Details of the Target

General Information of Target

Target ID LDTP10962
Target Name Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB)
Gene Name HNRNPAB
Gene ID 3182
Synonyms
ABBP1; HNRPAB; Heterogeneous nuclear ribonucleoprotein A/B; hnRNP A/B; APOBEC1-binding protein 1; ABBP-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP
VCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNEL
SDLKEDKPRKSLFNDAGNKKNSIKMWFSPRSKKVRYVVSKASVQTQPAIKKDASAQQDSY
EFVSPSPPADVSERAKKASARSGKKQKKKTLAEINQKWNLEAEKEDGEFDSKEESKQKLV
SFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIESPDTKSRNEVVTP
EKVCKNYLTSKKSLPLENNGKRGHHNRLSSPISKRCRTSILSTSGDFVKQTVPSENIPLP
ECSSPPSCKRKVGGTSGRKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNM
AVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELL
LQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMK
SLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEF
DSTVTHVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRS
RLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTV
AYHARPDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS
Target Bioclass
Other
Subcellular location
Nucleus
Function Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.
Uniprot ID
Q99729
Ensemble ID
ENST00000355836.9
HGNC ID
HGNC:5034

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 39 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY4
 Probe Info  		100.00  LDD0244  [1]
TH211
 Probe Info  		Y235(20.00); Y240(20.00)  LDD0260  [2]
C-Sul
 Probe Info  		3.59  LDD0066  [3]
TH214
 Probe Info  		Y240(20.00)  LDD0258  [2]
TH216
 Probe Info  		Y240(19.49)  LDD0259  [2]
BTD
 Probe Info  		C98(3.96)  LDD1699  [4]
ONAyne
 Probe Info  		K215(0.00); K143(0.00); K142(0.00); K83(0.00)  LDD0273  [5]
Probe 1
 Probe Info  		Y235(69.85); Y240(22.54)  LDD3495  [6]
AHL-Pu-1
 Probe Info  		C98(5.07)  LDD0172  [7]
HHS-482
 Probe Info  		Y235(0.82); Y240(0.82)  LDD0285  [8]
HHS-475
 Probe Info  		Y240(0.78); Y235(0.81)  LDD0264  [9]
HHS-465
 Probe Info  		Y235(10.00); Y240(10.00)  LDD2237  [10]
5E-2FA
 Probe Info  		N.A.  LDD2235  [11]
AMP probe
 Probe Info  		K101(0.00); K232(0.00)  LDD0200  [12]
ATP probe
 Probe Info  		K101(0.00); K232(0.00); K227(0.00); K223(0.00)  LDD0199  [12]
m-APA
 Probe Info  		N.A.  LDD2231  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [13]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [14]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [14]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [15]
ATP probe
 Probe Info  		K91(0.00); K223(0.00); K82(0.00); K101(0.00)  LDD0035  [16]
IPM
 Probe Info  		C224(0.00); C98(0.00)  LDD0025  [17]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [17]
WYneO
 Probe Info  		N.A.  LDD0022  [18]
1d-yne
 Probe Info  		N.A.  LDD0356  [19]
ENE
 Probe Info  		N.A.  LDD0006  [18]
NHS
 Probe Info  		K130(0.00); K232(0.00); K70(0.00); K82(0.00)  LDD0010  [18]
PPMS
 Probe Info  		N.A.  LDD0008  [18]
SF
 Probe Info  		Y235(0.00); K215(0.00); K125(0.00); Y240(0.00)  LDD0028  [20]
STPyne
 Probe Info  		K232(0.00); K223(0.00)  LDD0009  [18]
VSF
 Probe Info  		N.A.  LDD0007  [18]
Phosphinate-6
 Probe Info  		C98(0.00); C224(0.00)  LDD0018  [21]
1c-yne
 Probe Info  		K232(0.00); K125(0.00); K70(0.00); K91(0.00)  LDD0228  [19]
Acrolein
 Probe Info  		C98(0.00); H325(0.00); H217(0.00)  LDD0217  [22]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [22]
Crotonaldehyde
 Probe Info  		C98(0.00); H217(0.00)  LDD0219  [22]
Methacrolein
 Probe Info  		N.A.  LDD0218  [22]
NAIA_5
 Probe Info  		C98(0.00); C224(0.00)  LDD2223  [23]
TER-AC
 Probe Info  		N.A.  LDD0426  [24]
PAL-AfBPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		7.06  LDD1714  [25]
C129
 Probe Info  		4.96  LDD1811  [25]
C165
 Probe Info  		21.56  LDD1845  [25]
C166
 Probe Info  		6.96  LDD1846  [25]
C191
 Probe Info  		9.51  LDD1868  [25]
C232
 Probe Info  		47.84  LDD1905  [25]
C314
 Probe Info  		11.31  LDD1981  [25]
C322
 Probe Info  		6.23  LDD1988  [25]
C326
 Probe Info  		6.82  LDD1990  [25]
C338
 Probe Info  		19.84  LDD2001  [25]
C348
 Probe Info  		11.31  LDD2009  [25]
C353
 Probe Info  		7.06  LDD2014  [25]
C355
 Probe Info  		23.26  LDD2016  [25]
C361
 Probe Info  		18.13  LDD2022  [25]
C391
 Probe Info  		12.73  LDD2050  [25]
FFF probe11
 Probe Info  		14.68  LDD0471  [26]
FFF probe13
 Probe Info  		15.20  LDD0475  [26]
FFF probe2
 Probe Info  		15.93  LDD0463  [26]
FFF probe3
 Probe Info  		7.05  LDD0464  [26]
FFF probe6
 Probe Info  		6.31  LDD0482  [26]
JN0003
 Probe Info  		12.42  LDD0469  [26]
STS-1
 Probe Info  		N.A.  LDD0136  [27]
Diazir
 Probe Info  		N.A.  LDD0011  [18]
OEA-DA
 Probe Info  		3.52  LDD0046  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C224(0.44)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C224(0.44)  LDD2112  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C224(1.09)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C224(1.55)  LDD2152  [4]
 LDCM0025  4SU-RNA HEK-293T C98(5.07)  LDD0172  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C224(0.60)  LDD2113  [4]
 LDCM0498  BS-3668 MDA-MB-231 C224(0.46)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa C98(0.00); H217(0.00)  LDD0222  [22]
 LDCM0625  F8 Ramos C98(0.74)  LDD2187  [29]
 LDCM0572  Fragment10 Ramos C98(0.33)  LDD2189  [29]
 LDCM0574  Fragment12 Ramos C98(0.49)  LDD2191  [29]
 LDCM0575  Fragment13 Ramos C98(0.72)  LDD2192  [29]
 LDCM0576  Fragment14 Ramos C98(0.29)  LDD2193  [29]
 LDCM0579  Fragment20 Ramos C98(0.32)  LDD2194  [29]
 LDCM0580  Fragment21 Ramos C98(0.77)  LDD2195  [29]
 LDCM0582  Fragment23 Ramos C98(0.97)  LDD2196  [29]
 LDCM0578  Fragment27 Ramos C98(0.60)  LDD2197  [29]
 LDCM0586  Fragment28 Ramos C98(0.59)  LDD2198  [29]
 LDCM0588  Fragment30 Ramos C98(0.79)  LDD2199  [29]
 LDCM0589  Fragment31 Ramos C98(1.02)  LDD2200  [29]
 LDCM0590  Fragment32 Ramos C98(0.43)  LDD2201  [29]
 LDCM0468  Fragment33 Ramos C98(0.68)  LDD2202  [29]
 LDCM0596  Fragment38 Ramos C98(0.55)  LDD2203  [29]
 LDCM0566  Fragment4 Ramos C98(0.68)  LDD2184  [29]
 LDCM0610  Fragment52 Ramos C98(0.52)  LDD2204  [29]
 LDCM0569  Fragment7 Ramos C98(0.28)  LDD2186  [29]
 LDCM0571  Fragment9 Ramos C98(0.38)  LDD2188  [29]
 LDCM0116  HHS-0101 DM93 Y240(0.78); Y235(0.81)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y240(0.83); Y235(0.87)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y240(0.68); Y235(0.72)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y240(1.01); Y235(1.10)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y240(0.81); Y235(0.98)  LDD0268  [9]
 LDCM0107  IAA HeLa C98(0.00); H217(0.00)  LDD0221  [22]
 LDCM0123  JWB131 DM93 Y235(0.82); Y240(0.82)  LDD0285  [8]
 LDCM0124  JWB142 DM93 Y235(0.59); Y240(0.58)  LDD0286  [8]
 LDCM0125  JWB146 DM93 Y235(1.00); Y240(1.16)  LDD0287  [8]
 LDCM0126  JWB150 DM93 Y235(2.81); Y240(3.33)  LDD0288  [8]
 LDCM0127  JWB152 DM93 Y235(1.71); Y240(1.54)  LDD0289  [8]
 LDCM0128  JWB198 DM93 Y235(1.04); Y240(1.15)  LDD0290  [8]
 LDCM0129  JWB202 DM93 Y235(0.48); Y240(0.45)  LDD0291  [8]
 LDCM0130  JWB211 DM93 Y235(0.83); Y240(0.73)  LDD0292  [8]
 LDCM0022  KB02 Ramos C98(0.27)  LDD2182  [29]
 LDCM0023  KB03 Ramos C98(0.47)  LDD2183  [29]
 LDCM0024  KB05 Ramos C98(0.18)  LDD2185  [29]
 LDCM0109  NEM HeLa H217(0.00); C98(0.00); H325(0.00)  LDD0223  [22]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C224(0.92)  LDD2089  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C224(1.28)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C224(1.02)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C224(1.80)  LDD2094  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C224(0.18)  LDD2096  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C224(1.04)  LDD2097  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C224(0.58)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C224(1.42)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C224(0.30)  LDD2100  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C224(2.77)  LDD2105  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C224(1.10)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C224(0.38)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C224(0.66)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C224(1.28)  LDD2111  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C224(0.50)  LDD2115  [4]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C224(0.46)  LDD2116  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C224(0.43)  LDD2118  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C224(1.34)  LDD2119  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C224(0.59)  LDD2120  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C224(0.27)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C224(1.04)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C224(0.28)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C224(0.90)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C224(0.36)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C224(1.11)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C224(0.70)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C224(1.01)  LDD2129  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C224(0.30)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C224(0.74)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C224(1.11)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C224(1.15)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C224(0.99)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C224(2.05)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C224(1.05)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C224(0.25)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C224(0.74)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C224(1.95)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C224(0.95)  LDD2146  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C224(2.97)  LDD2147  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C224(0.40)  LDD2148  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C224(0.39)  LDD2149  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C224(0.59)  LDD2150  [4]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C224(0.34)  LDD2151  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor protein 63 (TP63) P53 family Q9H3D4
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Splicing factor 1 (SF1) BBP/SF1 family Q15637

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
20 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
23 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
24 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
25 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
26 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
27 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
28 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
29 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578