Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Experiment Method
ISO-TOP ABPP
Competitor Name Structure8  Competitor Info 
Competitor Concentration 50 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cells (Ramos)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 63 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03458  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) 20.0
 LDTP04262  Alanine--tRNA ligase, cytoplasmic (AARS1) 20.0
 LDTP03985  Caspase-2 (CASP2) 20.0
 LDTP13663  Dual specificity protein phosphatase 12 (DUSP12) 20.0
 LDTP10386  ERO1-like protein alpha (ERO1A) 20.0
 LDTP03540  Heme oxygenase 2 (HMOX2) 20.0
 LDTP14092  Protein phosphatase methylesterase 1 (PPME1) 20.0
 LDTP03496  Protein PML (PML) 20.0
 LDTP08217  Threonylcarbamoyl-AMP synthase (YRDC) 20.0
 LDTP11111  Tudor-interacting repair regulator protein (NUDT16L1) 20.0
 LDTP03859  V-type proton ATPase catalytic subunit A (ATP6V1A) 20.0
 LDTP03540  Heme oxygenase 2 (HMOX2) 18.2
 LDTP15370  Pseudouridylate synthase RPUSD2 (RPUSD2) 17.6
 LDTP06603  Cyclin-dependent kinase inhibitor 3 (CDKN3) 17.6
 LDTP01292  Protein phosphatase 1B (PPM1B) 17.5
 LDTP12586  Phenylalanine--tRNA ligase beta subunit (FARSB) 16.9
 LDTP05736  Bifunctional coenzyme A synthase (COASY) 16.8
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) 15.6
 LDTP05480  Amidophosphoribosyltransferase (PPAT) 14.0
 LDTP06211  Caspase-8 (CASP8) 13.9
 LDTP14535  6-phosphogluconolactonase (PGLS) 13.8
 LDTP04622  Branched-chain-amino-acid aminotransferase, cytosolic (BCAT1) 13.1
 LDTP11198  Alanyl-tRNA editing protein Aarsd1 (AARSD1) 12.9
 LDTP13885  Lysine-specific demethylase 2A (KDM2A) 12.8
 LDTP06384  Ribosomal protein S6 kinase alpha-1 (RPS6KA1) 12.8
 LDTP08482  3'-5' exoribonuclease 1 (ERI1) 12.3
 LDTP06320  [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (PDK1) 12.0
 LDTP05409  Antigen peptide transporter 2 (TAP2) 10.6
 LDTP05795  Nucleoside diphosphate kinase 3 (NME3) 9.3
 LDTP12539  DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) 8.7
 LDTP03540  Heme oxygenase 2 (HMOX2) 8.7
 LDTP03259  Ribonucleoside-diphosphate reductase large subunit (RRM1) 8.7
 LDTP15427  Ribonuclease P protein subunit p25-like protein (RPP25L) 7.8
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) 7.4
 LDTP13527  Aspartyl aminopeptidase (DNPEP) 7.3
 LDTP00988  Protein O-GlcNAcase (OGA) 6.8
 LDTP02971  DNA ligase 1 (LIG1) 6.7
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) 6.7
 LDTP04384  Cyclin-dependent kinase 9 (CDK9) 6.3
 LDTP13409  Anaphase-promoting complex subunit 7 (ANAPC7) 6.1
 LDTP03400  Deoxycytidine kinase (DCK) 6.1
 LDTP03458  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) 5.9
 LDTP11639  RNA exonuclease 4 (REXO4) 5.6
 LDTP00758  Thioredoxin-like protein 1 (TXNL1) 5.4
 LDTP11723  Cytosolic 5'-nucleotidase 3A (NT5C3A) 5.3
 LDTP02743  Insulin-degrading enzyme (IDE) 5.2
 LDTP09895  Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) 5.1
 LDTP02502  Thioredoxin (TXN) 5.1
 LDTP03893  Proteasome subunit beta type-10 (PSMB10) 5.0
 LDTP08254  Ubiquitin carboxyl-terminal hydrolase 48 (USP48) 5.0
 LDTP03259  Ribonucleoside-diphosphate reductase large subunit (RRM1) 4.9
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) 4.9
 LDTP13409  Anaphase-promoting complex subunit 7 (ANAPC7) 4.9
 LDTP06190  Ubiquitin carboxyl-terminal hydrolase 10 (USP10) 4.7
 LDTP10109  Protein ARK2N (ARK2N) 4.6
 LDTP02406  DNA-directed RNA polymerase II subunit GRINL1A (POLR2M) 4.4
 LDTP04690  Double-stranded RNA-specific adenosine deaminase (ADAR) 4.4
 LDTP12552  Lymphoid-specific helicase (HELLS) 4.3
 LDTP10716  CCA tRNA nucleotidyltransferase 1, mitochondrial (TRNT1) 4.2
 LDTP10903  Ribonucleases P/MRP protein subunit POP1 (POP1) 4.2
 LDTP12313  Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 (ALG13) 4.1
 LDTP13940  Nitric oxide synthase-interacting protein (NOSIP) 4.0
 LDTP03769  Sterol O-acyltransferase 1 (SOAT1) 4.0
Transporter and channel
Click to Show/Hide to Show 15 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 20.0
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) 19.0
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 16.1
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 14.0
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 8.4
 LDTP10148  Store-operated calcium entry-associated regulatory factor (SARAF) 7.1
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 7.0
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 5.7
 LDTP02057  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) 5.3
 LDTP11760  Protein unc-93 homolog B1 (UNC93B1) 5.3
 LDTP09204  Nucleoporin NUP35 (NUP35) 5.0
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 4.8
 LDTP04801  Gasdermin-D (GSDMD) 4.7
 LDTP05692  Inositol 1,4,5-triphosphate receptor associated 2 (IRAG2) 4.3
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 4.0
Transcription factor
Click to Show/Hide to Show 11 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13485  Zinc finger protein Aiolos (IKZF3) 20.0
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) 13.9
 LDTP05362  Interferon regulatory factor 8 (IRF8) 12.4
 LDTP10891  DnaJ homolog subfamily C member 2 (DNAJC2) 7.6
 LDTP06354  Interferon regulatory factor 4 (IRF4) 7.1
 LDTP03916  DNA-binding protein inhibitor ID-1 (ID1) 6.9
 LDTP05307  Transcription factor AP-4 (TFAP4) 5.7
 LDTP02016  Glucocorticoid receptor (NR3C1) 5.5
 LDTP05362  Interferon regulatory factor 8 (IRF8) 4.8
 LDTP06354  Interferon regulatory factor 4 (IRF4) 4.5
 LDTP05861  DNA-binding protein Ikaros (IKZF1) 4.4
Immunoglobulin
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02338  CD48 antigen (CD48) 20.0
 LDTP01909  Immunoglobulin heavy constant mu (IGHM) 6.8
Other
Click to Show/Hide to Show 76 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05772  FAS-associated death domain protein (FADD) 20.0
 LDTP09702  Nesprin-2 (SYNE2) 20.0
 LDTP06186  Protein RRP5 homolog (PDCD11) 20.0
 LDTP12800  Serine/threonine-protein phosphatase 4 regulatory subunit 2 (PPP4R2) 20.0
 LDTP10304  Sororin (CDCA5) 20.0
 LDTP10815  Spermatid perinuclear RNA-binding protein (STRBP) 20.0
 LDTP19918  Uncharacterized protein C7orf50 (C7orf50) 20.0
 LDTP11866  UPF0696 protein C11orf68 (C11orf68) 20.0
 LDTP04092  Crk-like protein (CRKL) 18.0
 LDTP00155  MIF4G domain-containing protein (MIF4GD) 17.9
 LDTP06046  Ribosome biogenesis protein BOP1 (BOP1) 16.0
 LDTP04487  Cyclin-H (CCNH) 14.7
 LDTP09363  TBC1 domain family member 15 (TBC1D15) 14.5
 LDTP17648  UPF0688 protein C1orf174 (C1orf174) 13.5
 LDTP09327  DEP domain-containing mTOR-interacting protein (DEPTOR) 12.6
 LDTP06182  Ribosomal RNA processing protein 1 homolog B (RRP1B) 12.4
 LDTP15861  Acyl-CoA-binding domain-containing protein 6 (ACBD6) 12.4
 LDTP13583  Targeting protein for Xklp2 (TPX2) 11.7
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) 11.4
 LDTP08195  Retrotransposon-derived protein PEG10 (PEG10) 10.6
 LDTP15066  CWF19-like protein 1 (CWF19L1) 10.3
 LDTP08931  Germinal center-associated signaling and motility protein (GCSAM) 9.9
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) 9.3
 LDTP07301  ADP-ribosylation factor-like protein 6-interacting protein 4 (ARL6IP4) 8.6
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) 8.4
 LDTP14910  MAP7 domain-containing protein 1 (MAP7D1) 8.0
 LDTP13091  Ataxin-10 (ATXN10) 7.8
 LDTP10786  Formin-binding protein 1 (FNBP1) 7.6
 LDTP12025  UPF0488 protein C8orf33 (C8orf33) 7.3
 LDTP13414  ADP-ribosylation factor-binding protein GGA2 (GGA2) 7.2
 LDTP04434  Host cell factor 1 (HCFC1) 7.1
 LDTP13414  ADP-ribosylation factor-binding protein GGA2 (GGA2) 7.0
 LDTP08383  CDK2-associated and cullin domain-containing protein 1 (CACUL1) 6.9
 LDTP16261  PALM2-AKAP2 fusion protein (PALM2AKAP2) 6.5
 LDTP16155  Opioid growth factor receptor (OGFR) 6.4
 LDTP14309  Influenza virus NS1A-binding protein (IVNS1ABP) 6.0
 LDTP10651  Regulation of nuclear pre-mRNA domain-containing protein 1A (RPRD1A) 6.0
 LDTP08018  Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1) 5.9
 LDTP13507  BAG family molecular chaperone regulator 5 (BAG5) 5.9
 LDTP10864  Calponin-2 (CNN2) 5.9
 LDTP00202  AH receptor-interacting protein (AIP) 5.8
 LDTP13580  Coronin-1C (CORO1C) 5.7
 LDTP11368  Oxysterol-binding protein-related protein 10 (OSBPL10) 5.7
 LDTP14011  Nucleolar complex protein 2 homolog (NOC2L) 5.7
 LDTP00306  Pescadillo homolog (PES1) 5.7
 LDTP07037  WD repeat domain phosphoinositide-interacting protein 3 (WDR45B) 5.5
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) 5.4
 LDTP06269  PCNA-associated factor (PCLAF) 5.3
 LDTP11993  Nucleolar protein 6 (NOL6) 5.3
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) 5.1
 LDTP08536  Coiled-coil domain-containing protein 117 (CCDC117) 5.1
 LDTP01090  Nibrin (NBN) 5.0
 LDTP06244  Nuclear mitotic apparatus protein 1 (NUMA1) 5.0
 LDTP14251  Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 (CHCHD2) 4.9
 LDTP10214  Splicing factor ESS-2 homolog (ESS2) 4.9
 LDTP15104  Ankyrin repeat domain-containing protein 54 (ANKRD54) 4.9
 LDTP05935  GRB2-related adapter protein (GRAP) 4.8
 LDTP06193  Raftlin (RFTN1) 4.8
 LDTP06126  Histone RNA hairpin-binding protein (SLBP) 4.7
 LDTP18146  RNA binding motif protein, X-linked-like-1 (RBMXL1) 4.6
 LDTP12571  LanC-like protein 2 (LANCL2) 4.5
 LDTP19976  Leucine-rich repeat-containing protein 40 (LRRC40) 4.5
 LDTP11135  rRNA-processing protein UTP23 homolog (UTP23) 4.5
 LDTP12689  Histone chaperone ASF1B (ASF1B) 4.4
 LDTP01021  Perilipin-3 (PLIN3) 4.4
 LDTP11457  MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK) 4.4
 LDTP10273  Small glutamine-rich tetratricopeptide repeat-containing protein beta (SGTB) 4.3
 LDTP13935  Protein SGT1 homolog (SUGT1) 4.3
 LDTP13925  Nucleolar protein 58 (NOP58) 4.3
 LDTP13770  Sex comb on midleg-like protein 2 (SCML2) 4.3
 LDTP02691  Plastin-2 (LCP1) 4.2
 LDTP10920  DnaJ homolog subfamily C member 7 (DNAJC7) 4.1
 LDTP18513  Cilia- and flagella-associated protein 97 (CFAP97) 4.1
 LDTP12689  Histone chaperone ASF1B (ASF1B) 4.0
 LDTP10213  Anaphase-promoting complex subunit 16 (ANAPC16) 4.0
 LDTP04783  tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 (WDR4) 4.0

References

1 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.