Details of the Probe

General Information of Probe

Probe ID
LDPC0593
Probe Name
C373
Synonyms
Z3433407833
Probe Type
PAL-AfBPP Probe
Structure
2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 322.4
Lipid-water partition coefficient (xlogp) 2.8
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C19H22N4O
IUPAC Name
N-[2-(3-but-3-ynyldiazirin-3-yl)ethyl]-2,3,3-trimethylindole-4-carboxamide
Canonical SMILES
CC1=NC2=CC=CC(=C2C1(C)C)C(=O)NCCC3(N=N3)CCC#C
InChI
InChI=1S/C19H22N4O/c1-5-6-10-19(22-23-19)11-12-20-17(24)14-8-7-9-15-16(14)18(3,4)13(2)21-15/h1,7-9H,6,10-12H2,2-4H3,(H,20,24)
InChIKey
GUYPCRGFUANTFT-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

53 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
3-ketodihydrosphingosine reductase (KDSR) LDTP05476 17.15  LDD2033 
5'-3' exonuclease PLD3 (PLD3) LDTP08476 6.23  LDD2033 
Adenosine deaminase (ADA) LDTP01803 5.98  LDD2033 
ADP-dependent glucokinase (ADPGK) LDTP11127 12.82  LDD2033 
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) LDTP04437 7.36  LDD2033 
Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) LDTP03560 5.17  LDD2033 
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) LDTP06618 5.78  LDD2033 
ATPase GET3 (GET3) LDTP00836 4.92  LDD2033 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 11.79  LDD2033 
Carbohydrate sulfotransferase 14 (CHST14) LDTP09096 6.73  LDD2033 
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) LDTP03257 5.13  LDD2033 
CDGSH iron-sulfur domain-containing protein 1 (CISD1) LDTP12873 7.94  LDD2033 
Ceramide synthase 2 (CERS2) LDTP10329 5.98  LDD2033 
Cytochrome b-c1 complex subunit 8 (UQCRQ) LDTP00486 5.46  LDD2033 
Cytochrome b-c1 complex subunit 9 (UQCR10) LDTP13189 8.69  LDD2033 
Cytochrome b5 type B (CYB5B) LDTP00697 23.10  LDD2033 
Delta(24)-sterol reductase (DHCR24) LDTP06375 7.06  LDD2033 
Endonuclease domain-containing 1 protein (ENDOD1) LDTP01462 5.50  LDD2033 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 9.00  LDD2033 
Epimerase family protein SDR39U1 (SDR39U1) LDTP16070 16.34  LDD2033 
Epoxide hydrolase 1 (EPHX1) LDTP02175 9.58  LDD2033 
Ferrochelatase, mitochondrial (FECH) LDTP03198 8.57  LDD2033 
Helicase-like transcription factor (HLTF) LDTP06139 7.89  LDD2033 
Heme oxygenase 1 (HMOX1) LDTP02359 4.99  LDD2033 
Heme oxygenase 2 (HMOX2) LDTP03540 11.39  LDD2033 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 9.85  LDD2033 
Lanosterol synthase (LSS) LDTP04183 7.41  LDD2033 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 7.41  LDD2033 
Minor histocompatibility antigen H13 (HM13) LDTP09396 7.11  LDD2033 
Mitochondrial-processing peptidase subunit alpha (PMPCA) LDTP05632 5.28  LDD2033 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 8.75  LDD2033 
NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) LDTP01168 4.96  LDD2033 
NADPH--cytochrome P450 reductase (POR) LDTP02848 17.15  LDD2033 
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (CPOX) LDTP03813 9.00  LDD2033 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 6.68  LDD2033 
Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) LDTP12720 5.74  LDD2033 
Peptidyl-prolyl cis-trans isomerase FKBP2 (FKBP2) LDTP03374 21.11  LDD2033 
Phospholipase A2 group XV (PLA2G15) LDTP09088 5.43  LDD2033 
Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) LDTP05624 5.39  LDD2033 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 9.38  LDD2033 
Prostaglandin E synthase 2 (PTGES2) LDTP12040 8.00  LDD2033 
Protein prenyltransferase alpha subunit repeat-containing protein 1 (PTAR1) LDTP19609 10.56  LDD2033 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 8.17  LDD2033 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 5.24  LDD2033 
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) LDTP00907 13.74  LDD2033 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 5.35  LDD2033 
S-methyl-5'-thioadenosine phosphorylase (MTAP) LDTP05758 17.15  LDD2033 
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) LDTP15484 11.63  LDD2033 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 17.27  LDD2033 
Squalene synthase (FDFT1) LDTP03842 8.51  LDD2033 
TLC domain-containing protein 1 (TLCD1) LDTP10182 6.92  LDD2033 
Transmembrane protein with metallophosphoesterase domain (TMPPE) LDTP07831 62.68  LDD2033 
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) LDTP08728 38.59  LDD2033 
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⏷ Show the Full List of 53 Enzyme
43 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 6.23  LDD2033 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 10.63  LDD2033 
B-cell receptor-associated protein 29 (BCAP29) LDTP16201 6.45  LDD2033 
Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial (COX16) LDTP16163 5.31  LDD2033 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 6.36  LDD2033 
Derlin-1 (DERL1) LDTP11245 4.92  LDD2033 
Equilibrative nucleoside transporter 1 (SLC29A1) LDTP10985 14.83  LDD2033 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 11.47  LDD2033 
Lipid scramblase CLPTM1L (CLPTM1L) LDTP10499 5.03  LDD2033 
Lysosome membrane protein 2 (SCARB2) LDTP06034 15.45  LDD2033 
Melanoma inhibitory activity protein 2 (MIA2) LDTP10669 5.70  LDD2033 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 16.91  LDD2033 
Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) LDTP00865 7.94  LDD2033 
Mitochondrial carrier homolog 1 (MTCH1) LDTP12909 4.92  LDD2033 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 7.41  LDD2033 
Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) LDTP13983 6.50  LDD2033 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 29.24  LDD2033 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 24.93  LDD2033 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 9.38  LDD2033 
Mpv17-like protein 2 (MPV17L2) LDTP14952 6.68  LDD2033 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 4.99  LDD2033 
Nucleoporin NDC1 (NDC1) LDTP11213 6.45  LDD2033 
Peroxisomal membrane protein 2 (PXMP2) LDTP16069 10.70  LDD2033 
Protein ARV1 (ARV1) LDTP11812 8.11  LDD2033 
Protein GPR108 (GPR108) LDTP12383 6.45  LDD2033 
Putative lipid scramblase CLPTM1 (CLPTM1) LDTP01745 8.28  LDD2033 
Reticulon-1 (RTN1) LDTP06633 16.45  LDD2033 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 7.78  LDD2033 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 13.45  LDD2033 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 12.82  LDD2033 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 8.40  LDD2033 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 5.13  LDD2033 
Thioredoxin-related transmembrane protein 2 (TMX2) LDTP13943 7.73  LDD2033 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 8.88  LDD2033 
Translocator protein (TSPO) LDTP03546 11.96  LDD2033 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 21.41  LDD2033 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 5.31  LDD2033 
Transmembrane protein 126A (TMEM126A) LDTP15948 12.82  LDD2033 
Transmembrane protein 160 (TMEM160) LDTP20002 17.15  LDD2033 
Transmembrane protein 199 (TMEM199) LDTP08881 13.55  LDD2033 
Transmembrane protein 205 (TMEM205) LDTP07667 19.29  LDD2033 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 33.13  LDD2033 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 17.15  LDD2033 
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⏷ Show the Full List of 43 Transporter and channel
1 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
DnaJ homolog subfamily C member 1 (DNAJC1) LDTP10501 6.23  LDD2033 
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1 Immunoglobulin Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Basigin (BSG) LDTP03772 9.99  LDD2033 
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33 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 20.53  LDD2033 
Apolipoprotein L2 (APOL2) LDTP11076 39.12  LDD2033 
Clustered mitochondria protein homolog (CLUH) LDTP14486 6.23  LDD2033 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 11.39  LDD2033 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 9.51  LDD2033 
ER lumen protein-retaining receptor 3 (KDELR3) LDTP00850 10.93  LDD2033 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 6.96  LDD2033 
Golgi phosphoprotein 3 (GOLPH3) LDTP11911 5.03  LDD2033 
Heme-binding protein 1 (HEBP1) LDTP16078 44.94  LDD2033 
Keratinocyte-associated transmembrane protein 2 (KCT2) LDTP19780 5.03  LDD2033 
Lipid droplet assembly factor 1 (LDAF1) LDTP10116 8.00  LDD2033 
LYR motif-containing protein 2 (LYRM2) LDTP18467 7.62  LDD2033 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 5.31  LDD2033 
Matrix-remodeling-associated protein 7 (MXRA7) LDTP17003 8.51  LDD2033 
Mitochondrial fission process protein 1 (MTFP1) LDTP16192 6.28  LDD2033 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 19.29  LDD2033 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 8.75  LDD2033 
Neudesin (NENF) LDTP13630 13.45  LDD2033 
Nucleobindin-2 (NUCB2) LDTP05160 4.96  LDD2033 
OCIA domain-containing protein 1 (OCIAD1) LDTP12755 5.54  LDD2033 
Protein CEBPZOS (CEBPZOS) LDTP18883 6.41  LDD2033 
Protein FAM114A2 (FAM114A2) LDTP16080 6.15  LDD2033 
Protein FAM162A (FAM162A) LDTP10056 7.94  LDD2033 
Protein YIF1A (YIF1A) LDTP01494 5.24  LDD2033 
Receptor expression-enhancing protein 3 (REEP3) LDTP15095 4.92  LDD2033 
Reticulon-3 (RTN3) LDTP01522 11.55  LDD2033 
Reticulon-4 (RTN4) LDTP12412 5.24  LDD2033 
Signal recognition particle receptor subunit beta (SRPRB) LDTP16323 6.68  LDD2033 
Syntaxin-18 (STX18) LDTP13086 8.63  LDD2033 
Tetratricopeptide repeat protein 38 (TTC38) LDTP19372 34.54  LDD2033 
Thioredoxin-related transmembrane protein 4 (TMX4) LDTP18373 5.90  LDD2033 
TraB domain-containing protein (TRABD) LDTP19963 9.78  LDD2033 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 12.82  LDD2033 
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⏷ Show the Full List of 33 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD2033 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587