Details of the Target

General Information of Target

Target ID LDTP16323
Target Name Signal recognition particle receptor subunit beta (SRPRB)
Gene Name SRPRB
Gene ID 58477
Synonyms
Signal recognition particle receptor subunit beta; SR-beta; Protein APMCF1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAELGEADEAELQRLVAAEQQKAQFTAQVHHFMELCWDKCVEKPGNRLDSRTENCLSSCV
DRFIDTTLAITSRFAQIVQKGGQ
Target Bioclass
Other
Family
SRP receptor beta subunit family
Subcellular location
Endoplasmic reticulum membrane
Function
Component of the signal recognition particle (SRP) complex receptor (SR). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. May mediate the membrane association of SR.
Uniprot ID
Q9Y5M8
Ensemble ID
ENST00000466490.7
HGNC ID
HGNC:24085
ChEMBL ID
CHEMBL4295993

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 39 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.65  LDD0402  [1]
FBPP2
 Probe Info  		2.68  LDD0318  [2]
CHEMBL5175495
 Probe Info  		10.74  LDD0196  [3]
TH211
 Probe Info  		Y22(6.03)  LDD0260  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
BTD
 Probe Info  		C179(2.01)  LDD1700  [6]
HPAP
 Probe Info  		4.16  LDD0064  [7]
EA-probe
 Probe Info  		N.A.  LDD0440  [8]
DBIA
 Probe Info  		C179(1.13); C73(1.09); C100(1.08); C246(1.03)  LDD0078  [9]
5E-2FA
 Probe Info  		N.A.  LDD2235  [10]
ATP probe
 Probe Info  		K227(0.00); K228(0.00); K181(0.00); K188(0.00)  LDD0199  [11]
1d-yne
 Probe Info  		N.A.  LDD0358  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C246(0.00); C179(0.00); C100(0.00); C73(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C100(0.00); C246(0.00)  LDD0032  [14]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		C73(0.00); C100(0.00); C179(0.00); C246(0.00)  LDD0037  [13]
JW-RF-010
 Probe Info  		C179(0.00); C100(0.00); C73(0.00)  LDD0026  [16]
NAIA_4
 Probe Info  		C73(0.00); C100(0.00); C179(0.00); C246(0.00)  LDD2226  [17]
TFBX
 Probe Info  		C179(0.00); C73(0.00); C100(0.00)  LDD0027  [16]
WYneN
 Probe Info  		N.A.  LDD0021  [18]
WYneO
 Probe Info  		N.A.  LDD0022  [18]
Compound 10
 Probe Info  		N.A.  LDD2216  [19]
ENE
 Probe Info  		N.A.  LDD0006  [18]
IPM
 Probe Info  		N.A.  LDD0005  [18]
NHS
 Probe Info  		K188(0.00); K191(0.00)  LDD0010  [18]
PF-06672131
 Probe Info  		N.A.  LDD0152  [20]
STPyne
 Probe Info  		K227(0.00); K228(0.00)  LDD0009  [18]
VSF
 Probe Info  		C179(0.00); C246(0.00)  LDD0007  [18]
Phosphinate-6
 Probe Info  		C179(0.00); C100(0.00); C246(0.00)  LDD0018  [21]
Ox-W18
 Probe Info  		N.A.  LDD2175  [22]
Acrolein
 Probe Info  		C73(0.00); C100(0.00); C179(0.00); C246(0.00)  LDD0217  [23]
Crotonaldehyde
 Probe Info  		C100(0.00); C73(0.00); C179(0.00); C246(0.00)  LDD0219  [23]
Methacrolein
 Probe Info  		C73(0.00); C100(0.00); C179(0.00); C246(0.00)  LDD0218  [23]
W1
 Probe Info  		C179(0.00); C246(0.00); C100(0.00)  LDD0236  [24]
AOyne
 Probe Info  		15.00  LDD0443  [25]
MPP-AC
 Probe Info  		N.A.  LDD0428  [26]
NAIA_5
 Probe Info  		C73(0.00); C246(0.00); C179(0.00)  LDD2223  [17]
TER-AC
 Probe Info  		N.A.  LDD0426  [26]
TPP-AC
 Probe Info  		N.A.  LDD0427  [26]
PAL-AfBPP Probe
Click To Hide/Show 114 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DR-1
 Probe Info  		4.26  LDD0398  [27]
C004
 Probe Info  		6.02  LDD1714  [28]
C017
 Probe Info  		7.67  LDD1725  [28]
C040
 Probe Info  		15.14  LDD1740  [28]
C041
 Probe Info  		6.11  LDD1741  [28]
C049
 Probe Info  		8.00  LDD1747  [28]
C055
 Probe Info  		19.16  LDD1752  [28]
C056
 Probe Info  		42.22  LDD1753  [28]
C063
 Probe Info  		11.71  LDD1760  [28]
C070
 Probe Info  		13.74  LDD1766  [28]
C091
 Probe Info  		42.22  LDD1782  [28]
C092
 Probe Info  		42.22  LDD1783  [28]
C094
 Probe Info  		51.98  LDD1785  [28]
C100
 Probe Info  		6.19  LDD1789  [28]
C106
 Probe Info  		35.26  LDD1793  [28]
C107
 Probe Info  		7.57  LDD1794  [28]
C108
 Probe Info  		11.31  LDD1795  [28]
C112
 Probe Info  		28.44  LDD1799  [28]
C130
 Probe Info  		7.46  LDD1812  [28]
C134
 Probe Info  		42.22  LDD1816  [28]
C135
 Probe Info  		20.39  LDD1817  [28]
C141
 Probe Info  		17.39  LDD1823  [28]
C143
 Probe Info  		25.63  LDD1825  [28]
C153
 Probe Info  		31.78  LDD1834  [28]
C159
 Probe Info  		16.68  LDD1839  [28]
C160
 Probe Info  		11.63  LDD1840  [28]
C161
 Probe Info  		18.90  LDD1841  [28]
C163
 Probe Info  		15.45  LDD1843  [28]
C165
 Probe Info  		14.22  LDD1845  [28]
C169
 Probe Info  		34.54  LDD1849  [28]
C178
 Probe Info  		32.67  LDD1857  [28]
C187
 Probe Info  		19.29  LDD1865  [28]
C194
 Probe Info  		13.93  LDD1870  [28]
C196
 Probe Info  		13.00  LDD1872  [28]
C198
 Probe Info  		22.01  LDD1874  [28]
C201
 Probe Info  		47.84  LDD1877  [28]
C206
 Probe Info  		19.29  LDD1881  [28]
C210
 Probe Info  		53.82  LDD1884  [28]
C218
 Probe Info  		46.85  LDD1892  [28]
C219
 Probe Info  		9.51  LDD1893  [28]
C220
 Probe Info  		55.72  LDD1894  [28]
C225
 Probe Info  		6.59  LDD1898  [28]
C226
 Probe Info  		5.58  LDD1899  [28]
C228
 Probe Info  		32.22  LDD1901  [28]
C231
 Probe Info  		12.13  LDD1904  [28]
C235
 Probe Info  		18.13  LDD1908  [28]
C238
 Probe Info  		19.29  LDD1911  [28]
C246
 Probe Info  		13.45  LDD1919  [28]
C252
 Probe Info  		12.82  LDD1925  [28]
C264
 Probe Info  		38.59  LDD1935  [28]
C265
 Probe Info  		15.89  LDD1936  [28]
C269
 Probe Info  		6.23  LDD1939  [28]
C270
 Probe Info  		8.17  LDD1940  [28]
C273
 Probe Info  		5.31  LDD1943  [28]
C277
 Probe Info  		12.64  LDD1947  [28]
C278
 Probe Info  		56.10  LDD1948  [28]
C282
 Probe Info  		16.00  LDD1952  [28]
C285
 Probe Info  		21.86  LDD1955  [28]
C287
 Probe Info  		17.39  LDD1957  [28]
C289
 Probe Info  		37.53  LDD1959  [28]
C293
 Probe Info  		21.41  LDD1963  [28]
C296
 Probe Info  		25.81  LDD1966  [28]
C299
 Probe Info  		9.71  LDD1968  [28]
C305
 Probe Info  		18.38  LDD1974  [28]
C307
 Probe Info  		6.63  LDD1975  [28]
C310
 Probe Info  		9.71  LDD1977  [28]
C314
 Probe Info  		19.43  LDD1981  [28]
C326
 Probe Info  		12.13  LDD1990  [28]
C338
 Probe Info  		11.00  LDD2001  [28]
C339
 Probe Info  		11.31  LDD2002  [28]
C343
 Probe Info  		31.12  LDD2005  [28]
C348
 Probe Info  		16.11  LDD2009  [28]
C349
 Probe Info  		34.78  LDD2010  [28]
C350
 Probe Info  		84.45  LDD2011  [28]
C355
 Probe Info  		35.02  LDD2016  [28]
C356
 Probe Info  		10.48  LDD2017  [28]
C357
 Probe Info  		5.46  LDD2018  [28]
C362
 Probe Info  		99.73  LDD2023  [28]
C363
 Probe Info  		25.46  LDD2024  [28]
C364
 Probe Info  		36.00  LDD2025  [28]
C366
 Probe Info  		12.47  LDD2027  [28]
C367
 Probe Info  		7.21  LDD2028  [28]
C373
 Probe Info  		6.68  LDD2033  [28]
C376
 Probe Info  		20.82  LDD2036  [28]
C378
 Probe Info  		7.94  LDD2037  [28]
C382
 Probe Info  		18.77  LDD2041  [28]
C383
 Probe Info  		18.13  LDD2042  [28]
C386
 Probe Info  		8.11  LDD2045  [28]
C388
 Probe Info  		92.41  LDD2047  [28]
C390
 Probe Info  		67.65  LDD2049  [28]
C399
 Probe Info  		7.84  LDD2058  [28]
C403
 Probe Info  		17.63  LDD2061  [28]
C407
 Probe Info  		19.56  LDD2064  [28]
C413
 Probe Info  		23.59  LDD2069  [28]
C419
 Probe Info  		12.04  LDD2074  [28]
C420
 Probe Info  		14.42  LDD2075  [28]
C424
 Probe Info  		11.39  LDD2079  [28]
C426
 Probe Info  		22.32  LDD2081  [28]
C429
 Probe Info  		14.42  LDD2084  [28]
C431
 Probe Info  		27.28  LDD2086  [28]
FFF probe11
 Probe Info  		20.00  LDD0471  [29]
FFF probe13
 Probe Info  		20.00  LDD0475  [29]
FFF probe14
 Probe Info  		20.00  LDD0477  [29]
FFF probe15
 Probe Info  		13.23  LDD0478  [29]
FFF probe2
 Probe Info  		20.00  LDD0463  [29]
FFF probe3
 Probe Info  		20.00  LDD0464  [29]
FFF probe4
 Probe Info  		18.63  LDD0466  [29]
FFF probe6
 Probe Info  		12.36  LDD0482  [29]
FFF probe7
 Probe Info  		20.00  LDD0483  [29]
JN0003
 Probe Info  		20.00  LDD0469  [29]
STS-2
 Probe Info  		N.A.  LDD0138  [30]
A-DA
 Probe Info  		2.63  LDD0145  [31]
DA-2
 Probe Info  		N.A.  LDD0072  [32]
OEA-DA
 Probe Info  		20.00  LDD0046  [33]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C179(0.48); C246(0.44); C73(0.73)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C179(0.65); C246(0.70); C73(0.54)  LDD2112  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C179(0.74)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C179(0.72); C246(1.02)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C179(1.02)  LDD2152  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C179(1.05)  LDD2103  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C246(1.17)  LDD2131  [6]
 LDCM0214  AC1 HCT 116 C100(0.91); C179(1.01); C246(1.30); C73(1.07)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C100(1.12); C179(0.96); C246(1.11); C73(1.11)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C100(0.81); C179(0.66); C246(0.82); C73(0.49)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C100(0.82); C179(0.58); C246(0.85); C73(0.62)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C100(0.84); C179(0.54); C246(0.73); C73(0.61)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C100(0.85); C179(0.53); C246(0.74); C73(0.50)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C100(0.79); C179(0.59); C246(0.71); C73(0.55)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C100(0.88); C179(0.52); C246(0.71); C73(0.49)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C100(0.79); C179(0.56); C246(0.69); C73(0.51)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C100(0.89); C179(0.66); C246(0.62); C73(0.76)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C100(0.85); C179(0.60); C246(0.72); C73(0.76)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C100(0.76); C179(0.62); C246(0.74); C73(0.69)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C100(1.25); C179(0.91); C246(0.90); C73(1.18)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C100(0.79); C179(0.60); C246(0.76); C73(0.69)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C100(0.81); C179(0.63); C246(0.77); C73(0.65)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C100(0.94); C179(0.55); C246(0.69); C73(0.64)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C100(1.11); C179(1.33); C246(1.00); C73(0.92)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C100(1.15); C179(1.04); C246(1.15); C73(0.86)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C100(1.23); C179(0.83); C246(0.86); C73(0.81)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C100(1.15); C179(0.81); C246(1.02); C73(0.80)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C100(1.23); C179(0.91); C246(1.10); C73(0.86)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C100(1.08); C179(1.15); C246(1.08); C73(0.95)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C100(1.04); C179(0.92); C246(1.06); C73(0.90)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C100(1.28); C179(1.03); C246(1.18); C73(1.13)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C100(1.11); C179(0.91); C246(1.01); C73(0.84)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C100(1.04); C179(1.37); C246(1.11); C73(0.94)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C100(1.16); C179(1.06); C246(1.19); C73(0.95)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C100(1.61); C179(1.15); C246(1.00); C73(1.15)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C100(1.12); C179(1.15); C246(1.14); C73(0.91)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C100(0.96); C179(1.09); C246(1.30); C73(0.92)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C100(1.09); C179(1.02); C246(1.16); C73(0.87)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C100(0.99); C179(1.06); C246(1.10); C73(0.86)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C179(1.19); C246(0.95); C73(1.14)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C179(1.42); C246(0.71); C73(1.09)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C179(1.24); C246(0.90); C73(1.03)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C179(1.60); C246(0.77); C73(0.95)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C179(1.17); C246(0.67); C73(1.17)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C179(1.16); C246(0.77); C73(1.04)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C179(1.19); C246(0.66); C73(1.01)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C179(1.27); C246(0.86); C73(1.09)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C179(1.04); C246(0.61); C73(1.11)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C179(1.09); C246(0.60); C73(1.09)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C179(1.14); C246(0.66); C73(1.10)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C179(1.22); C246(0.69); C73(1.12)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C100(1.12); C179(0.98); C246(1.00); C73(1.11)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C179(1.14); C246(0.55); C73(1.09)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C179(1.15); C246(0.63); C73(1.09)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C179(1.26); C246(0.65); C73(1.16)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C179(0.96); C73(0.98); C246(1.14); C100(1.15)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C73(0.91); C246(0.98); C179(1.03); C100(1.06)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C100(0.91); C73(0.95); C246(1.06); C179(1.26)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C246(0.88); C73(0.95); C100(0.99); C179(1.06)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C246(0.85); C179(0.86); C73(0.92); C100(1.06)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C246(0.91); C100(1.02); C73(1.08); C179(1.09)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C73(0.97); C100(0.99); C246(1.02); C179(1.11)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C179(0.94); C73(1.02); C246(1.06); C100(1.23)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C179(0.99); C73(1.01); C246(1.10); C100(1.10)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C73(0.96); C179(0.98); C246(1.06); C100(1.20)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C73(0.88); C179(0.90); C246(0.91); C100(0.93)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C73(0.98); C246(1.09); C100(1.20); C179(1.35)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C100(1.04); C179(0.97); C246(1.01); C73(0.95)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C100(1.19); C179(0.99); C246(1.06); C73(0.93)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C100(1.02); C179(1.03); C246(1.07); C73(1.12)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C100(1.01); C179(1.14); C246(0.99); C73(0.82)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C246(0.63); C179(1.00); C73(1.04); C100(1.18)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C246(0.57); C179(0.90); C73(0.92); C100(1.07)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C246(0.56); C73(0.87); C179(0.98); C100(1.00)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C100(0.94); C73(1.00); C179(1.02); C246(1.10)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C246(0.51); C73(0.97); C100(0.99); C179(1.07)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C246(0.49); C179(0.86); C73(0.87); C100(0.99)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C246(0.51); C179(0.86); C100(0.92); C73(1.13)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C246(0.55); C100(0.98); C179(0.99); C73(1.05)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C246(0.55); C100(1.00); C73(1.03); C179(1.29)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C179(0.95); C100(1.08); C73(1.09)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C179(0.97); C73(1.08); C100(1.17)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C179(0.98); C73(1.03); C100(1.09)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C179(0.97); C73(1.14); C100(1.17)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C179(0.97); C100(1.03); C73(1.09)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C100(0.96); C179(0.97); C73(0.98); C246(1.53)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C179(0.89); C73(1.09); C100(1.19)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C179(0.96); C73(1.10); C100(1.19)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C179(0.91); C73(1.11); C100(1.20)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C179(0.90); C73(1.04); C100(1.27)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C179(0.90); C73(1.08); C100(1.15)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C73(0.88); C179(0.92); C100(0.93)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C73(0.87); C100(0.94); C179(1.01)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C73(0.82); C100(0.99); C179(1.02)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C73(0.86); C179(1.02); C100(1.02)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C73(0.85); C179(0.90); C100(1.09)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C179(0.87); C73(0.92); C100(1.01); C246(1.46)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C73(0.74); C179(1.00); C100(1.05)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C73(0.85); C179(0.86); C100(1.07)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C73(0.86); C100(1.00); C179(1.28)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C73(0.85); C179(0.89); C100(1.15)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C73(0.78); C179(0.86); C100(1.00)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C73(0.79); C179(0.95); C100(1.10)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C100(0.86); C179(0.97); C246(0.97); C73(0.99)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C179(0.96); C73(0.99); C246(1.01); C100(1.09)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C246(0.92); C100(1.07); C179(1.09); C73(1.10)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C179(0.99); C246(1.09); C73(1.11); C100(1.18)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C100(0.84); C179(0.94); C73(1.02); C246(1.40)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C100(1.01); C73(1.04); C179(1.05); C246(1.06)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C100(0.69); C73(0.96); C179(0.97); C246(1.00)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C100(0.94); C73(0.96); C246(0.99); C179(1.02)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C179(0.92); C100(0.96); C246(1.00); C73(1.03)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C179(0.88); C73(0.98); C100(1.01); C246(1.02)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C246(1.03); C100(1.07); C179(1.08); C73(1.14)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C246(1.08); C179(1.16); C73(1.22); C100(1.50)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C246(0.88); C100(0.98); C73(1.08); C179(1.08)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C246(0.81); C73(0.96); C179(1.05); C100(1.22)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C246(0.86); C179(0.89); C73(0.93); C100(1.00)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C179(0.89); C73(0.99); C246(1.00); C100(1.15)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C100(0.71); C246(0.91); C73(0.92); C179(0.92)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C100(1.00); C73(1.04); C179(1.15); C246(1.23)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C246(1.00); C179(1.06); C73(1.08); C100(1.27)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C246(0.76); C100(0.94); C179(1.01); C73(1.03)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C246(0.89); C100(0.97); C179(1.00); C73(1.01)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C246(0.59); C73(1.19); C179(1.20); C100(1.27)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C246(0.49); C179(1.12); C73(1.30); C100(1.32)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C246(0.41); C179(0.99); C100(1.03); C73(1.15)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C246(0.85); C100(0.92); C73(1.02); C179(1.06)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C246(0.88); C100(0.89); C179(1.01); C73(1.07)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C246(0.94); C179(0.96); C73(1.10); C100(1.16)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C246(0.60); C73(0.93); C179(0.98); C100(1.11)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C246(0.88); C100(0.97); C179(1.00); C73(1.09)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C100(0.85); C179(0.87); C246(1.01); C73(1.02)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C179(0.98); C246(0.98); C100(1.00); C73(1.14)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C100(0.89); C246(0.92); C179(0.94); C73(1.19)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C100(1.01); C179(1.04); C246(1.11); C73(1.27)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C246(0.81); C100(0.96); C179(1.02); C73(1.05)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C246(0.85); C100(0.94); C179(1.02); C73(1.06)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C179(0.89); C100(0.93); C246(0.99); C73(1.13)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C179(0.93); C100(0.95); C246(1.02); C73(1.12)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C179(0.93); C246(1.02); C73(1.03); C100(1.25)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C246(0.91); C179(0.95); C100(0.99); C73(1.05)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C179(0.86); C100(0.96); C73(1.02); C246(1.15)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C246(0.86); C100(0.93); C179(1.00); C73(1.30)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C179(0.80); C73(0.89); C246(0.92); C100(0.99)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C179(0.71); C246(0.83); C73(0.85); C100(1.17)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C179(0.74); C246(0.90); C73(0.93); C100(1.47)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C179(0.77); C73(0.87); C246(0.93); C100(1.15)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C179(0.88); C73(0.89); C246(0.98); C100(1.17)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C179(0.75); C73(0.85); C246(0.92); C100(1.01)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C73(0.87); C179(0.88); C246(0.96); C100(1.02)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C179(0.86); C246(1.04); C100(1.04); C73(1.09)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C246(0.89); C73(0.91); C179(0.97); C100(1.19)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C179(0.68); C73(0.91); C246(0.93); C100(1.01)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C179(0.75); C246(0.90); C73(0.90); C100(0.95)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C179(0.77); C246(0.95); C100(0.95); C73(0.97)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C73(0.91); C246(0.99); C100(1.07); C179(1.09)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C179(0.75); C73(0.84); C246(0.97); C100(1.01)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C179(0.69); C246(0.81); C73(0.85); C100(1.00)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C179(0.46); C73(0.60); C246(0.78); C100(0.96)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C73(0.58); C179(0.66); C246(0.73); C100(0.84)  LDD0683  [9]
 LDCM0545  Acetamide MDA-MB-231 C179(0.39)  LDD2138  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C179(0.75); C246(0.67)  LDD2113  [6]
 LDCM0248  AKOS034007472 HCT 116 C100(1.18); C179(1.00); C246(1.21); C73(1.16)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C179(0.92); C246(1.05); C73(1.12); C100(1.26)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C179(0.91); C73(1.04); C246(1.19); C100(1.32)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 11.70  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C179(1.13); C73(1.09); C100(1.08); C246(1.03)  LDD0078  [9]
 LDCM0498  BS-3668 MDA-MB-231 C179(0.57); C246(0.98)  LDD2091  [6]
 LDCM0630  CCW28-3 231MFP C100(0.79)  LDD2214  [34]
 LDCM0108  Chloroacetamide HeLa C73(0.00); C179(0.00); C100(0.00); H121(0.00)  LDD0222  [23]
 LDCM0632  CL-Sc Hep-G2 C179(1.85); C246(0.80); C73(0.78); C246(0.63)  LDD2227  [17]
 LDCM0367  CL1 HCT 116 C179(0.84); C246(0.89); C73(0.93); C100(1.04)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C179(0.92); C73(1.14); C246(1.16); C100(1.32)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C179(0.84); C100(0.98); C73(1.01); C246(1.40)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C179(0.95); C246(0.96); C73(0.97); C100(1.12)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C100(1.05); C179(1.09); C246(1.11); C73(1.11)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C246(1.08); C100(1.08); C179(1.10); C73(1.10)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C246(1.01); C73(1.07); C179(1.12); C100(1.20)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C246(0.56); C179(0.76); C73(0.93); C100(1.08)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C246(0.52); C179(0.82); C73(0.88); C100(1.13)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C246(0.55); C179(0.81); C73(0.95); C100(1.29)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C246(0.70); C73(0.97); C179(1.00); C100(1.28)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C246(0.58); C179(0.84); C73(0.88); C100(0.94)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C179(0.98); C246(1.10); C73(1.20); C100(1.27)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C246(0.56); C73(0.83); C179(0.95); C100(1.05)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C246(0.43); C179(0.80); C73(0.92); C100(1.02)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C179(0.90); C100(0.92); C73(1.08)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C179(0.88); C73(1.07); C100(1.11)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C179(1.00); C73(1.11); C100(1.13)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C179(0.88); C100(1.02); C73(1.04)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C179(0.88); C73(1.01); C100(1.03)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C73(0.86); C179(0.90); C100(1.33)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C179(0.92); C73(1.01); C100(1.05)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C179(0.83); C73(0.93); C100(1.13)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C179(0.98); C73(1.11); C246(1.23); C100(1.49)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C73(0.89); C179(0.91); C100(1.11)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C246(0.80); C179(0.81); C73(0.90); C100(1.07)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C246(0.83); C100(0.97); C73(0.98); C179(1.01)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C179(0.87); C100(0.97); C246(0.99); C73(1.00)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C179(0.95); C73(1.06); C246(1.08); C100(1.12)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C73(1.00); C100(1.01); C246(1.08); C179(1.16)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C246(0.58); C100(0.86); C179(0.86); C73(0.93)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C246(0.75); C73(0.96); C100(1.03); C179(1.17)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C179(0.89); C73(0.95); C100(1.02); C246(1.12)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C100(1.00); C73(1.07); C246(1.10); C179(1.15)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C100(0.92); C73(0.99); C246(0.99); C179(1.01)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C179(1.06); C73(1.08); C246(1.14); C100(1.16)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C179(0.89); C246(1.10); C73(1.10); C100(1.19)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C246(0.95); C73(0.95); C179(1.02); C100(1.03)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C100(1.02); C73(1.05); C179(1.08); C246(1.09)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C179(0.95); C73(1.08); C100(1.10); C246(1.11)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C246(0.96); C73(1.01); C179(1.02); C100(1.02)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C73(0.91); C179(0.93); C246(1.12); C100(1.13)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C179(0.95); C73(1.07); C100(1.10); C246(1.16)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C179(1.06); C73(1.30); C246(1.34); C100(1.39)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C179(1.08); C100(1.08); C73(1.09); C246(1.33)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C100(1.28); C179(0.93); C246(1.46); C73(1.08)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C100(1.30); C179(1.00); C246(1.52); C73(1.17)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C100(1.30); C179(0.99); C246(1.22); C73(0.98)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C100(1.28); C179(0.94); C246(1.50); C73(1.03)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C100(1.15); C179(0.95); C246(1.31); C73(1.10)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C100(1.16); C179(1.02); C246(1.30); C73(1.15)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C100(1.12); C179(0.97); C246(0.90); C73(0.99)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C100(1.28); C179(1.15); C246(1.48); C73(1.11)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C100(1.19); C179(0.92); C246(0.88); C73(0.99)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C100(1.27); C179(0.90); C246(0.86); C73(1.03)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C100(0.95); C179(0.85); C246(0.93); C73(0.91)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C100(1.27); C179(0.96); C246(0.98); C73(1.05)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C100(1.22); C179(0.94); C246(0.90); C73(1.04)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C100(1.24); C179(1.20); C246(0.96); C73(0.97)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C100(1.51); C179(0.95); C246(0.96); C73(1.01)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C100(1.25); C179(0.85); C246(0.89); C73(0.99)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C100(1.06); C179(0.94); C246(1.01); C73(0.91)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C100(1.09); C179(0.92); C246(0.83); C73(0.96)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C100(1.13); C179(1.17); C246(0.95); C73(0.99)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C100(1.40); C179(1.11); C246(0.91); C73(1.17)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C100(1.25); C179(0.95); C246(0.97); C73(1.11)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C100(1.26); C179(1.12); C246(1.00); C73(1.02)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C100(1.41); C179(1.07); C246(0.99); C73(1.15)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C100(1.21); C179(1.19); C246(1.03); C73(0.99)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C100(1.19); C179(1.02); C246(0.99); C73(1.04)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C100(1.03); C179(1.14); C246(0.98); C73(0.94)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C100(1.19); C179(1.18); C246(1.10); C73(0.95)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C100(1.25); C179(1.00); C246(1.03); C73(1.02)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C100(1.03); C179(1.15); C246(0.98); C73(0.88)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C100(1.06); C179(1.17); C246(1.01); C73(0.91)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C100(1.04); C179(1.16); C246(0.86); C73(0.92)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C100(1.00); C179(1.15); C246(1.00); C73(0.95)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C100(1.06); C179(1.09); C246(0.98); C73(1.00)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C100(0.94); C179(1.27); C246(1.12); C73(0.99)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C100(1.01); C179(1.01); C246(1.12); C73(0.95)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C100(0.91); C179(1.26); C246(1.07); C73(0.91)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C100(1.16); C179(1.06); C246(1.08); C73(1.05)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C100(1.18); C179(1.12); C246(1.21); C73(0.98)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C100(1.51); C179(1.04); C246(1.02); C73(1.15)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C100(1.18); C179(0.97); C246(1.11); C73(1.00)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C100(0.95); C179(1.05); C73(0.97)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C100(0.99); C179(0.99); C73(0.99)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C100(1.04); C179(0.91); C73(0.86)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C100(0.83); C179(1.00); C73(0.87)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C100(0.86); C179(1.00); C73(0.92)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C100(1.09); C179(1.00); C73(0.95)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C100(0.97); C179(1.01); C73(0.89)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C100(0.96); C179(0.94); C73(0.87)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C100(0.96); C179(0.96); C73(1.05)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C100(1.26); C179(0.96); C246(1.18); C73(1.22)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C100(1.00); C179(1.01); C73(1.16)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C100(0.99); C179(1.06); C73(1.00)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C100(0.89); C179(1.00); C73(0.97)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C100(0.94); C179(0.98); C73(0.94)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C100(0.92); C179(0.93); C73(0.91)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C100(0.87); C179(0.97); C246(0.95); C73(0.91)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C100(0.88); C179(1.14); C246(0.90); C73(0.89)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C100(0.92); C179(1.00); C246(0.87); C73(0.89)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C100(0.82); C179(0.88); C246(1.02); C73(0.85)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C100(1.23); C179(0.98); C246(0.74); C73(1.05)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C100(0.84); C179(1.05); C246(0.91); C73(0.97)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C100(0.81); C179(0.88); C246(1.00); C73(0.90)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C100(0.91); C179(0.91); C246(1.20); C73(0.99)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C100(0.80); C179(0.84); C246(1.07); C73(0.95)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C100(0.88); C179(0.89); C246(0.98); C73(1.01)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C100(0.95); C179(0.89); C246(1.06); C73(0.99)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C100(0.92); C179(0.91); C246(1.00); C73(1.05)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C100(0.83); C179(0.86); C246(1.05); C73(0.94)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C100(0.76); C179(0.83); C246(1.08); C73(0.94)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C100(0.88); C179(0.79); C246(0.94); C73(1.19)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C100(1.04); C179(0.94); C246(0.96); C73(1.01)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C100(0.78); C179(1.00); C246(0.97); C73(0.92)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C100(0.73); C179(0.96); C246(1.07); C73(0.85)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C100(0.81); C179(0.97); C246(0.94); C73(0.75)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C100(0.86); C179(1.17); C246(1.16); C73(0.96)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C100(0.87); C179(0.89); C246(1.07); C73(0.91)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C100(0.92); C179(0.81); C246(1.18); C73(0.87)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C100(0.80); C179(0.88); C246(1.34); C73(0.91)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C100(0.92); C179(0.91); C246(1.30); C73(0.87)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C100(0.83); C179(0.76); C246(1.02); C73(0.93)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C100(0.90); C179(0.83); C246(1.08); C73(0.88)  LDD0811  [9]
 LDCM0634  CY-0357 Hep-G2 C100(1.96); C179(0.70)  LDD2228  [17]
 LDCM0495  E2913 HEK-293T C100(0.94); C246(0.72); C179(0.95); C73(0.80)  LDD1698  [35]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C179(6.68); C246(2.65); C73(1.61)  LDD1702  [6]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [8]
 LDCM0625  F8 Ramos C73(0.57); C100(1.10); C179(1.03)  LDD2187  [36]
 LDCM0572  Fragment10 Ramos C73(1.16); C100(1.32); C246(0.59); C179(2.40)  LDD2189  [36]
 LDCM0573  Fragment11 Ramos C73(0.14); C100(0.37); C179(0.29)  LDD2190  [36]
 LDCM0574  Fragment12 Ramos C73(1.64); C100(1.18); C246(1.60); C179(2.33)  LDD2191  [36]
 LDCM0575  Fragment13 Ramos C73(0.76); C100(0.91); C246(1.07); C179(0.85)  LDD2192  [36]
 LDCM0576  Fragment14 Ramos C73(3.94); C100(1.34); C246(0.98); C179(0.97)  LDD2193  [36]
 LDCM0579  Fragment20 Ramos C73(1.53); C100(1.19); C246(1.15)  LDD2194  [36]
 LDCM0580  Fragment21 Ramos C73(1.40); C100(0.93); C246(1.16); C179(1.14)  LDD2195  [36]
 LDCM0582  Fragment23 Ramos C73(1.31); C100(1.18); C246(0.91); C179(1.09)  LDD2196  [36]
 LDCM0578  Fragment27 Ramos C73(0.89); C100(0.93); C246(1.12); C179(0.91)  LDD2197  [36]
 LDCM0586  Fragment28 Ramos C73(1.76); C100(1.22); C246(0.95); C179(0.40)  LDD2198  [36]
 LDCM0588  Fragment30 Ramos C73(0.79); C100(1.12); C246(1.13); C179(0.87)  LDD2199  [36]
 LDCM0589  Fragment31 Ramos C73(1.27); C100(1.10); C246(0.98); C179(1.01)  LDD2200  [36]
 LDCM0590  Fragment32 Ramos C73(1.13); C100(1.07); C246(1.57); C179(1.62)  LDD2201  [36]
 LDCM0468  Fragment33 HCT 116 C100(0.93); C179(0.95); C73(0.88)  LDD0785  [9]
 LDCM0596  Fragment38 Ramos C73(0.86); C100(0.96); C246(1.24); C179(0.89)  LDD2203  [36]
 LDCM0566  Fragment4 Ramos C73(1.41); C100(1.42); C246(1.57); C179(1.07)  LDD2184  [36]
 LDCM0427  Fragment51 HCT 116 C100(1.44); C179(0.98); C246(0.81); C73(1.08)  LDD0744  [9]
 LDCM0610  Fragment52 Ramos C73(0.65); C100(1.71); C179(0.94)  LDD2204  [36]
 LDCM0614  Fragment56 Ramos C73(0.58); C100(1.12); C246(1.06); C179(0.77)  LDD2205  [36]
 LDCM0569  Fragment7 Ramos C73(1.59); C100(0.96); C246(1.29); C179(1.15)  LDD2186  [36]
 LDCM0571  Fragment9 Ramos C73(2.00); C100(1.46); C246(1.45); C179(2.51)  LDD2188  [36]
 LDCM0015  HNE MDA-MB-231 C246(0.97); C100(1.02); C73(0.90)  LDD0346  [36]
 LDCM0107  IAA HeLa C73(0.00); H121(0.00); C246(0.00)  LDD0221  [23]
 LDCM0022  KB02 HCT 116 C179(2.78); C73(2.63); C246(2.30); C100(1.93)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C179(7.91); C73(9.13); C246(4.66); C100(2.71)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C179(6.56); C73(4.82); C246(4.59); C100(2.20)  LDD0082  [9]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C179(1.18); C246(0.88)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C179(0.56)  LDD2121  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [23]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C179(0.53)  LDD2089  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C179(1.29); C246(1.09)  LDD2090  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C179(0.99)  LDD2093  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C179(0.76)  LDD2096  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C179(0.93)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C179(0.96)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C179(1.00); C246(1.05)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C179(1.42); C73(0.77)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C179(0.82); C246(0.82)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C179(0.50); C246(0.55); C73(0.54)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C179(1.65); C246(1.34)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C179(0.52); C246(0.44); C100(1.26); C73(0.54)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C179(0.85); C246(0.92); C100(0.99)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C179(0.47); C246(0.54)  LDD2108  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C179(0.80); C246(0.60); C73(1.09)  LDD2110  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C179(0.80); C246(0.87)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C73(0.91)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C179(0.59); C246(0.60)  LDD2115  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C179(1.64)  LDD2118  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C179(0.77); C246(0.93)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C179(0.87)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C179(0.83)  LDD2123  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C179(0.77)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C179(1.11)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C179(0.90)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C179(0.93); C246(0.93)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C179(0.89)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C179(0.58)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C179(0.56); C246(0.49)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C179(1.22); C246(0.81)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C179(1.09)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C179(1.07); C246(0.61)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C179(2.01)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C179(0.77)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C179(0.60); C246(0.90); C73(0.45)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C179(0.97); C246(0.82)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C179(2.71); C246(1.97)  LDD2144  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C179(1.60)  LDD2145  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C179(1.06)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C179(1.82)  LDD2147  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C179(0.56)  LDD2148  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C179(1.02)  LDD2149  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C179(0.54); C246(0.62)  LDD2150  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C179(0.83)  LDD2151  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C179(1.95); C246(1.59)  LDD2153  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C179(1.21); C246(1.18); C73(1.13); C100(0.87)  LDD2206  [37]
 LDCM0628  OTUB2-COV-1 HEK-293T C100(1.13); C179(0.99); C179(0.94); C246(0.80)  LDD2207  [37]
 LDCM0014  Panhematin hPBMC 4.16  LDD0064  [7]
 LDCM0131  RA190 MM1.R C179(1.32); C73(1.21); C100(1.15)  LDD0304  [38]
 LDCM0084  Ro 48-8071 A-549 2.63  LDD0145  [31]
 LDCM0021  THZ1 HCT 116 C100(1.08); C73(1.26)  LDD2173  [9]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
8 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
20 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
23 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
24 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
25 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
26 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
27 Quantitative Proteomics Reveals Cellular Off-Targets of a DDR1 Inhibitor. ACS Med Chem Lett. 2020 Feb 5;11(4):535-540. doi: 10.1021/acsmedchemlett.9b00658. eCollection 2020 Apr 9.
28 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
29 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
30 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
31 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
32 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
33 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
34 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
35 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
36 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
37 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
38 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.