Details of the Target

General Information of Target

Target ID LDTP16201
Target Name B-cell receptor-associated protein 29 (BCAP29)
Gene Name BCAP29
Gene ID 55973
Synonyms
BAP29; B-cell receptor-associated protein 29; BCR-associated protein 29; Bap29
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNMSKQPVSNVRAIQANINIPMGAFRPGAGQPPRRKECTPEVEEGVPPTSDEEKKPIPGA
KKLPGPAVNLSEIQNIKSELKYVPKAEQ
Target Bioclass
Transporter and channel
Family
BCAP29/BCAP31 family
Subcellular location
Endoplasmic reticulum membrane
Function May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis.
Uniprot ID
Q9UHQ4
Ensemble ID
ENST00000005259.9
HGNC ID
HGNC:24131

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Deletion: p.R160GfsTer3 .
ETK1 SNV: p.D231G .
HCC1806 SNV: p.E142K .
HT Deletion: p.W114GfsTer2 .
IM95 Deletion: p.W114GfsTer2 .
NALM6 Deletion: p.W114GfsTer2 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y90(20.00)  LDD0260  [2]
STPyne
 Probe Info  		K157(1.32); K163(4.63); K96(8.42)  LDD0277  [3]
BTD
 Probe Info  		C171(0.94)  LDD2092  [4]
AHL-Pu-1
 Probe Info  		C171(2.63)  LDD0168  [5]
DBIA
 Probe Info  		C171(0.97)  LDD1492  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
ATP probe
 Probe Info  		N.A.  LDD0035  [8]
IPM
 Probe Info  		N.A.  LDD0025  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [11]
Methacrolein
 Probe Info  		N.A.  LDD0218  [11]
W1
 Probe Info  		N.A.  LDD0236  [12]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C082
 Probe Info  		6.68  LDD1774  [13]
C083
 Probe Info  		7.78  LDD1775  [13]
C087
 Probe Info  		47.84  LDD1779  [13]
C111
 Probe Info  		6.96  LDD1798  [13]
C112
 Probe Info  		20.68  LDD1799  [13]
C158
 Probe Info  		11.71  LDD1838  [13]
C169
 Probe Info  		30.91  LDD1849  [13]
C362
 Probe Info  		34.78  LDD2023  [13]
C373
 Probe Info  		6.45  LDD2033  [13]
Dasatinib-CA-8PAP
 Probe Info  		8.00  LDD0364  [14]
OEA-DA
 Probe Info  		20.00  LDD0046  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C171(0.81)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C171(0.95)  LDD2112  [4]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C171(0.64)  LDD2095  [4]
 LDCM0025  4SU-RNA HEK-293T C171(2.63)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C171(2.30)  LDD0169  [5]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [11]
 LDCM0632  CL-Sc Hep-G2 C171(0.82); C171(0.49)  LDD2227  [10]
 LDCM0097  Dasatinib K562 8.00  LDD0364  [14]
 LDCM0625  F8 Ramos C171(5.99)  LDD2187  [16]
 LDCM0573  Fragment11 Ramos C171(12.06)  LDD2190  [16]
 LDCM0576  Fragment14 Ramos C171(0.55)  LDD2193  [16]
 LDCM0586  Fragment28 Ramos C171(1.09)  LDD2198  [16]
 LDCM0566  Fragment4 Ramos C171(0.87)  LDD2184  [16]
 LDCM0569  Fragment7 Ramos C171(0.99)  LDD2186  [16]
 LDCM0022  KB02 HEK-293T C171(0.97)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C171(1.01)  LDD1497  [6]
 LDCM0024  KB05 HEK-293T C171(0.87)  LDD1502  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [11]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C171(0.94)  LDD2092  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C171(0.70)  LDD2100  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C171(0.82)  LDD2104  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C171(0.55)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C171(0.82)  LDD2108  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C171(0.91)  LDD2114  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C171(1.08)  LDD2137  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C171(0.79)  LDD2141  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C171(1.62)  LDD2145  [4]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
15 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578