Details of the Target

General Information of Target

Target ID LDTP09144
Target Name Metal transporter CNNM3 (CNNM3)
Gene Name CNNM3
Gene ID 26505
Synonyms
ACDP3; Metal transporter CNNM3; Ancient conserved domain-containing protein 3; Cyclin-M3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAVAAAGRLGWLFAALCLGNAAGEAAPGPRVLGFCLEEDGAAGAGWVRGGAARDTPDA
TFLLRLFGPGFANSSWSWVAPEGAGCREEAASPAGEWRALLRLRLRAEAVRPHSALLAVR
VEPGGGAAEEAAPPWALGLGAAGLLALAALARGLQLSALALAPAEVQVLRESGSEAERAA
ARRLEPARRWAGCALGALLLLASLAQAALAVLLYRAAGQRAVPAVLGSAGLVFLVGEVVP
AAVSGRWTLALAPRALGLSRLAVLLTLPVALPVGQLLELAARPGRLRERVLELARGGGDP
YSDLSKGVLRCRTVEDVLTPLEDCFMLDASTVLDFGVLASIMQSGHTRIPVYEEERSNIV
DMLYLKDLAFVDPEDCTPLSTITRFYNHPLHFVFNDTKLDAVLEEFKRGKSHLAIVQKVN
NEGEGDPFYEVLGLVTLEDVIEEIIRSEILDESEDYRDTVVKRKPASLMAPLKRKEEFSL
FKVSDDEYKVTISPQLLLATQRFLSREVDVFSPLRISEKVLLHLLKHPSVNQEVRFDESN
RLATHHYLYQRSQPVDYFILILQGRVEVEIGKEGLKFENGAFTYYGVSALTVPSSVHQSP
VSSLQPIRHDLQPDPGDGTHSSAYCPDYTVRALSDLQLIKVTRLQYLNALLATRAQNLPQ
SPENTDLQVIPGSQTRLLGEKTTTAAGSSHSRPGVPVEGSPGRNPGV
Target Bioclass
Transporter and channel
Family
ACDP family
Subcellular location
Cell membrane
Function Probable metal transporter.
Uniprot ID
Q8NE01
Ensemble ID
ENST00000305510.4
HGNC ID
HGNC:104

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.A148T .
HEC1 SNV: p.G672D .
HEC1B SNV: p.G672D .
HEPG2 SNV: p.D635N .
NOMO1 SNV: p.A3G .
OVCAR4 SNV: p.L677F .
OVISE SNV: p.V49L .
TOV21G SNV: p.R87Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K407(1.59); K475(7.14); K519(7.94); K526(1.23)  LDD0277  [1]
DBIA
 Probe Info  		C376(1.59)  LDD3317  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
Acrolein
 Probe Info  		C625(0.00); C376(0.00)  LDD0217  [6]
W1
 Probe Info  		N.A.  LDD0236  [7]
AOyne
 Probe Info  		8.70  LDD0443  [8]
PAL-AfBPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		7.78  LDD1728  [9]
C026
 Probe Info  		5.06  LDD1732  [9]
C106
 Probe Info  		22.94  LDD1793  [9]
C107
 Probe Info  		5.66  LDD1794  [9]
C108
 Probe Info  		7.94  LDD1795  [9]
C134
 Probe Info  		23.43  LDD1816  [9]
C151
 Probe Info  		20.68  LDD1832  [9]
C153
 Probe Info  		16.11  LDD1834  [9]
C159
 Probe Info  		7.41  LDD1839  [9]
C161
 Probe Info  		10.34  LDD1841  [9]
C170
 Probe Info  		9.32  LDD1850  [9]
C218
 Probe Info  		11.96  LDD1892  [9]
C220
 Probe Info  		13.64  LDD1894  [9]
C288
 Probe Info  		6.15  LDD1958  [9]
C289
 Probe Info  		28.25  LDD1959  [9]
C293
 Probe Info  		21.56  LDD1963  [9]
C310
 Probe Info  		12.73  LDD1977  [9]
C350
 Probe Info  		23.26  LDD2011  [9]
C403
 Probe Info  		14.62  LDD2061  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C376(0.94)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C625(1.08); C376(0.96)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C376(1.22)  LDD1509  [10]
 LDCM0237  AC12 HEK-293T C625(1.13); C376(0.98)  LDD1510  [10]
 LDCM0259  AC14 HEK-293T C376(1.00)  LDD1512  [10]
 LDCM0270  AC15 HEK-293T C376(1.10)  LDD1513  [10]
 LDCM0276  AC17 HEK-293T C376(1.12)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C625(1.05); C376(1.19)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C376(1.01)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C625(1.02); C376(1.15)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C625(0.93); C376(1.08)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C376(1.01)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C376(1.03)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C376(1.01)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C625(1.26); C376(0.94)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C376(1.21)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C625(1.11); C376(1.03)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C376(1.06)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C625(0.97); C376(1.00)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C376(1.01)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C376(1.16)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C376(1.23)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C376(0.96)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C625(0.98); C376(1.00)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C376(1.00)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C625(1.11); C376(1.03)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C376(1.20)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C625(1.39); C376(1.05)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C376(1.01)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C376(1.23)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C376(1.13)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C625(0.84); C376(1.13)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C625(1.03); C376(1.00)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C376(0.91)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C625(1.21); C376(0.79)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C376(1.00)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C625(1.29); C376(1.03)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C376(1.01)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C376(1.14)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C376(1.14)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C625(1.34); C376(0.99)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C376(1.10)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C376(1.01)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C625(1.03); C376(1.16)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C376(1.11)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C625(1.02); C376(0.99)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C376(0.95)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C376(1.13)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C376(1.12)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C625(1.11); C376(1.10)  LDD1558  [10]
 LDCM0320  AC57 HEK-293T C376(0.97)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C625(1.01); C376(1.14)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C376(1.10)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C376(1.16)  LDD1562  [10]
 LDCM0324  AC60 HEK-293T C625(1.14); C376(0.97)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C376(1.04)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C376(0.99)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C376(1.07)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C625(1.17); C376(0.97)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C376(1.08)  LDD1568  [10]
 LDCM0345  AC8 HEK-293T C625(1.08); C376(1.04)  LDD1569  [10]
 LDCM0248  AKOS034007472 HEK-293T C376(0.96)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C376(1.06)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C625(1.06); C376(1.05)  LDD1514  [10]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0367  CL1 HEK-293T C625(1.11); C376(1.31)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C376(1.15)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C625(0.99); C376(1.18)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C625(1.10); C376(1.09)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C625(1.06); C376(0.94)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C376(1.29)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C625(0.95); C376(1.34)  LDD1577  [10]
 LDCM0374  CL105 HEK-293T C625(0.99); C376(1.13)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C625(1.05); C376(0.92)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C376(1.19)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C625(1.11); C376(1.17)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C625(1.10); C376(1.15)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C376(1.03)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C625(1.07); C376(0.93)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C376(1.08)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C625(1.07); C376(1.04)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C625(0.97); C376(1.13)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C625(1.00); C376(0.95)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C376(1.07)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C625(1.02); C376(1.17)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C625(1.13); C376(1.07)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C625(1.15); C376(0.95)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C376(1.30)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C625(1.61); C376(1.23)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C625(1.22); C376(1.26)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C625(1.01); C376(1.10)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C625(0.95); C376(0.93)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C376(0.87)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C625(1.01); C376(1.24)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C625(0.98); C376(1.13)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C625(1.01); C376(0.97)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C376(1.11)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C625(1.08); C376(1.22)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C625(0.91); C376(1.23)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C625(0.89); C376(0.96)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C376(1.09)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C625(1.09); C376(1.32)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C376(1.05)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C625(1.35); C376(1.14)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C376(0.98)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C625(0.93); C376(0.97)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C625(0.98); C376(1.18)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C376(1.00)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C376(1.35)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C376(1.09)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C625(1.13); C376(1.06)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C625(0.95); C376(1.04)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C625(1.18); C376(0.98)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C376(1.11)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C625(1.18); C376(1.09)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C376(0.91)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C376(0.90)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C625(1.44); C376(0.92)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C376(1.04)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C625(1.17); C376(0.96)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C376(0.88)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C376(1.01)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C376(1.19)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C625(1.53); C376(0.99)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C625(0.99); C376(1.09)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C376(1.11)  LDD1632  [10]
 LDCM0429  CL4 HEK-293T C625(1.05); C376(1.20)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C625(1.02); C376(1.16)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C376(0.96)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C625(1.27); C376(1.03)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C376(1.22)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C625(1.36); C376(1.04)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C376(0.72)  LDD1639  [10]
 LDCM0436  CL46 HEK-293T C376(1.02)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C376(0.93)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C625(1.29); C376(0.89)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C625(1.08); C376(1.08)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C376(1.12)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C625(0.87); C376(1.07)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C625(1.08); C376(1.20)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C376(0.87)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C625(1.54); C376(0.99)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C376(1.09)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C625(0.96); C376(1.03)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C376(0.93)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C376(1.10)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C376(1.13)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C625(1.17); C376(1.15)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C625(1.56); C376(1.11)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C625(1.08); C376(1.05)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C625(1.16); C376(0.94)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C376(1.21)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C625(1.00); C376(1.09)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C376(1.00)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C625(1.43); C376(0.96)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C376(1.07)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C625(1.21); C376(1.02)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C376(0.93)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C376(1.06)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C376(1.11)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C376(1.19)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C625(1.31); C376(1.03)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C625(0.99); C376(1.12)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C625(1.11); C376(0.89)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C625(1.08); C376(1.12)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C376(1.05)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C625(1.35); C376(1.02)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C376(1.07)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C625(0.88); C376(0.96)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C625(1.20); C376(1.10)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C376(1.04)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C376(1.01)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C376(1.07)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C625(1.04); C376(1.05)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C625(0.89); C376(1.13)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C625(0.82); C376(1.00)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C376(1.03)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C625(1.06); C376(1.14)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C376(1.03)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C376(1.04)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C625(1.24); C376(1.01)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C376(1.08)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C625(0.92); C376(0.97)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C376(0.98)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C376(1.12)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C376(1.00)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C625(0.90); C376(1.00)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C625(0.98); C376(1.12)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C625(0.92); C376(1.08)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C376(1.11)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C376(1.05)  LDD1698  [10]
 LDCM0468  Fragment33 HEK-293T C376(0.98)  LDD1671  [10]
 LDCM0427  Fragment51 HEK-293T C625(0.93); C376(1.02)  LDD1631  [10]
 LDCM0022  KB02 HEK-293T C376(0.97); C625(0.79)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C376(0.99); C625(0.98)  LDD1497  [10]
 LDCM0024  KB05 MEL182 C376(1.59)  LDD3317  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Anterior gradient protein 2 homolog (AGR2) AGR family O95994
Anterior gradient protein 3 (AGR3) AGR family Q8TD06
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Xaa-Arg dipeptidase (PM20D2) Peptidase M20A family Q8IYS1
Protein disulfide-isomerase (P4HB) Protein disulfide isomerase family P07237
Tensin-2 (TNS2) PTEN phosphatase protein family Q63HR2
Exosome complex component RRP43 (EXOSC8) RNase PH family Q96B26
Protein-glutamine gamma-glutamyltransferase K (TGM1) Transglutaminase family P22735
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-actinin-2 (ACTN2) Alpha-actinin family P35609
MyoD family inhibitor (MDFI) MDFI family Q99750
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Other
Click To Hide/Show 46 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
A-kinase anchor protein 8-like (AKAP8L) AKAP95 family Q9ULX6
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Cyclin-D1-binding protein 1 (CCNDBP1) CCNDBP1 family O95273
Protein chibby homolog 2 (CBY2) Chibby family Q8NA61
Conserved oligomeric Golgi complex subunit 6 (COG6) COG6 family Q9Y2V7
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) Fibulin family O95967
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha3-II (KRT33B) Intermediate filament family Q14525
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
KH domain-containing, RNA-binding, signal transduction-associated protein 2 (KHDRBS2) KHDRBS family Q5VWX1
KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3) KHDRBS family O75525
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 10-5 (KRTAP10-5) KRTAP type 10 family P60370
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Keratin-associated protein 12-2 (KRTAP12-2) KRTAP type 12 family P59991
Keratin-associated protein 12-3 (KRTAP12-3) KRTAP type 12 family P60328
Keratin-associated protein 2-3 (KRTAP2-3) KRTAP type 2 family P0C7H8
Keratin-associated protein 3-1 (KRTAP3-1) KRTAP type 3 family Q9BYR8
Keratin-associated protein 3-2 (KRTAP3-2) KRTAP type 3 family Q9BYR7
Keratin-associated protein 5-9 (KRTAP5-9) KRTAP type 5 family P26371
Keratin-associated protein 9-2 (KRTAP9-2) KRTAP type 9 family Q9BYQ4
Keratin-associated protein 9-3 (KRTAP9-3) KRTAP type 9 family Q9BYQ3
Keratin-associated protein 9-8 (KRTAP9-8) KRTAP type 9 family Q9BYQ0
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Zinc finger protein 330 (ZNF330) NOA36 family Q9Y3S2
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
Paraneoplastic antigen Ma2 (PNMA2) PNMA family Q9UL42
Paraneoplastic antigen Ma3 (PNMA3) PNMA family Q9UL41
Serine/arginine-rich splicing factor 3 (SRSF3) Splicing factor SR family P84103
Brorin (VWC2) . Q2TAL6
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Four and a half LIM domains protein 3 (FHL3) . Q13643
Four and a half LIM domains protein 5 (FHL5) . Q5TD97
Heat shock factor 2-binding protein (HSF2BP) . O75031
Keratin-associated protein 17-1 (KRTAP17-1) . Q9BYP8
Keratinocyte proline-rich protein (KPRP) . Q5T749
RNA-binding motif protein, X chromosome (RBMX) . P38159
RNA-binding motif protein, Y chromosome, family 1 member F/J (RBMY1F; RBMY1J) . Q15415
Ubiquilin-2 (UBQLN2) . Q9UHD9

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402