Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C307  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 57 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 49.2
 LDTP05493  Sulfotransferase 2A1 (SULT2A1) 19.4
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 18.3
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 16.9
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 16.7
 LDTP12056  Thiol S-methyltransferase TMT1A (TMT1A) 15.2
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 14.5
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 14.1
 LDTP02359  Heme oxygenase 1 (HMOX1) 12.4
 LDTP03540  Heme oxygenase 2 (HMOX2) 11.3
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 10.6
 LDTP01562  Peptidyl-prolyl cis-trans isomerase FKBP9 (FKBP9) 10.0
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 9.9
 LDTP00697  Cytochrome b5 type B (CYB5B) 9.7
 LDTP05905  Acid ceramidase (ASAH1) 8.5
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 8.5
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 8.5
 LDTP07931  Heme A synthase COX15 (COX15) 8.5
 LDTP11127  ADP-dependent glucokinase (ADPGK) 8.4
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 8.2
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 8.2
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 8.1
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 7.8
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 7.7
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 7.5
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 7.3
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 7.0
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 7.0
 LDTP02837  Beta-galactosidase (GLB1) 6.8
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 6.8
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 6.5
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 6.5
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 6.4
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 6.4
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 6.3
 LDTP05850  Probable methyltransferase TARBP1 (TARBP1) 6.1
 LDTP01769  Dihydrofolate reductase (DHFR) 6.1
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 6.0
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 6.0
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 5.9
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 5.7
 LDTP05029  Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) 5.7
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 5.6
 LDTP11259  Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (ALG12) 5.6
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 5.6
 LDTP00575  Glutathione S-transferase A4 (GSTA4) 5.6
 LDTP00988  Protein O-GlcNAcase (OGA) 5.6
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 5.5
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 5.4
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 5.4
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 5.3
 LDTP00186  Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) 5.2
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 5.2
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 5.2
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 5.2
 LDTP01219  NADH dehydrogenase 1 beta subcomplex subunit 1 (NDUFB1) 5.1
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 5.0
Transporter and channel
Click to Show/Hide to Show 48 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 30.5
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 24.4
 LDTP11615  Protein tweety homolog 3 (TTYH3) 17.9
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 15.6
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 14.5
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 12.6
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 12.3
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 11.9
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 10.8
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 9.8
 LDTP06275  Lysosomal-associated transmembrane protein 4A (LAPTM4A) 9.6
 LDTP16813  Tetraspanin-3 (TSPAN3) 9.3
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 8.8
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 8.8
 LDTP09261  Major facilitator superfamily domain-containing protein 8 (MFSD8) 8.7
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 8.6
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 8.6
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 8.1
 LDTP15948  Transmembrane protein 126A (TMEM126A) 8.1
 LDTP09180  Zinc transporter 7 (SLC30A7) 8.1
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 7.9
 LDTP08881  Transmembrane protein 199 (TMEM199) 7.2
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 7.1
 LDTP11213  Nucleoporin NDC1 (NDC1) 7.0
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 6.7
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 6.6
 LDTP13969  Transmembrane emp24 domain-containing protein 7 (TMED7) 6.6
 LDTP15648  BRI3-binding protein (BRI3BP) 6.6
 LDTP20002  Transmembrane protein 160 (TMEM160) 6.5
 LDTP00547  Secretory carrier-associated membrane protein 2 (SCAMP2) 6.2
 LDTP13262  Signal recognition particle subunit SRP68 (SRP68) 6.2
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 6.1
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 5.9
 LDTP15481  Transmembrane protein 87A (TMEM87A) 5.9
 LDTP04501  Importin subunit alpha-1 (KPNA2) 5.8
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 5.7
 LDTP03869  Protein Mpv17 (MPV17) 5.5
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 5.5
 LDTP09288  Vang-like protein 1 (VANGL1) 5.5
 LDTP00592  Surfeit locus protein 4 (SURF4) 5.4
 LDTP02215  Prosaposin (PSAP) 5.4
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 5.2
 LDTP15967  Tetraspanin-10 (TSPAN10) 5.2
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 5.2
 LDTP11869  Growth hormone-inducible transmembrane protein (GHITM) 5.1
 LDTP15845  Transmembrane 9 superfamily member 2 (TM9SF2) 5.0
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 5.0
 LDTP14174  Sorting nexin-5 (SNX5) 5.0
Other
Click to Show/Hide to Show 26 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 73.0
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 23.3
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 17.1
 LDTP18883  Protein CEBPZOS (CEBPZOS) 16.9
 LDTP12642  CYFIP-related Rac1 interactor B (CYRIB) 16.6
 LDTP05160  Nucleobindin-2 (NUCB2) 15.3
 LDTP00105  Protein unc-119 homolog B (UNC119B) 13.7
 LDTP10200  60S ribosomal export protein NMD3 (NMD3) 13.5
 LDTP14458  Tetraspanin-6 (TSPAN6) 12.4
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 9.4
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 7.8
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 7.3
 LDTP11076  Apolipoprotein L2 (APOL2) 6.9
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 6.9
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 6.6
 LDTP08594  Negative elongation factor C/D (NELFCD) 6.5
 LDTP01522  Reticulon-3 (RTN3) 6.3
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 6.2
 LDTP16080  Protein FAM114A2 (FAM114A2) 6.1
 LDTP15240  LysM and putative peptidoglycan-binding domain-containing protein 3 (LYSMD3) 5.8
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 5.7
 LDTP04382  Kinetochore-associated protein 1 (KNTC1) 5.7
 LDTP11906  Phosphatidylinositol glycan anchor biosynthesis class U protein (PIGU) 5.5
 LDTP10056  Protein FAM162A (FAM162A) 5.3
 LDTP13086  Syntaxin-18 (STX18) 5.2
 LDTP12412  Reticulon-4 (RTN4) 5.2

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587