Details of the Target

General Information of Target

Target ID LDTP00850
Target Name ER lumen protein-retaining receptor 3 (KDELR3)
Gene Name KDELR3
Gene ID 11015
Synonyms
ERD23; ER lumen protein-retaining receptor 3; KDEL endoplasmic reticulum protein retention receptor 3; KDEL receptor 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNVFRILGDLSHLLAMILLLGKIWRSKCCKGISGKSQILFALVFTTRYLDLFTNFISIYN
TVMKVVFLLCAYVTVYMIYGKFRKTFDSENDTFRLEFLLVPVIGLSFLENYSFTLLEILW
TFSIYLESVAILPQLFMISKTGEAETITTHYLFFLGLYRALYLANWIRRYQTENFYDQIA
VVSGVVQTIFYCDFFYLYVTKVLKGKKLSLPMPI
Target Bioclass
Other
Family
ERD2 family
Subcellular location
Endoplasmic reticulum membrane
Function Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.
Uniprot ID
O43731
Ensemble ID
ENST00000216014.9
HGNC ID
HGNC:6306

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
G415 SNV: p.S57C .
LN18 SNV: p.G142Ter .
OAW42 SNV: p.T146I .
SCC25 SNV: p.T188S .
SW1783 SNV: p.R169Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K207(10.00)  LDD0277  [1]
PAL-AfBPP Probe
Click To Hide/Show 85 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		8.94  LDD1714  [2]
C007
 Probe Info  		6.45  LDD1716  [2]
C022
 Probe Info  		31.12  LDD1728  [2]
C026
 Probe Info  		11.39  LDD1732  [2]
C039
 Probe Info  		8.94  LDD1739  [2]
C040
 Probe Info  		24.76  LDD1740  [2]
C041
 Probe Info  		20.39  LDD1741  [2]
C049
 Probe Info  		20.39  LDD1747  [2]
C063
 Probe Info  		14.52  LDD1760  [2]
C106
 Probe Info  		38.85  LDD1793  [2]
C107
 Probe Info  		22.47  LDD1794  [2]
C108
 Probe Info  		22.47  LDD1795  [2]
C112
 Probe Info  		54.19  LDD1799  [2]
C153
 Probe Info  		40.50  LDD1834  [2]
C177
 Probe Info  		11.88  LDD1856  [2]
C178
 Probe Info  		78.79  LDD1857  [2]
C183
 Probe Info  		9.32  LDD1861  [2]
C185
 Probe Info  		7.11  LDD1863  [2]
C186
 Probe Info  		27.10  LDD1864  [2]
C187
 Probe Info  		36.76  LDD1865  [2]
C191
 Probe Info  		14.72  LDD1868  [2]
C208
 Probe Info  		9.19  LDD1883  [2]
C210
 Probe Info  		71.51  LDD1884  [2]
C211
 Probe Info  		36.76  LDD1885  [2]
C213
 Probe Info  		77.71  LDD1887  [2]
C214
 Probe Info  		8.69  LDD1888  [2]
C222
 Probe Info  		8.94  LDD1896  [2]
C223
 Probe Info  		5.62  LDD1897  [2]
C225
 Probe Info  		32.45  LDD1898  [2]
C226
 Probe Info  		18.64  LDD1899  [2]
C228
 Probe Info  		59.30  LDD1901  [2]
C229
 Probe Info  		22.63  LDD1902  [2]
C231
 Probe Info  		34.54  LDD1904  [2]
C232
 Probe Info  		37.27  LDD1905  [2]
C233
 Probe Info  		34.78  LDD1906  [2]
C234
 Probe Info  		10.56  LDD1907  [2]
C235
 Probe Info  		35.75  LDD1908  [2]
C243
 Probe Info  		22.63  LDD1916  [2]
C244
 Probe Info  		21.71  LDD1917  [2]
C245
 Probe Info  		16.22  LDD1918  [2]
C246
 Probe Info  		39.95  LDD1919  [2]
C249
 Probe Info  		25.99  LDD1922  [2]
C264
 Probe Info  		45.57  LDD1935  [2]
C265
 Probe Info  		37.79  LDD1936  [2]
C270
 Probe Info  		27.47  LDD1940  [2]
C280
 Probe Info  		13.18  LDD1950  [2]
C282
 Probe Info  		19.29  LDD1952  [2]
C284
 Probe Info  		26.35  LDD1954  [2]
C285
 Probe Info  		30.91  LDD1955  [2]
C286
 Probe Info  		6.82  LDD1956  [2]
C287
 Probe Info  		38.85  LDD1957  [2]
C288
 Probe Info  		16.22  LDD1958  [2]
C289
 Probe Info  		35.26  LDD1959  [2]
C290
 Probe Info  		9.06  LDD1960  [2]
C293
 Probe Info  		22.78  LDD1963  [2]
C296
 Probe Info  		20.53  LDD1966  [2]
C307
 Probe Info  		17.15  LDD1975  [2]
C310
 Probe Info  		76.64  LDD1977  [2]
C313
 Probe Info  		17.39  LDD1980  [2]
C314
 Probe Info  		51.27  LDD1981  [2]
C317
 Probe Info  		7.16  LDD1983  [2]
C342
 Probe Info  		9.92  LDD2004  [2]
C343
 Probe Info  		85.04  LDD2005  [2]
C346
 Probe Info  		15.67  LDD2007  [2]
C347
 Probe Info  		8.57  LDD2008  [2]
C348
 Probe Info  		51.98  LDD2009  [2]
C349
 Probe Info  		88.03  LDD2010  [2]
C350
 Probe Info  		99.73  LDD2011  [2]
C353
 Probe Info  		19.03  LDD2014  [2]
C354
 Probe Info  		24.08  LDD2015  [2]
C355
 Probe Info  		31.12  LDD2016  [2]
C356
 Probe Info  		18.77  LDD2017  [2]
C357
 Probe Info  		14.93  LDD2018  [2]
C362
 Probe Info  		44.63  LDD2023  [2]
C363
 Probe Info  		23.59  LDD2024  [2]
C364
 Probe Info  		26.35  LDD2025  [2]
C366
 Probe Info  		12.55  LDD2027  [2]
C373
 Probe Info  		10.93  LDD2033  [2]
FFF probe11
 Probe Info  		20.00  LDD0471  [3]
FFF probe12
 Probe Info  		16.15  LDD0473  [3]
FFF probe13
 Probe Info  		20.00  LDD0475  [3]
FFF probe14
 Probe Info  		20.00  LDD0477  [3]
FFF probe2
 Probe Info  		20.00  LDD0463  [3]
A-DA
 Probe Info  		2.10  LDD0143  [4]
OEA-DA
 Probe Info  		20.00  LDD0046  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0083  Avasimibe A-549 2.10  LDD0143  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tetraspanin-2 (TSPAN2) Tetraspanin (TM4SF) family O60636

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
3 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
4 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
5 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570