Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C026  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 42 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 28.4
 LDTP02837  Beta-galactosidase (GLB1) 21.0
 LDTP02359  Heme oxygenase 1 (HMOX1) 16.3
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 15.8
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 15.5
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 14.2
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 14.1
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 13.1
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 12.0
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 11.7
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 11.5
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 10.9
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 10.4
 LDTP00697  Cytochrome b5 type B (CYB5B) 9.8
 LDTP00988  Protein O-GlcNAcase (OGA) 8.9
 LDTP09056  Inactive C-alpha-formylglycine-generating enzyme 2 (SUMF2) 8.5
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 8.2
 LDTP05396  Histone-lysine N-methyltransferase 2A (KMT2A) 8.1
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 8.0
 LDTP03540  Heme oxygenase 2 (HMOX2) 7.7
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 7.6
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 7.5
 LDTP09043  Lysine-specific histone demethylase 2 (KDM1B) 7.1
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 7.1
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 6.9
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 6.8
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 6.6
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 6.5
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 6.3
 LDTP02539  Lysosomal acid phosphatase (ACP2) 6.1
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 6.1
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 6.1
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 5.9
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 5.9
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 5.8
 LDTP05408  Antigen peptide transporter 1 (TAP1) 5.7
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 5.7
 LDTP05905  Acid ceramidase (ASAH1) 5.5
 LDTP01640  CCR4-NOT transcription complex subunit 4 (CNOT4) 5.4
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 5.3
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 5.1
 LDTP02505  Lysosomal protective protein (CTSA) 5.1
Transporter and channel
Click to Show/Hide to Show 38 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 73.5
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 37.5
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 32.7
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 28.1
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 26.0
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 22.9
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 20.5
 LDTP11615  Protein tweety homolog 3 (TTYH3) 18.9
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 17.8
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 17.1
 LDTP16813  Tetraspanin-3 (TSPAN3) 15.3
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 13.0
 LDTP13969  Transmembrane emp24 domain-containing protein 7 (TMED7) 12.8
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 12.6
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 12.6
 LDTP00970  Gasdermin-E (GSDME) 10.8
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 10.2
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 9.6
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 9.4
 LDTP08881  Transmembrane protein 199 (TMEM199) 9.3
 LDTP05900  Metaxin-1 (MTX1) 8.9
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 8.8
 LDTP15948  Transmembrane protein 126A (TMEM126A) 8.3
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 8.1
 LDTP17797  Transmembrane protein 104 (TMEM104) 7.8
 LDTP07236  Protein GPR107 (GPR107) 7.7
 LDTP02215  Prosaposin (PSAP) 7.5
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 7.3
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 7.3
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 7.1
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 6.4
 LDTP11213  Nucleoporin NDC1 (NDC1) 6.1
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 6.0
 LDTP09294  Proton-coupled zinc antiporter SLC30A5 (SLC30A5) 5.9
 LDTP12451  Integral membrane protein 2C (ITM2C) 5.8
 LDTP15648  BRI3-binding protein (BRI3BP) 5.6
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 5.5
 LDTP09144  Metal transporter CNNM3 (CNNM3) 5.1
Other
Click to Show/Hide to Show 37 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11143  Centromere protein K (CENPK) 42.5
 LDTP11076  Apolipoprotein L2 (APOL2) 28.1
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 25.5
 LDTP00105  Protein unc-119 homolog B (UNC119B) 22.9
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 20.8
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 16.7
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 13.7
 LDTP05160  Nucleobindin-2 (NUCB2) 13.7
 LDTP05868  Protein unc-119 homolog A (UNC119) 13.5
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 13.0
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 11.4
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 10.9
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 10.8
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 10.4
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 10.0
 LDTP00199  HCLS1-associated protein X-1 (HAX1) 9.8
 LDTP18883  Protein CEBPZOS (CEBPZOS) 8.8
 LDTP14458  Tetraspanin-6 (TSPAN6) 8.8
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 8.0
 LDTP13802  DNA replication complex GINS protein PSF2 (GINS2) 7.9
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 7.7
 LDTP08594  Negative elongation factor C/D (NELFCD) 7.1
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 6.7
 LDTP10056  Protein FAM162A (FAM162A) 6.7
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 6.7
 LDTP01522  Reticulon-3 (RTN3) 6.6
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 6.4
 LDTP08224  Protein LYRIC (MTDH) 6.3
 LDTP15253  HEAT repeat-containing protein 3 (HEATR3) 6.2
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 6.1
 LDTP07934  Synaptic vesicle glycoprotein 2A (SV2A) 5.7
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 5.7
 LDTP12412  Reticulon-4 (RTN4) 5.7
 LDTP13478  Ergosterol biosynthetic protein 28 homolog (ERG28) 5.6
 LDTP01652  Centrosomal protein 43 (CEP43) 5.5
 LDTP03465  General transcription factor IIE subunit 1 (GTF2E1) 5.4
 LDTP00859  Synaptogyrin-2 (SYNGR2) 5.1

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587