Details of the Target

General Information of Target

Target ID	LDTP00865
Target Name	Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20)
Gene Name	SLC25A20
Gene ID	788
Synonyms	CAC; CACT; Mitochondrial carnitine/acylcarnitine carrier protein; Carnitine/acylcarnitine translocase; CAC; CACT; Solute carrier family 25 member 20
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MADQPKPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFR KTLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLS GVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDV PASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTA PPGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKFLNWATPN L
Target Bioclass	Transporter and channel
Family	Mitochondrial carrier (TC 2.A.29) family
Subcellular location	Mitochondrion inner membrane
Function	Mediates the electroneutral exchange of acylcarnitines (O-acyl-(R)-carnitine or L-acylcarnitine) of different acyl chain lengths (ranging from O-acetyl-(R)-carnitine to long-chain O-acyl-(R)-carnitines) with free carnitine ((R)-carnitine or L-carnitine) across the mitochondrial inner membrane, via a ping-pong mechanism (Probable). Key player in the mitochondrial oxidation pathway, it translocates the fatty acids in the form of acylcarnitines into the mitochondrial matrix, where the carnitine palmitoyltransferase 2 (CPT-2) activates them to undergo fatty acid beta-oxidation (Probable). Catalyzes the unidirectional transport (uniport) of carnitine at lower rates than the antiport (exchange).
Uniprot ID	O43772
Ensemble ID	ENST00000319017.5
HGNC ID	HGNC:1421
ChEMBL ID	CHEMBL2216740

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 25 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
Alkylaryl probe 3 Probe Info	20.00	LDD0381	[1]
FBPP2 Probe Info	10.70	LDD0318	[2]
FBP2 Probe Info	6.24	LDD0317	[2]
IBr-1b Probe Info	20.00	LDD0306	[3]
STPyne Probe Info	K157(0.70)	LDD0277	[4]
IPM Probe Info	C155(0.00); C136(0.00); C58(0.00)	LDD0241	[5]
P13 Probe Info	7.56	LDD0203	[6]
BTD Probe Info	C155(0.91)	LDD2117	[7]
Jackson_1 Probe Info	2.13	LDD0120	[8]
EA-probe Probe Info	C58(1.21)	LDD2210	[9]
DBIA Probe Info	C58(1.01); C283(0.99)	LDD0078	[10]
4-Iodoacetamidophenylacetylene Probe Info	N.A.	LDD0038	[11]
IA-alkyne Probe Info	N.A.	LDD0036	[11]
Lodoacetamide azide Probe Info	C155(0.00); C136(0.00)	LDD0037	[11]
JW-RF-010 Probe Info	N.A.	LDD0026	[12]
TFBX Probe Info	C155(0.00); C283(0.00); C136(0.00)	LDD0027	[12]
WYneN Probe Info	N.A.	LDD0021	[13]
WYneO Probe Info	N.A.	LDD0022	[13]
ENE Probe Info	N.A.	LDD0006	[13]
VSF Probe Info	C58(0.00); C155(0.00)	LDD0007	[13]
Acrolein Probe Info	N.A.	LDD0217	[14]
Methacrolein Probe Info	N.A.	LDD0218	[14]
W1 Probe Info	N.A.	LDD0236	[5]
AOyne Probe Info	15.00	LDD0443	[15]
NAIA_5 Probe Info	N.A.	LDD2223	[16]

PAL-AfBPP Probe

Click To Hide/Show 159 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
ILS-1 PP Probe Info	4.62	LDD0417	[17]
C009 Probe Info	7.16	LDD1718	[18]
C018 Probe Info	6.45	LDD1726	[18]
C021 Probe Info	6.02	LDD1727	[18]
C022 Probe Info	10.20	LDD1728	[18]
C027 Probe Info	6.06	LDD1733	[18]
C036 Probe Info	6.59	LDD1736	[18]
C038 Probe Info	6.68	LDD1738	[18]
C039 Probe Info	7.78	LDD1739	[18]
C040 Probe Info	16.34	LDD1740	[18]
C041 Probe Info	11.08	LDD1741	[18]
C048 Probe Info	5.62	LDD1746	[18]
C052 Probe Info	4.92	LDD1750	[18]
C055 Probe Info	13.93	LDD1752	[18]
C059 Probe Info	5.86	LDD1756	[18]
C060 Probe Info	6.96	LDD1757	[18]
C061 Probe Info	6.02	LDD1758	[18]
C062 Probe Info	5.24	LDD1759	[18]
C063 Probe Info	13.74	LDD1760	[18]
C065 Probe Info	5.58	LDD1762	[18]
C068 Probe Info	6.23	LDD1764	[18]
C070 Probe Info	8.63	LDD1766	[18]
C071 Probe Info	8.75	LDD1767	[18]
C072 Probe Info	12.64	LDD1768	[18]
C082 Probe Info	9.45	LDD1774	[18]
C085 Probe Info	8.51	LDD1777	[18]
C102 Probe Info	5.10	LDD1790	[18]
C107 Probe Info	7.46	LDD1794	[18]
C110 Probe Info	5.03	LDD1797	[18]
C116 Probe Info	6.36	LDD1803	[18]
C130 Probe Info	8.28	LDD1812	[18]
C132 Probe Info	6.36	LDD1814	[18]
C137 Probe Info	5.90	LDD1819	[18]
C140 Probe Info	8.34	LDD1822	[18]
C141 Probe Info	10.41	LDD1823	[18]
C142 Probe Info	5.82	LDD1824	[18]
C143 Probe Info	13.27	LDD1825	[18]
C144 Probe Info	5.13	LDD1826	[18]
C145 Probe Info	13.18	LDD1827	[18]
C146 Probe Info	5.10	LDD1828	[18]
C147 Probe Info	7.16	LDD1829	[18]
C149 Probe Info	6.92	LDD1830	[18]
C158 Probe Info	11.16	LDD1838	[18]
C160 Probe Info	9.71	LDD1840	[18]
C161 Probe Info	11.63	LDD1841	[18]
C166 Probe Info	8.06	LDD1846	[18]
C176 Probe Info	6.23	LDD1855	[18]
C177 Probe Info	11.47	LDD1856	[18]
C180 Probe Info	6.41	LDD1859	[18]
C185 Probe Info	6.92	LDD1863	[18]
C187 Probe Info	20.11	LDD1865	[18]
C191 Probe Info	14.93	LDD1868	[18]
C199 Probe Info	6.68	LDD1875	[18]
C211 Probe Info	8.94	LDD1885	[18]
C212 Probe Info	7.84	LDD1886	[18]
C215 Probe Info	8.22	LDD1889	[18]
C216 Probe Info	12.91	LDD1890	[18]
C217 Probe Info	5.98	LDD1891	[18]
C219 Probe Info	5.90	LDD1893	[18]
C222 Probe Info	5.90	LDD1896	[18]
C223 Probe Info	5.82	LDD1897	[18]
C225 Probe Info	6.92	LDD1898	[18]
C226 Probe Info	10.63	LDD1899	[18]
C227 Probe Info	10.93	LDD1900	[18]
C228 Probe Info	16.45	LDD1901	[18]
C229 Probe Info	14.72	LDD1902	[18]
C230 Probe Info	8.40	LDD1903	[18]
C231 Probe Info	15.89	LDD1904	[18]
C233 Probe Info	16.22	LDD1906	[18]
C234 Probe Info	15.67	LDD1907	[18]
C235 Probe Info	22.01	LDD1908	[18]
C236 Probe Info	5.43	LDD1909	[18]
C237 Probe Info	9.25	LDD1910	[18]
C238 Probe Info	11.00	LDD1911	[18]
C239 Probe Info	9.78	LDD1912	[18]
C241 Probe Info	6.73	LDD1914	[18]
C244 Probe Info	17.63	LDD1917	[18]
C248 Probe Info	6.73	LDD1921	[18]
C256 Probe Info	5.43	LDD1929	[18]
C268 Probe Info	6.19	LDD1938	[18]
C269 Probe Info	10.13	LDD1939	[18]
C270 Probe Info	6.59	LDD1940	[18]
C271 Probe Info	5.21	LDD1941	[18]
C272 Probe Info	5.21	LDD1942	[18]
C273 Probe Info	5.43	LDD1943	[18]
C274 Probe Info	6.63	LDD1944	[18]
C279 Probe Info	6.63	LDD1949	[18]
C280 Probe Info	12.91	LDD1950	[18]
C286 Probe Info	7.41	LDD1956	[18]
C290 Probe Info	7.41	LDD1960	[18]
C292 Probe Info	5.31	LDD1962	[18]
C297 Probe Info	6.87	LDD1967	[18]
C300 Probe Info	6.15	LDD1969	[18]
C303 Probe Info	14.52	LDD1972	[18]
C320 Probe Info	8.11	LDD1986	[18]
C322 Probe Info	5.74	LDD1988	[18]
C326 Probe Info	9.65	LDD1990	[18]
C327 Probe Info	7.21	LDD1991	[18]
C328 Probe Info	5.50	LDD1992	[18]
C331 Probe Info	6.15	LDD1994	[18]
C333 Probe Info	6.73	LDD1996	[18]
C339 Probe Info	7.57	LDD2002	[18]
C342 Probe Info	6.82	LDD2004	[18]
C344 Probe Info	5.86	LDD2006	[18]
C346 Probe Info	10.48	LDD2007	[18]
C347 Probe Info	11.24	LDD2008	[18]
C348 Probe Info	14.03	LDD2009	[18]
C351 Probe Info	5.39	LDD2012	[18]
C353 Probe Info	9.38	LDD2014	[18]
C354 Probe Info	18.51	LDD2015	[18]
C356 Probe Info	8.88	LDD2017	[18]
C357 Probe Info	6.23	LDD2018	[18]
C358 Probe Info	5.94	LDD2019	[18]
C359 Probe Info	5.66	LDD2020	[18]
C360 Probe Info	8.00	LDD2021	[18]
C361 Probe Info	21.11	LDD2022	[18]
C367 Probe Info	6.82	LDD2028	[18]
C369 Probe Info	5.31	LDD2030	[18]
C373 Probe Info	7.94	LDD2033	[18]
C374 Probe Info	6.36	LDD2034	[18]
C375 Probe Info	8.11	LDD2035	[18]
C376 Probe Info	7.01	LDD2036	[18]
C378 Probe Info	6.28	LDD2037	[18]
C382 Probe Info	12.04	LDD2041	[18]
C385 Probe Info	5.54	LDD2044	[18]
C386 Probe Info	7.73	LDD2045	[18]
C387 Probe Info	5.28	LDD2046	[18]
C389 Probe Info	11.00	LDD2048	[18]
C390 Probe Info	25.46	LDD2049	[18]
C391 Probe Info	28.84	LDD2050	[18]
C393 Probe Info	22.01	LDD2052	[18]
C394 Probe Info	7.01	LDD2053	[18]
C396 Probe Info	9.25	LDD2055	[18]
C405 Probe Info	5.46	LDD2063	[18]
C409 Probe Info	5.66	LDD2066	[18]
C413 Probe Info	11.63	LDD2069	[18]
C416 Probe Info	5.46	LDD2071	[18]
C424 Probe Info	8.40	LDD2079	[18]
C425 Probe Info	5.28	LDD2080	[18]
C426 Probe Info	18.25	LDD2081	[18]
C429 Probe Info	19.56	LDD2084	[18]
C430 Probe Info	8.63	LDD2085	[18]
C432 Probe Info	7.73	LDD2087	[18]
C433 Probe Info	25.99	LDD2088	[18]
FFF probe11 Probe Info	12.84	LDD0471	[19]
FFF probe12 Probe Info	20.00	LDD0487	[19]
FFF probe13 Probe Info	8.69	LDD0475	[19]
FFF probe14 Probe Info	19.83	LDD0477	[19]
FFF probe15 Probe Info	6.58	LDD0478	[19]
FFF probe2 Probe Info	20.00	LDD0479	[19]
FFF probe3 Probe Info	17.98	LDD0464	[19]
FFF probe4 Probe Info	20.00	LDD0481	[19]
FFF probe6 Probe Info	8.81	LDD0467	[19]
FFF probe7 Probe Info	20.00	LDD0483	[19]
FFF probe9 Probe Info	7.12	LDD0470	[19]
JN0003 Probe Info	14.33	LDD0469	[19]
A-DA Probe Info	3.09	LDD0142	[20]
LD-F Probe Info	A87(0.00); M85(0.00); V88(0.00)	LDD0015	[21]
OEA-DA Probe Info	20.00	LDD0046	[22]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0524	2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide	MDA-MB-231	C155(0.91)	LDD2117	[7]
LDCM0026	4SU-RNA+native RNA	HEK-293T	C283(2.12)	LDD0372	[23]
LDCM0214	AC1	HCT 116	C136(0.95); C155(1.11); C58(0.77)	LDD0531	[10]
LDCM0215	AC10	HCT 116	C136(1.31); C58(0.70)	LDD0532	[10]
LDCM0216	AC100	HCT 116	C155(0.98); C58(0.88)	LDD0533	[10]
LDCM0217	AC101	HCT 116	C155(0.85); C58(0.67)	LDD0534	[10]
LDCM0218	AC102	HCT 116	C155(0.94); C58(0.70)	LDD0535	[10]
LDCM0219	AC103	HCT 116	C155(0.82); C58(0.64)	LDD0536	[10]
LDCM0220	AC104	HCT 116	C155(0.85); C58(0.72)	LDD0537	[10]
LDCM0221	AC105	HCT 116	C155(0.87); C58(0.75)	LDD0538	[10]
LDCM0222	AC106	HCT 116	C155(0.85); C58(0.71)	LDD0539	[10]
LDCM0223	AC107	HCT 116	C155(0.94); C58(0.76)	LDD0540	[10]
LDCM0224	AC108	HCT 116	C155(0.94); C58(0.71)	LDD0541	[10]
LDCM0225	AC109	HCT 116	C155(0.88); C58(0.70)	LDD0542	[10]
LDCM0226	AC11	HCT 116	C136(0.99); C58(0.65)	LDD0543	[10]
LDCM0227	AC110	HCT 116	C155(0.82); C58(0.64)	LDD0544	[10]
LDCM0228	AC111	HCT 116	C155(0.84); C58(0.64)	LDD0545	[10]
LDCM0229	AC112	HCT 116	C155(0.89); C58(0.69)	LDD0546	[10]
LDCM0230	AC113	HCT 116	C155(0.81); C58(0.89)	LDD0547	[10]
LDCM0231	AC114	HCT 116	C155(0.81); C58(0.81)	LDD0548	[10]
LDCM0232	AC115	HCT 116	C155(0.94); C58(0.91)	LDD0549	[10]
LDCM0233	AC116	HCT 116	C155(0.88); C58(0.96)	LDD0550	[10]
LDCM0234	AC117	HCT 116	C155(0.97); C58(1.07)	LDD0551	[10]
LDCM0235	AC118	HCT 116	C155(0.93); C58(0.94)	LDD0552	[10]
LDCM0236	AC119	HCT 116	C155(1.26); C58(0.87)	LDD0553	[10]
LDCM0237	AC12	HCT 116	C136(1.05); C58(0.82)	LDD0554	[10]
LDCM0238	AC120	HCT 116	C155(0.72); C58(0.91)	LDD0555	[10]
LDCM0239	AC121	HCT 116	C155(0.66); C58(1.06)	LDD0556	[10]
LDCM0240	AC122	HCT 116	C155(0.82); C58(0.97)	LDD0557	[10]
LDCM0241	AC123	HCT 116	C155(0.76); C58(1.13)	LDD0558	[10]
LDCM0242	AC124	HCT 116	C155(0.95); C58(0.99)	LDD0559	[10]
LDCM0243	AC125	HCT 116	C155(0.73); C58(0.91)	LDD0560	[10]
LDCM0244	AC126	HCT 116	C155(0.88); C58(0.96)	LDD0561	[10]
LDCM0245	AC127	HCT 116	C155(0.82); C58(0.94)	LDD0562	[10]
LDCM0246	AC128	HCT 116	C136(1.17); C155(0.89); C58(1.06)	LDD0563	[10]
LDCM0247	AC129	HCT 116	C136(0.99); C155(0.81); C58(1.13)	LDD0564	[10]
LDCM0249	AC130	HCT 116	C136(1.08); C155(0.96); C58(0.98)	LDD0566	[10]
LDCM0250	AC131	HCT 116	C136(1.01); C155(0.96); C58(1.07)	LDD0567	[10]
LDCM0251	AC132	HCT 116	C136(1.35); C155(1.03); C58(1.14)	LDD0568	[10]
LDCM0252	AC133	HCT 116	C136(1.12); C155(0.88); C58(1.01)	LDD0569	[10]
LDCM0253	AC134	HCT 116	C136(1.07); C155(1.02); C58(1.02)	LDD0570	[10]
LDCM0254	AC135	HCT 116	C136(1.05); C155(1.07); C58(1.05)	LDD0571	[10]
LDCM0255	AC136	HCT 116	C136(0.96); C155(0.85); C58(1.10)	LDD0572	[10]
LDCM0256	AC137	HCT 116	C136(1.07); C155(0.94); C58(1.17)	LDD0573	[10]
LDCM0257	AC138	HCT 116	C136(1.11); C155(1.00); C58(1.01)	LDD0574	[10]
LDCM0258	AC139	HCT 116	C136(1.22); C155(1.15); C58(1.18)	LDD0575	[10]
LDCM0259	AC14	HCT 116	C136(0.91); C58(0.61)	LDD0576	[10]
LDCM0260	AC140	HCT 116	C136(1.33); C155(1.02); C58(1.13)	LDD0577	[10]
LDCM0261	AC141	HCT 116	C136(1.27); C155(1.08); C58(1.11)	LDD0578	[10]
LDCM0262	AC142	HCT 116	C136(1.01); C155(0.87); C58(0.99)	LDD0579	[10]
LDCM0263	AC143	HCT 116	C58(0.87); C155(0.99)	LDD0580	[10]
LDCM0264	AC144	HCT 116	C58(0.80); C155(1.14)	LDD0581	[10]
LDCM0265	AC145	HCT 116	C58(1.04); C155(1.29)	LDD0582	[10]
LDCM0266	AC146	HCT 116	C58(0.92); C155(1.40)	LDD0583	[10]
LDCM0267	AC147	HCT 116	C58(0.84); C155(1.18)	LDD0584	[10]
LDCM0268	AC148	HCT 116	C58(0.90); C155(1.79)	LDD0585	[10]
LDCM0269	AC149	HCT 116	C58(0.90); C155(2.07)	LDD0586	[10]
LDCM0270	AC15	HCT 116	C58(0.74); C136(1.09)	LDD0587	[10]
LDCM0271	AC150	HCT 116	C58(1.03); C155(1.22)	LDD0588	[10]
LDCM0272	AC151	HCT 116	C58(1.01); C155(1.35)	LDD0589	[10]
LDCM0273	AC152	HCT 116	C58(0.84); C155(1.26)	LDD0590	[10]
LDCM0274	AC153	HCT 116	C58(0.99); C155(1.74)	LDD0591	[10]
LDCM0621	AC154	HCT 116	C155(1.65); C58(0.90)	LDD2158	[10]
LDCM0622	AC155	HCT 116	C155(1.64); C58(1.08)	LDD2159	[10]
LDCM0623	AC156	HCT 116	C155(1.43); C58(1.03)	LDD2160	[10]
LDCM0624	AC157	HCT 116	C155(1.50); C58(0.91)	LDD2161	[10]
LDCM0276	AC17	HCT 116	C58(1.11); C155(1.15)	LDD0593	[10]
LDCM0277	AC18	HCT 116	C155(0.75); C58(0.93)	LDD0594	[10]
LDCM0278	AC19	HCT 116	C155(0.53); C58(1.03)	LDD0595	[10]
LDCM0279	AC2	HCT 116	C155(0.55); C58(0.93); C136(1.11)	LDD0596	[10]
LDCM0280	AC20	HCT 116	C155(0.95); C58(1.08)	LDD0597	[10]
LDCM0281	AC21	HCT 116	C155(0.83); C58(1.03)	LDD0598	[10]
LDCM0282	AC22	HCT 116	C155(0.98); C58(1.04)	LDD0599	[10]
LDCM0283	AC23	HCT 116	C155(0.84); C58(1.28)	LDD0600	[10]
LDCM0284	AC24	HCT 116	C155(0.88); C58(1.15)	LDD0601	[10]
LDCM0285	AC25	HCT 116	C58(0.90); C136(0.99); C155(1.20)	LDD0602	[10]
LDCM0286	AC26	HCT 116	C58(0.88); C136(1.05); C155(1.21)	LDD0603	[10]
LDCM0287	AC27	HCT 116	C58(0.79); C136(0.90); C155(1.21)	LDD0604	[10]
LDCM0288	AC28	HCT 116	C58(0.84); C136(1.10); C155(1.23)	LDD0605	[10]
LDCM0289	AC29	HCT 116	C58(0.80); C136(0.95); C155(1.20)	LDD0606	[10]
LDCM0290	AC3	HCT 116	C58(0.97); C155(1.02); C136(1.11)	LDD0607	[10]
LDCM0291	AC30	HCT 116	C58(0.78); C136(0.85); C155(1.10)	LDD0608	[10]
LDCM0292	AC31	HCT 116	C58(0.82); C155(1.02); C136(1.59)	LDD0609	[10]
LDCM0293	AC32	HCT 116	C58(0.81); C136(0.87); C155(1.14)	LDD0610	[10]
LDCM0294	AC33	HCT 116	C58(0.75); C136(0.81); C155(1.13)	LDD0611	[10]
LDCM0295	AC34	HCT 116	C58(0.82); C136(0.89); C155(1.16)	LDD0612	[10]
LDCM0296	AC35	HCT 116	C155(0.90); C58(1.59)	LDD0613	[10]
LDCM0297	AC36	HCT 116	C155(0.93); C58(0.94)	LDD0614	[10]
LDCM0298	AC37	HCT 116	C155(0.89); C58(0.92)	LDD0615	[10]
LDCM0299	AC38	HCT 116	C155(0.83); C58(0.98)	LDD0616	[10]
LDCM0300	AC39	HCT 116	C155(0.85); C58(1.05)	LDD0617	[10]
LDCM0301	AC4	HCT 116	C155(0.89); C58(0.97); C136(1.12)	LDD0618	[10]
LDCM0302	AC40	HCT 116	C155(0.87); C58(1.04)	LDD0619	[10]
LDCM0303	AC41	HCT 116	C58(0.85); C155(0.89)	LDD0620	[10]
LDCM0304	AC42	HCT 116	C155(0.98); C58(1.06)	LDD0621	[10]
LDCM0305	AC43	HCT 116	C58(0.92); C155(1.05)	LDD0622	[10]
LDCM0306	AC44	HCT 116	C58(0.87); C155(0.91)	LDD0623	[10]
LDCM0307	AC45	HCT 116	C58(0.84); C155(0.87)	LDD0624	[10]
LDCM0308	AC46	HCT 116	C58(0.89); C155(1.11)	LDD0625	[10]
LDCM0309	AC47	HCT 116	C58(0.98); C155(1.52)	LDD0626	[10]
LDCM0310	AC48	HCT 116	C58(0.89); C155(1.21)	LDD0627	[10]
LDCM0311	AC49	HCT 116	C155(0.72); C58(0.96)	LDD0628	[10]
LDCM0312	AC5	HCT 116	C58(0.94); C155(0.95); C136(1.12)	LDD0629	[10]
LDCM0313	AC50	HCT 116	C58(0.87); C155(0.89)	LDD0630	[10]
LDCM0314	AC51	HCT 116	C155(0.80); C58(1.03)	LDD0631	[10]
LDCM0315	AC52	HCT 116	C155(0.64); C58(0.93)	LDD0632	[10]
LDCM0316	AC53	HCT 116	C155(0.86); C58(0.96)	LDD0633	[10]
LDCM0317	AC54	HCT 116	C58(0.97); C155(1.13)	LDD0634	[10]
LDCM0318	AC55	HCT 116	C58(0.98); C155(1.28)	LDD0635	[10]
LDCM0319	AC56	HCT 116	C58(1.00); C155(1.23)	LDD0636	[10]
LDCM0320	AC57	HCT 116	C58(0.82); C155(1.01); C136(1.03)	LDD0637	[10]
LDCM0321	AC58	HCT 116	C58(0.85); C136(0.90); C155(0.99)	LDD0638	[10]
LDCM0322	AC59	HCT 116	C155(0.71); C58(0.88); C136(0.98)	LDD0639	[10]
LDCM0323	AC6	HCT 116	C58(0.64); C136(1.13)	LDD0640	[10]
LDCM0324	AC60	HCT 116	C155(0.75); C58(0.80); C136(1.02)	LDD0641	[10]
LDCM0325	AC61	HCT 116	C58(0.74); C136(0.89); C155(0.91)	LDD0642	[10]
LDCM0326	AC62	HCT 116	C155(0.80); C58(0.86); C136(1.05)	LDD0643	[10]
LDCM0327	AC63	HCT 116	C58(0.74); C155(0.83); C136(0.96)	LDD0644	[10]
LDCM0328	AC64	HCT 116	C58(0.80); C155(0.87); C136(1.18)	LDD0645	[10]
LDCM0329	AC65	HCT 116	C155(0.85); C58(0.95); C136(1.35)	LDD0646	[10]
LDCM0330	AC66	HCT 116	C155(0.85); C58(0.91); C136(1.25)	LDD0647	[10]
LDCM0331	AC67	HCT 116	C58(0.74); C155(0.76); C136(1.27)	LDD0648	[10]
LDCM0332	AC68	HCT 116	C155(0.80); C58(0.93)	LDD0649	[10]
LDCM0333	AC69	HCT 116	C58(0.94); C155(1.06)	LDD0650	[10]
LDCM0334	AC7	HCT 116	C58(0.74); C136(1.11)	LDD0651	[10]
LDCM0335	AC70	HCT 116	C58(0.90); C155(1.09)	LDD0652	[10]
LDCM0336	AC71	HCT 116	C155(0.99); C58(1.12)	LDD0653	[10]
LDCM0337	AC72	HCT 116	C58(0.99); C155(1.20)	LDD0654	[10]
LDCM0338	AC73	HCT 116	C155(1.02); C58(1.06)	LDD0655	[10]
LDCM0339	AC74	HCT 116	C155(0.97); C58(1.08)	LDD0656	[10]
LDCM0340	AC75	HCT 116	C155(0.95); C58(1.07)	LDD0657	[10]
LDCM0341	AC76	HCT 116	C58(1.00); C155(1.26)	LDD0658	[10]
LDCM0342	AC77	HCT 116	C155(0.67); C58(0.88)	LDD0659	[10]
LDCM0343	AC78	HCT 116	C58(0.83); C155(0.99)	LDD0660	[10]
LDCM0344	AC79	HCT 116	C155(1.03); C58(1.07)	LDD0661	[10]
LDCM0345	AC8	HCT 116	C58(0.75); C136(1.11)	LDD0662	[10]
LDCM0346	AC80	HCT 116	C58(0.93); C155(1.03)	LDD0663	[10]
LDCM0347	AC81	HCT 116	C155(1.07); C58(1.09)	LDD0664	[10]
LDCM0348	AC82	HCT 116	C155(0.98); C58(1.13)	LDD0665	[10]
LDCM0349	AC83	HCT 116	C155(0.64); C58(0.88)	LDD0666	[10]
LDCM0350	AC84	HCT 116	C155(0.63); C58(0.84)	LDD0667	[10]
LDCM0351	AC85	HCT 116	C155(0.71); C58(0.85)	LDD0668	[10]
LDCM0352	AC86	HCT 116	C155(0.65); C58(0.94)	LDD0669	[10]
LDCM0353	AC87	HCT 116	C155(0.80); C58(0.96)	LDD0670	[10]
LDCM0354	AC88	HCT 116	C155(0.89); C58(0.95)	LDD0671	[10]
LDCM0355	AC89	HCT 116	C155(0.70); C58(0.78)	LDD0672	[10]
LDCM0357	AC90	HCT 116	C58(1.20); C155(1.57)	LDD0674	[10]
LDCM0358	AC91	HCT 116	C155(0.61); C58(0.84)	LDD0675	[10]
LDCM0359	AC92	HCT 116	C155(0.87); C58(0.90)	LDD0676	[10]
LDCM0360	AC93	HCT 116	C155(0.89); C58(0.90)	LDD0677	[10]
LDCM0361	AC94	HCT 116	C155(0.72); C58(0.91)	LDD0678	[10]
LDCM0362	AC95	HCT 116	C155(0.81); C58(0.90)	LDD0679	[10]
LDCM0363	AC96	HCT 116	C58(0.83); C155(1.09)	LDD0680	[10]
LDCM0364	AC97	HCT 116	C58(0.89); C155(1.05)	LDD0681	[10]
LDCM0365	AC98	HCT 116	C58(0.65); C155(0.86)	LDD0682	[10]
LDCM0366	AC99	HCT 116	C58(0.87); C155(0.96)	LDD0683	[10]
LDCM0248	AKOS034007472	HCT 116	C136(1.29); C58(0.82)	LDD0565	[10]
LDCM0356	AKOS034007680	HCT 116	C58(0.67); C136(0.82)	LDD0673	[10]
LDCM0275	AKOS034007705	HCT 116	C58(0.66); C136(1.02)	LDD0592	[10]
LDCM0020	ARS-1620	HCC44	C58(1.01); C283(0.99)	LDD0078	[10]
LDCM0083	Avasimibe	A-549	2.59	LDD0143	[20]
LDCM0088	C45	HEK-293T	7.56	LDD0203	[6]
LDCM0108	Chloroacetamide	HeLa	N.A.	LDD0222	[14]
LDCM0070	Cisar_cp37	MDA-MB-231	2.13	LDD0120	[8]
LDCM0367	CL1	HCT 116	C136(0.78); C58(1.25)	LDD0684	[10]
LDCM0368	CL10	HCT 116	C136(0.89); C58(0.90)	LDD0685	[10]
LDCM0369	CL100	HCT 116	C58(0.88); C136(0.94); C155(1.03)	LDD0686	[10]
LDCM0370	CL101	HCT 116	C58(0.64); C136(1.01)	LDD0687	[10]
LDCM0371	CL102	HCT 116	C58(0.71); C136(0.94)	LDD0688	[10]
LDCM0372	CL103	HCT 116	C58(0.74); C136(0.80)	LDD0689	[10]
LDCM0373	CL104	HCT 116	C58(0.67); C136(0.94)	LDD0690	[10]
LDCM0374	CL105	HCT 116	C58(0.99); C155(1.17)	LDD0691	[10]
LDCM0375	CL106	HCT 116	C155(0.90); C58(1.12)	LDD0692	[10]
LDCM0376	CL107	HCT 116	C155(0.98); C58(1.12)	LDD0693	[10]
LDCM0377	CL108	HCT 116	C155(1.10); C58(1.25)	LDD0694	[10]
LDCM0378	CL109	HCT 116	C155(0.71); C58(1.21)	LDD0695	[10]
LDCM0379	CL11	HCT 116	C136(0.88); C58(0.98)	LDD0696	[10]
LDCM0380	CL110	HCT 116	C155(0.74); C58(1.14)	LDD0697	[10]
LDCM0381	CL111	HCT 116	C155(0.66); C58(0.94)	LDD0698	[10]
LDCM0382	CL112	HCT 116	C136(0.48); C58(0.93); C155(1.28)	LDD0699	[10]
LDCM0383	CL113	HCT 116	C58(0.86); C136(0.93); C155(1.17)	LDD0700	[10]
LDCM0384	CL114	HCT 116	C58(0.89); C136(0.90); C155(1.07)	LDD0701	[10]
LDCM0385	CL115	HCT 116	C136(0.79); C58(0.83); C155(1.15)	LDD0702	[10]
LDCM0386	CL116	HCT 116	C136(0.83); C58(0.83); C155(1.05)	LDD0703	[10]
LDCM0387	CL117	HCT 116	C155(0.92); C58(1.41)	LDD0704	[10]
LDCM0388	CL118	HCT 116	C155(0.90); C58(0.96)	LDD0705	[10]
LDCM0389	CL119	HCT 116	C155(0.91); C58(0.94)	LDD0706	[10]
LDCM0390	CL12	HCT 116	C136(0.79); C58(1.11)	LDD0707	[10]
LDCM0391	CL120	HCT 116	C155(0.95); C58(1.04)	LDD0708	[10]
LDCM0392	CL121	HCT 116	C58(0.57); C155(1.04)	LDD0709	[10]
LDCM0393	CL122	HCT 116	C155(0.76); C58(0.89)	LDD0710	[10]
LDCM0394	CL123	HCT 116	C58(0.89); C155(1.02)	LDD0711	[10]
LDCM0395	CL124	HCT 116	C58(0.98); C155(1.24)	LDD0712	[10]
LDCM0396	CL125	HCT 116	C155(0.82); C136(0.95); C58(1.01)	LDD0713	[10]
LDCM0397	CL126	HCT 116	C58(0.65); C155(0.77); C136(0.94)	LDD0714	[10]
LDCM0398	CL127	HCT 116	C155(0.77); C58(0.85); C136(0.95)	LDD0715	[10]
LDCM0399	CL128	HCT 116	C58(0.87); C155(1.01); C136(1.13)	LDD0716	[10]
LDCM0400	CL13	HCT 116	C136(0.83); C58(1.00)	LDD0717	[10]
LDCM0401	CL14	HCT 116	C136(0.81); C58(1.09)	LDD0718	[10]
LDCM0402	CL15	HCT 116	C136(0.99); C58(1.03)	LDD0719	[10]
LDCM0403	CL16	HCT 116	C136(0.73); C58(0.82)	LDD0720	[10]
LDCM0404	CL17	HCT 116	C58(0.73); C136(0.81); C155(0.90)	LDD0721	[10]
LDCM0405	CL18	HCT 116	C58(0.63); C136(0.76); C155(1.14)	LDD0722	[10]
LDCM0406	CL19	HCT 116	C58(0.71); C136(0.79); C155(0.95)	LDD0723	[10]
LDCM0407	CL2	HCT 116	C136(0.72); C58(1.30)	LDD0724	[10]
LDCM0408	CL20	HCT 116	C58(0.66); C155(0.81); C136(1.03)	LDD0725	[10]
LDCM0409	CL21	HCT 116	C58(0.65); C155(0.92); C136(0.97)	LDD0726	[10]
LDCM0410	CL22	HCT 116	C155(0.72); C58(0.73); C136(1.16)	LDD0727	[10]
LDCM0411	CL23	HCT 116	C58(0.78); C155(0.97); C136(0.98)	LDD0728	[10]
LDCM0412	CL24	HCT 116	C136(1.18); C155(1.00); C58(0.70)	LDD0729	[10]
LDCM0413	CL25	HCT 116	C136(1.00); C155(1.01); C58(0.71)	LDD0730	[10]
LDCM0414	CL26	HCT 116	C136(0.76); C155(1.13); C58(0.74)	LDD0731	[10]
LDCM0415	CL27	HCT 116	C136(1.30); C155(1.13); C58(0.74)	LDD0732	[10]
LDCM0416	CL28	HCT 116	C136(0.85); C155(1.00); C58(0.63)	LDD0733	[10]
LDCM0417	CL29	HCT 116	C136(0.94); C155(0.58); C58(0.66)	LDD0734	[10]
LDCM0418	CL3	HCT 116	C136(1.02); C58(1.14)	LDD0735	[10]
LDCM0419	CL30	HCT 116	C136(0.85); C155(1.35); C58(0.80)	LDD0736	[10]
LDCM0420	CL31	HCT 116	C136(1.78); C155(1.10); C58(0.83)	LDD0737	[10]
LDCM0421	CL32	HCT 116	C136(0.67); C155(1.17); C58(0.67)	LDD0738	[10]
LDCM0422	CL33	HCT 116	C136(0.90); C155(1.06); C58(0.64)	LDD0739	[10]
LDCM0423	CL34	HCT 116	C136(1.55); C155(1.46); C58(0.75)	LDD0740	[10]
LDCM0424	CL35	HCT 116	C136(1.21); C155(0.99); C58(0.78)	LDD0741	[10]
LDCM0425	CL36	HCT 116	C136(1.39); C155(0.96); C58(0.76)	LDD0742	[10]
LDCM0426	CL37	HCT 116	C136(1.14); C155(1.02); C58(0.80)	LDD0743	[10]
LDCM0428	CL39	HCT 116	C136(1.18); C155(1.09); C58(0.81)	LDD0745	[10]
LDCM0429	CL4	HCT 116	C136(0.78); C58(0.95)	LDD0746	[10]
LDCM0430	CL40	HCT 116	C136(1.20); C155(1.05); C58(0.84)	LDD0747	[10]
LDCM0431	CL41	HCT 116	C136(0.93); C155(0.88); C58(0.79)	LDD0748	[10]
LDCM0432	CL42	HCT 116	C136(1.52); C155(0.88); C58(0.85)	LDD0749	[10]
LDCM0433	CL43	HCT 116	C136(1.23); C155(1.09); C58(0.82)	LDD0750	[10]
LDCM0434	CL44	HCT 116	C136(1.16); C155(0.96); C58(0.70)	LDD0751	[10]
LDCM0435	CL45	HCT 116	C136(1.13); C155(1.08); C58(0.73)	LDD0752	[10]
LDCM0436	CL46	HCT 116	C136(1.09); C155(1.07); C58(1.10)	LDD0753	[10]
LDCM0437	CL47	HCT 116	C136(0.92); C155(0.70); C58(1.12)	LDD0754	[10]
LDCM0438	CL48	HCT 116	C136(1.07); C155(1.02); C58(1.11)	LDD0755	[10]
LDCM0439	CL49	HCT 116	C136(1.21); C155(1.16); C58(1.11)	LDD0756	[10]
LDCM0440	CL5	HCT 116	C136(1.02); C58(1.09)	LDD0757	[10]
LDCM0441	CL50	HCT 116	C136(1.16); C155(0.94); C58(1.14)	LDD0758	[10]
LDCM0442	CL51	HCT 116	C136(1.17); C155(1.01); C58(1.13)	LDD0759	[10]
LDCM0443	CL52	HCT 116	C136(1.25); C155(1.32); C58(0.98)	LDD0760	[10]
LDCM0444	CL53	HCT 116	C136(0.63); C155(0.72); C58(1.08)	LDD0761	[10]
LDCM0445	CL54	HCT 116	C136(1.06); C155(0.96); C58(1.00)	LDD0762	[10]
LDCM0446	CL55	HCT 116	C136(0.98); C155(1.24); C58(1.16)	LDD0763	[10]
LDCM0447	CL56	HCT 116	C136(0.88); C155(0.75); C58(1.03)	LDD0764	[10]
LDCM0448	CL57	HCT 116	C136(0.92); C155(0.61); C58(1.02)	LDD0765	[10]
LDCM0449	CL58	HCT 116	C136(0.88); C155(1.28); C58(1.02)	LDD0766	[10]
LDCM0450	CL59	HCT 116	C136(0.98); C155(0.92); C58(1.14)	LDD0767	[10]
LDCM0451	CL6	HCT 116	C136(0.79); C58(0.93)	LDD0768	[10]
LDCM0452	CL60	HCT 116	C136(1.26); C155(0.96); C58(1.08)	LDD0769	[10]
LDCM0453	CL61	HCT 116	C155(1.12); C58(1.06)	LDD0770	[10]
LDCM0454	CL62	HCT 116	C155(0.94); C58(1.04)	LDD0771	[10]
LDCM0455	CL63	HCT 116	C155(0.84); C58(0.93)	LDD0772	[10]
LDCM0456	CL64	HCT 116	C155(1.04); C58(0.93)	LDD0773	[10]
LDCM0457	CL65	HCT 116	C155(1.11); C58(1.06)	LDD0774	[10]
LDCM0458	CL66	HCT 116	C155(0.92); C58(0.90)	LDD0775	[10]
LDCM0459	CL67	HCT 116	C155(0.95); C58(1.03)	LDD0776	[10]
LDCM0460	CL68	HCT 116	C155(1.03); C58(0.86)	LDD0777	[10]
LDCM0461	CL69	HCT 116	C155(0.79); C58(0.82)	LDD0778	[10]
LDCM0462	CL7	HCT 116	C136(1.02); C58(1.12)	LDD0779	[10]
LDCM0463	CL70	HCT 116	C155(1.13); C58(0.89)	LDD0780	[10]
LDCM0464	CL71	HCT 116	C155(1.04); C58(1.04)	LDD0781	[10]
LDCM0465	CL72	HCT 116	C155(1.14); C58(1.02)	LDD0782	[10]
LDCM0466	CL73	HCT 116	C155(0.97); C58(1.00)	LDD0783	[10]
LDCM0467	CL74	HCT 116	C155(1.01); C58(0.96)	LDD0784	[10]
LDCM0469	CL76	HCT 116	C155(0.97); C58(0.83)	LDD0786	[10]
LDCM0470	CL77	HCT 116	C155(0.97); C58(0.99)	LDD0787	[10]
LDCM0471	CL78	HCT 116	C155(1.16); C58(0.90)	LDD0788	[10]
LDCM0472	CL79	HCT 116	C155(1.03); C58(0.92)	LDD0789	[10]
LDCM0473	CL8	HCT 116	C136(0.86); C58(1.00)	LDD0790	[10]
LDCM0474	CL80	HCT 116	C155(1.19); C58(0.85)	LDD0791	[10]
LDCM0475	CL81	HCT 116	C155(1.15); C58(0.95)	LDD0792	[10]
LDCM0476	CL82	HCT 116	C155(1.23); C58(1.00)	LDD0793	[10]
LDCM0477	CL83	HCT 116	C155(1.08); C58(0.90)	LDD0794	[10]
LDCM0478	CL84	HCT 116	C155(0.98); C58(0.90)	LDD0795	[10]
LDCM0479	CL85	HCT 116	C155(1.02); C58(0.92)	LDD0796	[10]
LDCM0480	CL86	HCT 116	C155(1.01); C58(1.08)	LDD0797	[10]
LDCM0481	CL87	HCT 116	C155(0.92); C58(0.98)	LDD0798	[10]
LDCM0482	CL88	HCT 116	C155(0.96); C58(0.93)	LDD0799	[10]
LDCM0483	CL89	HCT 116	C155(1.40); C58(1.05)	LDD0800	[10]
LDCM0484	CL9	HCT 116	C136(0.82); C58(1.08)	LDD0801	[10]
LDCM0485	CL90	HCT 116	C155(1.20); C58(1.18)	LDD0802	[10]
LDCM0486	CL91	HCT 116	C136(1.04); C155(1.17); C58(0.86)	LDD0803	[10]
LDCM0487	CL92	HCT 116	C136(0.98); C155(1.17); C58(0.94)	LDD0804	[10]
LDCM0488	CL93	HCT 116	C136(0.90); C155(0.73); C58(0.98)	LDD0805	[10]
LDCM0489	CL94	HCT 116	C136(0.96); C155(1.07); C58(0.80)	LDD0806	[10]
LDCM0490	CL95	HCT 116	C136(0.94); C155(0.92); C58(0.83)	LDD0807	[10]
LDCM0491	CL96	HCT 116	C136(1.04); C155(1.33); C58(0.84)	LDD0808	[10]
LDCM0492	CL97	HCT 116	C136(1.03); C155(1.22); C58(0.80)	LDD0809	[10]
LDCM0493	CL98	HCT 116	C136(0.97); C155(1.12); C58(0.90)	LDD0810	[10]
LDCM0494	CL99	HCT 116	C136(0.77); C155(0.82); C58(0.84)	LDD0811	[10]
LDCM0189	Compound 16	HEK-293T	9.30	LDD0492	[19]
LDCM0185	Compound 17	HEK-293T	3.02	LDD0504	[19]
LDCM0182	Compound 18	HEK-293T	5.39	LDD0501	[19]
LDCM0184	Compound 20	HEK-293T	13.61	LDD0503	[19]
LDCM0191	Compound 21	HEK-293T	3.55	LDD0508	[19]
LDCM0187	Compound 32	HEK-293T	19.61	LDD0507	[19]
LDCM0190	Compound 34	HEK-293T	6.12	LDD0497	[19]
LDCM0192	Compound 35	HEK-293T	3.94	LDD0509	[19]
LDCM0193	Compound 36	HEK-293T	9.39	LDD0494	[19]
LDCM0194	Compound 37	HEK-293T	4.41	LDD0498	[19]
LDCM0195	Compound 38	HEK-293T	5.80	LDD0499	[19]
LDCM0196	Compound 39	HEK-293T	11.70	LDD0496	[19]
LDCM0197	Compound 40	HEK-293T	15.50	LDD0495	[19]
LDCM0183	Compound 42	HEK-293T	8.33	LDD0500	[19]
LDCM0495	E2913	HEK-293T	C136(1.04); C283(1.01); C155(0.91); C58(1.10)	LDD1698	[24]
LDCM0175	Ethacrynic acid	HeLa	C58(1.21)	LDD2210	[9]
LDCM0625	F8	Ramos	C155(0.99); C136(0.91); C58(1.49)	LDD2187	[25]
LDCM0082	FK866	A-549	3.09	LDD0142	[20]
LDCM0572	Fragment10	Ramos	C155(1.65); C136(0.99); C58(3.57)	LDD2189	[25]
LDCM0573	Fragment11	Ramos	C155(0.26); C136(0.16); C58(0.31)	LDD2190	[25]
LDCM0574	Fragment12	Ramos	C155(2.29); C136(2.24); C58(3.93)	LDD2191	[25]
LDCM0575	Fragment13	Ramos	C155(1.12); C136(1.21); C58(1.51)	LDD2192	[25]
LDCM0576	Fragment14	Ramos	C155(1.32); C136(1.40); C58(2.00)	LDD2193	[25]
LDCM0579	Fragment20	Ramos	C155(1.25); C136(1.61); C58(2.27)	LDD2194	[25]
LDCM0580	Fragment21	Ramos	C155(1.01); C136(0.90); C58(1.16)	LDD2195	[25]
LDCM0582	Fragment23	Ramos	C155(1.18); C136(1.15); C58(1.26)	LDD2196	[25]
LDCM0578	Fragment27	Ramos	C155(1.20); C136(0.87); C58(0.91)	LDD2197	[25]
LDCM0586	Fragment28	Ramos	C155(0.67); C136(1.07); C58(1.01)	LDD2198	[25]
LDCM0588	Fragment30	Ramos	C155(1.07); C136(1.06); C58(1.21)	LDD2199	[25]
LDCM0589	Fragment31	Ramos	C155(0.80); C136(0.90); C58(1.02)	LDD2200	[25]
LDCM0590	Fragment32	Ramos	C155(1.80); C136(1.30); C58(2.65)	LDD2201	[25]
LDCM0468	Fragment33	HCT 116	C155(1.08); C58(0.91)	LDD0785	[10]
LDCM0596	Fragment38	Ramos	C155(1.07); C136(0.81); C58(0.91)	LDD2203	[25]
LDCM0566	Fragment4	Ramos	C155(1.61); C136(1.34); C58(2.04)	LDD2184	[25]
LDCM0427	Fragment51	HCT 116	C136(1.82); C155(1.06); C58(0.80)	LDD0744	[10]
LDCM0610	Fragment52	Ramos	C155(1.63); C136(1.90); C58(1.82)	LDD2204	[25]
LDCM0614	Fragment56	Ramos	C155(1.07); C136(1.33); C58(0.94)	LDD2205	[25]
LDCM0569	Fragment7	Ramos	C155(2.76); C136(1.29); C58(2.19)	LDD2186	[25]
LDCM0571	Fragment9	Ramos	C155(1.53); C136(1.38); C58(2.64)	LDD2188	[25]
LDCM0022	KB02	HCT 116	C58(5.90)	LDD0080	[10]
LDCM0023	KB03	HCT 116	C58(1.79)	LDD0081	[10]
LDCM0024	KB05	HCT 116	C58(9.57)	LDD0082	[10]
LDCM0531	Nucleophilic fragment 28b	MDA-MB-231	C136(0.68)	LDD2124	[7]
LDCM0532	Nucleophilic fragment 29a	MDA-MB-231	C155(1.17)	LDD2125	[7]
LDCM0628	OTUB2-COV-1	HEK-293T	C155(2.00); C58(1.00); C283(0.48)	LDD2207	[26]
LDCM0131	RA190	MM1.R	C136(1.79); C58(1.62)	LDD0304	[27]
LDCM0084	Ro 48-8071	A-549	4.60	LDD0145	[20]
LDCM0136	SR-4559	HEK-293T	4.76	LDD0330	[22]
LDCM0021	THZ1	HCT 116	C58(0.96)	LDD2173	[10]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved

Click To Hide/Show 1 Drug(s) Interacting with This Target

Drug Name				Drug Type	External ID
Levocarnitine				Small molecular drug	DB00583

References

1	Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2	Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1. Mass spectrometry data entry: PXD018580
3	Site-Specific Labeling of Endogenous Proteins Using CoLDR Chemistry. J Am Chem Soc. 2021 Dec 8;143(48):20095-20108. doi: 10.1021/jacs.1c06167. Epub 2021 Nov 24.
4	A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10. Mass spectrometry data entry: PXD028270
5	Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6	Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
7	Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29. Mass spectrometry data entry: PXD039908 , PXD029761
8	Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
9	Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
10	Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11	Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23. Mass spectrometry data entry: PXD028853
12	Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24. Mass spectrometry data entry: PXD029255
13	A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21. Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15	Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16	N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w. Mass spectrometry data entry: PXD041264
17	A Chemical Proteomic Analysis of Illudin-Interacting Proteins. Chemistry. 2019 Sep 25;25(54):12644-12651. doi: 10.1002/chem.201902919. Epub 2019 Sep 3. Mass spectrometry data entry: PXD014175
18	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587
19	Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20	A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
21	Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b. Mass spectrometry data entry: PXD025652
22	Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20. Mass spectrometry data entry: PXD007570
23	Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z. Mass spectrometry data entry: PXD044625
24	Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19. Mass spectrometry data entry: PXD044402
25	Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7. Mass spectrometry data entry: PXD027578
26	Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
27	Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.

Details of the Target

Citation

Visitor Map

Correspondence

Prof. Feng Zhu

Prof. Feng Ni