Details of the Target

General Information of Target

Target ID LDTP05935
Target Name GRB2-related adapter protein (GRAP)
Gene Name GRAP
Gene ID 10750
Synonyms
GRB2-related adapter protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW
YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL
WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFR
RGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPVHL
Target Bioclass
Other
Family
GRB2/sem-5/DRK family
Subcellular location
Membrane
Function Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing.
Uniprot ID
Q13588
Ensemble ID
ENST00000284154.10
HGNC ID
HGNC:4562

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C161(5.31)  LDD3339  [1]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0150  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 T cell C161(8.01)  LDD1703  [4]
 LDCM0023  KB03 JeKo-1 C161(3.37)  LDD2820  [1]
 LDCM0024  KB05 NALM-6 C161(5.31)  LDD3339  [1]
 LDCM0131  RA190 MM1.R C161(1.38)  LDD0304  [5]
 LDCM0170  Structure8 Ramos 4.83  LDD0433  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase TRIM21 (TRIM21) TRIM/RBCC family P19474
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) . O14672
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Thymocyte selection-associated high mobility group box protein TOX (TOX) High motility group (HMG) box superfamily O94900
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Developmental pluripotency-associated protein 4 (DPPA4) . Q7L190
RNA-binding protein with multiple splicing (RBPMS) . Q93062

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning. Biochemistry. 2018 Jan 30;57(4):451-460. doi: 10.1021/acs.biochem.7b00897. Epub 2017 Oct 26.
4 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
5 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
6 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.