Details of the Probe

General Information of Probe

Probe ID
LDPC0274
Probe Name
C004
Synonyms
Z4282860244
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 370.5
Lipid-water partition coefficient (xlogp) 2.9
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C18H18N4OS2
IUPAC Name
3-(3-but-3-ynyldiazirin-3-yl)-1-[7-(1,3-thiazol-4-yl)-5,7-dihydro-4H-thieno[2,3-c]pyridin-6-yl]propan-1-one
Canonical SMILES
C#CCCC1(N=N1)CCC(=O)N2CCC3=C(C2C4=CSC=N4)SC=C3
InChI
InChI=1S/C18H18N4OS2/c1-2-3-7-18(20-21-18)8-4-15(23)22-9-5-13-6-10-25-17(13)16(22)14-11-24-12-19-14/h1,6,10-12,16H,3-5,7-9H2
InChIKey
IDSIMYBTASGDLN-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

132 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
2-hydroxyacyl-CoA lyase 2 (ILVBL) LDTP00032 11.55  LDD1714 
3-ketodihydrosphingosine reductase (KDSR) LDTP05476 5.70  LDD1714 
5'-3' exonuclease PLD3 (PLD3) LDTP08476 8.22  LDD1714 
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) LDTP04620 9.99  LDD1714 
5'-nucleotidase domain-containing protein 2 (NT5DC2) LDTP18414 5.94  LDD1714 
7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) LDTP10032 8.69  LDD1714 
Abasic site processing protein HMCES (HMCES) LDTP10322 7.26  LDD1714 
Acid ceramidase (ASAH1) LDTP05905 5.82  LDD1714 
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) LDTP04437 8.63  LDD1714 
Aldehyde dehydrogenase, mitochondrial (ALDH2) LDTP02074 5.62  LDD1714 
All-trans-retinol 13,14-reductase (RETSAT) LDTP15097 6.28  LDD1714 
Alpha-galactosidase A (GLA) LDTP02141 5.54  LDD1714 
Alpha-N-acetylglucosaminidase (NAGLU) LDTP04634 9.45  LDD1714 
Antigen peptide transporter 1 (TAP1) LDTP05408 6.23  LDD1714 
Antigen peptide transporter 2 (TAP2) LDTP05409 6.28  LDD1714 
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial (CLPX) LDTP01382 5.78  LDD1714 
ATP-dependent translocase ABCB1 (ABCB1) LDTP02254 7.16  LDD1714 
ATPase family AAA domain-containing protein 3B (ATAD3B) LDTP07154 5.70  LDD1714 
Beta-1,4-galactosyltransferase 3 (B4GALT3) LDTP00994 17.88  LDD1714 
Beta-galactosidase (GLB1) LDTP02837 14.03  LDD1714 
Beta-glucuronidase (GUSB) LDTP02260 5.50  LDD1714 
Beta-hexosaminidase subunit alpha (HEXA) LDTP02169 5.58  LDD1714 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 8.69  LDD1714 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 15.56  LDD1714 
Calcium-independent phospholipase A2-gamma (PNPLA8) LDTP12318 5.66  LDD1714 
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) LDTP03257 15.35  LDD1714 
Cartilage-associated protein (CRTAP) LDTP01300 9.32  LDD1714 
Catechol O-methyltransferase (COMT) LDTP03145 5.50  LDD1714 
Ceramide synthase 2 (CERS2) LDTP10329 8.06  LDD1714 
Cytochrome b-c1 complex subunit 8 (UQCRQ) LDTP00486 7.21  LDD1714 
Cytochrome b-c1 complex subunit 9 (UQCR10) LDTP13189 10.06  LDD1714 
Cytochrome b5 type B (CYB5B) LDTP00697 19.43  LDD1714 
Cytochrome c oxidase subunit 2 (MT-CO2) LDTP01773 15.78  LDD1714 
Cytosolic purine 5'-nucleotidase (NT5C2) LDTP04327 7.16  LDD1714 
DCN1-like protein 4 (DCUN1D4) LDTP09799 21.86  LDD1714 
DCN1-like protein 5 (DCUN1D5) LDTP11199 5.70  LDD1714 
Dehydrogenase/reductase SDR family member 1 (DHRS1) LDTP10550 5.98  LDD1714 
Delta(14)-sterol reductase LBR (LBR) LDTP06200 6.19  LDD1714 
Delta(24)-sterol reductase (DHCR24) LDTP06375 16.80  LDD1714 
Dephospho-CoA kinase domain-containing protein (DCAKD) LDTP18087 5.70  LDD1714 
Dermatan-sulfate epimerase (DSE) LDTP13504 9.78  LDD1714 
Diacylglycerol kinase epsilon (DGKE) LDTP04506 6.11  LDD1714 
Dihydrofolate reductase (DHFR) LDTP01769 9.92  LDD1714 
DNA-directed RNA polymerase, mitochondrial (POLRMT) LDTP00267 5.82  LDD1714 
E3 ubiquitin-protein ligase NEDD4 (NEDD4) LDTP04114 8.75  LDD1714 
E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) LDTP10699 6.36  LDD1714 
Endonuclease domain-containing 1 protein (ENDOD1) LDTP01462 6.87  LDD1714 
Endoplasmic reticulum aminopeptidase 1 (ERAP1) LDTP12868 6.77  LDD1714 
Endoplasmic reticulum protein SC65 (P3H4) LDTP09874 6.23  LDD1714 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 15.35  LDD1714 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 10.27  LDD1714 
Epoxide hydrolase 1 (EPHX1) LDTP02175 7.57  LDD1714 
FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) LDTP10188 5.58  LDD1714 
Fatty acyl-CoA reductase 2 (FAR2) LDTP10491 5.50  LDD1714 
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (ALG11) LDTP06721 5.46  LDD1714 
Glutathione S-transferase A4 (GSTA4) LDTP00575 29.86  LDD1714 
Heme oxygenase 1 (HMOX1) LDTP02359 10.93  LDD1714 
Heme oxygenase 2 (HMOX2) LDTP03540 13.36  LDD1714 
Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) LDTP07990 8.00  LDD1714 
Histone acetyltransferase type B catalytic subunit (HAT1) LDTP00479 8.17  LDD1714 
Histone-lysine N-methyltransferase SMYD3 (SMYD3) LDTP12020 6.41  LDD1714 
Holocytochrome c-type synthase (HCCS) LDTP04581 7.06  LDD1714 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 10.56  LDD1714 
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) LDTP01333 31.12  LDD1714 
Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) LDTP04211 21.11  LDD1714 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 6.36  LDD1714 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 7.73  LDD1714 
Lysine-specific histone demethylase 2 (KDM1B) LDTP09043 6.77  LDD1714 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 9.13  LDD1714 
Lysophospholipid acyltransferase 7 (MBOAT7) LDTP10612 6.73  LDD1714 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 15.67  LDD1714 
Lysosomal cobalamin transporter ABCD4 (ABCD4) LDTP00404 5.70  LDD1714 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 6.41  LDD1714 
Lysosomal protective protein (CTSA) LDTP02505 6.15  LDD1714 
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (MAN1A2) LDTP00975 6.11  LDD1714 
Methionine synthase (MTR) LDTP10951 5.50  LDD1714 
Methylsterol monooxygenase 1 (MSMO1) LDTP06477 9.38  LDD1714 
Minor histocompatibility antigen H13 (HM13) LDTP09396 5.46  LDD1714 
Mitochondrial cardiolipin hydrolase (PLD6) LDTP08790 7.11  LDD1714 
Mitochondrial intermediate peptidase (MIPEP) LDTP10981 5.46  LDD1714 
N-acetylglucosamine-6-sulfatase (GNS) LDTP02799 6.41  LDD1714 
N-alpha-acetyltransferase 40 (NAA40) LDTP08265 9.71  LDD1714 
NAD(P) transhydrogenase, mitochondrial (NNT) LDTP05862 7.41  LDD1714 
NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) LDTP08385 7.06  LDD1714 
NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) LDTP12959 7.21  LDD1714 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 17.39  LDD1714 
NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) LDTP01982 10.06  LDD1714 
NADPH--cytochrome P450 reductase (POR) LDTP02848 6.06  LDD1714 
Nicotinamide phosphoribosyltransferase (NAMPT) LDTP04051 14.83  LDD1714 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 17.27  LDD1714 
Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) LDTP12628 6.23  LDD1714 
Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) LDTP12720 6.87  LDD1714 
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) LDTP14218 11.39  LDD1714 
Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) LDTP00589 5.46  LDD1714 
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (PIP4K2C) LDTP09355 5.94  LDD1714 
Phospholipase A2 group XV (PLA2G15) LDTP09088 9.19  LDD1714 
Plasma alpha-L-fucosidase (FUCA2) LDTP11215 6.54  LDD1714 
Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4) LDTP08859 7.01  LDD1714 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 11.08  LDD1714 
Presequence protease, mitochondrial (PITRM1) LDTP07003 9.51  LDD1714 
Probable ATP-dependent RNA helicase DDX31 (DDX31) LDTP12055 6.87  LDD1714 
Prolyl 3-hydroxylase 1 (P3H1) LDTP06750 15.35  LDD1714 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 7.57  LDD1714 
Proteasome subunit beta type-6 (PSMB6) LDTP03418 6.59  LDD1714 
Protein arginine N-methyltransferase 9 (PRMT9) LDTP07525 5.54  LDD1714 
Protein O-GlcNAcase (OGA) LDTP00988 7.31  LDD1714 
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGNT2) LDTP09031 8.51  LDD1714 
Protein O-mannosyl-transferase TMTC3 (TMTC3) LDTP07868 6.06  LDD1714 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 10.56  LDD1714 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 11.63  LDD1714 
Ras-related protein Rab-11B (RAB11B) LDTP06501 5.54  LDD1714 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 14.83  LDD1714 
S-methyl-5'-thioadenosine phosphorylase (MTAP) LDTP05758 8.57  LDD1714 
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) LDTP15484 9.00  LDD1714 
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) LDTP02860 5.58  LDD1714 
Serine palmitoyltransferase 1 (SPTLC1) LDTP00597 5.46  LDD1714 
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) LDTP06199 5.78  LDD1714 
Serum paraoxonase/arylesterase 2 (PON2) LDTP06333 7.62  LDD1714 
SET domain-containing protein 4 (SETD4) LDTP12670 5.46  LDD1714 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 6.96  LDD1714 
Sphingosine-1-phosphate lyase 1 (SGPL1) LDTP01613 9.45  LDD1714 
Squalene monooxygenase (SQLE) LDTP06142 8.11  LDD1714 
Squalene synthase (FDFT1) LDTP03842 7.06  LDD1714 
Sterol O-acyltransferase 1 (SOAT1) LDTP03769 5.78  LDD1714 
Sulfotransferase 2A1 (SULT2A1) LDTP05493 7.52  LDD1714 
Trimethyllysine dioxygenase, mitochondrial (TMLHE) LDTP12679 6.63  LDD1714 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 7.11  LDD1714 
Ubiquitin carboxyl-terminal hydrolase 47 (USP47) LDTP10495 5.78  LDD1714 
V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) LDTP14030 6.92  LDD1714 
Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) LDTP06901 5.66  LDD1714 
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) LDTP08728 18.13  LDD1714 
Vitamin K-dependent gamma-carboxylase (GGCX) LDTP03854 7.73  LDD1714 
------------------------------------------------------------------------------------
⏷ Show the Full List of 132 Enzyme
77 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
45 kDa calcium-binding protein (SDF4) LDTP11116 9.71  LDD1714 
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 11.39  LDD1714 
ADP/ATP translocase 1 (SLC25A4) LDTP02608 6.28  LDD1714 
Amyloid-beta precursor protein (APP) LDTP02071 6.41  LDD1714 
Annexin A1 (ANXA1) LDTP02010 7.31  LDD1714 
Anoctamin-6 (ANO6) LDTP06855 7.11  LDD1714 
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) LDTP03284 7.62  LDD1714 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 12.55  LDD1714 
Beclin-1 (BECN1) LDTP06124 5.46  LDD1714 
BRI3-binding protein (BRI3BP) LDTP15648 8.57  LDD1714 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 10.70  LDD1714 
Cytoskeleton-associated protein 4 (CKAP4) LDTP05511 5.78  LDD1714 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 25.99  LDD1714 
Golgin subfamily A member 5 (GOLGA5) LDTP09333 5.58  LDD1714 
Hsp90 co-chaperone Cdc37 (CDC37) LDTP06549 6.11  LDD1714 
Importin subunit alpha-5 (KPNA1) LDTP04502 8.28  LDD1714 
Importin subunit alpha-7 (KPNA6) LDTP01031 6.59  LDD1714 
Integral membrane protein 2B (ITM2B) LDTP13833 6.73  LDD1714 
Integral membrane protein 2C (ITM2C) LDTP12451 6.19  LDD1714 
Lysosome membrane protein 2 (SCARB2) LDTP06034 10.85  LDD1714 
Lysosome-associated membrane glycoprotein 2 (LAMP2) LDTP02655 5.98  LDD1714 
Major facilitator superfamily domain-containing protein 3 (MFSD3) LDTP18153 15.24  LDD1714 
Melanoma inhibitory activity protein 2 (MIA2) LDTP10669 6.19  LDD1714 
Membrane-associated progesterone receptor component 1 (PGRMC1) LDTP00235 7.52  LDD1714 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 8.82  LDD1714 
Metal cation symporter ZIP14 (SLC39A14) LDTP06293 6.68  LDD1714 
Metaxin-1 (MTX1) LDTP05900 11.00  LDD1714 
Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) LDTP11095 7.21  LDD1714 
Mitochondrial carrier homolog 2 (MTCH2) LDTP14235 7.46  LDD1714 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 20.11  LDD1714 
Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) LDTP13983 5.74  LDD1714 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 9.78  LDD1714 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 17.51  LDD1714 
Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) LDTP14099 8.28  LDD1714 
Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) LDTP00477 6.41  LDD1714 
Mitochondrial inner membrane protein OXA1L (OXA1L) LDTP06308 6.82  LDD1714 
Mitochondrial ornithine transporter 1 (SLC25A15) LDTP14200 13.00  LDD1714 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 18.25  LDD1714 
Mitoguardin 1 (MIGA1) LDTP09028 7.78  LDD1714 
Monocarboxylate transporter 1 (SLC16A1) LDTP04592 5.58  LDD1714 
Mpv17-like protein 2 (MPV17L2) LDTP14952 7.26  LDD1714 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 8.63  LDD1714 
Nuclear pore complex protein Nup88 (NUP88) LDTP10897 14.12  LDD1714 
Nucleoporin NDC1 (NDC1) LDTP11213 9.19  LDD1714 
Peroxisomal membrane protein 2 (PXMP2) LDTP16069 8.11  LDD1714 
Prosaposin (PSAP) LDTP02215 15.14  LDD1714 
Protein FAM8A1 (FAM8A1) LDTP16190 5.66  LDD1714 
Protein GPR107 (GPR107) LDTP07236 10.48  LDD1714 
Protein GPR108 (GPR108) LDTP12383 8.69  LDD1714 
Protein spinster homolog 1 (SPNS1) LDTP11844 12.64  LDD1714 
Protein tweety homolog 3 (TTYH3) LDTP11615 16.56  LDD1714 
Putative lipid scramblase CLPTM1 (CLPTM1) LDTP01745 7.57  LDD1714 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 7.06  LDD1714 
Secretory carrier-associated membrane protein 2 (SCAMP2) LDTP00547 10.13  LDD1714 
Sideroflexin-4 (SFXN4) LDTP07531 6.06  LDD1714 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 16.22  LDD1714 
Solute carrier family 25 member 3 (SLC25A3) LDTP05238 6.28  LDD1714 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 12.47  LDD1714 
Solute carrier family 25 member 33 (SLC25A33) LDTP11162 10.85  LDD1714 
Sorting and assembly machinery component 50 homolog (SAMM50) LDTP14084 5.54  LDD1714 
StAR-related lipid transfer protein 3 (STARD3) LDTP06221 15.89  LDD1714 
Surfeit locus protein 4 (SURF4) LDTP00592 8.88  LDD1714 
Synaptojanin-2-binding protein (SYNJ2BP) LDTP04789 5.98  LDD1714 
Syntenin-1 (SDCBP) LDTP00310 5.62  LDD1714 
Tetraspanin-3 (TSPAN3) LDTP16813 8.00  LDD1714 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 8.40  LDD1714 
Translocator protein (TSPO) LDTP03546 31.12  LDD1714 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 15.24  LDD1714 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 9.32  LDD1714 
Transmembrane 9 superfamily member 4 (TM9SF4) LDTP09789 5.86  LDD1714 
Transmembrane protein 126A (TMEM126A) LDTP15948 20.82  LDD1714 
Transmembrane protein 199 (TMEM199) LDTP08881 16.45  LDD1714 
Transportin-1 (TNPO1) LDTP09949 6.41  LDD1714 
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) LDTP09968 6.23  LDD1714 
Vacuole membrane protein 1 (VMP1) LDTP10343 6.73  LDD1714 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 21.71  LDD1714 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 18.64  LDD1714 
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⏷ Show the Full List of 77 Transporter and channel
3 Immunoglobulin Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Basigin (BSG) LDTP03772 5.58  LDD1714 
HLA class I histocompatibility antigen, A alpha chain (HLA-A) LDTP02040 5.90  LDD1714 
IgG receptor FcRn large subunit p51 (FCGRT) LDTP04720 8.63  LDD1714 
------------------------------------------------------------------------------------
83 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 7.16  LDD1714 
Apolipoprotein L2 (APOL2) LDTP11076 31.34  LDD1714 
Bcl-2-like protein 13 (BCL2L13) LDTP11389 6.92  LDD1714 
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) LDTP13755 7.31  LDD1714 
Centrosomal protein 43 (CEP43) LDTP01652 6.54  LDD1714 
Clustered mitochondria protein homolog (CLUH) LDTP14486 8.00  LDD1714 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 17.63  LDD1714 
DnaJ homolog subfamily C member 16 (DNAJC16) LDTP13863 5.86  LDD1714 
Dynactin subunit 4 (DCTN4) LDTP13402 6.87  LDD1714 
Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) LDTP08689 9.13  LDD1714 
EF-hand calcium-binding domain-containing protein 14 (EFCAB14) LDTP19021 8.57  LDD1714 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 8.82  LDD1714 
ER lumen protein-retaining receptor 3 (KDELR3) LDTP00850 8.94  LDD1714 
Eukaryotic translation initiation factor 3 subunit L (EIF3L) LDTP13813 7.26  LDD1714 
Eukaryotic translation initiation factor 5 (EIF5) LDTP04652 29.86  LDD1714 
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (ECSIT) LDTP11065 15.78  LDD1714 
Fragile X messenger ribonucleoprotein 1 (FMR1) LDTP05501 6.50  LDD1714 
Ganglioside GM2 activator (GM2A) LDTP02927 10.56  LDD1714 
Glycosylphosphatidylinositol anchor attachment 1 protein (GPAA1) LDTP00729 6.63  LDD1714 
Golgi apparatus protein 1 (GLG1) LDTP09920 5.58  LDD1714 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 15.56  LDD1714 
Heme-binding protein 2 (HEBP2) LDTP14186 12.04  LDD1714 
Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB) LDTP10962 7.06  LDD1714 
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) LDTP00500 8.63  LDD1714 
Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) LDTP06032 7.31  LDD1714 
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) LDTP03615 6.59  LDD1714 
Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) LDTP04714 6.63  LDD1714 
Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) LDTP03614 6.23  LDD1714 
Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) LDTP00991 6.73  LDD1714 
Heterogeneous nuclear ribonucleoprotein R (HNRNPR) LDTP00756 6.63  LDD1714 
Heterogeneous nuclear ribonucleoprotein U-like protein 2 (HNRNPUL2) LDTP17065 5.98  LDD1714 
Integral membrane protein GPR180 (GPR180) LDTP19625 5.90  LDD1714 
Keratin, type I cytoskeletal 18 (KRT18) LDTP02124 5.66  LDD1714 
Large proline-rich protein BAG6 (BAG6) LDTP04094 5.74  LDD1714 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 11.96  LDD1714 
MAU2 chromatid cohesion factor homolog (MAU2) LDTP14304 6.11  LDD1714 
Mitochondrial fission process protein 1 (MTFP1) LDTP16192 14.22  LDD1714 
Mitochondrial import inner membrane translocase subunit Tim13 (TIMM13) LDTP14136 8.06  LDD1714 
Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B) LDTP16322 6.68  LDD1714 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 23.75  LDD1714 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 8.82  LDD1714 
Neuferricin (CYB5D2) LDTP15623 8.00  LDD1714 
NHP2-like protein 1 (SNU13) LDTP04708 7.94  LDD1714 
Nucleobindin-1 (NUCB1) LDTP05375 5.86  LDD1714 
Nucleobindin-2 (NUCB2) LDTP05160 28.64  LDD1714 
Nucleosome assembly protein 1-like 1 (NAP1L1) LDTP04684 9.92  LDD1714 
Nucleosome assembly protein 1-like 4 (NAP1L4) LDTP10965 6.68  LDD1714 
Nurim (NRM) LDTP08606 7.21  LDD1714 
OCIA domain-containing protein 1 (OCIAD1) LDTP12755 6.32  LDD1714 
Poly(U)-binding-splicing factor PUF60 (PUF60) LDTP13311 8.28  LDD1714 
Pre-mRNA-splicing factor SLU7 (SLU7) LDTP01582 6.02  LDD1714 
Programmed cell death protein 5 (PDCD5) LDTP00417 7.06  LDD1714 
Proteasome adapter and scaffold protein ECM29 (ECPAS) LDTP07255 10.20  LDD1714 
Protein CutA (CUTA) LDTP01075 11.88  LDD1714 
Protein FAM114A2 (FAM114A2) LDTP16080 7.78  LDD1714 
Protein FAM162A (FAM162A) LDTP10056 9.00  LDD1714 
Protein LYRIC (MTDH) LDTP08224 5.66  LDD1714 
Protein unc-119 homolog B (UNC119B) LDTP00105 10.70  LDD1714 
Ran guanine nucleotide release factor (RANGRF) LDTP12287 8.69  LDD1714 
Required for meiotic nuclear division protein 1 homolog (RMND1) LDTP12729 6.82  LDD1714 
Reticulocalbin-2 (RCN2) LDTP06097 7.84  LDD1714 
Reticulon-3 (RTN3) LDTP01522 7.84  LDD1714 
RNA-binding protein 10 (RBM10) LDTP05224 5.50  LDD1714 
RNA-binding protein 27 (RBM27) LDTP18517 6.82  LDD1714 
RNA-binding protein EWS (EWSR1) LDTP05318 5.50  LDD1714 
RNA-binding protein FUS (FUS) LDTP03775 6.02  LDD1714 
RNA-binding protein FXR1 (FXR1) LDTP04395 9.51  LDD1714 
RNA-binding protein FXR2 (FXR2) LDTP04396 8.82  LDD1714 
Scm-like with four MBT domains protein 1 (SFMBT1) LDTP13288 5.98  LDD1714 
Signal recognition particle receptor subunit beta (SRPRB) LDTP16323 6.02  LDD1714 
Small ribosomal subunit protein uS9m (MRPS9) LDTP14792 6.87  LDD1714 
Syntaxin-18 (STX18) LDTP13086 7.89  LDD1714 
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) LDTP14263 6.77  LDD1714 
TATA-binding protein-associated factor 2N (TAF15) LDTP09881 6.19  LDD1714 
Tetraspanin-6 (TSPAN6) LDTP14458 10.70  LDD1714 
Tetratricopeptide repeat protein 19, mitochondrial (TTC19) LDTP07368 9.58  LDD1714 
Thioredoxin-related transmembrane protein 4 (TMX4) LDTP18373 7.06  LDD1714 
Torsin-1A-interacting protein 2 (TOR1AIP2) LDTP09215 9.58  LDD1714 
TraB domain-containing protein (TRABD) LDTP19963 10.27  LDD1714 
Tudor and KH domain-containing protein (TDRKH) LDTP13922 12.55  LDD1714 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 20.82  LDD1714 
Ubiquitin-like protein 4A (UBL4A) LDTP02570 8.00  LDD1714 
WD repeat-containing protein 48 (WDR48) LDTP09298 7.26  LDD1714 
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Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1714 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587