Details of the Probe

General Information of Probe

Probe ID
LDPC0288
Probe Name
C022
Synonyms
Z4225924154
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 333.8
Lipid-water partition coefficient (xlogp) 3.7
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C17H20ClN3O2
IUPAC Name
N-[2-(3-but-3-ynyldiazirin-3-yl)ethyl]-2-(4-chlorophenoxy)-2-methylpropanamide
Canonical SMILES
CC(C)(C(=O)NCCC1(N=N1)CCC#C)OC2=CC=C(C=C2)Cl
InChI
InChI=1S/C17H20ClN3O2/c1-4-5-10-17(20-21-17)11-12-19-15(22)16(2,3)23-14-8-6-13(18)7-9-14/h1,6-9H,5,10-12H2,2-3H3,(H,19,22)
InChIKey
ONRILYPWNZNSAO-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

134 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
2-hydroxyacylsphingosine 1-beta-galactosyltransferase (UGT8) LDTP06657 13.09  LDD1728 
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) LDTP06325 13.93  LDD1728 
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) LDTP02000 9.71  LDD1728 
3-ketodihydrosphingosine reductase (KDSR) LDTP05476 15.24  LDD1728 
5'-3' exonuclease PLD3 (PLD3) LDTP08476 10.48  LDD1728 
Acid ceramidase (ASAH1) LDTP05905 24.93  LDD1728 
Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (LPGAT1) LDTP09814 7.57  LDD1728 
ADP-dependent glucokinase (ADPGK) LDTP11127 11.55  LDD1728 
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) LDTP04437 18.13  LDD1728 
All-trans-retinol 13,14-reductase (RETSAT) LDTP15097 9.71  LDD1728 
Alpha-galactosidase A (GLA) LDTP02141 8.51  LDD1728 
Alpha-N-acetylglucosaminidase (NAGLU) LDTP04634 14.32  LDD1728 
Antigen peptide transporter 1 (TAP1) LDTP05408 12.13  LDD1728 
Atlastin-2 (ATL2) LDTP09251 7.89  LDD1728 
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) LDTP06618 19.03  LDD1728 
ATP-dependent RNA helicase DHX29 (DHX29) LDTP08064 7.73  LDD1728 
ATP-dependent translocase ABCB1 (ABCB1) LDTP02254 10.70  LDD1728 
ATP-dependent zinc metalloprotease YME1L1 (YME1L1) LDTP10848 6.59  LDD1728 
ATPase family AAA domain-containing protein 3A (ATAD3A) LDTP12681 7.84  LDD1728 
Beta-1,3-galactosyltransferase 6 (B3GALT6) LDTP10530 7.89  LDD1728 
Beta-1,4-glucuronyltransferase 1 (B4GAT1) LDTP00783 8.06  LDD1728 
Beta-galactosidase (GLB1) LDTP02837 16.91  LDD1728 
Beta-hexosaminidase subunit alpha (HEXA) LDTP02169 9.00  LDD1728 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 13.09  LDD1728 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 18.90  LDD1728 
Carbohydrate sulfotransferase 14 (CHST14) LDTP09096 18.25  LDD1728 
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) LDTP03257 11.24  LDD1728 
Cathepsin Z (CTSZ) LDTP13147 7.52  LDD1728 
CCR4-NOT transcription complex subunit 4 (CNOT4) LDTP01640 7.84  LDD1728 
CDGSH iron-sulfur domain-containing protein 1 (CISD1) LDTP12873 21.56  LDD1728 
Ceramide synthase 2 (CERS2) LDTP10329 14.83  LDD1728 
Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) LDTP11178 6.68  LDD1728 
Choline kinase alpha (CHKA) LDTP03787 8.57  LDD1728 
Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) LDTP03189 16.00  LDD1728 
Cytochrome b-c1 complex subunit 8 (UQCRQ) LDTP00486 26.91  LDD1728 
Cytochrome b-c1 complex subunit 9 (UQCR10) LDTP13189 67.18  LDD1728 
Cytochrome b5 type B (CYB5B) LDTP00697 31.34  LDD1728 
Cytochrome c oxidase subunit 2 (MT-CO2) LDTP01773 10.13  LDD1728 
Cytochrome P450 20A1 (CYP20A1) LDTP17410 17.51  LDD1728 
DCN1-like protein 5 (DCUN1D5) LDTP11199 15.78  LDD1728 
Delta(14)-sterol reductase LBR (LBR) LDTP06200 9.65  LDD1728 
Delta(24)-sterol reductase (DHCR24) LDTP06375 16.91  LDD1728 
Dephospho-CoA kinase domain-containing protein (DCAKD) LDTP18087 9.99  LDD1728 
Dihydrofolate reductase (DHFR) LDTP01769 17.15  LDD1728 
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (ALG12) LDTP11259 15.24  LDD1728 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) LDTP04120 9.85  LDD1728 
Dolichyldiphosphatase 1 (DOLPP1) LDTP15328 10.93  LDD1728 
Dynamin-like 120 kDa protein, mitochondrial (OPA1) LDTP00950 9.06  LDD1728 
E3 ubiquitin-protein ligase NEDD4 (NEDD4) LDTP04114 27.28  LDD1728 
Endonuclease domain-containing 1 protein (ENDOD1) LDTP01462 9.99  LDD1728 
Endoplasmic reticulum aminopeptidase 1 (ERAP1) LDTP12868 11.71  LDD1728 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 15.14  LDD1728 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 15.78  LDD1728 
Enolase-phosphatase E1 (ENOPH1) LDTP13314 6.63  LDD1728 
Epoxide hydrolase 1 (EPHX1) LDTP02175 6.73  LDD1728 
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) LDTP09063 6.92  LDD1728 
FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) LDTP10188 19.56  LDD1728 
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (ALG11) LDTP06721 7.11  LDD1728 
Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) LDTP12253 7.78  LDD1728 
Haloacid dehalogenase-like hydrolase domain-containing protein 3 (HDHD3) LDTP15879 8.88  LDD1728 
Heme A synthase COX15 (COX15) LDTP07931 15.14  LDD1728 
Heme oxygenase 1 (HMOX1) LDTP02359 41.36  LDD1728 
Heme oxygenase 2 (HMOX2) LDTP03540 29.04  LDD1728 
Histone-lysine N-methyltransferase 2A (KMT2A) LDTP05396 8.22  LDD1728 
Holocytochrome c-type synthase (HCCS) LDTP04581 7.01  LDD1728 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 19.29  LDD1728 
Isochorismatase domain-containing protein 1 (ISOC1) LDTP19851 6.68  LDD1728 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 11.08  LDD1728 
Lathosterol oxidase (SC5D) LDTP01329 8.69  LDD1728 
Leukotriene A-4 hydrolase (LTA4H) LDTP02385 8.06  LDD1728 
Lipid droplet-associated hydrolase (LDAH) LDTP16007 19.43  LDD1728 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 11.24  LDD1728 
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) LDTP09188 10.56  LDD1728 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 21.71  LDD1728 
Lysosomal acid phosphatase (ACP2) LDTP02539 16.80  LDD1728 
Lysosomal alpha-glucosidase (GAA) LDTP02486 12.47  LDD1728 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 13.45  LDD1728 
Lysosomal protective protein (CTSA) LDTP02505 15.89  LDD1728 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 10.41  LDD1728 
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (MAN1A2) LDTP00975 6.59  LDD1728 
Methylsterol monooxygenase 1 (MSMO1) LDTP06477 15.45  LDD1728 
Minor histocompatibility antigen H13 (HM13) LDTP09396 17.03  LDD1728 
Mitochondrial tRNA-specific 2-thiouridylase 1 (TRMU) LDTP01284 6.73  LDD1728 
Mitofusin-1 (MFN1) LDTP08530 9.32  LDD1728 
N-acetylglucosamine-6-sulfatase (GNS) LDTP02799 9.00  LDD1728 
N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) LDTP11273 32.22  LDD1728 
NAD(P) transhydrogenase, mitochondrial (NNT) LDTP05862 25.28  LDD1728 
NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) LDTP12959 14.12  LDD1728 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 41.36  LDD1728 
NADP-dependent malic enzyme (ME1) LDTP04164 26.17  LDD1728 
NADPH--cytochrome P450 reductase (POR) LDTP02848 8.40  LDD1728 
Pachytene checkpoint protein 2 homolog (TRIP13) LDTP06432 6.68  LDD1728 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 57.28  LDD1728 
Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10) LDTP10101 6.82  LDD1728 
Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) LDTP12720 10.56  LDD1728 
Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) LDTP05029 7.84  LDD1728 
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) LDTP14218 26.35  LDD1728 
Peroxisomal trans-2-enoyl-CoA reductase (PECR) LDTP11437 8.94  LDD1728 
Phospholipase A2 group XV (PLA2G15) LDTP09088 10.20  LDD1728 
Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (PHKA1) LDTP04080 6.92  LDD1728 
Plasma alpha-L-fucosidase (FUCA2) LDTP11215 8.22  LDD1728 
Plasma membrane calcium-transporting ATPase 1 (ATP2B1) LDTP03024 7.52  LDD1728 
Poly [ADP-ribose] polymerase 2 (PARP2) LDTP13240 7.89  LDD1728 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 15.67  LDD1728 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 13.83  LDD1728 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 24.42  LDD1728 
Proteasome subunit beta type-6 (PSMB6) LDTP03418 7.26  LDD1728 
Protein O-GlcNAcase (OGA) LDTP00988 9.32  LDD1728 
Protein O-mannosyl-transferase TMTC3 (TMTC3) LDTP07868 11.63  LDD1728 
Protein SCO2 homolog, mitochondrial (SCO2) LDTP00877 10.78  LDD1728 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 16.68  LDD1728 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 35.02  LDD1728 
Ras-related protein Rab-11B (RAB11B) LDTP06501 9.32  LDD1728 
Ras-related protein Rab-24 (RAB24) LDTP10020 9.00  LDD1728 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 25.99  LDD1728 
Retinol dehydrogenase 13 (RDH13) LDTP09061 7.62  LDD1728 
S-methyl-5'-thioadenosine phosphorylase (MTAP) LDTP05758 20.82  LDD1728 
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) LDTP15484 12.04  LDD1728 
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) LDTP02860 10.13  LDD1728 
Serine palmitoyltransferase 1 (SPTLC1) LDTP00597 8.28  LDD1728 
Serum paraoxonase/arylesterase 2 (PON2) LDTP06333 28.84  LDD1728 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 16.11  LDD1728 
Signal peptidase complex subunit 2 (SPCS2) LDTP06270 6.92  LDD1728 
Soluble calcium-activated nucleotidase 1 (CANT1) LDTP09620 7.73  LDD1728 
Sphingosine-1-phosphate lyase 1 (SGPL1) LDTP01613 14.22  LDD1728 
Squalene monooxygenase (SQLE) LDTP06142 7.46  LDD1728 
Squalene synthase (FDFT1) LDTP03842 15.89  LDD1728 
Thioredoxin-related transmembrane protein 1 (TMX1) LDTP11874 6.82  LDD1728 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 12.21  LDD1728 
V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) LDTP14030 16.68  LDD1728 
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) LDTP12954 9.92  LDD1728 
Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) LDTP06901 7.62  LDD1728 
Vesicle transport protein GOT1B (GOLT1B) LDTP13986 8.40  LDD1728 
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) LDTP08728 29.65  LDD1728 
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⏷ Show the Full List of 134 Enzyme
108 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
45 kDa calcium-binding protein (SDF4) LDTP11116 12.21  LDD1728 
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 16.56  LDD1728 
ADP/ATP translocase 1 (SLC25A4) LDTP02608 8.17  LDD1728 
ADP/ATP translocase 2 (SLC25A5) LDTP02087 7.67  LDD1728 
ADP/ATP translocase 3 (SLC25A6) LDTP02609 10.63  LDD1728 
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) LDTP03284 16.91  LDD1728 
ATP synthase subunit e, mitochondrial (ATP5ME) LDTP14717 7.21  LDD1728 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 24.25  LDD1728 
ATP-binding cassette sub-family F member 3 (ABCF3) LDTP16103 7.52  LDD1728 
B-cell receptor-associated protein 31 (BCAP31) LDTP04426 6.82  LDD1728 
BRI3-binding protein (BRI3BP) LDTP15648 33.82  LDD1728 
Calcium uptake protein 1, mitochondrial (MICU1) LDTP11041 7.26  LDD1728 
Calnexin (CANX) LDTP03405 7.11  LDD1728 
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) LDTP02645 15.24  LDD1728 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 39.95  LDD1728 
Cytoskeleton-associated protein 4 (CKAP4) LDTP05511 17.88  LDD1728 
Derlin-1 (DERL1) LDTP11245 12.47  LDD1728 
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (SLC25A12) LDTP01301 6.54  LDD1728 
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13) LDTP13393 11.16  LDD1728 
Endoplasmic reticulum membrane protein complex subunit 7 (EMC7) LDTP12331 8.69  LDD1728 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 86.82  LDD1728 
Flotillin-1 (FLOT1) LDTP01366 6.68  LDD1728 
Gasdermin-E (GSDME) LDTP00970 16.00  LDD1728 
Growth hormone-inducible transmembrane protein (GHITM) LDTP11869 8.88  LDD1728 
Importin subunit alpha-1 (KPNA2) LDTP04501 13.27  LDD1728 
Importin-9 (IPO9) LDTP10663 8.75  LDD1728 
Integral membrane protein 2C (ITM2C) LDTP12451 14.32  LDD1728 
Intermembrane lipid transfer protein VPS13A (VPS13A) LDTP10769 10.70  LDD1728 
Lipid scramblase CLPTM1L (CLPTM1L) LDTP10499 14.52  LDD1728 
Lysosome membrane protein 2 (SCARB2) LDTP06034 57.28  LDD1728 
Lysosome-associated membrane glycoprotein 1 (LAMP1) LDTP02562 9.71  LDD1728 
Lysosome-associated membrane glycoprotein 2 (LAMP2) LDTP02655 18.00  LDD1728 
Major facilitator superfamily domain-containing protein 3 (MFSD3) LDTP18153 12.82  LDD1728 
Melanoma inhibitory activity protein 2 (MIA2) LDTP10669 10.63  LDD1728 
Membrane-associated progesterone receptor component 1 (PGRMC1) LDTP00235 8.17  LDD1728 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 20.68  LDD1728 
Metal cation symporter ZIP14 (SLC39A14) LDTP06293 8.63  LDD1728 
Metal transporter CNNM3 (CNNM3) LDTP09144 7.78  LDD1728 
Metal transporter CNNM4 (CNNM4) LDTP07537 8.28  LDD1728 
Metaxin-1 (MTX1) LDTP05900 27.28  LDD1728 
MICOS complex subunit MIC26 (APOO) LDTP11250 9.51  LDD1728 
MICOS complex subunit MIC60 (IMMT) LDTP06660 6.96  LDD1728 
Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) LDTP11095 10.13  LDD1728 
Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) LDTP00865 10.20  LDD1728 
Mitochondrial carrier homolog 1 (MTCH1) LDTP12909 12.38  LDD1728 
Mitochondrial carrier homolog 2 (MTCH2) LDTP14235 12.82  LDD1728 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 20.68  LDD1728 
Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) LDTP13983 19.70  LDD1728 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 38.59  LDD1728 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 69.55  LDD1728 
Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) LDTP00477 16.34  LDD1728 
Mitochondrial inner membrane protein OXA1L (OXA1L) LDTP06308 19.16  LDD1728 
Mitochondrial ornithine transporter 1 (SLC25A15) LDTP14200 8.00  LDD1728 
Mitochondrial proton/calcium exchanger protein (LETM1) LDTP01525 10.27  LDD1728 
Mitochondrial thiamine pyrophosphate carrier (SLC25A19) LDTP12210 6.96  LDD1728 
Mpv17-like protein 2 (MPV17L2) LDTP14952 78.25  LDD1728 
Nucleoporin NDC1 (NDC1) LDTP11213 9.00  LDD1728 
PAT complex subunit CCDC47 (CCDC47) LDTP10059 10.85  LDD1728 
Peroxisomal membrane protein 2 (PXMP2) LDTP16069 24.25  LDD1728 
Peroxisomal membrane protein PEX14 (PEX14) LDTP01200 8.06  LDD1728 
Prosaposin (PSAP) LDTP02215 35.51  LDD1728 
Protein FAM8A1 (FAM8A1) LDTP16190 6.96  LDD1728 
Protein GPR107 (GPR107) LDTP07236 15.78  LDD1728 
Protein sel-1 homolog 1 (SEL1L) LDTP13164 10.13  LDD1728 
Protein spinster homolog 1 (SPNS1) LDTP11844 11.96  LDD1728 
Protein tweety homolog 3 (TTYH3) LDTP11615 53.08  LDD1728 
Proton-coupled zinc antiporter SLC30A5 (SLC30A5) LDTP09294 16.80  LDD1728 
Putative divalent cation/proton antiporter TMEM165 (TMEM165) LDTP12207 14.93  LDD1728 
Putative lipid scramblase CLPTM1 (CLPTM1) LDTP01745 16.91  LDD1728 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 12.91  LDD1728 
Secretory carrier-associated membrane protein 2 (SCAMP2) LDTP00547 15.45  LDD1728 
Sideroflexin-4 (SFXN4) LDTP07531 11.39  LDD1728 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 12.73  LDD1728 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 23.92  LDD1728 
Signal recognition particle subunit SRP68 (SRP68) LDTP13262 6.59  LDD1728 
Sodium bicarbonate cotransporter 3 (SLC4A7) LDTP14275 10.34  LDD1728 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 59.71  LDD1728 
Solute carrier family 25 member 33 (SLC25A33) LDTP11162 11.63  LDD1728 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 8.46  LDD1728 
Sorting and assembly machinery component 50 homolog (SAMM50) LDTP14084 7.57  LDD1728 
StAR-related lipid transfer protein 3 (STARD3) LDTP06221 20.53  LDD1728 
StAR-related lipid transfer protein 7, mitochondrial (STARD7) LDTP18459 11.63  LDD1728 
Stomatin (STOM) LDTP03380 14.93  LDD1728 
Surfeit locus protein 4 (SURF4) LDTP00592 8.46  LDD1728 
Synaptojanin-2-binding protein (SYNJ2BP) LDTP04789 9.06  LDD1728 
Syntaxin-5 (STX5) LDTP05780 8.28  LDD1728 
Tetraspanin-3 (TSPAN3) LDTP16813 52.35  LDD1728 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 15.03  LDD1728 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 99.73  LDD1728 
Transmembrane 9 superfamily member 2 (TM9SF2) LDTP15845 6.63  LDD1728 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 14.93  LDD1728 
Transmembrane 9 superfamily member 4 (TM9SF4) LDTP09789 6.54  LDD1728 
Transmembrane emp24 domain-containing protein 10 (TMED10) LDTP04293 7.21  LDD1728 
Transmembrane emp24 domain-containing protein 2 (TMED2) LDTP06365 19.43  LDD1728 
Transmembrane emp24 domain-containing protein 7 (TMED7) LDTP13969 16.11  LDD1728 
Transmembrane protein 104 (TMEM104) LDTP17797 13.36  LDD1728 
Transmembrane protein 126A (TMEM126A) LDTP15948 18.90  LDD1728 
Transmembrane protein 160 (TMEM160) LDTP20002 16.45  LDD1728 
Transmembrane protein 199 (TMEM199) LDTP08881 11.63  LDD1728 
Transmembrane protein 214 (TMEM214) LDTP07477 8.57  LDD1728 
Transmembrane protein 33 (TMEM33) LDTP04787 8.22  LDD1728 
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) LDTP09968 9.71  LDD1728 
V-type proton ATPase subunit S1 (ATP6AP1) LDTP06499 6.92  LDD1728 
Vacuole membrane protein 1 (VMP1) LDTP10343 11.88  LDD1728 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 23.75  LDD1728 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 24.25  LDD1728 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 13.64  LDD1728 
Wolframin (WFS1) LDTP01380 8.40  LDD1728 
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⏷ Show the Full List of 108 Transporter and channel
1 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
DnaJ homolog subfamily C member 1 (DNAJC1) LDTP10501 14.42  LDD1728 
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3 Immunoglobulin Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Basigin (BSG) LDTP03772 10.20  LDD1728 
HLA class I histocompatibility antigen, A alpha chain (HLA-A) LDTP02040 7.84  LDD1728 
Leukocyte surface antigen CD47 (CD47) LDTP05572 7.21  LDD1728 
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84 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A) LDTP03871 8.63  LDD1728 
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 6.73  LDD1728 
Apolipoprotein L2 (APOL2) LDTP11076 98.36  LDD1728 
Bcl-2-like protein 13 (BCL2L13) LDTP11389 7.21  LDD1728 
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) LDTP13755 7.94  LDD1728 
Calumenin (CALU) LDTP00887 7.01  LDD1728 
Centromere protein I (CENPI) LDTP09839 6.54  LDD1728 
Centromere protein K (CENPK) LDTP11143 22.47  LDD1728 
Centrosomal protein 43 (CEP43) LDTP01652 7.16  LDD1728 
Clustered mitochondria protein homolog (CLUH) LDTP14486 10.85  LDD1728 
Collectin-12 (COLEC12) LDTP07031 9.99  LDD1728 
CYFIP-related Rac1 interactor B (CYRIB) LDTP12642 8.00  LDD1728 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 71.51  LDD1728 
DNA replication complex GINS protein PSF2 (GINS2) LDTP13802 9.38  LDD1728 
Dynactin subunit 3 (DCTN3) LDTP01359 7.46  LDD1728 
Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) LDTP08689 16.22  LDD1728 
Emerin (EMD) LDTP04356 8.11  LDD1728 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 14.83  LDD1728 
ER lumen protein-retaining receptor 2 (KDELR2) LDTP03678 43.41  LDD1728 
ER lumen protein-retaining receptor 3 (KDELR3) LDTP00850 31.12  LDD1728 
Ergosterol biosynthetic protein 28 homolog (ERG28) LDTP13478 8.00  LDD1728 
Eukaryotic translation initiation factor 5 (EIF5) LDTP04652 14.52  LDD1728 
Galectin-3-binding protein (LGALS3BP) LDTP05558 8.34  LDD1728 
Ganglioside GM2 activator (GM2A) LDTP02927 17.03  LDD1728 
General transcription factor IIF subunit 1 (GTF2F1) LDTP03729 7.01  LDD1728 
Golgi apparatus protein 1 (GLG1) LDTP09920 8.82  LDD1728 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 27.67  LDD1728 
Golgi phosphoprotein 3 (GOLPH3) LDTP11911 7.94  LDD1728 
HCLS1-associated protein X-1 (HAX1) LDTP00199 7.21  LDD1728 
Heat shock 70 kDa protein 13 (HSPA13) LDTP04207 7.46  LDD1728 
Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) LDTP07891 14.03  LDD1728 
Integrator complex subunit 14 (INTS14) LDTP15834 7.16  LDD1728 
Keratin, type I cytoskeletal 18 (KRT18) LDTP02124 7.52  LDD1728 
Keratinocyte-associated transmembrane protein 2 (KCT2) LDTP19780 25.11  LDD1728 
Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) LDTP03968 8.40  LDD1728 
Large ribosomal subunit protein mL45 (MRPL45) LDTP15863 7.26  LDD1728 
MICOS complex subunit MIC13 (MICOS13) LDTP07274 8.17  LDD1728 
MICOS complex subunit MIC27 (APOOL) LDTP07718 6.54  LDD1728 
Mitochondrial fission factor (MFF) LDTP11670 7.46  LDD1728 
Mitochondrial fission process protein 1 (MTFP1) LDTP16192 30.48  LDD1728 
Mitochondrial import receptor subunit TOM20 homolog (TOMM20) LDTP06373 8.88  LDD1728 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 54.95  LDD1728 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 46.21  LDD1728 
MOB-like protein phocein (MOB4) LDTP13964 10.48  LDD1728 
Motile sperm domain-containing protein 2 (MOSPD2) LDTP09255 6.68  LDD1728 
MRG/MORF4L-binding protein (MRGBP) LDTP12658 10.41  LDD1728 
Negative elongation factor C/D (NELFCD) LDTP08594 12.47  LDD1728 
Neudesin (NENF) LDTP13630 10.20  LDD1728 
Nicastrin (NCSTN) LDTP09787 9.51  LDD1728 
Nucleobindin-1 (NUCB1) LDTP05375 30.06  LDD1728 
Nucleobindin-2 (NUCB2) LDTP05160 46.85  LDD1728 
OCIA domain-containing protein 1 (OCIAD1) LDTP12755 11.71  LDD1728 
Poly(U)-binding-splicing factor PUF60 (PUF60) LDTP13311 53.08  LDD1728 
Programmed cell death protein 5 (PDCD5) LDTP00417 7.46  LDD1728 
Protein CEBPZOS (CEBPZOS) LDTP18883 37.01  LDD1728 
Protein FAM114A2 (FAM114A2) LDTP16080 16.56  LDD1728 
Protein FAM162A (FAM162A) LDTP10056 29.45  LDD1728 
Protein FAM177A1 (FAM177A1) LDTP15398 14.52  LDD1728 
Protein jagunal homolog 1 (JAGN1) LDTP08904 7.78  LDD1728 
Protein LYRIC (MTDH) LDTP08224 15.78  LDD1728 
Protein S100-A13 (S100A13) LDTP10908 6.73  LDD1728 
Protein SET (SET) LDTP05277 7.78  LDD1728 
Protein SYS1 homolog (SYS1) LDTP08796 18.51  LDD1728 
Protein unc-119 homolog A (UNC119) LDTP05868 13.74  LDD1728 
Protein unc-119 homolog B (UNC119B) LDTP00105 14.72  LDD1728 
Reticulocalbin-2 (RCN2) LDTP06097 10.41  LDD1728 
Reticulon-3 (RTN3) LDTP01522 30.48  LDD1728 
Reticulon-4 (RTN4) LDTP12412 20.39  LDD1728 
SLC35A4 upstream open reading frame protein (SLC35A4) LDTP19005 6.68  LDD1728 
Splicing factor U2AF 65 kDa subunit (U2AF2) LDTP03352 10.85  LDD1728 
Superkiller complex protein 3 (SKIC3) LDTP07574 9.32  LDD1728 
Synaptic vesicle glycoprotein 2A (SV2A) LDTP07934 12.30  LDD1728 
Synaptogyrin-2 (SYNGR2) LDTP00859 17.03  LDD1728 
Syntaxin-7 (STX7) LDTP00632 6.59  LDD1728 
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) LDTP14263 9.00  LDD1728 
Tetraspanin-6 (TSPAN6) LDTP14458 26.35  LDD1728 
Thioredoxin-related transmembrane protein 4 (TMX4) LDTP18373 17.39  LDD1728 
TraB domain-containing protein (TRABD) LDTP19963 15.67  LDD1728 
Transducin beta-like protein 2 (TBL2) LDTP16285 10.56  LDD1728 
Ubiquilin-2 (UBQLN2) LDTP13273 6.92  LDD1728 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 34.54  LDD1728 
Uncharacterized protein KIAA2013 (KIAA2013) LDTP17652 8.94  LDD1728 
Vesicle transport protein SEC20 (BNIP1) LDTP05715 9.06  LDD1728 
Vimentin (VIM) LDTP02297 7.06  LDD1728 
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Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1728 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587