Details of the Target

General Information of Target

Target ID LDTP02141
Target Name Alpha-galactosidase A (GLA)
Gene Name GLA
Gene ID 2717
Synonyms
Alpha-galactosidase A; EC 3.2.1.22; Alpha-D-galactosidase A; Alpha-D-galactoside galactohydrolase; Galactosylgalactosylglucosylceramidase GLA; Melibiase; Agalsidase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEP
DSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHGIRQL
ANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENL
ADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEIRQYCNHWRNFADIDDSWKSIK
SILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDL
RHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIG
GPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLENT
MQMSLKDLL
Target Type
Successful
Target Bioclass
Enzyme
Family
Glycosyl hydrolase 27 family
Subcellular location
Lysosome
Function Catalyzes the hydrolysis of glycosphingolipids and participates in their degradation in the lysosome.
TTD ID
T21678
Uniprot ID
P06280
DrugMap ID
TTHF0JV
Ensemble ID
ENST00000218516.4
HGNC ID
HGNC:4296
ChEMBL ID
CHEMBL2524

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 1
 Probe Info  		11.00  LDD0385  [1]
P11
 Probe Info  		17.91  LDD0201  [2]
m-APA
 Probe Info  		11.52  LDD0403  [3]
FBPP2
 Probe Info  		4.00  LDD0054  [4]
DBIA
 Probe Info  		C52(11.48); C63(11.48); C56(4.95); C90(6.45)  LDD0080  [5]
ATP probe
 Probe Info  		K237(0.00); K240(0.00); K393(0.00); K326(0.00)  LDD0199  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [7]
IPM
 Probe Info  		C172(0.00); C174(0.00); C52(0.00); C223(0.00)  LDD2156  [8]
1c-yne
 Probe Info  		K326(0.00); K240(0.00); K314(0.00)  LDD0228  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
AOyne
 Probe Info  		12.20  LDD0443  [11]
NAIA_5
 Probe Info  		C382(0.00); C378(0.00)  LDD2223  [12]
HHS-482
 Probe Info  		Y123(0.79)  LDD2239  [13]
PAL-AfBPP Probe
Click To Hide/Show 77 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		5.54  LDD1714  [14]
C022
 Probe Info  		8.51  LDD1728  [14]
C041
 Probe Info  		6.87  LDD1741  [14]
C045
 Probe Info  		10.20  LDD1744  [14]
C073
 Probe Info  		6.92  LDD1769  [14]
C106
 Probe Info  		21.56  LDD1793  [14]
C108
 Probe Info  		9.58  LDD1795  [14]
C115
 Probe Info  		7.78  LDD1802  [14]
C125
 Probe Info  		4.99  LDD1809  [14]
C140
 Probe Info  		8.11  LDD1822  [14]
C141
 Probe Info  		9.92  LDD1823  [14]
C145
 Probe Info  		9.38  LDD1827  [14]
C147
 Probe Info  		6.59  LDD1829  [14]
C149
 Probe Info  		12.13  LDD1830  [14]
C159
 Probe Info  		7.16  LDD1839  [14]
C160
 Probe Info  		7.57  LDD1840  [14]
C161
 Probe Info  		12.30  LDD1841  [14]
C164
 Probe Info  		10.20  LDD1844  [14]
C170
 Probe Info  		37.01  LDD1850  [14]
C171
 Probe Info  		8.82  LDD1851  [14]
C177
 Probe Info  		9.00  LDD1856  [14]
C178
 Probe Info  		17.88  LDD1857  [14]
C186
 Probe Info  		18.25  LDD1864  [14]
C187
 Probe Info  		21.41  LDD1865  [14]
C194
 Probe Info  		9.58  LDD1870  [14]
C197
 Probe Info  		17.51  LDD1873  [14]
C201
 Probe Info  		28.64  LDD1877  [14]
C206
 Probe Info  		15.24  LDD1881  [14]
C208
 Probe Info  		16.91  LDD1883  [14]
C211
 Probe Info  		9.65  LDD1885  [14]
C219
 Probe Info  		5.24  LDD1893  [14]
C220
 Probe Info  		14.03  LDD1894  [14]
C221
 Probe Info  		14.32  LDD1895  [14]
C223
 Probe Info  		16.56  LDD1897  [14]
C232
 Probe Info  		56.10  LDD1905  [14]
C237
 Probe Info  		10.70  LDD1910  [14]
C249
 Probe Info  		12.64  LDD1922  [14]
C277
 Probe Info  		8.51  LDD1947  [14]
C281
 Probe Info  		8.63  LDD1951  [14]
C288
 Probe Info  		6.50  LDD1958  [14]
C293
 Probe Info  		18.90  LDD1963  [14]
C296
 Probe Info  		12.21  LDD1966  [14]
C302
 Probe Info  		13.93  LDD1971  [14]
C305
 Probe Info  		10.06  LDD1974  [14]
C310
 Probe Info  		26.72  LDD1977  [14]
C314
 Probe Info  		12.38  LDD1981  [14]
C326
 Probe Info  		10.27  LDD1990  [14]
C334
 Probe Info  		6.96  LDD1997  [14]
C336
 Probe Info  		5.70  LDD1999  [14]
C346
 Probe Info  		14.83  LDD2007  [14]
C350
 Probe Info  		32.67  LDD2011  [14]
C355
 Probe Info  		22.63  LDD2016  [14]
C356
 Probe Info  		7.94  LDD2017  [14]
C363
 Probe Info  		17.75  LDD2024  [14]
C369
 Probe Info  		5.62  LDD2030  [14]
C376
 Probe Info  		7.94  LDD2036  [14]
C383
 Probe Info  		12.38  LDD2042  [14]
C386
 Probe Info  		7.94  LDD2045  [14]
C390
 Probe Info  		39.40  LDD2049  [14]
C413
 Probe Info  		14.52  LDD2069  [14]
C419
 Probe Info  		13.36  LDD2074  [14]
C420
 Probe Info  		15.45  LDD2075  [14]
C425
 Probe Info  		22.63  LDD2080  [14]
C431
 Probe Info  		16.11  LDD2086  [14]
FFF probe11
 Probe Info  		13.80  LDD0471  [15]
FFF probe12
 Probe Info  		20.00  LDD0473  [15]
FFF probe13
 Probe Info  		18.63  LDD0475  [15]
FFF probe14
 Probe Info  		14.04  LDD0477  [15]
FFF probe15
 Probe Info  		14.07  LDD0478  [15]
FFF probe2
 Probe Info  		6.28  LDD0463  [15]
FFF probe3
 Probe Info  		13.85  LDD0464  [15]
FFF probe4
 Probe Info  		12.78  LDD0466  [15]
FFF probe6
 Probe Info  		14.20  LDD0482  [15]
FFF probe7
 Probe Info  		10.98  LDD0483  [15]
FFF probe9
 Probe Info  		20.00  LDD0470  [15]
JN0003
 Probe Info  		18.06  LDD0469  [15]
OEA-DA
 Probe Info  		14.28  LDD0046  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C52(0.78); C56(1.34); C63(0.90)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C52(1.79); C63(1.79); C94(1.27)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C172(2.18); C174(2.18); C52(0.60); C63(0.60)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C172(0.96); C174(0.96); C52(0.73); C63(0.73)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C172(1.18); C174(1.18); C52(0.67); C63(0.67)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C172(0.81); C174(0.81); C52(0.67); C63(0.67)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C172(0.83); C174(0.83); C52(0.79); C63(0.79)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C172(1.18); C174(1.18); C52(0.84); C63(0.84)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C172(0.80); C174(0.80); C52(0.72); C63(0.72)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C172(0.86); C174(0.66); C52(0.60); C63(0.60)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C172(1.22); C174(1.42); C52(0.73); C63(0.73)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C172(1.12); C174(1.38); C52(0.76); C63(0.76)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C52(1.31); C63(1.31); C94(0.95)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C172(0.82); C174(0.92); C52(0.83); C63(0.83)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C172(0.94); C174(1.05); C52(0.79); C63(0.79)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C172(0.94); C174(0.94); C52(0.67); C63(0.67)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C52(1.04); C63(1.04)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C52(1.01); C63(1.01)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C52(1.11); C63(1.11)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C52(1.27); C63(1.27)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C52(1.09); C63(1.09)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C52(1.40); C63(1.40)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C52(1.44); C63(1.44)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C52(0.95); C63(0.95); C94(0.95)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C52(1.10); C63(1.10)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C52(1.19); C63(1.19)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C52(1.30); C63(1.30)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C52(0.90); C63(0.90)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C52(1.02); C63(1.02)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C52(1.01); C63(1.01)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C52(1.13); C63(1.13)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C52(1.57); C63(1.57)  LDD0562  [5]
 LDCM0246  AC128 HEK-293T C172(1.18); C174(1.18); C223(1.41); C56(0.99)  LDD0844  [5]
 LDCM0247  AC129 HEK-293T C172(0.85); C174(0.85); C223(1.48); C56(1.40)  LDD0845  [5]
 LDCM0249  AC130 HEK-293T C172(0.77); C174(0.77); C223(1.53); C56(1.19)  LDD0847  [5]
 LDCM0250  AC131 HEK-293T C172(1.18); C174(1.18); C223(1.24); C56(1.06)  LDD0848  [5]
 LDCM0251  AC132 HEK-293T C172(0.87); C174(0.87); C223(1.42); C56(1.17)  LDD0849  [5]
 LDCM0252  AC133 HEK-293T C172(0.77); C174(0.77); C223(1.51); C56(1.33)  LDD0850  [5]
 LDCM0253  AC134 HEK-293T C172(0.91); C174(0.91); C223(1.71); C56(1.68)  LDD0851  [5]
 LDCM0254  AC135 HEK-293T C172(0.80); C174(0.80); C223(1.94); C56(1.22)  LDD0852  [5]
 LDCM0255  AC136 HEK-293T C172(1.01); C174(1.01); C223(2.16); C56(1.46)  LDD0853  [5]
 LDCM0256  AC137 HEK-293T C172(1.02); C174(1.02); C223(1.62); C56(1.68)  LDD0854  [5]
 LDCM0257  AC138 HEK-293T C172(0.92); C174(0.92); C223(2.00); C56(1.70)  LDD0855  [5]
 LDCM0258  AC139 HEK-293T C172(0.86); C174(0.86); C223(2.17); C56(1.86)  LDD0856  [5]
 LDCM0259  AC14 HCT 116 C52(0.95); C63(0.95); C94(0.90)  LDD0576  [5]
 LDCM0260  AC140 HEK-293T C172(0.99); C174(0.99); C223(1.27); C56(1.60)  LDD0858  [5]
 LDCM0261  AC141 HEK-293T C172(1.11); C174(1.11); C223(1.57); C56(1.69)  LDD0859  [5]
 LDCM0262  AC142 HEK-293T C172(1.11); C174(1.11); C223(1.94); C56(1.60)  LDD0860  [5]
 LDCM0263  AC143 HCT 116 C172(1.09); C174(1.09); C52(0.94); C63(0.94)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C52(1.21); C63(1.21); C172(1.22); C174(1.22)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C52(1.14); C63(1.14); C172(1.14); C174(1.14)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C172(0.78); C174(0.78); C52(1.06); C63(1.06)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C52(1.11); C63(1.11); C172(1.40); C174(1.40)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C172(0.55); C174(0.55); C52(1.03); C63(1.03)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C172(0.74); C174(0.74); C52(1.12); C63(1.12)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C94(0.86); C52(1.32); C63(1.32)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C52(1.05); C63(1.05); C172(2.04); C174(2.04)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C52(0.99); C63(0.99); C172(1.11); C174(1.11)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C52(1.10); C63(1.10); C172(1.40); C174(1.40)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C172(0.43); C174(0.43); C52(0.98); C63(0.98)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C172(1.04); C174(1.04); C52(1.20); C63(1.20)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C172(1.11); C174(1.11); C52(1.15); C63(1.15)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C172(1.37); C174(1.37); C52(0.97); C63(0.97)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C172(0.99); C174(0.99); C52(0.98); C63(0.98)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C94(0.88); C52(1.38); C63(1.38)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C94(1.08); C52(1.42); C63(1.42)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C94(1.02); C52(1.85); C63(1.85)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C63(0.89); C52(0.89); C56(0.90)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C94(0.89); C52(1.51); C63(1.51)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C94(0.95); C52(1.62); C63(1.62)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C94(0.88); C52(1.47); C63(1.47)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C94(0.95); C52(1.53); C63(1.53)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C94(0.87); C52(1.29); C63(1.29)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C52(0.68); C63(1.07); C94(1.11); C56(1.46)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C52(1.00); C94(1.10); C63(1.29); C56(1.59)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C52(1.05); C94(1.14); C63(1.16); C56(1.27)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C52(0.82); C63(1.09); C94(1.25); C56(1.37)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C52(0.84); C63(1.17); C94(1.27); C56(1.49)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C52(0.90); C56(0.91); C63(0.93)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C52(1.03); C63(1.17); C94(1.19); C56(1.32)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C52(0.97); C94(1.09); C63(1.30); C56(1.62)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C52(1.02); C94(1.23); C63(1.23); C56(1.44)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C52(0.97); C63(1.25); C94(1.45); C56(1.53)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C52(0.93); C63(1.15); C94(1.28); C56(1.36)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C52(0.88); C63(1.12); C172(1.20); C174(1.20)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C52(0.83); C63(0.97); C172(1.09); C174(1.09)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C56(0.84); C63(0.86); C52(0.88); C172(1.26)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C52(0.90); C63(1.02); C56(1.14); C172(1.14)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C172(0.89); C174(0.89); C52(0.97); C63(1.04)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C52(0.79); C63(0.85); C56(1.10)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C56(0.80); C63(0.81); C52(0.81); C172(0.84)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C172(0.99); C174(0.99); C52(1.03); C63(1.06)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C56(1.09); C63(1.09); C52(1.10); C172(1.11)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C172(1.05); C174(1.05); C52(1.09); C63(1.16)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C52(0.89); C63(1.00); C172(1.05); C174(1.05)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C172(0.80); C174(0.80); C52(0.98); C63(1.03)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C172(0.98); C174(0.98); C52(1.01); C63(1.01)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C172(0.83); C174(0.83); C52(1.16); C63(1.16)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C172(1.02); C174(1.02); C52(1.03); C63(1.03)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C172(0.51); C174(0.51); C52(0.95); C63(0.95)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C52(0.88); C63(0.93); C56(1.05)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C172(0.51); C174(0.51); C52(1.07); C63(1.07)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C52(1.00); C63(1.00); C172(1.29); C174(1.29)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C172(0.68); C174(0.68); C52(0.96); C63(0.96)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C172(0.69); C174(0.69); C52(1.03); C63(1.03)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C172(0.62); C174(0.62); C52(1.10); C63(1.10)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C172(0.45); C174(0.45); C52(1.03); C63(1.03)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C172(0.28); C174(0.28); C52(0.75); C63(0.75)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C52(0.99); C63(0.99); C172(1.01); C174(1.01)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C172(0.68); C174(0.68); C52(1.07); C63(1.07)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C172(0.59); C174(0.59); C52(1.05); C63(1.05)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C94(0.82); C52(1.10); C63(1.10)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C172(0.72); C174(0.72); C52(1.09); C63(1.09)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C172(0.74); C174(0.74); C52(1.18); C63(1.18)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C172(0.55); C174(0.55); C52(1.03); C63(1.03)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C172(0.84); C174(0.84); C52(1.18); C63(1.18)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C172(0.56); C174(0.56); C52(1.06); C63(1.06)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C172(0.60); C174(0.60); C52(1.16); C63(1.16)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C172(0.80); C174(0.80); C52(1.29); C63(1.29)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C172(0.36); C174(0.36); C52(0.88); C63(0.88)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C172(0.91); C174(0.91); C94(0.99); C56(1.03)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C172(0.74); C174(0.74); C94(0.85); C56(1.08)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C94(0.80); C52(1.33); C63(1.33)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C172(0.47); C174(0.47); C94(0.78); C56(0.82)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C56(1.00); C63(1.00); C172(1.12); C174(1.12)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C172(0.71); C174(0.71); C94(0.73); C56(0.98)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C172(0.31); C174(0.31); C94(0.69); C56(1.02)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C172(0.34); C174(0.34); C94(0.67); C56(1.01)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C172(0.20); C174(0.20); C94(0.54); C56(0.83)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C172(0.54); C174(0.54); C94(0.90); C56(1.14)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C172(0.67); C174(0.67); C94(0.98); C56(1.24)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C94(0.90); C172(1.08); C174(1.08); C56(1.19)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C94(0.84); C172(0.84); C174(0.84); C56(1.02)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C52(1.00); C63(1.00); C94(1.28)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C94(0.89); C172(0.92); C174(0.92); C56(1.00)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C94(0.63); C172(0.81); C174(0.81); C56(0.93)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C172(0.13); C174(0.13); C94(0.39); C56(0.68)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C94(0.99); C52(1.46); C63(1.46)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C94(1.06); C52(1.51); C63(1.51)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C94(0.91); C52(1.45); C63(1.45)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C94(1.40); C52(1.56); C63(1.56)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C94(0.92); C52(1.19); C63(1.19)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C94(0.75); C52(1.23); C63(1.23)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C94(0.66); C52(1.23); C63(1.23)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C94(1.10); C52(1.18); C63(1.18)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C94(1.15); C52(1.40); C63(1.40)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C94(0.90); C52(1.46); C63(1.46)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C94(0.71); C52(1.30); C63(1.30)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C94(1.46); C52(1.74); C63(1.74)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C94(0.89); C52(1.25); C63(1.25)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C94(0.91); C52(1.69); C63(1.69)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C94(0.77); C52(1.53); C63(1.53)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C172(0.15); C174(0.15); C52(0.36); C63(0.36)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C52(0.66); C63(0.66); C172(1.16); C174(1.16)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C52(0.82); C63(0.82); C94(1.36)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C94(1.12); C52(1.57); C63(1.57)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C94(1.06); C52(1.46); C63(1.46)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 11.52  LDD0403  [3]
 LDCM0020  ARS-1620 HCC44 C56(1.41); C63(1.41); C52(0.96); C223(0.89)  LDD2171  [5]
 LDCM0088  C45 HEK-293T 17.91  LDD0201  [2]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0367  CL1 HCT 116 C172(0.97); C174(0.97); C56(1.05); C63(1.05)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C172(0.98); C174(0.98); C56(1.14); C63(1.14)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C52(0.81); C63(0.87); C56(1.15)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C52(1.36); C63(1.36); C94(1.49)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C94(1.04); C52(1.11); C63(1.11)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C52(0.97); C63(0.97); C94(1.40)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C94(1.00); C52(1.10); C63(1.10)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C94(1.03); C52(1.87); C63(1.87)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C94(1.16); C52(2.02); C63(2.02)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C94(1.10); C52(1.61); C63(1.61)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C94(1.17); C52(2.03); C63(2.03)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C94(1.03); C52(1.73); C63(1.73)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C172(0.79); C174(0.79); C56(1.27); C63(1.27)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C94(1.11); C52(2.22); C63(2.22)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C94(1.04); C52(1.78); C63(1.78)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C52(0.87); C94(1.02); C63(1.18); C56(1.49)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C52(0.88); C94(1.17); C63(1.31); C56(1.75)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C52(0.89); C63(1.18); C94(1.22); C56(1.47)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C52(0.95); C94(1.11); C63(1.37); C56(1.80)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C52(0.80); C63(1.05); C94(1.18); C56(1.31)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C172(0.50); C174(0.50); C56(0.93); C63(0.93)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C56(0.87); C172(0.88); C174(0.88); C63(0.98)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C52(0.90); C63(0.97); C172(0.98); C174(0.98)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C172(0.66); C174(0.66); C56(1.32); C63(1.32)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C52(1.03); C63(1.05); C56(1.06); C172(1.22)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C172(1.89); C174(1.89); C52(2.15); C63(2.15)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C172(0.76); C174(0.76); C52(1.00); C63(1.00)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C172(0.76); C174(0.76); C52(1.22); C63(1.22)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C172(0.57); C174(0.57); C52(1.16); C63(1.16)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C172(0.95); C174(0.95); C52(1.04); C63(1.04)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C172(0.86); C174(0.86); C52(1.13); C63(1.13)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C172(0.80); C174(0.80); C52(1.30); C63(1.30)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C172(0.63); C174(0.63); C52(1.12); C63(1.12)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C56(1.06); C63(1.06); C172(1.10); C174(1.10)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C172(0.94); C174(0.94); C56(1.06); C63(1.06)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C172(1.11); C174(1.11); C56(1.30); C63(1.30)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C52(0.90); C63(0.93); C56(0.95); C172(0.97)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C172(0.88); C174(0.88); C56(0.89); C52(1.07)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C63(0.90); C172(1.07); C174(1.07); C52(1.08)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C63(1.00); C172(1.05); C174(1.05); C52(1.30)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C56(1.15); C63(1.15); C172(1.16); C174(1.16)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C172(0.71); C174(0.71); C63(1.06); C52(1.09)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C172(0.79); C174(0.79); C63(1.13); C52(1.27)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C172(0.30); C174(0.30); C63(0.67); C52(0.70)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C172(0.71); C174(0.71); C63(0.85); C52(1.00)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C172(0.57); C174(0.57); C63(0.87); C52(1.06)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C172(0.67); C174(0.67); C52(1.10); C56(1.07)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C172(0.75); C174(0.75); C52(1.12); C56(1.58)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C172(0.98); C174(0.98); C52(1.38); C56(2.37)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C172(0.82); C174(0.82); C52(1.13); C56(1.43)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C172(0.71); C174(0.71); C52(1.04); C56(1.18)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C172(1.09); C174(1.09); C56(1.20); C63(1.20)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C172(0.89); C174(0.89); C52(0.92); C56(0.99)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C52(0.96); C63(0.96); C94(1.35)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C52(1.00); C63(1.00); C94(0.97)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C52(0.90); C63(0.90); C94(1.14)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C52(0.84); C63(0.84); C94(0.88)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C52(0.84); C63(0.84); C94(1.17)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C52(0.98); C63(0.98); C94(1.08)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C52(0.89); C63(0.89); C94(1.11)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C52(0.96); C63(0.96); C94(1.01)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C172(0.91); C174(0.91); C56(1.24); C63(1.24)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C52(0.99); C63(0.99); C94(0.91)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C52(1.15); C63(1.15); C94(1.14)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C52(0.63); C63(0.63); C94(1.01)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C52(0.86); C63(0.86); C94(1.22)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C52(0.89); C63(0.89); C94(1.15)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C52(0.91); C63(0.91); C94(1.16)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C52(0.95); C56(0.97); C63(0.97); C94(0.73)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C52(0.91); C56(0.94); C63(0.91); C94(0.68)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C52(0.87); C56(0.92); C63(0.79); C94(0.69)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C52(1.03); C56(1.09); C63(0.98); C94(0.76)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C172(0.86); C174(0.86); C56(1.06); C63(1.06)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C52(1.09); C56(1.16); C63(1.04); C94(1.07)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C52(1.02); C56(1.02); C63(1.05); C94(0.55)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C52(1.10); C56(1.08); C63(1.07); C94(0.90)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C52(1.07); C56(1.19); C63(1.01); C94(0.95)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C52(1.07); C56(1.09); C63(0.97); C94(0.70)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C52(1.01); C56(1.08); C63(0.92); C94(0.68)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C52(0.94); C56(1.03); C63(0.95); C94(0.93)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C52(1.05); C56(1.09); C63(0.97); C94(0.86)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C52(0.89); C56(1.00); C63(0.80); C94(0.84)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C52(0.98); C56(1.05); C63(0.94); C94(1.04)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C172(1.59); C174(1.59); C56(1.26); C63(1.26)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C52(1.05); C56(1.10); C63(1.03); C94(0.74)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C172(1.20); C174(1.20); C52(1.34); C56(1.38)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C172(1.03); C174(1.03); C52(1.15); C56(1.66)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C172(1.00); C174(1.00); C52(1.34); C56(1.39)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C172(0.82); C174(0.82); C52(1.37); C56(1.86)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C172(1.02); C174(1.02); C52(1.19); C56(1.58)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C172(0.70); C174(0.70); C52(1.24); C56(1.58)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C172(0.86); C174(0.86); C52(1.28); C56(1.65)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C172(0.97); C174(0.97); C52(1.29); C56(1.56)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C172(0.95); C174(0.95); C52(1.23); C56(1.23)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C172(0.94); C174(0.94); C56(1.17); C63(1.17)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C172(1.11); C174(1.11); C52(1.39); C56(1.73)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C172(0.77); C174(0.77); C52(1.07); C56(1.91)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C172(1.01); C174(1.01); C52(0.92); C56(1.55)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C172(0.88); C174(0.88); C52(1.25); C56(1.68)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C172(0.85); C174(0.85); C52(1.27); C56(1.80)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C52(0.78); C63(0.78); C94(0.79)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C52(0.96); C63(0.96); C94(0.89)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C52(0.97); C63(0.97); C94(1.10)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C52(1.15); C63(1.15); C94(1.08)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C172(0.57); C174(0.57); C56(0.98); C63(0.98)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C52(0.82); C63(0.82); C94(1.07)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C52(1.12); C63(1.12); C94(0.86)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C52(0.79); C63(0.79); C94(1.01)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C52(0.99); C63(0.99); C94(1.05)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C52(0.76); C63(0.76); C94(0.99)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C52(1.02); C63(1.02); C94(0.95)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C52(1.01); C63(1.01); C94(1.02)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C52(1.14); C63(1.14); C94(1.04)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C52(0.83); C63(0.83); C94(1.24)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C52(0.65); C63(0.65); C94(0.98)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C172(0.84); C174(0.84); C56(1.11); C63(1.11)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C52(0.76); C63(0.76); C94(1.07)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C52(0.91); C56(1.13); C63(0.99)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C52(0.80); C56(1.45); C63(0.96)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C52(0.92); C56(0.97); C63(0.89)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C52(0.89); C56(1.30); C63(1.00)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C52(0.93); C56(1.27); C63(1.03)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C52(0.95); C56(1.08); C63(1.00)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C52(0.94); C56(1.15); C63(1.00)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C52(1.05); C56(1.56); C63(1.15)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C52(1.00); C56(1.32); C63(1.08)  LDD0811  [5]
 LDCM0185  Compound 17 HEK-293T 8.97  LDD0504  [15]
 LDCM0184  Compound 20 HEK-293T 12.86  LDD0503  [15]
 LDCM0186  Compound 31 HEK-293T 8.97  LDD0506  [15]
 LDCM0187  Compound 32 HEK-293T 12.86  LDD0507  [15]
 LDCM0495  E2913 HEK-293T C223(1.08); C202(1.10); C142(1.04); C378(1.07)  LDD1698  [17]
 LDCM0468  Fragment33 HCT 116 C172(0.82); C174(0.82); C52(1.18); C56(1.67)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C52(0.67); C63(0.67); C94(1.03)  LDD0744  [5]
 LDCM0107  IAA HeLa N.A.  LDD0221  [10]
 LDCM0022  KB02 HCT 116 C52(11.48); C63(11.48); C56(4.95); C90(6.45)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C52(14.19); C63(14.19); C56(7.98); C90(13.70)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C52(15.41); C63(15.41); C56(7.65); C90(6.63)  LDD0082  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [10]
 LDCM0099  Phenelzine HEK-293T 3.00  LDD0386  [1]
 LDCM0131  RA190 MM1.R C172(1.52); C174(1.52)  LDD0304  [18]
 LDCM0021  THZ1 HCT 116 C56(1.41); C63(1.41); C52(0.96); C223(0.89)  LDD2173  [5]
 LDCM0008  Tranylcypromine SH-SY5Y 4.00  LDD0054  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sortilin (SORT1) VPS10-related sortilin family Q99523

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Migalastat Small molecular drug D0MU9L
Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Avr-rd-01 Gene therapy DT28NV
Prx-102 . D07URD
Investigative
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(+)-5-deoxyadeenophorine Small molecular drug D0V0WB
2,5-dideoxy-2,5-imino-d-altritol Small molecular drug D0SQ1T
Alpha-d-mannose Small molecular drug D07LUR
Beta-1-c-butenyl-1-deoxygalactonojirimycin Small molecular drug D0RU5N
Beta-1-c-butyl-1-deoxygalactonojirimycin Small molecular drug D07RRH
Calystegine B2 Small molecular drug D0S4DV
Fucose Small molecular drug D0G6XS

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
9 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
16 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.