunit ALG13 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDEDVLTTLKILIIGESGVGKSSLLLRFTDDTFDPELAATIGVDFKVKTISVDGNKAKLA
IWDTAGQERFRTLTPSYYRGAQGVILVYDVTRRDTFVKLDNWLNELETYCTRNDIVNMLV
GNKIDKENREVDRNEGLKFARKHSMLFIEASAKTCDGVQCAFEELVEKIIQTPGLWESEN
QNKGVKLSHREEGQGGGACGGYCSVL
Target Bioclass
Enzyme
Family
Glycosyltransferase 28 family
Subcellular location
Endoplasmic reticulum
Function
[Isoform 1]: Possible multifunctional enzyme with both glycosyltransferase and deubiquitinase activities.; [Isoform 2]: May be involved in protein N-glycosylation, second step of the dolichol-linked oligosaccharide pathway.
Uniprot ID
Q9NP73
Ensemble ID
ENST00000371979.7
HGNC ID
HGNC:30881

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.I71V .
AGS SNV: p.S154P .
HCC1937 SNV: p.D329H .
HCT116 SNV: p.L231M .
HEC1B SNV: p.L32I .
IGROV1 SNV: p.V280M .
Ishikawa (Heraklio) 02 ER SNV: p.N660S; p.P945A .
NCIH1944 SNV: p.G120C .
PC9 SNV: p.S772N .
SHP77 SNV: p.Y621D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.24  LDD0403  [1]
DBIA
 Probe Info  		C424(2.82); C499(2.21); C502(2.21)  LDD0080  [2]
5E-2FA
 Probe Info  		N.A.  LDD2235  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [5]
Compound 10
 Probe Info  		N.A.  LDD2216  [6]
Compound 11
 Probe Info  		N.A.  LDD2213  [6]
IPM
 Probe Info  		N.A.  LDD0005  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
AOyne
 Probe Info  		15.00  LDD0443  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]
TER-AC
 Probe Info  		N.A.  LDD0426  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C19(0.80); C3(2.20)  LDD0812  [2]
 LDCM0215  AC10 HEK-293T C19(0.87)  LDD0813  [2]
 LDCM0216  AC100 HEK-293T C19(1.05)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C19(0.96)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C19(1.27)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C19(1.12)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C19(1.15)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C19(2.99)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C19(1.26)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C19(1.15)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C19(1.24)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C19(1.09)  LDD0823  [2]
 LDCM0226  AC11 HEK-293T C19(1.07)  LDD0824  [2]
 LDCM0227  AC110 HEK-293T C19(1.27)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C19(1.36)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C19(1.00)  LDD0827  [2]
 LDCM0230  AC113 HEK-293T C19(0.91)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C19(0.94)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C19(0.73)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C19(0.83)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C19(0.63)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C19(1.02)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C19(0.75)  LDD0834  [2]
 LDCM0237  AC12 HEK-293T C19(0.93)  LDD0835  [2]
 LDCM0238  AC120 HEK-293T C19(0.64)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C19(0.78)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C19(0.97)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C19(1.00)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C19(0.72)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C19(0.69)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C19(0.84)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C19(1.17)  LDD0843  [2]
 LDCM0246  AC128 HEK-293T C3(0.91)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C3(0.96)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C3(0.89)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C3(0.94)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C3(1.02)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C3(1.22)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C3(1.09)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C3(1.15)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C3(0.98)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C3(1.54)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C3(1.44)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C3(1.24)  LDD0856  [2]
 LDCM0259  AC14 HEK-293T C19(1.09)  LDD0857  [2]
 LDCM0260  AC140 HEK-293T C3(1.10)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C3(1.26)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C3(1.08)  LDD0860  [2]
 LDCM0270  AC15 HEK-293T C19(1.10)  LDD0868  [2]
 LDCM0276  AC17 HEK-293T C242(0.95); C86(1.14); C708(0.97)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C242(0.96); C86(1.01); C3(0.96)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C242(1.11); C86(0.99); C424(0.80)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C19(1.04); C3(1.15)  LDD0877  [2]
 LDCM0280  AC20 HEK-293T C242(0.96); C86(1.08)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C242(1.05); C86(0.96)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C242(0.97); C86(1.02)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C86(1.10); C3(0.85)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C242(1.07); C86(1.07); C708(1.01)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C3(0.94)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C3(0.95)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C3(0.94)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C3(1.85)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C3(0.93)  LDD0887  [2]
 LDCM0290  AC3 HEK-293T C19(0.87); C3(0.94)  LDD0888  [2]
 LDCM0291  AC30 HEK-293T C3(0.82)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C3(0.87)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C3(0.87)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C3(0.78)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C3(0.82)  LDD0893  [2]
 LDCM0296  AC35 HEK-293T C242(1.12); C86(1.16); C424(1.07)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C242(1.04); C86(1.07)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C242(1.06); C86(1.02)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C242(0.97); C86(1.06)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C86(1.04); C3(1.35)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C19(1.14); C3(1.10)  LDD0899  [2]
 LDCM0302  AC40 HEK-293T C242(1.03); C86(1.20); C708(1.04)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C242(0.98); C86(1.04); C708(1.12)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C242(0.98); C86(1.16); C3(1.16)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C242(1.02); C86(1.13); C424(1.11)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C242(0.99); C86(0.99)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C242(1.03); C86(1.02)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C242(1.02); C86(1.13)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C86(1.01); C3(0.98)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C242(1.00); C86(1.10); C708(1.15)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C242(1.01); C86(1.04); C708(1.07)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C19(0.78); C3(1.04)  LDD0910  [2]
 LDCM0313  AC50 HEK-293T C242(0.96); C86(1.04); C3(0.95)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C242(1.04); C86(1.12); C424(1.02)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C242(0.98); C86(0.92)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C242(1.15); C86(1.01)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C242(1.07); C86(0.88)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C86(1.12); C3(0.93)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C242(1.12); C86(1.04); C708(1.15)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C3(1.05)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C3(0.85)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C3(0.96)  LDD0920  [2]
 LDCM0323  AC6 HEK-293T C19(1.65)  LDD0921  [2]
 LDCM0324  AC60 HEK-293T C3(3.85)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C3(1.25)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C3(1.02)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C3(1.01)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C3(0.90)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C3(0.99)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C3(0.79)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C3(0.87)  LDD0929  [2]
 LDCM0332  AC68 HEK-293T C19(1.16); C3(1.19)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C19(1.25); C3(1.56)  LDD0931  [2]
 LDCM0334  AC7 HEK-293T C19(0.81)  LDD0932  [2]
 LDCM0335  AC70 HEK-293T C19(1.50); C3(1.37)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C19(3.06); C3(1.19)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C19(1.13); C3(1.49)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C19(1.04); C3(1.58)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C19(2.28); C3(2.21)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C19(1.58); C3(1.28)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C19(1.82); C3(1.45)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C19(1.15); C3(1.21)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C19(2.13); C3(1.16)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C19(1.82); C3(1.16)  LDD0942  [2]
 LDCM0345  AC8 HEK-293T C19(1.19)  LDD0943  [2]
 LDCM0346  AC80 HEK-293T C19(1.42); C3(1.50)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C19(1.30); C3(1.35)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C19(1.44); C3(1.44)  LDD0946  [2]
 LDCM0365  AC98 HEK-293T C19(1.51)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C19(1.92)  LDD0964  [2]
 LDCM0248  AKOS034007472 HEK-293T C19(1.10)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C19(1.08)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C19(1.09)  LDD0873  [2]
 LDCM0156  Aniline NCI-H1299 13.24  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0632  CL-Sc Hep-G2 C86(1.00)  LDD2227  [11]
 LDCM0367  CL1 HEK-293T C242(0.96); C86(1.16)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C242(0.98); C86(0.94)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C19(0.88); C3(1.07)  LDD0967  [2]
 LDCM0370  CL101 HEK-293T C19(0.98)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C19(0.98)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C19(0.98)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C19(1.20)  LDD0971  [2]
 LDCM0374  CL105 HEK-293T C242(0.96); C86(1.18)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C242(1.05); C86(1.08)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C242(0.92); C86(0.93)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C242(0.97); C86(1.01); C708(1.03)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C242(1.00); C86(1.02)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C86(0.88); C3(1.00)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C242(0.89); C86(1.01)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C242(0.96); C86(0.92)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C3(0.94)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C3(0.86)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C3(1.06)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C3(1.03)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C3(0.85)  LDD0984  [2]
 LDCM0387  CL117 HEK-293T C242(1.00); C86(0.90)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C242(0.93); C86(0.87)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C242(1.07); C86(0.94)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C242(1.13); C86(1.16); C708(1.15)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C242(0.99); C86(1.04); C708(1.19)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C242(1.08); C86(0.97)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C242(0.94); C86(1.28)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C242(1.03); C86(0.77)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C242(0.93); C86(1.00); C708(1.02)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C3(0.99)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C3(1.17)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C3(0.94)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C3(0.85)  LDD0997  [2]
 LDCM0400  CL13 HEK-293T C242(0.93); C86(0.86)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C242(0.94); C86(0.80)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C242(0.84); C86(1.56)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C242(0.95); C86(0.93); C708(1.09)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C242(0.96); C86(0.97); C708(1.19)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C242(1.03); C86(1.01); C3(0.96)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C242(1.05); C86(1.14); C424(1.13)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C242(0.96); C86(0.95)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C242(1.04); C86(1.04)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C242(0.94); C86(1.88)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C242(1.06); C86(0.94)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C86(1.12); C3(1.06)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C242(1.14); C86(1.07); C708(1.05)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C242(0.87); C86(0.92)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C242(1.02); C86(1.29)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C242(0.94); C86(0.94)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C242(0.85); C86(0.92); C708(0.95)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C242(1.01); C86(0.98); C708(1.09)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C242(1.00); C86(0.98)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C242(1.01); C86(0.98); C3(1.07)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C242(1.24); C86(0.98); C424(0.97)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C242(0.93); C86(0.99)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C242(1.04); C86(0.78)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C242(1.02); C86(1.18)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C86(1.08); C3(1.10)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C242(1.02); C86(1.20); C708(1.08)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C242(1.01); C86(0.92)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C242(1.00); C86(0.70)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C242(1.02); C86(0.92); C708(1.07)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C242(0.95); C86(0.98); C708(1.08)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C242(1.02); C86(1.02); C708(1.06)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C242(1.04); C86(1.03); C3(0.99)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C242(1.10); C86(1.04); C424(1.11)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C242(1.08); C86(1.08)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C242(1.22); C86(0.79)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C242(0.95); C86(1.17)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C86(0.93); C3(1.12)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C242(1.06); C86(1.18); C708(1.02)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C242(0.90); C86(0.90)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C242(0.98); C86(0.94); C708(1.22)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C242(0.95); C86(1.07)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C242(0.83); C86(0.96); C708(1.14)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C242(0.95); C86(1.23); C708(1.11)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C242(0.88); C86(1.04); C3(0.84)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C242(1.13); C86(1.08); C424(1.11)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C242(0.91); C86(0.75)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C242(0.99); C86(1.02)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C242(1.02); C86(0.99)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C86(1.03); C3(1.03)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C242(0.98); C86(1.18); C3(0.88)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C242(0.99); C86(1.15); C708(1.14)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C242(1.00); C86(0.95)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C242(1.10); C86(0.87)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C242(1.01); C86(0.91)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C242(0.93); C86(1.05); C708(1.14)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C242(1.05); C86(1.02); C708(1.11)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C242(1.01); C86(1.20); C3(0.95)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C242(1.03); C86(1.14); C424(1.06)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C242(1.02); C86(0.80)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C242(0.91); C86(0.89)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C242(1.18); C86(1.01); C424(1.16)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C242(1.08); C86(1.06)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C86(1.15); C3(1.15)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C242(1.16); C86(1.07); C708(1.31)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C242(1.02); C86(1.22)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C242(0.97); C86(0.97)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C19(0.64)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C19(0.40)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C19(0.41)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C19(0.96)  LDD1070  [2]
 LDCM0473  CL8 HEK-293T C242(0.81); C86(2.31)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C19(0.57)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C19(0.50)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C19(0.72)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C19(0.88)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C19(0.38)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C19(0.46)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C19(0.62)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C19(0.67)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C19(0.56)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C19(0.80)  LDD1081  [2]
 LDCM0484  CL9 HEK-293T C242(1.09); C86(0.97)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C19(0.62)  LDD1083  [2]
 LDCM0486  CL91 HEK-293T C19(1.10); C3(0.83)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C19(1.17); C3(1.03)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C19(0.82); C3(0.95)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C19(0.73); C3(1.05)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C19(1.02); C3(1.38)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C19(0.95); C3(0.99)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C19(0.91); C3(0.93)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C19(0.64); C3(1.01)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C19(1.25); C3(0.97)  LDD1092  [2]
 LDCM0495  E2913 HEK-293T C242(0.99); C86(0.91)  LDD1698  [13]
 LDCM0625  F8 Ramos C86(0.85)  LDD2187  [14]
 LDCM0572  Fragment10 Ramos C86(1.32)  LDD2189  [14]
 LDCM0573  Fragment11 MDA-MB-231 C86(0.66)  LDD1467  [15]
 LDCM0574  Fragment12 Ramos C86(1.02)  LDD2191  [14]
 LDCM0575  Fragment13 MDA-MB-231 C86(0.87)  LDD1469  [15]
 LDCM0576  Fragment14 MDA-MB-231 C86(1.09)  LDD1471  [15]
 LDCM0579  Fragment20 Ramos C86(1.06)  LDD2194  [14]
 LDCM0580  Fragment21 Ramos C86(1.05)  LDD2195  [14]
 LDCM0582  Fragment23 Ramos C86(1.19)  LDD2196  [14]
 LDCM0578  Fragment27 MDA-MB-231 C86(0.43)  LDD1474  [15]
 LDCM0586  Fragment28 Ramos C86(0.85)  LDD2198  [14]
 LDCM0587  Fragment29 Ramos C86(1.98)  LDD1476  [15]
 LDCM0588  Fragment30 Ramos C86(0.71)  LDD2199  [14]
 LDCM0589  Fragment31 Ramos C86(0.97)  LDD2200  [14]
 LDCM0590  Fragment32 Ramos C86(0.98)  LDD2201  [14]
 LDCM0468  Fragment33 HEK-293T C242(0.99); C86(0.82)  LDD1671  [13]
 LDCM0596  Fragment38 MDA-MB-231 C86(1.30)  LDD1480  [15]
 LDCM0566  Fragment4 MDA-MB-231 C86(20.00)  LDD1461  [15]
 LDCM0599  Fragment41 MDA-MB-231 C86(0.45)  LDD1481  [15]
 LDCM0603  Fragment45 MDA-MB-231 C86(20.00)  LDD1482  [15]
 LDCM0427  Fragment51 MDA-MB-231 C86(1.25)  LDD1483  [15]
 LDCM0610  Fragment52 Ramos C86(0.56)  LDD2204  [14]
 LDCM0614  Fragment56 Ramos C86(0.51)  LDD2205  [14]
 LDCM0569  Fragment7 Ramos C86(2.12)  LDD2186  [14]
 LDCM0571  Fragment9 Ramos C86(2.75)  LDD2188  [14]
 LDCM0022  KB02 HCT 116 C424(2.82); C499(2.21); C502(2.21)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C424(1.41); C499(1.92); C502(1.92)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C424(2.44); C499(1.98); C502(1.98)  LDD0082  [2]
 LDCM0169  KB63 Ramos 4.14  LDD0432  [16]
 LDCM0131  RA190 MM1.R C86(2.56)  LDD0304  [17]
 LDCM0170  Structure8 Ramos 4.05  LDD0433  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tyrosine-protein kinase transmembrane receptor ROR2 (ROR2) Tyr protein kinase family Q01974
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BAG family molecular chaperone regulator 4 (BAG4) . O95429
Mitogen-activated protein kinase-binding protein 1 (MAPKBP1) . O60336

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
15 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
16 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.
17 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.