Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C373  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 53 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP07831  Transmembrane protein with metallophosphoesterase domain (TMPPE) 62.7
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 38.6
 LDTP00697  Cytochrome b5 type B (CYB5B) 23.1
 LDTP03374  Peptidyl-prolyl cis-trans isomerase FKBP2 (FKBP2) 21.1
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 17.3
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 17.1
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 17.1
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 17.1
 LDTP16070  Epimerase family protein SDR39U1 (SDR39U1) 16.3
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 13.7
 LDTP11127  ADP-dependent glucokinase (ADPGK) 12.8
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 11.8
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 11.6
 LDTP03540  Heme oxygenase 2 (HMOX2) 11.4
 LDTP19609  Protein prenyltransferase alpha subunit repeat-containing protein 1 (PTAR1) 10.6
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 9.8
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 9.6
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 9.4
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 9.0
 LDTP03813  Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (CPOX) 9.0
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 8.8
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 8.7
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 8.6
 LDTP03842  Squalene synthase (FDFT1) 8.5
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 8.2
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 8.0
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 7.9
 LDTP06139  Helicase-like transcription factor (HLTF) 7.9
 LDTP04183  Lanosterol synthase (LSS) 7.4
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 7.4
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 7.4
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 7.1
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 7.1
 LDTP10182  TLC domain-containing protein 1 (TLCD1) 6.9
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 6.7
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 6.7
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 6.2
 LDTP01803  Adenosine deaminase (ADA) 6.0
 LDTP10329  Ceramide synthase 2 (CERS2) 6.0
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 5.8
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 5.7
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 5.5
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 5.5
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 5.4
 LDTP05624  Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) 5.4
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 5.4
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 5.3
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 5.2
 LDTP03560  Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) 5.2
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 5.1
 LDTP02359  Heme oxygenase 1 (HMOX1) 5.0
 LDTP01168  NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) 5.0
 LDTP00836  ATPase GET3 (GET3) 4.9
Transporter and channel
Click to Show/Hide to Show 43 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 33.1
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 29.2
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 24.9
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 21.4
 LDTP07667  Transmembrane protein 205 (TMEM205) 19.3
 LDTP20002  Transmembrane protein 160 (TMEM160) 17.1
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 17.1
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 16.9
 LDTP06633  Reticulon-1 (RTN1) 16.4
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 15.5
 LDTP10985  Equilibrative nucleoside transporter 1 (SLC29A1) 14.8
 LDTP08881  Transmembrane protein 199 (TMEM199) 13.5
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 13.5
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 12.8
 LDTP15948  Transmembrane protein 126A (TMEM126A) 12.8
 LDTP03546  Translocator protein (TSPO) 12.0
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 11.5
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 10.7
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 10.6
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 9.4
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 8.9
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 8.4
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 8.3
 LDTP11812  Protein ARV1 (ARV1) 8.1
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 7.9
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 7.8
 LDTP13943  Thioredoxin-related transmembrane protein 2 (TMX2) 7.7
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 7.4
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 6.7
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 6.5
 LDTP16201  B-cell receptor-associated protein 29 (BCAP29) 6.5
 LDTP11213  Nucleoporin NDC1 (NDC1) 6.5
 LDTP12383  Protein GPR108 (GPR108) 6.5
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 6.4
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 6.2
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 5.7
 LDTP16163  Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial (COX16) 5.3
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 5.3
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 5.1
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 5.0
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 5.0
 LDTP11245  Derlin-1 (DERL1) 4.9
 LDTP12909  Mitochondrial carrier homolog 1 (MTCH1) 4.9
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 6.2
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03772  Basigin (BSG) 10.0
Other
Click to Show/Hide to Show 33 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP16078  Heme-binding protein 1 (HEBP1) 44.9
 LDTP11076  Apolipoprotein L2 (APOL2) 39.1
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 34.5
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 20.5
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 19.3
 LDTP13630  Neudesin (NENF) 13.5
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 12.8
 LDTP01522  Reticulon-3 (RTN3) 11.6
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 11.4
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 10.9
 LDTP19963  TraB domain-containing protein (TRABD) 9.8
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 9.5
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 8.8
 LDTP13086  Syntaxin-18 (STX18) 8.6
 LDTP17003  Matrix-remodeling-associated protein 7 (MXRA7) 8.5
 LDTP10116  Lipid droplet assembly factor 1 (LDAF1) 8.0
 LDTP10056  Protein FAM162A (FAM162A) 7.9
 LDTP18467  LYR motif-containing protein 2 (LYRM2) 7.6
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 7.0
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 6.7
 LDTP18883  Protein CEBPZOS (CEBPZOS) 6.4
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 6.3
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 6.2
 LDTP16080  Protein FAM114A2 (FAM114A2) 6.1
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 5.9
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 5.5
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 5.3
 LDTP01494  Protein YIF1A (YIF1A) 5.2
 LDTP12412  Reticulon-4 (RTN4) 5.2
 LDTP11911  Golgi phosphoprotein 3 (GOLPH3) 5.0
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 5.0
 LDTP05160  Nucleobindin-2 (NUCB2) 5.0
 LDTP15095  Receptor expression-enhancing protein 3 (REEP3) 4.9

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587