General Information of Experiment

Probe Name C369  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 13 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 7.5
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 6.3
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 6.2
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 6.1
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 6.1
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 6.0
 LDTP02141  Alpha-galactosidase A (GLA) 5.6
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 5.6
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 5.4
 LDTP07831  Transmembrane protein with metallophosphoesterase domain (TMPPE) 5.4
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 5.3
 LDTP02539  Lysosomal acid phosphatase (ACP2) 5.1
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 5.0
Transporter and channel
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 5.9
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 5.4
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 5.3

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587