Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name CY4  Probe Info 
Probe concentration 20 uM
Criteria Quantification: Probe vs DMSO
Quantitative Method
LFQ
In Vivo Experiment Model Model Type Living cell
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cells (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 208 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06658  Thioredoxin reductase 1, cytoplasmic (TXNRD1) 111.9
 LDTP10869  26S proteasome non-ATPase regulatory subunit 1 (PSMD1) 100.0
 LDTP00224  26S proteasome non-ATPase regulatory subunit 12 (PSMD12) 100.0
 LDTP00714  26S proteasome non-ATPase regulatory subunit 3 (PSMD3) 100.0
 LDTP04962  26S proteasome regulatory subunit 4 (PSMC1) 100.0
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) 100.0
 LDTP04499  6-phosphogluconate dehydrogenase, decarboxylating (PGD) 100.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) 100.0
 LDTP10982  Aconitate hydratase, mitochondrial (ACO2) 100.0
 LDTP05073  Actin, alpha skeletal muscle (ACTA1) 100.0
 LDTP16274  Acyl-coenzyme A thioesterase 9, mitochondrial (ACOT9) 100.0
 LDTP02942  ADP-ribosylation factor 4 (ARF4) 100.0
 LDTP13462  ADP-sugar pyrophosphatase (NUDT5) 100.0
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) 100.0
 LDTP00186  Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) 100.0
 LDTP05408  Antigen peptide transporter 1 (TAP1) 100.0
 LDTP05409  Antigen peptide transporter 2 (TAP2) 100.0
 LDTP01675  Antiviral innate immune response receptor RIG-I (RIGI) 100.0
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1) 100.0
 LDTP07362  Atlastin-3 (ATL3) 100.0
 LDTP02150  ATP synthase subunit beta, mitochondrial (ATP5F1B) 100.0
 LDTP03424  ATP-binding cassette sub-family D member 3 (ABCD3) 100.0
 LDTP04909  ATP-binding cassette sub-family E member 1 (ABCE1) 100.0
 LDTP04561  ATP-citrate synthase (ACLY) 100.0
 LDTP02925  ATP-dependent 6-phosphofructokinase, liver type (PFKL) 100.0
 LDTP09766  ATP-dependent RNA helicase DDX1 (DDX1) 100.0
 LDTP08369  ATP-dependent RNA helicase DDX42 (DDX42) 100.0
 LDTP12681  ATPase family AAA domain-containing protein 3A (ATAD3A) 100.0
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) 100.0
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) 100.0
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 100.0
 LDTP12163  Calcyclin-binding protein (CACYBP) 100.0
 LDTP02204  Calpain-1 catalytic subunit (CAPN1) 100.0
 LDTP02911  Calpain-2 catalytic subunit (CAPN2) 100.0
 LDTP04358  Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) 100.0
 LDTP04886  Cell division control protein 42 homolog (CDC42) 100.0
 LDTP10329  Ceramide synthase 2 (CERS2) 100.0
 LDTP11178  Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) 100.0
 LDTP01205  Citrate synthase, mitochondrial (CS) 100.0
 LDTP13675  COP9 signalosome complex subunit 3 (COPS3) 100.0
 LDTP02922  CTP synthase 1 (CTPS1) 100.0
 LDTP08296  Cullin-associated NEDD8-dissociated protein 1 (CAND1) 100.0
 LDTP03610  Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1) 100.0
 LDTP04144  Cytochrome b-c1 complex subunit Rieske, mitochondrial (UQCRFS1) 100.0
 LDTP00697  Cytochrome b5 type B (CYB5B) 100.0
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 100.0
 LDTP00194  Cytosolic acyl coenzyme A thioester hydrolase (ACOT7) 100.0
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 100.0
 LDTP04646  Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1) 100.0
 LDTP02362  Dihydrolipoyl dehydrogenase, mitochondrial (DLD) 100.0
 LDTP03398  DNA repair nuclease/redox regulator APEX1 (APEX1) 100.0
 LDTP03316  DNA replication licensing factor MCM3 (MCM3) 100.0
 LDTP03681  DNA replication licensing factor MCM5 (MCM5) 100.0
 LDTP02568  DNA topoisomerase 2-alpha (TOP2A) 100.0
 LDTP03564  DNA-directed RNA polymerase II subunit RPB2 (POLR2B) 100.0
 LDTP04120  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) 100.0
 LDTP09388  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (STT3B) 100.0
 LDTP04690  Double-stranded RNA-specific adenosine deaminase (ADAR) 100.0
 LDTP00273  Dynamin-1-like protein (DNM1L) 100.0
 LDTP04374  Dynamin-2 (DNM2) 100.0
 LDTP00950  Dynamin-like 120 kDa protein, mitochondrial (OPA1) 100.0
 LDTP04310  E3 SUMO-protein ligase RanBP2 (RANBP2) 100.0
 LDTP08135  E3 ubiquitin-protein ligase HUWE1 (HUWE1) 100.0
 LDTP07118  E3 ubiquitin-protein ligase UBR4 (UBR4) 100.0
 LDTP06098  E3 ubiquitin/ISG15 ligase TRIM25 (TRIM25) 100.0
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) 100.0
 LDTP03474  Ephrin type-A receptor 2 (EPHA2) 100.0
 LDTP01785  Epidermal growth factor receptor (EGFR) 100.0
 LDTP10386  ERO1-like protein alpha (ERO1A) 100.0
 LDTP09063  Estradiol 17-beta-dehydrogenase 11 (HSD17B11) 100.0
 LDTP03861  Eukaryotic initiation factor 4A-III (EIF4A3) 100.0
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) 100.0
 LDTP01063  Eukaryotic translation initiation factor 5B (EIF5B) 100.0
 LDTP14109  FACT complex subunit SPT16 (SUPT16H) 100.0
 LDTP02721  Farnesyl pyrophosphate synthase (FDPS) 100.0
 LDTP04243  Fatty acid synthase (FASN) 100.0
 LDTP02235  Fumarate hydratase, mitochondrial (FH) 100.0
 LDTP02569  Glucose-6-phosphate 1-dehydrogenase (G6PD) 100.0
 LDTP02162  Glucose-6-phosphate isomerase (GPI) 100.0
 LDTP01768  Glutamate dehydrogenase 1, mitochondrial (GLUD1) 100.0
 LDTP05481  Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (GFPT1) 100.0
 LDTP02350  Glutathione S-transferase Mu 1 (GSTM1) 100.0
 LDTP03103  Glutathione S-transferase Mu 3 (GSTM3) 100.0
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) 100.0
 LDTP03946  Glycine--tRNA ligase (GARS1) 100.0
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) 100.0
 LDTP04333  GMP synthase [glutamine-hydrolyzing] (GMPS) 100.0
 LDTP11297  Guanine nucleotide-binding protein-like 3 (GNL3) 100.0
 LDTP03540  Heme oxygenase 2 (HMOX2) 100.0
 LDTP04581  Holocytochrome c-type synthase (HCCS) 100.0
 LDTP01782  Hypoxanthine-guanine phosphoribosyltransferase (HPRT1) 100.0
 LDTP10935  Kinesin-like protein KIF2C (KIF2C) 100.0
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 100.0
 LDTP03907  Malate dehydrogenase, cytoplasmic (MDH1) 100.0
 LDTP04375  Methionine aminopeptidase 2 (METAP2) 100.0
 LDTP02506  Microsomal glutathione S-transferase 1 (MGST1) 100.0
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 100.0
 LDTP03401  Multifunctional protein CAD (CAD) 100.0
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) 100.0
 LDTP00886  Nardilysin (NRDC) 100.0
 LDTP07591  Neutral cholesterol ester hydrolase 1 (NCEH1) 100.0
 LDTP03169  Nucleoside diphosphate kinase B (NME2) 100.0
 LDTP03626  Peroxiredoxin-2 (PRDX2) 100.0
 LDTP05773  Peroxiredoxin-4 (PRDX4) 100.0
 LDTP03510  Peroxiredoxin-6 (PRDX6) 100.0
 LDTP12586  Phenylalanine--tRNA ligase beta subunit (FARSB) 100.0
 LDTP11284  Phosphatidylserine synthase 2 (PTDSS2) 100.0
 LDTP03818  Phosphoglucomutase-1 (PGM1) 100.0
 LDTP10326  Phosphopentomutase (PGM2) 100.0
 LDTP03024  Plasma membrane calcium-transporting ATPase 1 (ATP2B1) 100.0
 LDTP02375  Poly [ADP-ribose] polymerase 1 (PARP1) 100.0
 LDTP14888  Pre-rRNA-processing protein TSR1 homolog (TSR1) 100.0
 LDTP03348  Probable ATP-dependent RNA helicase DDX6 (DDX6) 100.0
 LDTP09961  Probable ubiquitin carboxyl-terminal hydrolase FAF-X (USP9X) 100.0
 LDTP04163  Prolyl endopeptidase (PREP) 100.0
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 100.0
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) 100.0
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) 100.0
 LDTP00418  Protein arginine N-methyltransferase 5 (PRMT5) 100.0
 LDTP02188  Protein disulfide-isomerase (P4HB) 100.0
 LDTP00616  Protein phosphatase 1G (PPM1G) 100.0
 LDTP14092  Protein phosphatase methylesterase 1 (PPME1) 100.0
 LDTP03496  Protein PML (PML) 100.0
 LDTP03152  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) 100.0
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 100.0
 LDTP05037  Ras-related C3 botulinum toxin substrate 1 (RAC1) 100.0
 LDTP04901  Ras-related protein Rab-14 (RAB14) 100.0
 LDTP05006  Ras-related protein Rab-1A (RAB1A) 100.0
 LDTP04398  Ras-related protein Rab-5C (RAB5C) 100.0
 LDTP04399  Ras-related protein Rab-7a (RAB7A) 100.0
 LDTP04888  Ras-related protein Rab-8A (RAB8A) 100.0
 LDTP09364  Retinol dehydrogenase 11 (RDH11) 100.0
 LDTP05195  Rho-related GTP-binding protein RhoG (RHOG) 100.0
 LDTP05588  RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) 100.0
 LDTP03577  S-adenosylmethionine synthase isoform type-2 (MAT2A) 100.0
 LDTP12667  Septin-11 (SEPTIN11) 100.0
 LDTP06279  Septin-2 (SEPTIN2) 100.0
 LDTP06513  Septin-7 (SEPTIN7) 100.0
 LDTP13272  Septin-9 (SEPTIN9) 100.0
 LDTP01420  Serine/threonine-protein kinase 10 (STK10) 100.0
 LDTP03522  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) 100.0
 LDTP03008  Spermidine synthase (SRM) 100.0
 LDTP03769  Sterol O-acyltransferase 1 (SOAT1) 100.0
 LDTP07813  Sulfhydryl oxidase 2 (QSOX2) 100.0
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) 100.0
 LDTP11874  Thioredoxin-related transmembrane protein 1 (TMX1) 100.0
 LDTP03365  Threonine--tRNA ligase 1, cytoplasmic (TARS1) 100.0
 LDTP02022  Thymidine kinase, cytosolic (TK1) 100.0
 LDTP03847  Transaldolase (TALDO1) 100.0
 LDTP04422  Transcription activator BRG1 (SMARCA4) 100.0
 LDTP05808  Transcription intermediary factor 1-beta (TRIM28) 100.0
 LDTP04927  Transforming protein RhoA (RHOA) 100.0
 LDTP03912  Trifunctional enzyme subunit alpha, mitochondrial (HADHA) 100.0
 LDTP04617  Tyrosine--tRNA ligase, cytoplasmic (YARS1) 100.0
 LDTP02935  Tyrosine-protein phosphatase non-receptor type 1 (PTPN1) 100.0
 LDTP01283  U5 small nuclear ribonucleoprotein 200 kDa helicase (SNRNP200) 100.0
 LDTP00013  Ubiquitin-like modifier-activating enzyme 6 (UBA6) 100.0
 LDTP03859  V-type proton ATPase catalytic subunit A (ATP6V1A) 100.0
 LDTP04289  Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL) 100.0
 LDTP12954  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) 100.0
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 100.0
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 100.0
 LDTP02642  X-ray repair cross-complementing protein 5 (XRCC5) 100.0
 LDTP01439  [F-actin]-monooxygenase MICAL2 (MICAL2) 100.0
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 90.2
 LDTP03915  Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3) 30.7
 LDTP05550  ATP-dependent RNA helicase A (DHX9) 23.4
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) 17.0
 LDTP03242  Adenosylhomocysteinase (AHCY) 16.0
 LDTP05782  26S proteasome non-ATPase regulatory subunit 2 (PSMD2) 15.6
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) 13.8
 LDTP03216  Peptidyl-prolyl cis-trans isomerase B (PPIB) 12.1
 LDTP02796  Nucleoside diphosphate kinase A (NME1) 9.4
 LDTP05136  DNA-dependent protein kinase catalytic subunit (PRKDC) 8.0
 LDTP02534  Endoplasmic reticulum chaperone BiP (HSPA5) 7.8
 LDTP03366  Valine--tRNA ligase (VARS1) 7.5
 LDTP05503  Peroxiredoxin-1 (PRDX1) 7.1
 LDTP03166  Ubiquitin-like modifier-activating enzyme 1 (UBA1) 6.9
 LDTP02640  X-ray repair cross-complementing protein 6 (XRCC6) 6.9
 LDTP03764  Myosin-9 (MYH9) 6.0
 LDTP02225  Heat shock protein HSP 90-alpha (HSP90AA1) 5.7
 LDTP01770  NADH-cytochrome b5 reductase 3 (CYB5R3) 5.7
 LDTP02672  Elongation factor 2 (EEF2) 5.6
 LDTP03146  Protein-glutamine gamma-glutamyltransferase 2 (TGM2) 5.0
 LDTP02752  Aspartate--tRNA ligase, cytoplasmic (DARS1) 4.7
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) 4.4
 LDTP04665  Transitional endoplasmic reticulum ATPase (VCP) 4.4
 LDTP04851  Triosephosphate isomerase (TPI1) 4.4
 LDTP05028  Peptidyl-prolyl cis-trans isomerase A (PPIA) 4.3
 LDTP02963  Phosphoglycerate mutase 1 (PGAM1) 4.2
 LDTP02333  Glutathione S-transferase P (GSTP1) 4.1
 LDTP03487  Transketolase (TKT) 4.1
 LDTP02222  Bifunctional glutamate/proline--tRNA ligase (EPRS1) 4.0
 LDTP02179  L-lactate dehydrogenase B chain (LDHB) 4.0
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) 3.7
 LDTP05007  GTP-binding nuclear protein Ran (RAN) 3.7
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) 3.5
 LDTP02008  Fructose-bisphosphate aldolase A (ALDOA) 3.4
 LDTP02733  Pyruvate kinase PKM (PKM) 3.3
 LDTP04878  Eukaryotic initiation factor 4A-I (EIF4A1) 2.9
 LDTP01787  Phosphoglycerate kinase 1 (PGK1) 2.8
 LDTP01766  L-lactate dehydrogenase A chain (LDHA) 2.5
 LDTP02159  Alpha-enolase (ENO1) 2.5
 LDTP05074  Tubulin alpha-1B chain (TUBA1B) 2.4
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 2.3
 LDTP05991  Spliceosome RNA helicase DDX39B (DDX39B) 2.2
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) 2.1
 LDTP12469  Nucleolar RNA helicase 2 (DDX21) 2.1
Transporter and channel
Click to Show/Hide to Show 85 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04953  14-3-3 protein gamma (YWHAG) 100.0
 LDTP03385  14-3-3 protein theta (YWHAQ) 100.0
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 100.0
 LDTP02256  Amino acid transporter heavy chain SLC3A2 (SLC3A2) 100.0
 LDTP02010  Annexin A1 (ANXA1) 100.0
 LDTP02247  Annexin A6 (ANXA6) 100.0
 LDTP05038  AP-2 complex subunit beta (AP2B1) 100.0
 LDTP03284  ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) 100.0
 LDTP04426  B-cell receptor-associated protein 31 (BCAP31) 100.0
 LDTP03405  Calnexin (CANX) 100.0
 LDTP03402  Calreticulin (CALR) 100.0
 LDTP04187  CD151 antigen (CD151) 100.0
 LDTP02320  CD63 antigen (CD63) 100.0
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) 100.0
 LDTP10989  Copine-1 (CPNE1) 100.0
 LDTP02009  Cystatin-B (CSTB) 100.0
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 100.0
 LDTP02057  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) 100.0
 LDTP02058  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (RPN2) 100.0
 LDTP11934  EH domain-containing protein 1 (EHD1) 100.0
 LDTP13393  Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13) 100.0
 LDTP10985  Equilibrative nucleoside transporter 1 (SLC29A1) 100.0
 LDTP04662  Exportin-2 (CSE1L) 100.0
 LDTP12142  Exportin-5 (XPO5) 100.0
 LDTP01197  Filamin-B (FLNB) 100.0
 LDTP06103  Filamin-C (FLNC) 100.0
 LDTP01366  Flotillin-1 (FLOT1) 100.0
 LDTP05020  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (GNB2) 100.0
 LDTP03506  Guanine nucleotide-binding protein subunit alpha-11 (GNA11) 100.0
 LDTP09515  Importin-4 (IPO4) 100.0
 LDTP00266  Importin-5 (IPO5) 100.0
 LDTP01574  Importin-7 (IPO7) 100.0
 LDTP03664  Kinesin-1 heavy chain (KIF5B) 100.0
 LDTP05305  Large neutral amino acids transporter small subunit 1 (SLC7A5) 100.0
 LDTP10081  Leucine-rich repeat-containing protein 59 (LRRC59) 100.0
 LDTP06660  MICOS complex subunit MIC60 (IMMT) 100.0
 LDTP05384  Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11) 100.0
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 100.0
 LDTP12078  Mitochondrial glutamate carrier 1 (SLC25A22) 100.0
 LDTP00821  Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) 100.0
 LDTP01748  Mitochondrial import receptor subunit TOM40 homolog (TOMM40) 100.0
 LDTP00635  Monocarboxylate transporter 4 (SLC16A3) 100.0
 LDTP10806  Myeloid-associated differentiation marker (MYADM) 100.0
 LDTP12916  Myoferlin (MYOF) 100.0
 LDTP06462  Neutral amino acid transporter B(0) (SLC1A5) 100.0
 LDTP01295  Nuclear pore complex protein Nup155 (NUP155) 100.0
 LDTP09825  Nuclear pore complex protein Nup205 (NUP205) 100.0
 LDTP10897  Nuclear pore complex protein Nup88 (NUP88) 100.0
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) 100.0
 LDTP00590  Protein RER1 (RER1) 100.0
 LDTP12207  Putative divalent cation/proton antiporter TMEM165 (TMEM165) 100.0
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 100.0
 LDTP00451  Secretory carrier-associated membrane protein 3 (SCAMP3) 100.0
 LDTP12090  Sideroflexin-1 (SFXN1) 100.0
 LDTP02544  Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) 100.0
 LDTP05273  Spectrin beta chain, non-erythrocytic 1 (SPTBN1) 100.0
 LDTP01454  SUN domain-containing protein 1 (SUN1) 100.0
 LDTP00592  Surfeit locus protein 4 (SURF4) 100.0
 LDTP13943  Thioredoxin-related transmembrane protein 2 (TMX2) 100.0
 LDTP01969  Transferrin receptor protein 1 (TFRC) 100.0
 LDTP15845  Transmembrane 9 superfamily member 2 (TM9SF2) 100.0
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 100.0
 LDTP09789  Transmembrane 9 superfamily member 4 (TM9SF4) 100.0
 LDTP07477  Transmembrane protein 214 (TMEM214) 100.0
 LDTP15979  Transmembrane protein 245 (TMEM245) 100.0
 LDTP10741  Vacuolar protein sorting-associated protein 35 (VPS35) 100.0
 LDTP12966  Vesicle-associated membrane protein-associated protein A (VAPA) 100.0
 LDTP14031  Talin-1 (TLN1) 45.0
 LDTP06242  Importin subunit beta-1 (KPNB1) 42.5
 LDTP03107  Filamin-A (FLNA) 13.7
 LDTP09149  ATP-binding cassette sub-family F member 1 (ABCF1) 10.8
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 10.6
 LDTP00501  Exportin-1 (XPO1) 8.5
 LDTP05238  Solute carrier family 25 member 3 (SLC25A3) 8.2
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 7.0
 LDTP04932  Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1) 6.6
 LDTP05043  14-3-3 protein zeta/delta (YWHAZ) 5.8
 LDTP04969  14-3-3 protein epsilon (YWHAE) 5.5
 LDTP05394  Caveolin-1 (CAV1) 4.8
 LDTP02262  Heat shock protein HSP 90-beta (HSP90AB1) 4.5
 LDTP04391  T-complex protein 1 subunit delta (CCT4) 3.5
 LDTP02087  ADP/ATP translocase 2 (SLC25A5) 3.2
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) 3.1
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) 2.9
 LDTP05252  Clathrin heavy chain 1 (CLTC) 2.4
Transcription factor
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05577  FACT complex subunit SSRP1 (SSRP1) 100.0
 LDTP01414  Metastasis-associated protein MTA2 (MTA2) 100.0
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) 100.0
 LDTP03903  Signal transducer and activator of transcription 3 (STAT3) 100.0
 LDTP05417  Transcription factor p65 (RELA) 100.0
 LDTP02343  High mobility group protein B1 (HMGB1) 32.2
GPCR
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04221  Adhesion G protein-coupled receptor E5 (ADGRE5) 100.0
Immunoglobulin
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02491  HLA class I histocompatibility antigen, C alpha chain (HLA-C) 100.0
 LDTP00671  Tapasin (TAPBP) 100.0
Other
Click to Show/Hide to Show 193 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05442  14-3-3 protein eta (YWHAH) 100.0
 LDTP11597  182 kDa tankyrase-1-binding protein (TNKS1BP1) 100.0
 LDTP00223  26S proteasome non-ATPase regulatory subunit 11 (PSMD11) 100.0
 LDTP06273  26S proteasome non-ATPase regulatory subunit 6 (PSMD6) 100.0
 LDTP08885  Actin filament-associated protein 1 (AFAP1) 100.0
 LDTP04903  Actin-related protein 2 (ACTR2) 100.0
 LDTP04844  Actin-related protein 2/3 complex subunit 4 (ARPC4) 100.0
 LDTP04902  Actin-related protein 3 (ACTR3) 100.0
 LDTP05294  Adenylyl cyclase-associated protein 1 (CAP1) 100.0
 LDTP12443  Anillin (ANLN) 100.0
 LDTP13091  Ataxin-10 (ATXN10) 100.0
 LDTP00078  CCR4-NOT transcription complex subunit 1 (CNOT1) 100.0
 LDTP02398  CDGSH iron-sulfur domain-containing protein 3, mitochondrial (CISD3) 100.0
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 100.0
 LDTP06024  Coactosin-like protein (COTL1) 100.0
 LDTP04571  Coatomer subunit alpha (COPA) 100.0
 LDTP14216  Coatomer subunit gamma-1 (COPG1) 100.0
 LDTP06281  Condensin complex subunit 1 (NCAPD2) 100.0
 LDTP12883  Constitutive coactivator of PPAR-gamma-like protein 1 (FAM120A) 100.0
 LDTP06030  Cytochrome c oxidase copper chaperone (COX17) 100.0
 LDTP06021  Cytoskeleton-associated protein 5 (CKAP5) 100.0
 LDTP10920  DnaJ homolog subfamily C member 7 (DNAJC7) 100.0
 LDTP05049  Dynein light chain 1, cytoplasmic (DYNLL1) 100.0
 LDTP06450  ELAV-like protein 1 (ELAVL1) 100.0
 LDTP03499  Elongation factor 1-delta (EEF1D) 100.0
 LDTP07521  Enhancer of mRNA-decapping protein 4 (EDC4) 100.0
 LDTP11998  Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8L2) 100.0
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 100.0
 LDTP02101  Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) 100.0
 LDTP03027  Eukaryotic translation initiation factor 2 subunit 2 (EIF2S2) 100.0
 LDTP06055  Eukaryotic translation initiation factor 3 subunit A (EIF3A) 100.0
 LDTP00619  Eukaryotic translation initiation factor 3 subunit D (EIF3D) 100.0
 LDTP04853  Eukaryotic translation initiation factor 3 subunit E (EIF3E) 100.0
 LDTP01319  Eukaryotic translation initiation factor 3 subunit G (EIF3G) 100.0
 LDTP05834  Eukaryotic translation initiation factor 3 subunit I (EIF3I) 100.0
 LDTP05421  Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) 100.0
 LDTP04743  Eukaryotic translation initiation factor 6 (EIF6) 100.0
 LDTP04127  F-actin-capping protein subunit beta (CAPZB) 100.0
 LDTP09938  Far upstream element-binding protein 2 (KHSRP) 100.0
 LDTP06255  GTPase-activating protein and VPS9 domain-containing protein 1 (GAPVD1) 100.0
 LDTP02059  Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2) 100.0
 LDTP02435  Heat shock 70 kDa protein 1B (HSPA1B) 100.0
 LDTP03695  Heat shock 70 kDa protein 4 (HSPA4) 100.0
 LDTP09811  Heat shock protein 105 kDa (HSPH1) 100.0
 LDTP02053  Heat shock protein beta-1 (HSPB1) 100.0
 LDTP10962  Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB) 100.0
 LDTP00500  Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) 100.0
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) 100.0
 LDTP04500  Heterogeneous nuclear ribonucleoprotein M (HNRNPM) 100.0
 LDTP00991  Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) 100.0
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) 100.0
 LDTP11238  Heterogeneous nuclear ribonucleoprotein U-like protein 1 (HNRNPUL1) 100.0
 LDTP02227  Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) 100.0
 LDTP06562  Histone-binding protein RBBP7 (RBBP7) 100.0
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) 100.0
 LDTP00463  Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) 100.0
 LDTP06681  Inverted formin-2 (INF2) 100.0
 LDTP06051  Kelch-like ECH-associated protein 1 (KEAP1) 100.0
 LDTP05525  KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1) 100.0
 LDTP11695  Kinesin light chain 2 (KLC2) 100.0
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) 100.0
 LDTP05051  Large ribosomal subunit protein eL38 (RPL38) 100.0
 LDTP04926  Large ribosomal subunit protein eL43 (RPL37A) 100.0
 LDTP05001  Large ribosomal subunit protein uL23 (RPL23A) 100.0
 LDTP03557  Leukocyte elastase inhibitor (SERPINB1) 100.0
 LDTP06220  LIM and SH3 domain protein 1 (LASP1) 100.0
 LDTP04027  Matrin-3 (MATR3) 100.0
 LDTP05159  Metallothionein-1X (MT1X) 100.0
 LDTP03404  Microtubule-associated protein 4 (MAP4) 100.0
 LDTP00838  Mitotic checkpoint protein BUB3 (BUB3) 100.0
 LDTP04875  Myosin light polypeptide 6 (MYL6) 100.0
 LDTP02982  Myosin regulatory light chain 12A (MYL12A) 100.0
 LDTP05597  Neuroblast differentiation-associated protein AHNAK (AHNAK) 100.0
 LDTP02990  Nucleolin (NCL) 100.0
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) 100.0
 LDTP10383  PDZ and LIM domain protein 5 (PDLIM5) 100.0
 LDTP12461  PDZ and LIM domain protein 7 (PDLIM7) 100.0
 LDTP04015  Platelet-activating factor acetylhydrolase IB subunit beta (PAFAH1B1) 100.0
 LDTP02595  Polyadenylate-binding protein 1 (PABPC1) 100.0
 LDTP05821  Polyadenylate-binding protein 4 (PABPC4) 100.0
 LDTP13906  Polymerase delta-interacting protein 2 (POLDIP2) 100.0
 LDTP03364  Polypyrimidine tract-binding protein 1 (PTBP1) 100.0
 LDTP09580  Programmed cell death 6-interacting protein (PDCD6IP) 100.0
 LDTP10924  Prohibitin-2 (PHB2) 100.0
 LDTP09383  Protein CIP2A (CIP2A) 100.0
 LDTP03778  Protein DEK (DEK) 100.0
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) 100.0
 LDTP10847  Protein Niban 2 (NIBAN2) 100.0
 LDTP13020  Protein RCC2 (RCC2) 100.0
 LDTP12694  Protein SDA1 homolog (SDAD1) 100.0
 LDTP06391  Protein transport protein Sec23B (SEC23B) 100.0
 LDTP03574  Rab GDP dissociation inhibitor alpha (GDI1) 100.0
 LDTP03397  Replication protein A 70 kDa DNA-binding subunit (RPA1) 100.0
 LDTP01522  Reticulon-3 (RTN3) 100.0
 LDTP12412  Reticulon-4 (RTN4) 100.0
 LDTP04510  Rho GDP-dissociation inhibitor 1 (ARHGDIA) 100.0
 LDTP06046  Ribosome biogenesis protein BOP1 (BOP1) 100.0
 LDTP13966  Ribosome maturation protein SBDS (SBDS) 100.0
 LDTP13044  Ribosome-binding protein 1 (RRBP1) 100.0
 LDTP04395  RNA-binding protein FXR1 (FXR1) 100.0
 LDTP05898  Sequestosome-1 (SQSTM1) 100.0
 LDTP04363  Serpin H1 (SERPINH1) 100.0
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) 100.0
 LDTP03321  Small ribosomal subunit protein eS12 (RPS12) 100.0
 LDTP02302  Small ribosomal subunit protein eS17 (RPS17) 100.0
 LDTP03864  Small ribosomal subunit protein eS19 (RPS19) 100.0
 LDTP04880  Small ribosomal subunit protein uS10 (RPS20) 100.0
 LDTP02312  Small ribosomal subunit protein uS2 (RPSA) 100.0
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) 100.0
 LDTP05985  Spectrin alpha chain, non-erythrocytic 1 (SPTAN1) 100.0
 LDTP01251  Splicing factor 3B subunit 1 (SF3B1) 100.0
 LDTP06094  Src substrate cortactin (CTTN) 100.0
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) 100.0
 LDTP12606  Structural maintenance of chromosomes protein 4 (SMC4) 100.0
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) 100.0
 LDTP02238  Thrombospondin-1 (THBS1) 100.0
 LDTP13192  Tight junction protein ZO-2 (TJP2) 100.0
 LDTP03846  Transgelin-2 (TAGLN2) 100.0
 LDTP00759  Tumor protein D54 (TPD52L2) 100.0
 LDTP07632  Type-1 angiotensin II receptor-associated protein (AGTRAP) 100.0
 LDTP11534  Uveal autoantigen with coiled-coil domains and ankyrin repeats (UACA) 100.0
 LDTP01206  Vesicle-trafficking protein SEC22b (SEC22B) 100.0
 LDTP02946  Vinculin (VCL) 100.0
 LDTP01143  Zinc finger CCCH domain-containing protein 11A (ZC3H11A) 100.0
 LDTP00580  Zinc finger protein 185 (ZNF185) 100.0
 LDTP15762  Zinc finger RNA-binding protein (ZFR) 100.0
 LDTP03619  Stress-induced-phosphoprotein 1 (STIP1) 56.0
 LDTP04355  Rab GDP dissociation inhibitor beta (GDI2) 54.0
 LDTP04570  Coatomer subunit beta (COPB1) 39.6
 LDTP01932  Prelamin-A/C (LMNA) 23.7
 LDTP04181  Coatomer subunit delta (ARCN1) 22.4
 LDTP04117  Ras GTPase-activating-like protein IQGAP1 (IQGAP1) 19.3
 LDTP00550  Actin-related protein 2/3 complex subunit 1B (ARPC1B) 19.2
 LDTP03997  Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC) 17.7
 LDTP04718  Eukaryotic translation initiation factor 3 subunit B (EIF3B) 17.1
 LDTP06032  Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) 14.5
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) 14.4
 LDTP03244  Cofilin-1 (CFL1) 14.3
 LDTP01118  WD repeat-containing protein 1 (WDR1) 13.3
 LDTP11079  Myb-binding protein 1A (MYBBP1A) 13.2
 LDTP02750  Heterogeneous nuclear ribonucleoprotein L (HNRNPL) 12.5
 LDTP02779  Ezrin (EZR) 12.2
 LDTP05024  Large ribosomal subunit protein uL1 (RPL10A) 11.3
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) 11.2
 LDTP07526  Pre-mRNA-processing-splicing factor 8 (PRPF8) 10.7
 LDTP05026  Large ribosomal subunit protein uL5 (RPL11) 10.0
 LDTP13813  Eukaryotic translation initiation factor 3 subunit L (EIF3L) 9.9
 LDTP00551  Actin-related protein 2/3 complex subunit 2 (ARPC2) 9.6
 LDTP05013  Small ribosomal subunit protein eS25 (RPS25) 8.9
 LDTP06330  Plectin (PLEC) 8.8
 LDTP00306  Pescadillo homolog (PES1) 8.0
 LDTP04965  Small ribosomal subunit protein uS8 (RPS15A) 7.8
 LDTP02961  Large ribosomal subunit protein uL22 (RPL17) 6.9
 LDTP05259  Heterogeneous nuclear ribonucleoprotein U (HNRNPU) 6.9
 LDTP04390  T-complex protein 1 subunit theta (CCT8) 6.7
 LDTP10919  Eukaryotic translation initiation factor 3 subunit C (EIF3C) 6.1
 LDTP04495  Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3) 6.1
 LDTP04970  Small ribosomal subunit protein uS11 (RPS14) 6.0
 LDTP10990  T-complex protein 1 subunit eta (CCT7) 5.9
 LDTP04106  Large ribosomal subunit protein uL18 (RPL5) 5.4
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) 5.4
 LDTP02631  Alpha-actinin-1 (ACTN1) 5.4
 LDTP02092  Ubiquitin-like protein ISG15 (ISG15) 5.2
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) 5.0
 LDTP06083  Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) 4.9
 LDTP03517  Large ribosomal subunit protein uL11 (RPL12) 4.8
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) 4.6
 LDTP08018  Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1) 4.5
 LDTP03658  Large ribosomal subunit protein uL6 (RPL9; RPL9P7; RPL9P8; RPL9P9) 4.5
 LDTP02218  Profilin-1 (PFN1) 4.4
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) 4.2
 LDTP03888  T-complex protein 1 subunit zeta (CCT6A) 4.1
 LDTP02364  Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) 4.0
 LDTP03182  Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) 3.9
 LDTP05113  T-complex protein 1 subunit beta (CCT2) 3.8
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) 3.7
 LDTP02809  Small ribosomal subunit protein uS5 (RPS2) 3.7
 LDTP02205  Tubulin beta chain (TUBB) 3.5
 LDTP02164  Nucleophosmin (NPM1) 3.5
 LDTP04249  T-complex protein 1 subunit gamma (CCT3) 3.5
 LDTP02940  Large ribosomal subunit protein eL33 (RPL35A) 3.4
 LDTP02297  Vimentin (VIM) 3.4
 LDTP04913  Small ribosomal subunit protein eS1 (RPS3A) 3.3
 LDTP00843  Alpha-actinin-4 (ACTN4) 2.9
 LDTP04966  Small ribosomal subunit protein uS9 (RPS16) 2.8
 LDTP05188  Large ribosomal subunit protein eL42 (RPL36A) 2.8
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) 2.7
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) 2.4
 LDTP02109  Large ribosomal subunit protein uL10 (RPLP0) 2.3
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) 2.2
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) 2.2
 LDTP03367  Elongation factor 1-gamma (EEF1G) 2.1
 LDTP05076  Tubulin beta-4B chain (TUBB4B) 2.1

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.