Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C433  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 67 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP07054  Exosome complex component MTR3 (EXOSC6) 27.9
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 25.3
 LDTP03145  Catechol O-methyltransferase (COMT) 23.9
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 22.5
 LDTP01803  Adenosine deaminase (ADA) 18.5
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 17.9
 LDTP03540  Heme oxygenase 2 (HMOX2) 17.8
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 16.8
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 16.1
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 16.0
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 16.0
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 15.8
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 14.1
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 13.4
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 12.8
 LDTP03680  DNA replication licensing factor MCM4 (MCM4) 12.6
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 11.6
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 11.4
 LDTP02359  Heme oxygenase 1 (HMOX1) 11.2
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 11.0
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 10.9
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 10.7
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 10.6
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 10.1
 LDTP06384  Ribosomal protein S6 kinase alpha-1 (RPS6KA1) 10.1
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 9.9
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 9.7
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 9.5
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 9.4
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 9.3
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 8.7
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 8.6
 LDTP01419  Retinal dehydrogenase 2 (ALDH1A2) 8.5
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 8.5
 LDTP00697  Cytochrome b5 type B (CYB5B) 8.4
 LDTP08265  N-alpha-acetyltransferase 40 (NAA40) 8.3
 LDTP03560  Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) 8.2
 LDTP00589  Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) 8.2
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 8.1
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 7.9
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 7.9
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 7.9
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 7.8
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 7.7
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 7.6
 LDTP11225  Deoxyhypusine hydroxylase (DOHH) 7.5
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 7.4
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 7.3
 LDTP04581  Holocytochrome c-type synthase (HCCS) 7.0
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 6.9
 LDTP02837  Beta-galactosidase (GLB1) 6.8
 LDTP04120  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) 6.7
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 6.6
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 6.5
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 6.5
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 6.5
 LDTP10862  Proteasome subunit beta type-7 (PSMB7) 6.4
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 6.4
 LDTP02505  Lysosomal protective protein (CTSA) 6.2
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 6.0
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 6.0
 LDTP00639  ATP-binding cassette sub-family C member 4 (ABCC4) 5.9
 LDTP10329  Ceramide synthase 2 (CERS2) 5.9
 LDTP04248  Deoxyhypusine synthase (DHPS) 5.8
 LDTP01743  NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) 5.8
 LDTP04689  Adenosine kinase (ADK) 5.7
 LDTP04090  Transcriptional regulator ATRX (ATRX) 5.6
Transporter and channel
Click to Show/Hide to Show 39 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 61.4
 LDTP07236  Protein GPR107 (GPR107) 39.4
 LDTP07667  Transmembrane protein 205 (TMEM205) 34.8
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 32.7
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 26.0
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 26.0
 LDTP07462  MFS-type transporter SLC18B1 (SLC18B1) 25.8
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 22.2
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 20.0
 LDTP01804  ATP synthase subunit a (MT-ATP6) 19.6
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 15.6
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 15.2
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 14.5
 LDTP08016  Proton-coupled amino acid transporter 1 (SLC36A1) 14.2
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 14.0
 LDTP02215  Prosaposin (PSAP) 13.9
 LDTP08881  Transmembrane protein 199 (TMEM199) 13.2
 LDTP12383  Protein GPR108 (GPR108) 11.6
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 11.6
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 9.6
 LDTP04592  Monocarboxylate transporter 1 (SLC16A1) 9.5
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 9.1
 LDTP20002  Transmembrane protein 160 (TMEM160) 8.7
 LDTP03952  Reduced folate transporter (SLC19A1) 8.6
 LDTP04956  Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) 8.5
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 8.5
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 7.2
 LDTP03061  Cation-dependent mannose-6-phosphate receptor (M6PR) 7.2
 LDTP12451  Integral membrane protein 2C (ITM2C) 6.8
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 6.8
 LDTP05538  Prolow-density lipoprotein receptor-related protein 1 (LRP1) 6.6
 LDTP05900  Metaxin-1 (MTX1) 6.4
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 6.2
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 6.1
 LDTP11844  Protein spinster homolog 1 (SPNS1) 6.1
 LDTP09294  Proton-coupled zinc antiporter SLC30A5 (SLC30A5) 5.9
 LDTP03869  Protein Mpv17 (MPV17) 5.9
 LDTP03546  Translocator protein (TSPO) 5.8
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 5.6
Other
Click to Show/Hide to Show 48 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15269  Large ribosomal subunit protein mL55 (MRPL55) 57.3
 LDTP15623  Neuferricin (CYB5D2) 42.5
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 18.0
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 17.3
 LDTP00105  Protein unc-119 homolog B (UNC119B) 16.7
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 15.5
 LDTP06097  Reticulocalbin-2 (RCN2) 14.4
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 13.6
 LDTP15714  Mdm2-binding protein (MTBP) 11.2
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 10.9
 LDTP05160  Nucleobindin-2 (NUCB2) 10.8
 LDTP01652  Centrosomal protein 43 (CEP43) 9.4
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 9.3
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 9.1
 LDTP01359  Dynactin subunit 3 (DCTN3) 8.9
 LDTP19963  TraB domain-containing protein (TRABD) 8.8
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 8.7
 LDTP01638  YEATS domain-containing protein 4 (YEATS4) 8.6
 LDTP02297  Vimentin (VIM) 7.9
 LDTP13630  Neudesin (NENF) 7.6
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 7.5
 LDTP14458  Tetraspanin-6 (TSPAN6) 7.4
 LDTP00871  Microtubule nucleation factor SSNA1 (SSNA1) 7.4
 LDTP16080  Protein FAM114A2 (FAM114A2) 7.3
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 7.0
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 7.0
 LDTP06022  Cold-inducible RNA-binding protein (CIRBP) 6.6
 LDTP06527  Alpha-internexin (INA) 6.5
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 6.4
 LDTP19867  Protein FAM89A (FAM89A) 6.4
 LDTP07221  Myomegalin (PDE4DIP) 6.4
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 6.3
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 6.1
 LDTP09920  Golgi apparatus protein 1 (GLG1) 6.1
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 6.1
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 6.0
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 6.0
 LDTP06255  GTPase-activating protein and VPS9 domain-containing protein 1 (GAPVD1) 5.9
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) 5.9
 LDTP11995  WD repeat and coiled-coil-containing protein (WDCP) 5.9
 LDTP00880  A-kinase anchor protein 8 (AKAP8) 5.9
 LDTP00887  Calumenin (CALU) 5.9
 LDTP12468  Diablo IAP-binding mitochondrial protein (DIABLO) 5.9
 LDTP14259  Testis-expressed protein 264 (TEX264) 5.9
 LDTP08606  Nurim (NRM) 5.7
 LDTP10403  DDRGK domain-containing protein 1 (DDRGK1) 5.7
 LDTP05375  Nucleobindin-1 (NUCB1) 5.6
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 5.6

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587