Details of the Target

General Information of Target

Target ID LDTP10651
Target Name Regulation of nuclear pre-mRNA domain-containing protein 1A (RPRD1A)
Gene Name RPRD1A
Gene ID 55197
Synonyms
P15RS; Regulation of nuclear pre-mRNA domain-containing protein 1A; Cyclin-dependent kinase inhibitor 2B-related protein; p15INK4B-related protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSLSTANVEFCLDVFKELNSNNIGDNIFFSSLSLLYALSMVLLGARGETEEQLEKVLHF
SHTVDSLKPGFKDSPKCSQAGRIHSEFGVEFSQINQPDSNCTLSIANRLYGTKTMAFHQQ
YLSCSEKWYQARLQTVDFEQSTEETRKTINAWVENKTNGKVANLFGKSTIDPSSVMVLVN
AIYFKGQWQNKFQVRETVKSPFQLSEGKNVTVEMMYQIGTFKLAFVKEPQMQVLELPYVN
NKLSMIILLPVGIANLKQIEKQLNSGTFHEWTSSSNMMEREVEVHLPRFKLETKYELNSL
LKSLGVTDLFNQVKADLSGMSPTKGLYLSKAIHKSYLDVSEEGTEAAAATGDSIAVKSLP
MRAQFKANHPFLFFIRHTHTNTILFCGKLASP
Target Bioclass
Other
Family
UPF0400 (RTT103) family
Subcellular location
Nucleus
Function
Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.
Uniprot ID
Q96P16
Ensemble ID
ENST00000357384.8
HGNC ID
HGNC:25560

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO678 SNV: p.S298R .
HCC1395 SNV: p.Q21H .
MEWO SNV: p.S273F DBIA    Probe Info 
RCC10RGB SNV: p.V41F .
SW756 SNV: p.D201H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH216
 Probe Info  		Y61(20.00); Y117(8.46)  LDD0259  [2]
AHL-Pu-1
 Probe Info  		C151(2.49); C100(2.35)  LDD0169  [3]
HHS-465
 Probe Info  		Y61(2.65)  LDD2237  [4]
DBIA
 Probe Info  		C220(1.19)  LDD0080  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C220(0.00); C100(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C220(0.00); C100(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C220(0.00); C100(0.00)  LDD0037  [6]
ATP probe
 Probe Info  		N.A.  LDD0035  [7]
IPM
 Probe Info  		N.A.  LDD0025  [8]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
NAIA_4
 Probe Info  		C100(0.00); C151(0.00)  LDD2226  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
1d-yne
 Probe Info  		N.A.  LDD0356  [10]
Compound 10
 Probe Info  		N.A.  LDD2216  [11]
ENE
 Probe Info  		N.A.  LDD0006  [12]
NHS
 Probe Info  		N.A.  LDD0010  [12]
VSF
 Probe Info  		N.A.  LDD0007  [12]
Phosphinate-6
 Probe Info  		C151(0.00); C100(0.00)  LDD0018  [13]
1c-yne
 Probe Info  		N.A.  LDD0228  [10]
Acrolein
 Probe Info  		C100(0.00); C220(0.00)  LDD0217  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [14]
W1
 Probe Info  		N.A.  LDD0236  [15]
AOyne
 Probe Info  		15.00  LDD0443  [16]
NAIA_5
 Probe Info  		C250(0.00); C100(0.00); C220(0.00)  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C151(2.49); C100(2.35)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C151(0.94); C220(0.94)  LDD0531  [5]
 LDCM0215  AC10 HEK-293T C100(1.05); C151(1.06); C220(1.04)  LDD1508  [18]
 LDCM0216  AC100 HCT 116 C220(0.74)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C220(0.67)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C220(0.68)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C220(0.82)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C220(0.87)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C220(0.78)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C220(0.67)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C220(1.25)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C220(0.79)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C220(0.61)  LDD0542  [5]
 LDCM0226  AC11 HEK-293T C100(0.94); C151(1.10); C220(0.97)  LDD1509  [18]
 LDCM0227  AC110 HCT 116 C220(0.51)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C220(0.60)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C220(0.79)  LDD0546  [5]
 LDCM0230  AC113 HEK-293T C151(0.92)  LDD0828  [5]
 LDCM0231  AC114 HEK-293T C151(1.43)  LDD0829  [5]
 LDCM0232  AC115 HEK-293T C151(1.28)  LDD0830  [5]
 LDCM0233  AC116 HEK-293T C151(1.00)  LDD0831  [5]
 LDCM0234  AC117 HEK-293T C151(2.11)  LDD0832  [5]
 LDCM0235  AC118 HEK-293T C151(1.04)  LDD0833  [5]
 LDCM0236  AC119 HEK-293T C151(0.98)  LDD0834  [5]
 LDCM0237  AC12 HEK-293T C100(1.05); C151(1.07); C220(0.89)  LDD1510  [18]
 LDCM0238  AC120 HEK-293T C151(1.28)  LDD0836  [5]
 LDCM0239  AC121 HEK-293T C151(1.76)  LDD0837  [5]
 LDCM0240  AC122 HEK-293T C151(0.85)  LDD0838  [5]
 LDCM0241  AC123 HEK-293T C151(1.11)  LDD0839  [5]
 LDCM0242  AC124 HEK-293T C151(1.03)  LDD0840  [5]
 LDCM0243  AC125 HEK-293T C151(1.18)  LDD0841  [5]
 LDCM0244  AC126 HEK-293T C151(1.23)  LDD0842  [5]
 LDCM0245  AC127 HEK-293T C151(1.19)  LDD0843  [5]
 LDCM0246  AC128 HCT 116 C220(1.35)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C220(1.13)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C220(1.06)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C220(1.04)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C220(1.02)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C220(0.93)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C220(0.86)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C220(1.01)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C220(1.08)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C220(1.40)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C220(1.24)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C220(1.03)  LDD0575  [5]
 LDCM0259  AC14 HEK-293T C100(1.00); C151(0.96); C220(0.94)  LDD1512  [18]
 LDCM0260  AC140 HCT 116 C220(1.16)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C220(1.17)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C220(1.14)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C151(1.16)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C151(1.12)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C151(1.25)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C151(0.75)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C151(1.33)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C151(0.88)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C151(1.03)  LDD0586  [5]
 LDCM0270  AC15 HEK-293T C100(1.06); C151(1.01); C220(0.99)  LDD1513  [18]
 LDCM0271  AC150 HCT 116 C151(0.86)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C151(1.12)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C151(0.85)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C151(1.38)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C151(1.22)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C151(0.83)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C151(0.72)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C151(0.99)  LDD2161  [5]
 LDCM0276  AC17 HEK-293T C100(1.02); C151(0.80); C220(0.78)  LDD1515  [18]
 LDCM0277  AC18 HEK-293T C100(0.93); C151(1.08); C220(0.98)  LDD1516  [18]
 LDCM0278  AC19 HEK-293T C100(0.93); C151(1.25); C220(0.78)  LDD1517  [18]
 LDCM0279  AC2 HCT 116 C220(1.23); C151(1.24)  LDD0596  [5]
 LDCM0280  AC20 HEK-293T C100(1.11); C151(1.06); C220(1.03)  LDD1519  [18]
 LDCM0281  AC21 HEK-293T C100(0.95); C151(1.06); C220(1.09)  LDD1520  [18]
 LDCM0282  AC22 HEK-293T C100(1.00); C151(0.97); C220(0.92)  LDD1521  [18]
 LDCM0283  AC23 HEK-293T C100(1.03); C151(1.00); C220(0.99)  LDD1522  [18]
 LDCM0284  AC24 HEK-293T C100(1.00); C151(1.04); C220(1.05)  LDD1523  [18]
 LDCM0285  AC25 HEK-293T C151(0.87)  LDD0883  [5]
 LDCM0286  AC26 HEK-293T C151(1.29)  LDD0884  [5]
 LDCM0287  AC27 HEK-293T C151(1.08)  LDD0885  [5]
 LDCM0288  AC28 HEK-293T C151(1.01)  LDD0886  [5]
 LDCM0289  AC29 HEK-293T C151(1.04)  LDD0887  [5]
 LDCM0290  AC3 HCT 116 C220(1.01); C151(1.16)  LDD0607  [5]
 LDCM0291  AC30 HEK-293T C151(1.05)  LDD0889  [5]
 LDCM0292  AC31 HEK-293T C151(1.06)  LDD0890  [5]
 LDCM0293  AC32 HEK-293T C151(0.98)  LDD0891  [5]
 LDCM0294  AC33 HEK-293T C151(1.15)  LDD0892  [5]
 LDCM0295  AC34 HEK-293T C151(1.01)  LDD0893  [5]
 LDCM0296  AC35 HEK-293T C100(0.98); C151(1.04); C220(0.92)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C100(1.13); C151(1.04); C220(1.03)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C100(1.00); C151(1.03); C220(1.11)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C100(0.90); C151(1.10); C220(0.99)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C100(1.02); C151(0.98); C220(1.02)  LDD1539  [18]
 LDCM0301  AC4 HCT 116 C151(1.01); C220(1.13)  LDD0618  [5]
 LDCM0302  AC40 HEK-293T C100(0.93); C151(1.01); C220(1.04)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C100(1.03); C151(1.03); C220(0.88)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C100(1.08); C151(1.11); C220(0.80)  LDD1543  [18]
 LDCM0305  AC43 HEK-293T C100(0.95); C151(1.00); C220(0.95)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C100(1.06); C151(0.99); C220(0.93)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C100(1.00); C151(1.04); C220(0.99)  LDD1546  [18]
 LDCM0308  AC46 HCT 116 C220(0.91)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C220(1.08)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C220(0.98)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C220(0.87)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C151(0.93); C220(0.95)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C220(0.91)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C220(0.86)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C220(1.05)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C220(1.15)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C220(0.98)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C220(1.10)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C220(0.96)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C151(0.81); C220(1.15)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C220(1.20); C151(1.32)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C151(1.05); C220(1.46)  LDD0639  [5]
 LDCM0323  AC6 HEK-293T C100(0.90); C151(1.08); C220(0.97)  LDD1562  [18]
 LDCM0324  AC60 HCT 116 C151(1.20); C220(1.29)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C151(0.81); C220(1.56)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C151(1.10); C220(1.42)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C151(0.93); C220(1.13)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C151(0.96); C220(1.52)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C220(0.89); C151(1.06)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C151(0.76); C220(0.96)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C220(1.15); C151(1.40)  LDD0648  [5]
 LDCM0334  AC7 HEK-293T C100(1.00); C151(0.94); C220(1.04)  LDD1568  [18]
 LDCM0345  AC8 HEK-293T C100(0.96); C151(0.95); C220(0.93)  LDD1569  [18]
 LDCM0349  AC83 HCT 116 C151(1.55)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C151(1.97)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C151(2.18)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C151(1.47)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C151(1.74)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C151(1.46)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C151(1.97)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C151(1.56)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C151(2.18)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C151(1.96)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C151(1.58)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C151(3.01)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C151(1.17)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C151(1.60)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C151(2.86)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C220(0.92)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C220(0.68)  LDD0683  [5]
 LDCM0248  AKOS034007472 HEK-293T C100(0.96); C151(0.98); C220(1.06)  LDD1511  [18]
 LDCM0356  AKOS034007680 HEK-293T C100(1.04); C151(0.88); C220(0.98)  LDD1570  [18]
 LDCM0275  AKOS034007705 HEK-293T C100(0.96); C151(0.97); C220(0.95)  LDD1514  [18]
 LDCM0156  Aniline NCI-H1299 14.09  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C100(1.07); C100(0.48)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C151(0.54); C220(0.98)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C151(0.58); C220(1.09)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C220(0.95); C151(1.02)  LDD0686  [5]
 LDCM0370  CL101 HEK-293T C100(0.85); C151(0.96); C220(0.99)  LDD1574  [18]
 LDCM0371  CL102 HEK-293T C100(0.98); C151(0.98); C220(0.86)  LDD1575  [18]
 LDCM0372  CL103 HEK-293T C100(1.02); C151(0.87); C220(1.13)  LDD1576  [18]
 LDCM0373  CL104 HEK-293T C100(0.91); C151(1.06); C220(1.08)  LDD1577  [18]
 LDCM0374  CL105 HEK-293T C100(0.93); C151(0.96); C220(0.92)  LDD1578  [18]
 LDCM0375  CL106 HEK-293T C100(0.97); C151(1.03); C220(0.84)  LDD1579  [18]
 LDCM0376  CL107 HEK-293T C100(1.00); C151(0.99); C220(1.05)  LDD1580  [18]
 LDCM0377  CL108 HEK-293T C100(0.92); C151(0.97); C220(1.04)  LDD1581  [18]
 LDCM0378  CL109 HEK-293T C100(0.92); C151(0.93); C220(0.94)  LDD1582  [18]
 LDCM0379  CL11 HCT 116 C151(0.53); C220(1.19)  LDD0696  [5]
 LDCM0380  CL110 HEK-293T C100(1.01); C151(1.19); C220(0.77)  LDD1584  [18]
 LDCM0381  CL111 HEK-293T C100(0.98); C151(0.88); C220(0.89)  LDD1585  [18]
 LDCM0382  CL112 HEK-293T C151(1.14)  LDD0980  [5]
 LDCM0383  CL113 HEK-293T C151(0.85)  LDD0981  [5]
 LDCM0384  CL114 HEK-293T C151(1.21)  LDD0982  [5]
 LDCM0385  CL115 HEK-293T C151(1.19)  LDD0983  [5]
 LDCM0386  CL116 HEK-293T C151(1.36)  LDD0984  [5]
 LDCM0387  CL117 HEK-293T C100(0.93); C151(1.07); C220(1.02)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C100(1.00); C151(0.98); C220(0.93)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C100(1.05); C151(0.89); C220(1.09)  LDD1593  [18]
 LDCM0390  CL12 HCT 116 C151(0.57); C220(1.18)  LDD0707  [5]
 LDCM0391  CL120 HEK-293T C100(1.01); C151(1.09); C220(1.01)  LDD1595  [18]
 LDCM0392  CL121 HCT 116 C220(1.08)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C220(1.55)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C220(0.92)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C220(1.25)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C151(0.83); C220(1.10)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C151(0.84); C220(1.18)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C151(0.75); C220(1.27)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C151(0.92); C220(1.41)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C151(0.49); C220(1.20)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C151(0.55); C220(1.09)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C151(0.44); C220(1.22)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C151(0.88)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C151(0.91)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C151(1.01)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C151(0.70)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C151(0.48); C220(1.02)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C151(1.05)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C151(0.84)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C151(0.59)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C151(0.88)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C151(0.65)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C151(0.73)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C151(1.32)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C151(0.81)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C151(0.81)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C151(1.01)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C151(0.69); C220(1.04)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C151(0.82)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C151(1.19)  LDD0737  [5]
 LDCM0421  CL32 HEK-293T C100(0.90); C151(1.03); C220(0.84)  LDD1625  [18]
 LDCM0422  CL33 HEK-293T C100(0.75); C151(0.85); C220(1.07)  LDD1626  [18]
 LDCM0423  CL34 HEK-293T C100(1.61); C151(0.86); C220(0.93)  LDD1627  [18]
 LDCM0424  CL35 HEK-293T C100(1.61); C151(1.01); C220(0.88)  LDD1628  [18]
 LDCM0425  CL36 HEK-293T C100(1.18); C151(1.07); C220(1.06)  LDD1629  [18]
 LDCM0426  CL37 HEK-293T C100(0.72); C151(0.88); C220(1.12)  LDD1630  [18]
 LDCM0428  CL39 HEK-293T C100(1.03); C151(0.84); C220(1.02)  LDD1632  [18]
 LDCM0429  CL4 HCT 116 C151(0.57); C220(0.92)  LDD0746  [5]
 LDCM0430  CL40 HEK-293T C100(0.99); C151(0.96); C220(1.00)  LDD1634  [18]
 LDCM0431  CL41 HEK-293T C100(1.02); C151(0.92); C220(0.93)  LDD1635  [18]
 LDCM0432  CL42 HEK-293T C100(0.98); C151(0.97); C220(0.98)  LDD1636  [18]
 LDCM0433  CL43 HEK-293T C100(0.98); C151(1.06); C220(0.95)  LDD1637  [18]
 LDCM0434  CL44 HEK-293T C100(0.98); C151(0.91); C220(0.86)  LDD1638  [18]
 LDCM0435  CL45 HEK-293T C100(0.90); C151(1.05); C220(1.10)  LDD1639  [18]
 LDCM0436  CL46 HCT 116 C220(0.98)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C220(1.08)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C220(1.89)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C220(1.27)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C151(0.37); C220(1.11)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C220(1.12)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C220(1.33)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C220(1.54)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C220(0.90)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C220(0.88)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C220(1.20)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C220(1.00)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C220(1.31)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C220(1.65)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C220(1.41)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C151(0.56); C220(1.12)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C220(0.95)  LDD0769  [5]
 LDCM0453  CL61 HEK-293T C100(0.68); C151(0.94); C220(1.05)  LDD1656  [18]
 LDCM0454  CL62 HEK-293T C100(1.13); C151(1.05); C220(1.14)  LDD1657  [18]
 LDCM0455  CL63 HEK-293T C100(1.06); C151(0.87); C220(1.03)  LDD1658  [18]
 LDCM0456  CL64 HEK-293T C100(0.89); C151(0.97); C220(0.99)  LDD1659  [18]
 LDCM0457  CL65 HEK-293T C100(1.09); C151(0.93); C220(0.85)  LDD1660  [18]
 LDCM0458  CL66 HEK-293T C100(0.90); C151(1.06); C220(1.04)  LDD1661  [18]
 LDCM0459  CL67 HEK-293T C100(0.97); C151(1.06); C220(0.99)  LDD1662  [18]
 LDCM0460  CL68 HEK-293T C100(0.87); C151(1.07); C220(0.88)  LDD1663  [18]
 LDCM0461  CL69 HEK-293T C100(0.89); C151(0.97); C220(1.04)  LDD1664  [18]
 LDCM0462  CL7 HCT 116 C151(0.51); C220(1.17)  LDD0779  [5]
 LDCM0463  CL70 HEK-293T C100(1.55); C151(0.95); C220(1.10)  LDD1666  [18]
 LDCM0464  CL71 HEK-293T C100(1.35); C151(1.01); C220(0.96)  LDD1667  [18]
 LDCM0465  CL72 HEK-293T C100(1.16); C151(1.15); C220(0.92)  LDD1668  [18]
 LDCM0466  CL73 HEK-293T C100(0.73); C151(1.03); C220(0.95)  LDD1669  [18]
 LDCM0467  CL74 HEK-293T C100(1.16); C151(0.95); C220(0.95)  LDD1670  [18]
 LDCM0469  CL76 HEK-293T C100(0.97); C151(1.03); C220(1.03)  LDD1672  [18]
 LDCM0470  CL77 HEK-293T C100(0.93); C151(0.91); C220(0.88)  LDD1673  [18]
 LDCM0471  CL78 HEK-293T C100(0.97); C151(1.01); C220(1.08)  LDD1674  [18]
 LDCM0472  CL79 HEK-293T C100(0.90); C151(1.01); C220(1.02)  LDD1675  [18]
 LDCM0473  CL8 HCT 116 C151(0.77); C220(1.06)  LDD0790  [5]
 LDCM0474  CL80 HEK-293T C100(0.89); C151(1.00); C220(0.97)  LDD1677  [18]
 LDCM0475  CL81 HEK-293T C100(0.91); C151(1.03); C220(1.06)  LDD1678  [18]
 LDCM0476  CL82 HEK-293T C100(1.39); C151(0.99); C220(1.00)  LDD1679  [18]
 LDCM0477  CL83 HEK-293T C100(1.36); C151(1.03); C220(0.86)  LDD1680  [18]
 LDCM0478  CL84 HEK-293T C100(0.94); C151(1.01); C220(0.89)  LDD1681  [18]
 LDCM0479  CL85 HEK-293T C100(0.52); C151(1.01); C220(1.08)  LDD1682  [18]
 LDCM0480  CL86 HEK-293T C100(0.90); C151(0.99); C220(1.08)  LDD1683  [18]
 LDCM0481  CL87 HEK-293T C100(0.88); C151(0.86); C220(0.94)  LDD1684  [18]
 LDCM0482  CL88 HEK-293T C100(0.75); C151(0.93); C220(1.16)  LDD1685  [18]
 LDCM0483  CL89 HEK-293T C100(0.76); C151(0.84); C220(0.99)  LDD1686  [18]
 LDCM0484  CL9 HCT 116 C151(0.46); C220(1.22)  LDD0801  [5]
 LDCM0485  CL90 HEK-293T C100(0.73); C151(1.00); C220(0.81)  LDD1688  [18]
 LDCM0486  CL91 HCT 116 C151(1.11); C220(1.20)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C151(0.77); C220(1.08)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C151(0.87); C220(1.05)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C151(0.93); C220(1.08)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C151(1.08); C220(1.02)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C151(0.95); C220(1.08)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C151(0.96); C220(1.07)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C151(0.96); C220(0.94)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C151(0.95); C220(0.99)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C100(1.00); C151(0.99); C220(0.98)  LDD1698  [18]
 LDCM0625  F8 Ramos C100(2.68); C151(1.10)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C100(0.65)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C100(0.73)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C100(0.64); C151(0.55)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C100(0.62); C151(0.81)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C100(0.34); C151(0.75)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C100(0.73); C151(0.67)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C100(0.65); C151(0.85)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C100(1.11)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C100(1.51); C151(0.82)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C100(0.68); C151(0.86)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C100(0.77); C151(0.73)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C100(1.06); C151(0.72)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C100(1.16); C151(0.80)  LDD2201  [19]
 LDCM0468  Fragment33 HEK-293T C100(0.94); C151(0.85); C220(1.04)  LDD1671  [18]
 LDCM0596  Fragment38 Ramos C100(1.44); C151(0.35)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C100(0.67); C151(0.56)  LDD2184  [19]
 LDCM0427  Fragment51 HEK-293T C100(0.94); C151(0.96); C220(1.09)  LDD1631  [18]
 LDCM0610  Fragment52 Ramos C100(1.12); C151(0.71)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C100(0.59); C151(0.69)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C100(0.87); C151(0.52)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C100(0.46); C151(0.81)  LDD2188  [19]
 LDCM0022  KB02 HCT 116 C220(1.19)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C220(1.68)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C220(1.10)  LDD0082  [5]
 LDCM0109  NEM HeLa N.A.  LDD0226  [14]
 LDCM0628  OTUB2-COV-1 HEK-293T C151(0.79)  LDD2207  [20]
 LDCM0131  RA190 MM1.R C151(1.56)  LDD0304  [21]
 LDCM0170  Structure8 Ramos 5.97  LDD0433  [22]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
DNA-directed RNA polymerase II subunit RPB1 (POLR2A) RNA polymerase beta' chain family P24928
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 (RPAP2) RPAP2 family Q8IXW5
LON peptidase N-terminal domain and RING finger protein 1 (LONRF1) . Q17RB8
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Importin subunit alpha-4 (KPNA3) Importin alpha family O00505
Nuclear RNA export factor 1 (NXF1) NXF family Q9UBU9
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 76 (ZNF76) Krueppel C2H2-type zinc-finger protein family P36508
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Regulation of nuclear pre-mRNA domain-containing protein 1B (RPRD1B) UPF0400 (RTT103) family Q9NQG5
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
11 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
21 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
22 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.