Details of the Target

General Information of Target

Target ID LDTP10920
Target Name DnaJ homolog subfamily C member 7 (DNAJC7)
Gene Name DNAJC7
Gene ID 7266
Synonyms
TPR2; TTC2; DnaJ homolog subfamily C member 7; Tetratricopeptide repeat protein 2; TPR repeat protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRFFTTGSDSESESSLSGEELVTKPVGGNYGKQPLLLSEDEEDTKRVVRSAKDKRFEEL
TNLIRTIRNAMKIRDVTKCLEEFELLGKAYGKAKSIVDKEGVPRFYIRILADLEDYLNEL
WEDKEGKKKMNKNNAKALSTLRQKIRKYNRDFESHITSYKQNPEQSADEDAEKNEEDSEG
SSDEDEDEDGVSAATFLKKKSEAPSGESRKFLKKMDDEDEDSEDSEDDEDWDTGSTSSDS
DSEEEEGKQTALASRFLKKAPTTDEDKKAAEKKREDKAKKKHDRKSKRLDEEEEDNEGGE
WERVRGGVPLVKEKPKMFAKGTEITHAVVIKKLNEILQARGKKGTDRAAQIELLQLLVQI
AAENNLGEGVIVKIKFNIIASLYDYNPNLATYMKPEMWGKCLDCINELMDILFANPNIFV
GENILEESENLHNADQPLRVRGCILTLVERMDEEFTKIMQNTDPHSQEYVEHLKDEAQVC
AIIERVQRYLEEKGTTEEVCRIYLLRILHTYYKFDYKAHQRQLTPPEGSSKSEQDQAENE
GEDSAVLMERLCKYIYAKDRTDRIRTCAILCHIYHHALHSRWYQARDLMLMSHLQDNIQH
ADPPVQILYNRTMVQLGICAFRQGLTKDAHNALLDIQSSGRAKELLGQGLLLRSLQERNQ
EQEKVERRRQVPFHLHINLELLECVYLVSAMLLEIPYMAAHESDARRRMISKQFHHQLRV
GERQPLLGPPESMREHVVAASKAMKMGDWKTCHSFIINEKMNGKVWDLFPEADKVRTMLV
RKIQEESLRTYLFTYSSVYDSISMETLSDMFELDLPTVHSIISKMIINEELMASLDQPTQ
TVVMHRTEPTAQQNLALQLAEKLGSLVENNERVFDHKQGTYGGYFRDQKDGYRKNEGYMR
RGGYRQQQSQTAY
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Acts as a co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm.
Uniprot ID
Q99615
Ensemble ID
ENST00000316603.12
HGNC ID
HGNC:12392

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL33 SNV: p.E358V DBIA    Probe Info 
HCT116 SNV: p.K426E DBIA    Probe Info 
JURKAT SNV: p.A253T Compound 10    Probe Info 
KMS12BM SNV: p.Y39F DBIA    Probe Info 
L428 SNV: p.F489L DBIA    Probe Info 
OSRC2 SNV: p.S393P DBIA    Probe Info 
OVK18 SNV: p.R77M DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 42 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
CY4
 Probe Info  		100.00  LDD0244  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
TH211
 Probe Info  		Y214(10.11)  LDD0257  [3]
STPyne
 Probe Info  		K128(8.33); K160(1.85); K254(4.93); K268(4.26)  LDD0277  [4]
ONAyne
 Probe Info  		N.A.  LDD0273  [4]
Probe 1
 Probe Info  		Y39(17.57); Y192(19.93); Y327(30.59); Y355(55.15)  LDD3495  [5]
BTD
 Probe Info  		C58(1.39); C175(1.37)  LDD1700  [6]
AHL-Pu-1
 Probe Info  		C58(2.26)  LDD0168  [7]
HHS-475
 Probe Info  		Y145(0.67); Y38(0.86)  LDD0264  [8]
HHS-465
 Probe Info  		Y145(10.00); Y355(10.00); Y38(10.00)  LDD2237  [9]
DBIA
 Probe Info  		C58(0.90); C175(0.89)  LDD0078  [10]
5E-2FA
 Probe Info  		N.A.  LDD2235  [11]
AMP probe
 Probe Info  		N.A.  LDD0200  [12]
ATP probe
 Probe Info  		K128(0.00); K306(0.00); K137(0.00); K104(0.00)  LDD0199  [12]
1d-yne
 Probe Info  		N.A.  LDD0358  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C185(0.00); C58(0.00); C175(0.00); C337(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C7(0.00); C164(0.00); C185(0.00); C58(0.00)  LDD0032  [15]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C185(0.00); C58(0.00); C175(0.00); C337(0.00)  LDD0037  [14]
JW-RF-010
 Probe Info  		C7(0.00); C247(0.00); C250(0.00)  LDD0026  [17]
NAIA_4
 Probe Info  		N.A.  LDD2226  [18]
TFBX
 Probe Info  		N.A.  LDD0027  [17]
WYneO
 Probe Info  		N.A.  LDD0022  [19]
Compound 10
 Probe Info  		C175(0.00); C298(0.00)  LDD2216  [20]
Compound 11
 Probe Info  		N.A.  LDD2213  [20]
IPM
 Probe Info  		C247(0.00); C164(0.00); C175(0.00)  LDD0005  [19]
NHS
 Probe Info  		K329(0.00); K368(0.00); K128(0.00)  LDD0010  [19]
OSF
 Probe Info  		N.A.  LDD0029  [21]
PF-06672131
 Probe Info  		N.A.  LDD0152  [22]
PPMS
 Probe Info  		N.A.  LDD0008  [19]
SF
 Probe Info  		K147(0.00); Y39(0.00); Y145(0.00); Y38(0.00)  LDD0028  [21]
VSF
 Probe Info  		N.A.  LDD0007  [19]
Phosphinate-6
 Probe Info  		C58(0.00); C7(0.00); C175(0.00); C225(0.00)  LDD0018  [23]
1c-yne
 Probe Info  		K295(0.00); K25(0.00); K273(0.00); K60(0.00)  LDD0228  [13]
Acrolein
 Probe Info  		C337(0.00); H413(0.00); C317(0.00); C185(0.00)  LDD0217  [24]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [24]
Methacrolein
 Probe Info  		C337(0.00); C175(0.00); C317(0.00); C185(0.00)  LDD0218  [24]
W1
 Probe Info  		C58(0.00); C175(0.00); C317(0.00); C164(0.00)  LDD0236  [25]
AOyne
 Probe Info  		15.00  LDD0443  [26]
NAIA_5
 Probe Info  		C185(0.00); C175(0.00); C337(0.00); C164(0.00)  LDD2223  [18]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		5.50  LDD0475  [27]
FFF probe14
 Probe Info  		6.28  LDD0477  [27]
FFF probe3
 Probe Info  		9.07  LDD0465  [27]
STS-1
 Probe Info  		N.A.  LDD0137  [28]
STS-2
 Probe Info  		N.A.  LDD0138  [28]
VE-P
 Probe Info  		N.A.  LDD0396  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C175(0.92)  LDD2112  [6]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C175(0.49)  LDD2095  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C175(0.82); C58(1.06)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C175(1.07); C164(1.38); C185(1.06); C58(0.89)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C175(1.26); C164(1.31); C58(1.09)  LDD2152  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C175(1.00)  LDD2103  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C175(0.49); C58(0.84)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C175(0.69); C58(0.95)  LDD2131  [6]
 LDCM0025  4SU-RNA HEK-293T C58(2.26)  LDD0168  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C317(2.18); C58(2.37); C247(2.33); C225(3.27)  LDD0169  [7]
 LDCM0214  AC1 HCT 116 C58(2.26); C164(1.34); C219(0.65); C175(0.94)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C58(1.28); C164(0.96); C219(0.96); C175(0.76)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C58(1.06); C164(1.16); C219(0.47); C175(1.05)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C58(0.95); C164(1.01); C219(0.46); C175(1.07)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C58(1.10); C164(0.99); C219(0.44); C175(1.03)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C58(1.05); C164(1.31); C219(0.27); C175(0.94)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C58(0.91); C164(1.24); C219(0.31); C175(1.03)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C58(0.89); C164(1.20); C219(0.33); C175(0.89)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C58(1.06); C164(1.33); C219(0.33); C175(0.89)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C58(1.04); C164(1.07); C219(0.54); C175(0.95)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C58(0.91); C164(1.10); C219(0.33); C175(0.87)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C58(0.81); C164(0.97); C219(0.31); C175(0.93)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C58(1.28); C164(0.88); C219(0.92); C175(0.71)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C58(0.89); C164(1.09); C219(0.37); C175(0.86)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C58(0.91); C164(1.05); C219(0.34); C175(0.88)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C58(1.03); C164(1.18); C219(0.37); C175(0.70)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C58(0.96); C164(1.52); C175(1.08); C225(0.97)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C58(1.03); C164(1.04); C175(0.89); C225(1.14)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C58(1.04); C164(1.19); C175(0.73); C225(1.28)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C58(1.02); C164(1.26); C175(0.66); C225(1.02)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C58(1.08); C164(1.06); C175(0.81); C225(1.03)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C58(1.12); C164(1.00); C175(0.88); C225(1.07)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C58(1.08); C164(1.20); C175(0.72); C225(1.13)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C58(1.17); C164(1.03); C219(1.03); C175(0.88)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C58(1.10); C164(1.27); C175(0.87); C225(1.40)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C58(1.05); C164(1.32); C175(0.85); C225(1.19)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C58(1.15); C164(1.39); C175(0.78); C225(0.71)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C58(1.05); C164(1.25); C175(0.99); C225(1.10)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C58(1.07); C164(1.22); C175(0.91); C225(1.33)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C58(1.09); C164(1.18); C175(0.85); C225(1.14)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C58(1.04); C164(1.31); C175(0.75); C225(0.81)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C58(1.00); C164(1.25); C175(0.78); C225(1.17)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C58(0.82); C164(0.73); C219(0.99); C175(0.93)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C58(0.92); C164(1.23); C219(1.19); C175(1.84)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C58(1.07); C164(1.27); C219(0.92); C175(1.07)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C58(0.94); C164(1.31); C219(1.22); C175(2.29)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C58(1.19); C164(1.27); C219(1.29); C175(0.92)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C58(0.95); C164(1.17); C219(1.11); C175(0.83)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C58(1.07); C164(0.95); C219(1.09); C175(0.82)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C58(1.09); C164(1.06); C219(1.03); C175(0.68)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C58(1.23); C164(1.23); C219(1.10); C175(0.83)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C58(1.13); C164(1.14); C219(1.10); C175(0.84)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C58(1.49); C164(1.15); C219(1.03); C175(0.69)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C58(1.36); C164(1.29); C219(1.10); C175(0.74)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C58(1.23); C164(1.14); C219(0.91); C175(1.17)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C58(1.48); C164(1.02); C219(1.00); C175(0.63)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C58(1.40); C164(1.36); C219(1.10); C175(0.75)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C58(1.28); C164(1.85); C219(1.35); C175(1.14)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C58(1.14); C164(0.89); C219(0.74); C175(0.78)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C219(0.58); C225(0.59); C185(0.66); C175(0.78)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C225(0.71); C185(0.74); C164(0.77); C175(0.78)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C225(0.60); C219(0.74); C185(0.76); C175(0.78)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C225(0.57); C219(0.61); C175(0.67); C185(0.73)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C225(0.47); C185(0.50); C219(0.59); C175(0.66)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C225(0.49); C185(0.62); C337(0.67); C219(0.70)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C185(0.81); C219(0.85); C225(0.87); C337(0.93)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C225(0.74); C185(0.75); C164(0.77); C219(0.83)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C225(0.83); C219(0.90); C175(0.92); C164(1.15)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C225(0.56); C219(0.60); C185(0.62); C175(0.79)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C225(0.48); C185(0.62); C337(0.62); C219(0.70)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C58(1.48); C164(1.17); C219(0.72); C175(0.79)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C58(1.55); C164(1.10); C219(0.77); C175(0.90)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C58(1.45); C164(0.88); C219(1.02); C175(1.12)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C58(1.44); C164(1.00); C219(0.95); C175(1.30)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C337(0.84); C219(0.84); C225(0.88); C58(0.98)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C337(0.60); C219(0.67); C225(0.73); C175(0.78)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C337(0.71); C185(0.83); C164(0.87); C225(0.89)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C219(0.72); C175(0.73); C337(0.92); C225(1.01)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C185(0.69); C337(0.80); C219(0.95); C225(0.95)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C337(0.72); C225(0.83); C219(0.85); C175(0.87)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C185(0.88); C337(0.92); C219(0.99); C58(1.00)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C337(0.82); C225(0.84); C219(0.85); C58(0.92)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C185(0.74); C337(0.87); C225(0.99); C219(0.99)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C225(0.77); C219(0.88); C175(0.90); C337(0.91)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C225(0.56); C219(0.68); C175(0.69); C337(0.73)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C225(0.61); C219(0.64); C175(0.74); C337(0.78)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C225(0.57); C219(0.63); C175(0.67); C337(0.79)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C225(0.53); C219(0.58); C337(0.62); C175(0.62)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C175(0.70); C219(0.71); C225(0.79); C337(1.05)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C225(0.54); C219(0.57); C337(0.62); C175(0.65)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C225(0.59); C219(0.65); C175(0.69); C337(0.83)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C225(0.47); C219(0.49); C175(0.68); C185(0.73)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C225(0.58); C219(0.58); C337(0.60); C175(0.88)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C225(0.47); C219(0.56); C337(0.58); C175(1.04)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C58(0.83); C225(1.04); C175(1.04); C337(1.08)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C337(0.76); C175(0.85); C58(0.88); C185(1.02)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C58(0.87); C175(1.01); C337(1.02); C225(1.07)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C337(0.89); C58(0.95); C225(0.97); C185(0.99)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C225(0.81); C337(0.90); C175(0.91); C185(0.98)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C219(0.51); C225(0.65); C175(0.74); C337(0.97)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C225(0.72); C219(0.77); C58(0.87); C337(0.89)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C337(0.74); C175(0.83); C164(0.98); C58(1.01)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C337(0.71); C175(0.90); C219(0.97); C225(0.99)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C175(0.75); C337(0.86); C225(1.11); C219(1.12)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C225(0.97); C175(1.03); C58(1.05); C337(1.10)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C225(0.82); C219(0.87); C58(0.94); C337(0.94)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C175(0.60); C164(0.78); C337(0.82); C185(0.91)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C175(0.68); C164(0.78); C337(0.86); C225(0.96)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C175(0.72); C164(0.86); C337(0.95); C219(0.99)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C175(0.64); C164(0.68); C337(0.69); C219(0.77)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C219(0.53); C175(0.57); C225(0.65); C337(0.85)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C219(0.68); C225(0.82); C337(0.84); C175(0.96)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C337(0.71); C175(0.76); C185(0.84); C164(1.01)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C175(0.74); C219(0.82); C164(0.86); C225(0.93)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C164(0.77); C175(0.80); C225(0.83); C219(0.84)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C164(0.72); C219(0.74); C175(0.79); C225(0.80)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C175(0.68); C225(0.81); C337(0.87); C219(0.91)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C175(0.60); C337(0.78); C164(0.80); C219(0.87)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C337(0.74); C219(0.86); C225(0.86); C58(0.95)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C219(0.71); C225(0.71); C337(0.80); C58(0.99)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C337(0.75); C219(0.79); C225(0.79); C164(1.10)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C185(0.59); C175(0.70); C337(0.73); C219(0.75)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C58(0.81); C337(0.85); C219(0.87); C225(0.87)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C164(0.88); C58(1.03); C219(1.04); C225(1.04)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C337(0.67); C219(0.80); C225(0.80); C58(0.90)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C337(0.71); C58(0.82); C175(0.88); C219(0.94)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C337(0.68); C58(0.79); C175(0.84); C219(0.85)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C337(0.73); C175(0.85); C219(0.88); C225(0.88)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C219(0.89); C225(0.89); C337(0.91); C58(0.95)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C337(0.67); C219(0.82); C225(0.82); C175(0.88)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C219(0.74); C337(0.77); C225(0.80); C164(0.87)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C219(0.58); C225(0.62); C337(0.80); C164(0.81)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C175(0.81); C337(0.89); C185(0.94); C225(0.95)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C219(0.41); C225(0.59); C337(0.65); C58(0.78)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C219(0.78); C225(0.80); C58(0.92); C337(0.96)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C219(0.55); C225(0.71); C337(0.73); C175(0.89)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C219(0.54); C225(0.64); C337(0.66); C175(0.83)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C219(0.59); C225(0.63); C337(0.72); C58(0.81)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C337(0.66); C219(0.66); C225(0.74); C175(0.82)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C219(0.44); C225(0.52); C337(0.71); C58(0.73)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C219(0.50); C337(0.63); C225(0.73); C58(0.77)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C225(0.85); C219(0.91); C175(0.93); C58(1.02)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C219(0.67); C225(0.72); C337(0.84); C175(0.88)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C185(0.64); C219(0.82); C225(0.83); C175(0.86)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C219(0.53); C225(0.64); C58(0.77); C337(0.81)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C225(0.87); C175(0.90); C58(0.94); C219(0.95)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C337(0.75); C58(0.86); C225(0.90); C219(0.90)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C225(0.46); C337(0.46); C219(0.52); C175(0.58)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C337(0.46); C225(0.48); C219(0.52); C175(0.67)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C337(0.58); C175(0.61); C225(0.61); C219(0.63)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C337(0.64); C175(0.69); C225(0.69); C219(0.70)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C337(0.81); C225(0.86); C219(0.93); C175(0.99)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C225(0.62); C219(0.66); C337(0.74); C175(0.79)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C337(0.52); C225(0.56); C219(0.59); C175(0.71)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C337(0.88); C175(0.94); C185(1.00); C58(1.16)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C337(0.49); C219(0.57); C175(0.58); C225(0.62)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C337(0.46); C225(0.48); C219(0.50); C175(0.57)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C225(0.63); C337(0.64); C219(0.66); C175(0.77)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C337(0.72); C175(0.76); C219(0.78); C185(0.81)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C225(0.74); C219(0.82); C337(0.84); C185(0.94)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C337(0.63); C219(0.69); C175(0.77); C225(0.79)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C337(0.47); C225(0.48); C219(0.51); C175(0.54)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C219(0.25); C225(0.25); C337(0.73); C58(0.91)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C219(0.58); C225(0.58); C337(0.79); C58(0.97)  LDD0683  [10]
 LDCM0545  Acetamide MDA-MB-231 C175(0.35); C58(0.83); C317(0.69)  LDD2138  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C58(0.79)  LDD2113  [6]
 LDCM0248  AKOS034007472 HCT 116 C58(1.11); C164(1.24); C219(1.18); C175(0.85)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C175(0.77); C185(0.80); C337(0.88); C225(0.91)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C185(0.43); C219(0.55); C225(0.58); C337(0.61)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 13.11  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C58(0.90); C175(0.89)  LDD0078  [10]
 LDCM0498  BS-3668 MDA-MB-231 C58(0.74)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa C317(0.00); C337(0.00); C185(0.00); C175(0.00)  LDD0222  [24]
 LDCM0632  CL-Sc Hep-G2 C175(2.17)  LDD2227  [18]
 LDCM0367  CL1 HCT 116 C58(0.81); C164(0.92); C225(0.96); C185(1.08)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C219(0.64); C185(0.79); C337(0.82); C175(0.87)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C219(0.59); C225(0.70); C175(0.82); C337(0.93)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C185(0.55); C337(0.72); C225(0.79); C219(0.83)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C185(0.71); C164(0.98); C225(1.03); C337(1.04)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C58(1.01); C225(1.01); C164(1.06); C337(1.08)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C185(0.82); C219(0.95); C225(0.95); C337(0.96)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C175(0.69); C337(0.70); C225(0.84); C58(0.91)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C225(0.64); C219(0.73); C337(0.74); C175(0.75)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C175(0.64); C337(0.69); C225(0.72); C185(0.75)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C175(0.66); C225(0.72); C219(0.81); C337(0.84)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C337(0.65); C175(0.72); C185(0.73); C219(0.77)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C219(0.42); C225(0.62); C164(0.76); C337(0.79)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C185(0.64); C337(0.72); C175(0.73); C225(0.81)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C337(0.75); C175(0.82); C164(0.89); C185(0.90)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C175(0.77); C225(0.89); C219(0.91); C185(0.94)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C225(0.46); C219(0.51); C337(0.69); C175(0.72)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C219(0.64); C225(0.64); C337(0.74); C175(0.82)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C225(0.61); C337(0.67); C219(0.68); C175(0.86)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C225(0.65); C219(0.72); C337(0.76); C185(1.02)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C225(0.81); C337(0.82); C175(0.89); C58(0.90)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C225(0.88); C175(0.92); C337(0.93); C164(0.96)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C175(0.77); C337(0.80); C225(0.91); C219(0.91)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C219(0.39); C225(0.70); C175(0.75); C337(0.76)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C337(0.75); C175(0.81); C58(1.02); C225(1.11)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C175(0.64); C337(0.76); C164(0.80); C185(0.97)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C219(0.72); C175(0.76); C164(0.86); C337(0.89)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C164(0.49); C219(0.67); C175(0.70); C225(0.75)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C175(0.56); C164(0.61); C219(0.77); C337(0.77)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C337(0.80); C175(0.94); C58(1.00); C219(1.07)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C219(1.04); C225(1.04); C337(1.07); C58(1.11)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C175(0.94); C219(1.11); C225(1.11); C337(1.15)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C337(0.77); C219(0.81); C225(0.81); C175(0.93)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C185(0.75); C219(0.79); C337(0.86); C225(0.87)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C58(0.79); C219(0.86); C225(0.93); C185(0.98)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C219(0.61); C225(0.75); C185(0.83); C337(0.88)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C185(0.65); C219(0.76); C175(0.77); C337(1.00)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C58(0.68); C185(0.84); C225(0.89); C337(0.99)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C58(0.85); C219(0.86); C185(0.88); C225(1.02)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C185(0.71); C58(0.79); C337(0.86); C175(1.11)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C219(0.90); C58(0.90); C225(0.96); C337(1.07)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C185(0.66); C337(0.69); C58(0.84); C225(0.88)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C185(0.35); C337(0.69); C58(0.69); C225(1.01)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C337(0.74); C58(0.82); C185(0.85); C225(1.14)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C337(0.66); C219(0.79); C185(0.85); C225(0.89)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C185(0.53); C337(0.62); C175(0.82); C219(0.87)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C58(0.99); C164(1.49); C219(0.88); C175(0.99)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C58(0.95); C164(1.33); C219(0.85); C175(0.81)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C58(0.91); C164(1.75); C219(1.14); C175(1.01)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C58(0.95); C164(1.23); C219(0.85); C175(0.83)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C58(0.92); C164(1.43); C219(0.93); C175(1.02)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C58(0.83); C164(1.19); C219(1.16); C175(1.20)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C58(0.91); C164(1.19); C219(1.08); C175(1.00)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C58(0.73); C164(1.00); C219(0.71); C175(0.85)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C58(0.97); C164(1.02); C219(0.69); C175(0.86)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C58(1.04); C164(0.90); C219(0.63); C175(0.81)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C58(1.11); C164(0.71); C219(0.51); C175(0.66)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C58(1.03); C164(0.92); C219(0.59); C175(0.64)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C58(0.92); C164(0.80); C219(0.59); C175(0.94)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C58(1.09); C164(0.81); C219(0.68); C175(0.69)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C58(1.00); C164(0.89); C219(0.47); C175(0.57)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C58(0.85); C164(1.30); C219(1.12); C175(1.09)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C58(0.83); C164(0.74); C219(0.37); C175(0.70)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C58(1.04); C164(1.04); C219(0.50); C175(0.92)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C58(0.95); C164(1.01); C219(0.57); C175(0.88)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C58(0.94); C164(0.88); C219(0.54); C175(0.71)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C58(1.03); C164(0.99); C219(0.54); C175(0.82)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C58(0.93); C164(0.79); C219(0.66); C175(0.69)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C58(1.14); C164(0.94); C219(0.88); C175(0.96)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C58(1.17); C164(1.28); C219(1.03); C175(1.01)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C58(1.13); C164(1.16); C219(1.07); C175(1.08)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C58(1.02); C164(1.30); C219(1.35); C175(1.23)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C58(0.89); C164(1.62); C219(0.90); C175(1.20)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C58(1.05); C164(1.22); C219(1.21); C175(1.27)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C58(0.61); C164(1.84); C219(1.08); C175(1.24)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C58(1.13); C164(1.15); C219(0.95); C175(0.99)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C58(1.27); C164(1.16); C219(0.97); C175(1.28)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C58(1.08); C164(0.89); C219(1.02); C175(1.14)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C58(1.02); C164(0.94); C219(0.87); C175(1.21)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C58(1.08); C164(1.11); C219(1.09); C175(1.34)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C58(1.03); C164(1.24); C219(1.29); C175(1.23)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C58(1.28); C164(1.01); C219(1.21); C175(1.18)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C58(1.04); C164(1.22); C219(1.08); C175(1.06)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C58(0.96); C164(1.69); C219(0.58); C175(1.03)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C58(1.23); C164(1.38); C219(1.06); C175(1.23)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C58(1.09); C164(1.19); C219(0.87); C175(0.91)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C58(1.15); C164(1.43); C219(0.81); C175(0.94)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C58(0.96); C164(2.03); C219(0.76); C175(0.99)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C58(1.04); C164(1.52); C219(0.72); C175(1.01)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C58(1.00); C164(1.33); C219(0.86); C175(1.04)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C58(1.02); C164(3.40); C219(0.64); C175(1.08)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C58(0.88); C164(1.55); C219(0.67); C175(1.14)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C58(1.02); C164(1.91); C219(0.70); C175(1.25)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C58(1.10); C164(1.89); C219(0.85); C175(0.88)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C58(0.79); C164(1.65); C219(0.51); C175(0.81)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C58(1.15); C164(1.44); C219(0.74); C175(1.12)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C58(1.11); C164(1.62); C219(0.65); C175(1.08)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C58(1.25); C164(1.33); C219(0.80); C175(1.02)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C58(1.11); C164(2.57); C219(0.71); C175(1.04)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C58(0.98); C164(1.64); C219(0.69); C175(0.99)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C58(0.99); C164(0.84); C219(0.75); C175(1.08)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C58(0.86); C164(0.97); C219(0.87); C175(1.25)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C58(1.07); C164(0.81); C219(0.78); C175(1.11)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C58(1.16); C164(0.76); C219(0.48); C175(1.26)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C58(0.77); C164(0.74); C219(0.41); C175(0.73)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C58(1.05); C164(1.09); C219(0.85); C175(1.20)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C58(0.97); C164(0.81); C219(0.63); C175(1.30)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C58(1.00); C164(0.72); C219(0.42); C175(1.38)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C58(1.00); C164(0.69); C219(0.41); C175(1.15)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C58(1.09); C164(0.75); C219(0.50); C175(1.15)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C58(1.01); C164(0.74); C219(0.63); C175(1.11)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C58(1.24); C164(0.95); C219(0.84); C175(1.17)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C58(0.95); C164(0.83); C219(0.62); C175(1.30)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C58(1.04); C164(0.68); C219(0.45); C175(1.35)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C58(1.39); C164(0.79); C219(0.57); C175(1.26)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C58(0.93); C164(1.19); C219(0.79); C175(1.02)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C58(0.81); C164(0.88); C219(1.04); C175(1.37)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C58(1.38); C164(1.23); C219(0.79); C175(0.81)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C58(1.47); C164(1.28); C219(0.81); C175(1.34)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C58(2.00); C164(1.16); C219(0.70); C175(1.29)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C58(2.17); C164(1.18); C219(0.53); C175(2.22)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C58(2.63); C164(1.00); C219(0.59); C175(1.21)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C58(3.70); C164(1.39); C219(0.71); C175(0.85)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C58(3.16); C164(1.20); C219(0.68); C175(0.75)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C58(1.16); C164(1.10); C219(0.57); C175(0.67)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C58(1.92); C164(1.00); C219(0.58); C175(0.71)  LDD0811  [10]
 LDCM0634  CY-0357 Hep-G2 C7(1.35); C7(0.88)  LDD2228  [18]
 LDCM0495  E2913 HEK-293T C317(1.13); C185(1.05); C164(0.94); C175(0.97)  LDD1698  [30]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C175(3.13); C58(0.98); C317(0.98)  LDD1702  [6]
 LDCM0625  F8 Ramos C164(1.37); C185(0.90); C175(1.32); C58(1.42)  LDD2187  [31]
 LDCM0572  Fragment10 Ramos C164(0.71); C185(0.53); C175(0.81); C58(0.58)  LDD2189  [31]
 LDCM0573  Fragment11 Ramos C164(4.17); C185(0.28); C175(0.01); 0.28  LDD2190  [31]
 LDCM0574  Fragment12 Ramos C164(0.66); C185(0.54); C175(0.95); C58(0.65)  LDD2191  [31]
 LDCM0575  Fragment13 Ramos C164(0.92); C185(1.34); C175(1.05); C58(0.94)  LDD2192  [31]
 LDCM0576  Fragment14 Ramos C164(0.97); C185(1.00); C175(1.32); C58(0.62)  LDD2193  [31]
 LDCM0579  Fragment20 Ramos C164(0.48); C185(0.47); C175(0.69); C58(0.46)  LDD2194  [31]
 LDCM0580  Fragment21 Ramos C164(0.52); C185(0.80); C175(0.89); C58(0.91)  LDD2195  [31]
 LDCM0582  Fragment23 Ramos C164(0.36); C185(0.78); C175(0.25); C58(1.00)  LDD2196  [31]
 LDCM0578  Fragment27 Ramos C164(0.84); C185(0.94); C175(0.82); C58(0.99)  LDD2197  [31]
 LDCM0586  Fragment28 Ramos C164(0.77); C185(0.71); C175(0.68); C58(0.57)  LDD2198  [31]
 LDCM0588  Fragment30 Ramos C164(0.83); C185(0.84); C175(1.12); C58(1.19)  LDD2199  [31]
 LDCM0589  Fragment31 Ramos C164(0.99); C185(0.97); C175(1.02); C58(1.06)  LDD2200  [31]
 LDCM0590  Fragment32 Ramos C164(0.59); C185(0.54); C175(0.96); C58(0.60)  LDD2201  [31]
 LDCM0468  Fragment33 HCT 116 C58(1.24); C164(1.86); C219(0.80); C175(1.10)  LDD0785  [10]
 LDCM0596  Fragment38 Ramos C164(1.00); C185(0.59); C175(1.18); C58(1.00)  LDD2203  [31]
 LDCM0566  Fragment4 Ramos C164(0.72); C185(0.59); C175(1.23); C58(0.77)  LDD2184  [31]
 LDCM0427  Fragment51 HCT 116 C58(0.86); C164(0.69); C219(0.73); C175(0.58)  LDD0744  [10]
 LDCM0610  Fragment52 Ramos C164(1.05); C185(0.79); C175(1.55); C58(1.30)  LDD2204  [31]
 LDCM0614  Fragment56 Ramos C164(2.08); C185(0.71); C175(1.16); C58(1.20)  LDD2205  [31]
 LDCM0569  Fragment7 Ramos C164(0.94); C185(0.59); C175(1.03); C58(0.59)  LDD2186  [31]
 LDCM0571  Fragment9 Ramos C164(0.55); C185(0.42); C175(0.85); C58(0.50)  LDD2188  [31]
 LDCM0116  HHS-0101 DM93 Y145(0.67); Y38(0.86)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y38(0.60); Y145(0.68)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y145(0.67); Y38(1.46)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y145(0.68); Y38(0.76)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y38(0.76); Y145(1.22)  LDD0268  [8]
 LDCM0107  IAA HeLa C337(0.00); C185(0.00); C317(0.00); H176(0.00)  LDD0221  [24]
 LDCM0022  KB02 HCT 116 C175(3.15); C225(1.42); C58(1.16)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C175(3.61); C225(0.94); C58(1.11)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C175(2.73); C225(1.30); C58(1.07)  LDD0082  [10]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C175(0.79)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C175(0.53); C58(0.88)  LDD2121  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [24]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C175(0.51); C58(1.03)  LDD2089  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C175(1.38); C58(1.02)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C175(1.00)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C175(1.46)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C175(1.07)  LDD2094  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C175(0.93); C58(0.91)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C175(0.97)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C175(1.01); C164(1.15); C185(1.10); C58(1.27)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C175(0.86)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C58(1.08)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C317(0.64)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C175(1.44)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C317(0.61)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C175(0.85); C164(1.08); C185(0.89); C58(0.90)  LDD2107  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C175(1.04); C185(0.60); C58(0.80)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C175(1.04); C164(1.07); C58(1.00)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C175(1.07)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C317(0.27)  LDD2115  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C185(0.83); C317(0.66)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C175(2.72); C164(1.29); C58(1.95)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C175(0.75)  LDD2120  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C175(0.99); C164(1.09); C185(0.88); C58(1.01)  LDD2123  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C175(0.89); C164(1.02); C58(1.04)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C185(1.24); C317(0.75)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C175(1.11); C164(1.30); C185(1.00); C58(1.09)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C175(0.91); C58(1.07)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C164(1.40); C185(1.01); C58(0.98)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C58(0.76)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C175(0.42); C185(0.88); C58(0.50)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C175(1.10); C164(1.22); C185(0.97); C58(1.10)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C175(1.22); C164(1.58); C185(0.94); C58(1.04)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C175(1.02); C164(1.02); C185(0.99); C58(0.91)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C58(1.39); C175(1.37)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C175(0.70); C164(0.96); C185(0.68); C58(0.76)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C175(0.63)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C175(0.81)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C175(0.88); C164(1.55); C185(1.46); C58(2.04)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C175(1.08); C185(1.06); C58(0.94); C317(1.43)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C175(1.30); C317(1.98)  LDD2147  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C175(0.67); C185(0.54); C58(0.71)  LDD2148  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C175(0.54); C58(0.53); C317(0.50)  LDD2150  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C175(2.27)  LDD2153  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C7(3.45); C105(1.90); C7(1.81)  LDD2206  [32]
 LDCM0628  OTUB2-COV-1 HEK-293T C164(2.91); C7(1.07); C175(0.71); C7(0.20)  LDD2207  [32]
 LDCM0131  RA190 MM1.R C225(1.16)  LDD0304  [33]
 LDCM0170  Structure8 Ramos 4.13  LDD0433  [34]
 LDCM0021  THZ1 HCT 116 C175(0.98)  LDD2173  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BAG family molecular chaperone regulator 2 (BAG2) . O95816
BAG family molecular chaperone regulator 4 (BAG4) . O95429
Disrupted in schizophrenia 1 protein (DISC1) . Q9NRI5

References

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2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
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11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD022279
21 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
22 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
23 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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29 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
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Mass spectrometry data entry: PXD044402
31 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
32 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
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