Details of the Target

General Information of Target

Target ID LDTP01462
Target Name Endonuclease domain-containing 1 protein (ENDOD1)
Gene Name ENDOD1
Gene ID 23052
Synonyms
KIAA0830; Endonuclease domain-containing 1 protein; EC 3.1.30.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGTARWLALGSLFALAGLLEGRLVGEEEAGFGECDKFFYAGTPPAGLAADSHVKICQRAE
GAERFATLYSTRDRIPVYSAFRAPRPAPGGAEQRWLVEPQIDDPNSNLEEAINEAEAITS
VNSLGSKQALNTDYLDSDYQRGQLYPFSLSSDVQVATFTLTNSAPMTQSFQERWYVNLHS
LMDRALTPQCGSGEDLYILTGTVPSDYRVKDKVAVPEFVWLAACCAVPGGGWAMGFVKHT
RDSDIIEDVMVKDLQKLLPFNPQLFQNNCGETEQDTEKMKKILEVVNQIQDEERMVQSQK
SSSPLSSTRSKRSTLLPPEASEGSSSFLGKLMGFIATPFIKLFQLIYYLVVAILKNIVYF
LWCVTKQVINGIESCLYRLGSATISYFMAIGEELVSIPWKVLKVVAKVIRALLRILCCLL
KAICRVLSIPVRVLVDVATFPVYTMGAIPIVCKDIALGLGGTVSLLFDTAFGTLGGLFQV
VFSVCKRIGYKVTFDNSGEL
Target Bioclass
Enzyme
Family
DNA/RNA non-specific endonuclease family
Subcellular location
Secreted
Function May act as a DNase and a RNase. Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26.
Uniprot ID
O94919
Ensemble ID
ENST00000278505.5
HGNC ID
HGNC:29129

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HDSF-alk
 Probe Info  		1.67  LDD0197  [1]
FBPP2
 Probe Info  		3.87  LDD0318  [2]
CHEMBL5175495
 Probe Info  		12.84  LDD0196  [3]
TG42
 Probe Info  		5.85  LDD0043  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
Curcusone 37
 Probe Info  		2.97  LDD0188  [6]
Johansson_61
 Probe Info  		_(4.64)  LDD1485  [7]
YY4-yne
 Probe Info  		2.16  LDD0400  [8]
HPAP
 Probe Info  		3.26  LDD0063  [9]
Alkyne-RA190
 Probe Info  		4.11  LDD0299  [10]
DBIA
 Probe Info  		C375(1.03)  LDD0531  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0163  [12]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [13]
TFBX
 Probe Info  		N.A.  LDD0027  [14]
IPM
 Probe Info  		N.A.  LDD2156  [15]
AOyne
 Probe Info  		6.00  LDD0443  [16]
NAIA_5
 Probe Info  		N.A.  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 80 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		6.87  LDD1714  [18]
C017
 Probe Info  		12.73  LDD1725  [18]
C022
 Probe Info  		9.99  LDD1728  [18]
C040
 Probe Info  		17.15  LDD1740  [18]
C041
 Probe Info  		7.06  LDD1741  [18]
C055
 Probe Info  		27.67  LDD1752  [18]
C056
 Probe Info  		33.36  LDD1753  [18]
C063
 Probe Info  		17.27  LDD1760  [18]
C067
 Probe Info  		5.39  LDD1763  [18]
C070
 Probe Info  		18.64  LDD1766  [18]
C072
 Probe Info  		11.16  LDD1768  [18]
C082
 Probe Info  		6.45  LDD1774  [18]
C106
 Probe Info  		19.84  LDD1793  [18]
C107
 Probe Info  		6.54  LDD1794  [18]
C108
 Probe Info  		8.28  LDD1795  [18]
C112
 Probe Info  		24.59  LDD1799  [18]
C134
 Probe Info  		22.63  LDD1816  [18]
C135
 Probe Info  		11.55  LDD1817  [18]
C141
 Probe Info  		13.00  LDD1823  [18]
C143
 Probe Info  		21.11  LDD1825  [18]
C147
 Probe Info  		6.54  LDD1829  [18]
C153
 Probe Info  		21.71  LDD1834  [18]
C161
 Probe Info  		10.20  LDD1841  [18]
C163
 Probe Info  		6.28  LDD1843  [18]
C169
 Probe Info  		36.50  LDD1849  [18]
C186
 Probe Info  		7.78  LDD1864  [18]
C187
 Probe Info  		23.59  LDD1865  [18]
C191
 Probe Info  		9.51  LDD1868  [18]
C194
 Probe Info  		9.45  LDD1870  [18]
C196
 Probe Info  		13.64  LDD1872  [18]
C198
 Probe Info  		11.63  LDD1874  [18]
C201
 Probe Info  		27.47  LDD1877  [18]
C206
 Probe Info  		16.80  LDD1881  [18]
C210
 Probe Info  		41.07  LDD1884  [18]
C218
 Probe Info  		36.00  LDD1892  [18]
C219
 Probe Info  		9.85  LDD1893  [18]
C220
 Probe Info  		41.64  LDD1894  [18]
C225
 Probe Info  		7.26  LDD1898  [18]
C226
 Probe Info  		5.70  LDD1899  [18]
C228
 Probe Info  		33.13  LDD1901  [18]
C231
 Probe Info  		17.03  LDD1904  [18]
C235
 Probe Info  		18.13  LDD1908  [18]
C243
 Probe Info  		11.79  LDD1916  [18]
C246
 Probe Info  		14.32  LDD1919  [18]
C258
 Probe Info  		5.31  LDD1931  [18]
C273
 Probe Info  		5.82  LDD1943  [18]
C277
 Probe Info  		11.88  LDD1947  [18]
C285
 Probe Info  		32.00  LDD1955  [18]
C287
 Probe Info  		15.67  LDD1957  [18]
C288
 Probe Info  		7.67  LDD1958  [18]
C289
 Probe Info  		43.71  LDD1959  [18]
C293
 Probe Info  		31.34  LDD1963  [18]
C296
 Probe Info  		21.71  LDD1966  [18]
C307
 Probe Info  		5.62  LDD1975  [18]
C310
 Probe Info  		9.58  LDD1977  [18]
C314
 Probe Info  		17.63  LDD1981  [18]
C343
 Probe Info  		34.78  LDD2005  [18]
C348
 Probe Info  		16.45  LDD2009  [18]
C349
 Probe Info  		25.11  LDD2010  [18]
C350
 Probe Info  		53.45  LDD2011  [18]
C362
 Probe Info  		31.78  LDD2023  [18]
C366
 Probe Info  		7.26  LDD2027  [18]
C373
 Probe Info  		5.50  LDD2033  [18]
C376
 Probe Info  		12.13  LDD2036  [18]
C378
 Probe Info  		7.06  LDD2037  [18]
C382
 Probe Info  		14.72  LDD2041  [18]
C383
 Probe Info  		11.55  LDD2042  [18]
C388
 Probe Info  		45.89  LDD2047  [18]
C390
 Probe Info  		23.75  LDD2049  [18]
C403
 Probe Info  		14.83  LDD2061  [18]
C407
 Probe Info  		13.83  LDD2064  [18]
C413
 Probe Info  		12.82  LDD2069  [18]
C429
 Probe Info  		10.93  LDD2084  [18]
C431
 Probe Info  		16.22  LDD2086  [18]
FFF probe11
 Probe Info  		20.00  LDD0471  [19]
FFF probe13
 Probe Info  		20.00  LDD0475  [19]
FFF probe14
 Probe Info  		20.00  LDD0477  [19]
FFF probe2
 Probe Info  		20.00  LDD0463  [19]
FFF probe3
 Probe Info  		20.00  LDD0464  [19]
OEA-DA
 Probe Info  		20.00  LDD0046  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C375(1.03)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C375(0.90)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C375(0.91)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C375(0.78)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C375(0.74)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C375(0.70)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C375(0.79)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C375(0.83)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C375(0.77)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C375(0.72)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C375(0.75)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C375(0.73)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C375(0.99)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C375(0.79)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C375(0.77)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C375(0.70)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C375(1.04)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C375(0.87)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C375(1.02)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C375(1.01)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C375(1.03)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C375(1.01)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C375(1.02)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C375(0.98)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C375(1.11)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C375(1.08)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C375(0.97)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C375(0.95)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C375(0.95)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C375(1.08)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C375(0.91)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C375(0.93)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C375(1.37)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C375(1.56)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C375(1.24)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C375(0.91)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C375(1.35)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C375(1.22)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C375(1.20)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C375(1.17)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C375(1.03)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C375(1.06)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C375(1.03)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C375(1.06)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C375(1.23)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C375(0.98)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C375(1.02)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C375(1.10)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C375(0.98)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C375(1.03)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C375(0.84)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C375(0.84)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C375(1.03)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C375(1.14)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C375(0.90)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C375(0.92)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C375(0.91)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C375(0.87)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C375(1.07)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C375(1.08)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C375(0.85)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C375(0.88)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C375(0.80)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C375(0.89)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C375(0.98)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C375(0.87)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C375(1.04)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C375(1.14)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C375(0.93)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C375(0.91)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C375(0.98)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C375(1.02)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C375(0.93)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C375(1.06)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C375(1.13)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C375(1.01)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C375(1.11)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C375(0.94)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C375(1.20)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C375(1.00)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C375(1.17)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C375(1.02)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C375(0.92)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C375(0.92)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C375(1.08)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C375(0.96)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C375(1.17)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C375(1.13)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C375(1.02)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C375(1.05)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C375(1.16)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C375(1.05)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C375(1.02)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C375(1.17)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C375(1.21)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C375(1.09)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C375(0.95)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C375(1.18)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C375(0.91)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C375(1.09)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C375(1.05)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C375(0.99)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C375(0.99)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C375(1.02)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C375(1.05)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C375(1.11)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C375(1.06)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C375(1.14)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C375(1.38)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C375(1.22)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C375(1.35)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C375(0.92)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C375(1.20)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C375(1.16)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C375(1.39)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C375(1.30)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C375(1.44)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C375(1.85)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C375(1.80)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C375(1.57)  LDD0648  [11]
 LDCM0334  AC7 HCT 116 C375(1.07)  LDD0651  [11]
 LDCM0345  AC8 HCT 116 C375(0.95)  LDD0662  [11]
 LDCM0349  AC83 HCT 116 C375(1.17)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C375(1.00)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C375(1.00)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C375(1.45)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C375(1.12)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C375(1.08)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C375(1.04)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C375(1.17)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C375(1.03)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C375(1.16)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C375(0.80)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C375(1.67)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C375(1.23)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C375(1.14)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C375(1.58)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C375(0.86)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C375(0.85)  LDD0683  [11]
 LDCM0248  AKOS034007472 HCT 116 C375(0.98)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C375(1.01)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C375(1.07)  LDD0592  [11]
 LDCM0367  CL1 HCT 116 C375(1.07)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C375(1.06)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C375(1.17)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C375(0.95)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C375(0.99)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C375(1.38)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C375(0.83)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C375(1.09)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C375(1.04)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C375(1.05)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C375(1.28)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C375(0.97)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C375(1.27)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C375(1.10)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C375(1.14)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C375(1.11)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C375(0.98)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C375(1.12)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C375(0.94)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C375(0.91)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C375(1.23)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C375(1.07)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C375(1.12)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C375(1.18)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C375(1.14)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C375(1.19)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C375(0.96)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C375(1.13)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C375(1.17)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C375(1.40)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C375(1.40)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C375(1.30)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C375(1.28)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C375(0.98)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C375(1.02)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C375(0.97)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C375(0.87)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C375(1.04)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C375(0.91)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C375(1.19)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C375(1.20)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C375(1.11)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C375(1.14)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C375(1.12)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C375(1.05)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C375(1.10)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C375(1.21)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C375(0.81)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C375(1.23)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C375(1.18)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C375(1.71)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C375(1.02)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C375(1.00)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C375(1.16)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C375(1.00)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C375(1.04)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C375(1.06)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C375(1.22)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C375(1.08)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C375(1.30)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C375(1.00)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C375(1.20)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C375(0.91)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C375(0.99)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C375(1.16)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C375(1.10)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C375(1.13)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C375(1.14)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C375(1.05)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C375(1.01)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C375(0.99)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C375(1.13)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C375(1.08)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C375(1.02)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C375(1.02)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C375(1.02)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C375(0.92)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C375(0.98)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C375(0.93)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C375(0.92)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C375(0.99)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C375(1.03)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C375(1.02)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C375(1.13)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C375(1.07)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C375(0.93)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C375(0.93)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C375(0.87)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C375(1.20)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C375(0.92)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C375(1.03)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C375(1.04)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C375(0.91)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C375(1.03)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C375(1.06)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C375(1.03)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C375(0.99)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C375(0.98)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C375(1.02)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C375(0.92)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C375(1.18)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C375(0.84)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C375(0.88)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C375(1.04)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C375(1.48)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C375(1.04)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C375(0.83)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C375(1.16)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C375(1.35)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C375(1.04)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C375(0.96)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C375(1.06)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C375(1.09)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C375(0.91)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C375(1.04)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C375(0.93)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C375(1.19)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C375(1.11)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C375(1.00)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C375(1.02)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C375(1.11)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C375(1.37)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C375(1.30)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C375(1.22)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C375(1.05)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C375(0.99)  LDD0811  [11]
 LDCM0033  Curcusone1d MCF-7 2.97  LDD0188  [6]
 LDCM0495  E2913 HEK-293T C452(1.10)  LDD1698  [21]
 LDCM0468  Fragment33 HCT 116 C375(1.01)  LDD0785  [11]
 LDCM0427  Fragment51 HCT 116 C375(1.05)  LDD0744  [11]
 LDCM0615  Fragment63-R Jurkat _(4.79)  LDD1487  [7]
 LDCM0617  Fragment63-S Jurkat _(10.38)  LDD1490  [7]
 LDCM0569  Fragment7 Jurkat _(4.64)  LDD1485  [7]
 LDCM0022  KB02 HEK-293T C452(0.98)  LDD1492  [21]
 LDCM0023  KB03 HEK-293T C452(0.94)  LDD1497  [21]
 LDCM0024  KB05 WM115 C452(1.53)  LDD3327  [22]
 LDCM0014  Panhematin K562 3.26  LDD0063  [9]
 LDCM0131  RA190 MM1.R 4.11  LDD0299  [10]
 LDCM0154  YY4 T cell 2.16  LDD0400  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Visinin-like protein 1 (VSNL1) Recoverin family P62760

References

1 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
7 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
8 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
9 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
10 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840