Details of the Target

General Information of Target

Target ID LDTP04652
Target Name Eukaryotic translation initiation factor 5 (EIF5)
Gene Name EIF5
Gene ID 1983
Synonyms
Eukaryotic translation initiation factor 5; eIF-5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSVNVNRSVSDQFYRYKMPRLIAKVEGKGNGIKTVIVNMVDVAKALNRPPTYPTKYFGCE
LGAQTQFDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPECENPETDLHVNPKKQTIGN
SCKACGYRGMLDTHHKLCTFILKNPPENSDSGTGKKEKEKKNRKGKDKENGSVSSSETPP
PPPPPNEINPPPHTMEEEEDDDWGEDTTEEAQRRRMDEISDHAKVLTLSDDLERTIEERV
NILFDFVKKKKEEGVIDSSDKEIVAEAERLDVKAMGPLVLTEVLFNEKIREQIKKYRRHF
LRFCHNNKKAQRYLLHGLECVVAMHQAQLISKIPHILKEMYDADLLEEEVIISWSEKASK
KYVSKELAKEIRVKAEPFIKWLKEAEEESSGGEEEDEDENIEVVYSKAASVPKVETVKSD
NKDDDIDIDAI
Target Bioclass
Other
Family
EIF-2-beta/eIF-5 family
Function
Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. In this complex, acts as a GTPase-activating protein, by promoting GTP hydrolysis by eIF2G (EIF2S3). During scanning, interacts with both EIF1 (via its C-terminal domain (CTD)) and EIF1A (via its NTD). This interaction with EIF1A contributes to the maintenance of EIF1 within the open 43S PIC. When start codon is recognized, EIF5, via its NTD, induces eIF2G (EIF2S3) to hydrolyze the GTP. Start codon recognition also induces a conformational change of the PIC to a closed state. This change increases the affinity of EIF5-CTD for EIF2-beta (EIF2S2), which allows the release, by an indirect mechanism, of EIF1 from the PIC. Finally, EIF5 stabilizes the PIC in its closed conformation.
Uniprot ID
P55010
Ensemble ID
ENST00000216554.8
HGNC ID
HGNC:3299

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
FBPP2
 Probe Info  		2.23  LDD0318  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
C-Sul
 Probe Info  		2.85  LDD0066  [4]
TH211
 Probe Info  		Y52(20.00)  LDD0257  [5]
STPyne
 Probe Info  		K115(0.44); K224(10.00); K24(4.62); K248(0.55)  LDD0277  [6]
Probe 1
 Probe Info  		Y14(30.53); Y52(22.45); Y74(62.38)  LDD3495  [7]
THZ1-DTB
 Probe Info  		C102(1.17)  LDD0460  [8]
BTD
 Probe Info  		C304(2.55); C122(1.15)  LDD1700  [9]
WP
 Probe Info  		2.25  LDD0192  [10]
HHS-465
 Probe Info  		Y313(9.37); Y52(10.00)  LDD2237  [11]
DBIA
 Probe Info  		C320(0.99); C122(0.89)  LDD0078  [12]
ATP probe
 Probe Info  		K365(0.00); K115(0.00); K95(0.00); K114(0.00)  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C138(0.00); C122(0.00); C59(0.00); C320(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C59(0.00); C122(0.00)  LDD0032  [15]
Lodoacetamide azide
 Probe Info  		C138(0.00); C59(0.00); C320(0.00); C304(0.00)  LDD0037  [14]
ATP probe
 Probe Info  		N.A.  LDD0035  [16]
Compound 10
 Probe Info  		N.A.  LDD2216  [17]
IPM
 Probe Info  		N.A.  LDD0005  [18]
NHS
 Probe Info  		N.A.  LDD0010  [18]
PF-06672131
 Probe Info  		N.A.  LDD0017  [19]
TFBX
 Probe Info  		C122(0.00); C138(0.00); C304(0.00); C99(0.00)  LDD0148  [20]
1c-yne
 Probe Info  		K55(0.00); K273(0.00); K33(0.00)  LDD0228  [21]
Acrolein
 Probe Info  		C102(0.00); C99(0.00)  LDD0217  [22]
Methacrolein
 Probe Info  		N.A.  LDD0218  [22]
W1
 Probe Info  		C99(0.00); C102(0.00); C122(0.00); C138(0.00)  LDD0236  [23]
AOyne
 Probe Info  		15.00  LDD0443  [24]
NAIA_5
 Probe Info  		C59(0.00); C304(0.00); C99(0.00); C138(0.00)  LDD2223  [25]
HHS-482
 Probe Info  		Y313(1.00)  LDD2239  [11]
PAL-AfBPP Probe
Click To Hide/Show 120 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		5.03  LDD1711  [26]
C004
 Probe Info  		29.86  LDD1714  [26]
C022
 Probe Info  		14.52  LDD1728  [26]
C041
 Probe Info  		9.00  LDD1741  [26]
C056
 Probe Info  		26.35  LDD1753  [26]
C063
 Probe Info  		31.56  LDD1760  [26]
C087
 Probe Info  		10.41  LDD1779  [26]
C106
 Probe Info  		43.41  LDD1793  [26]
C108
 Probe Info  		10.85  LDD1795  [26]
C112
 Probe Info  		21.71  LDD1799  [26]
C129
 Probe Info  		7.06  LDD1811  [26]
C138
 Probe Info  		4.92  LDD1820  [26]
C139
 Probe Info  		11.00  LDD1821  [26]
C141
 Probe Info  		9.00  LDD1823  [26]
C145
 Probe Info  		9.19  LDD1827  [26]
C147
 Probe Info  		7.06  LDD1829  [26]
C153
 Probe Info  		18.64  LDD1834  [26]
C158
 Probe Info  		10.27  LDD1838  [26]
C159
 Probe Info  		14.22  LDD1839  [26]
C160
 Probe Info  		8.51  LDD1840  [26]
C161
 Probe Info  		11.47  LDD1841  [26]
C163
 Probe Info  		6.73  LDD1843  [26]
C165
 Probe Info  		13.45  LDD1845  [26]
C169
 Probe Info  		33.13  LDD1849  [26]
C177
 Probe Info  		13.00  LDD1856  [26]
C178
 Probe Info  		71.01  LDD1857  [26]
C183
 Probe Info  		5.03  LDD1861  [26]
C191
 Probe Info  		15.14  LDD1868  [26]
C193
 Probe Info  		10.34  LDD1869  [26]
C194
 Probe Info  		11.24  LDD1870  [26]
C196
 Probe Info  		15.35  LDD1872  [26]
C197
 Probe Info  		4.96  LDD1873  [26]
C198
 Probe Info  		17.15  LDD1874  [26]
C201
 Probe Info  		43.41  LDD1877  [26]
C205
 Probe Info  		6.63  LDD1880  [26]
C206
 Probe Info  		33.59  LDD1881  [26]
C211
 Probe Info  		8.28  LDD1885  [26]
C213
 Probe Info  		52.35  LDD1887  [26]
C216
 Probe Info  		10.48  LDD1890  [26]
C218
 Probe Info  		10.70  LDD1892  [26]
C220
 Probe Info  		13.00  LDD1894  [26]
C226
 Probe Info  		9.65  LDD1899  [26]
C228
 Probe Info  		22.47  LDD1901  [26]
C229
 Probe Info  		9.58  LDD1902  [26]
C231
 Probe Info  		12.04  LDD1904  [26]
C232
 Probe Info  		42.81  LDD1905  [26]
C233
 Probe Info  		15.56  LDD1906  [26]
C238
 Probe Info  		14.42  LDD1911  [26]
C244
 Probe Info  		24.76  LDD1917  [26]
C249
 Probe Info  		15.89  LDD1922  [26]
C252
 Probe Info  		9.99  LDD1925  [26]
C264
 Probe Info  		28.84  LDD1935  [26]
C265
 Probe Info  		21.86  LDD1936  [26]
C269
 Probe Info  		7.01  LDD1939  [26]
C277
 Probe Info  		14.22  LDD1947  [26]
C282
 Probe Info  		17.03  LDD1952  [26]
C284
 Probe Info  		45.25  LDD1954  [26]
C288
 Probe Info  		12.47  LDD1958  [26]
C290
 Probe Info  		5.46  LDD1960  [26]
C293
 Probe Info  		32.22  LDD1963  [26]
C296
 Probe Info  		16.11  LDD1966  [26]
C297
 Probe Info  		6.06  LDD1967  [26]
C305
 Probe Info  		17.03  LDD1974  [26]
C310
 Probe Info  		11.39  LDD1977  [26]
C313
 Probe Info  		12.38  LDD1980  [26]
C314
 Probe Info  		15.67  LDD1981  [26]
C317
 Probe Info  		7.67  LDD1983  [26]
C320
 Probe Info  		5.21  LDD1986  [26]
C326
 Probe Info  		10.48  LDD1990  [26]
C328
 Probe Info  		9.00  LDD1992  [26]
C333
 Probe Info  		6.28  LDD1996  [26]
C338
 Probe Info  		25.11  LDD2001  [26]
C343
 Probe Info  		15.24  LDD2005  [26]
C346
 Probe Info  		11.00  LDD2007  [26]
C347
 Probe Info  		5.62  LDD2008  [26]
C349
 Probe Info  		8.57  LDD2010  [26]
C350
 Probe Info  		70.52  LDD2011  [26]
C353
 Probe Info  		10.78  LDD2014  [26]
C354
 Probe Info  		8.82  LDD2015  [26]
C355
 Probe Info  		30.70  LDD2016  [26]
C356
 Probe Info  		9.00  LDD2017  [26]
C361
 Probe Info  		23.92  LDD2022  [26]
C362
 Probe Info  		25.63  LDD2023  [26]
C363
 Probe Info  		18.90  LDD2024  [26]
C364
 Probe Info  		17.39  LDD2025  [26]
C366
 Probe Info  		7.06  LDD2027  [26]
C376
 Probe Info  		7.11  LDD2036  [26]
C378
 Probe Info  		6.02  LDD2037  [26]
C380
 Probe Info  		5.90  LDD2039  [26]
C382
 Probe Info  		11.47  LDD2041  [26]
C383
 Probe Info  		21.11  LDD2042  [26]
C386
 Probe Info  		10.41  LDD2045  [26]
C387
 Probe Info  		5.46  LDD2046  [26]
C388
 Probe Info  		50.91  LDD2047  [26]
C389
 Probe Info  		6.02  LDD2048  [26]
C390
 Probe Info  		27.28  LDD2049  [26]
C391
 Probe Info  		23.10  LDD2050  [26]
C399
 Probe Info  		8.06  LDD2058  [26]
C403
 Probe Info  		13.93  LDD2061  [26]
C407
 Probe Info  		13.45  LDD2064  [26]
C413
 Probe Info  		16.80  LDD2069  [26]
C419
 Probe Info  		14.42  LDD2074  [26]
C420
 Probe Info  		32.45  LDD2075  [26]
C429
 Probe Info  		12.13  LDD2084  [26]
C431
 Probe Info  		72.00  LDD2086  [26]
C433
 Probe Info  		6.41  LDD2088  [26]
FFF probe11
 Probe Info  		9.53  LDD0471  [27]
FFF probe12
 Probe Info  		13.53  LDD0473  [27]
FFF probe13
 Probe Info  		20.00  LDD0475  [27]
FFF probe14
 Probe Info  		20.00  LDD0477  [27]
FFF probe2
 Probe Info  		9.56  LDD0463  [27]
FFF probe3
 Probe Info  		18.56  LDD0464  [27]
FFF probe4
 Probe Info  		12.88  LDD0466  [27]
FFF probe6
 Probe Info  		13.34  LDD0467  [27]
FFF probe7
 Probe Info  		5.54  LDD0483  [27]
FFF probe9
 Probe Info  		15.45  LDD0470  [27]
JN0003
 Probe Info  		16.98  LDD0469  [27]
STS-2
 Probe Info  		2.00  LDD0139  [28]
VE-P
 Probe Info  		N.A.  LDD0396  [29]
OEA-DA
 Probe Info  		10.09  LDD0046  [30]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C304(1.41)  LDD2112  [9]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C304(0.51); C122(0.45)  LDD2095  [9]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C304(1.21); C122(0.84)  LDD2117  [9]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C304(1.62); C122(0.96)  LDD2152  [9]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C304(0.60); C122(0.41)  LDD2132  [9]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C122(0.81)  LDD2131  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C59(2.11)  LDD0372  [31]
 LDCM0214  AC1 HCT 116 C102(1.45); C122(1.14); C138(1.30); C59(0.98)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C102(1.49); C122(0.94); C138(0.95); C59(1.07)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C102(0.73); C122(0.76); C138(0.77); C59(0.88)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C102(0.62); C122(0.88); C138(0.81); C59(0.98)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C102(0.66); C122(0.91); C138(0.84); C59(0.92)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C102(0.56); C122(0.76); C138(0.73); C59(0.91)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C102(0.67); C122(1.00); C138(0.85); C59(0.92)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C102(0.62); C122(0.84); C138(0.75); C59(0.88)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C102(0.58); C122(0.73); C138(0.69); C59(0.89)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C102(0.57); C122(0.73); C138(0.99); C59(0.66)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C102(0.69); C122(0.90); C138(0.76); C59(0.70)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C102(0.72); C122(0.89); C138(0.85); C59(0.78)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C102(1.64); C122(1.11); C138(0.93); C59(1.16)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C102(0.65); C122(0.80); C138(0.82); C59(0.77)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C102(0.56); C122(0.80); C138(0.75); C59(0.79)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C102(0.57); C122(0.78); C138(0.86); C59(0.77)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C102(0.97); C122(1.45); C138(1.19); C59(0.95)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C102(0.88); C122(1.15); C138(1.17); C59(1.11)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C102(0.75); C122(0.94); C138(1.10); C59(0.95)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C102(0.81); C122(1.22); C138(1.07); C59(1.05)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C102(0.96); C122(1.04); C138(1.05); C59(1.05)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C102(1.03); C122(1.42); C138(1.09); C59(1.01)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C102(0.92); C122(1.19); C138(1.01); C59(1.27)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C102(1.49); C122(1.28); C138(1.12); C59(1.21)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C102(0.88); C122(1.15); C138(1.48); C59(1.14)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C102(1.16); C122(1.36); C138(1.28); C59(0.98)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C102(1.14); C122(1.36); C138(1.15); C59(1.03)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C102(1.16); C122(1.22); C138(1.31); C59(0.95)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C102(1.11); C122(1.62); C138(1.17); C59(0.99)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C102(1.09); C122(1.29); C138(1.33); C59(1.02)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C102(0.86); C122(1.19); C138(1.22); C59(1.10)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C102(1.02); C122(1.90); C138(1.12); C59(1.01)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C102(1.09); C122(0.62); C138(1.03); C59(0.93)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C102(1.16); C122(0.53); C138(0.99); C59(0.98)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C102(1.02); C122(0.63); C138(0.93); C59(1.09)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C102(1.07); C122(0.57); C138(1.09); C59(0.97)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C102(0.90); C122(0.47); C138(0.89); C59(1.02)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C102(1.00); C122(0.63); C138(1.01); C59(1.01)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C102(0.88); C122(0.41); C138(0.95); C59(1.00)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C102(0.92); C122(0.61); C138(0.96); C59(1.06)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C102(0.98); C122(0.45); C138(0.96); C59(1.07)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C102(1.05); C122(0.57); C138(0.99); C59(1.08)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C102(0.77); C122(0.36); C138(0.93); C59(1.14)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C102(0.86); C122(0.36); C138(0.82); C59(1.10)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C102(1.23); C122(1.55); C138(1.29); C59(1.21)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C102(0.72); C122(0.33); C138(0.77); C59(1.05)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C102(0.72); C122(0.33); C138(0.80); C59(1.07)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C102(1.02); C122(0.53); C138(0.88); C59(1.14)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C102(0.78); C122(1.03); C138(0.94); C59(1.01)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C102(0.61); C99(0.61); C138(0.88); C59(0.99)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C102(0.67); C99(0.67); C122(0.76); C138(0.87)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C102(0.68); C99(0.68); C138(1.01); C122(1.04)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C102(0.68); C99(0.68); C138(0.84); C59(1.04)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C102(0.42); C99(0.42); C138(0.75); C59(0.85)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C102(0.59); C99(0.59); C138(0.82); C59(1.13)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C59(1.08); C138(1.10); C102(1.38); C99(1.38)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C102(0.71); C99(0.71); C59(0.93); C138(0.96)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C102(0.78); C99(0.78); C59(0.92); C138(1.00)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C102(0.56); C99(0.56); C138(0.94); C59(0.94)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C102(0.39); C99(0.39); C138(0.65); C59(0.80)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C102(0.65); C122(1.14); C138(0.95); C59(0.99)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C102(0.65); C122(0.98); C138(0.80); C59(1.22)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C102(0.89); C122(1.30); C138(0.96); C59(1.07)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C102(0.86); C122(1.07); C138(1.11); C59(0.87)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C102(0.83); C99(0.83); C138(0.93); C59(1.09)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C102(0.75); C99(0.75); C59(0.93); C138(1.03)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C102(0.97); C99(0.97); C59(1.00); C138(1.03)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C59(0.82); C138(0.98); C122(1.02); C102(1.10)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C59(0.89); C102(0.96); C99(0.96); C138(1.10)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C102(1.09); C99(1.09); C59(1.10); C138(1.26)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C59(0.99); C102(1.01); C99(1.01); C138(1.17)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C59(0.75); C102(0.93); C99(0.93); C138(1.03)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C59(0.92); C102(1.03); C99(1.03); C138(1.06)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C122(0.71); C138(0.93); C102(0.97); C99(0.97)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C122(0.61); C102(0.77); C99(0.77); C138(0.83)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C122(0.63); C102(0.76); C99(0.76); C138(0.83)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C122(0.47); C102(0.74); C99(0.74); C138(0.92)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C122(0.40); C102(0.71); C99(0.71); C138(0.87)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C59(1.05); C138(1.13); C102(1.17); C99(1.17)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C122(0.47); C102(0.69); C99(0.69); C138(1.08)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C122(0.62); C102(0.85); C99(0.85); C138(0.99)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C122(0.36); C102(0.62); C99(0.62); C138(0.99)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C102(0.66); C99(0.66); C122(0.75); C138(0.98)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C102(0.59); C99(0.59); C122(0.63); C138(0.79)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C59(1.02); C122(1.29); C138(1.34); C102(1.56)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C59(0.89); C122(1.00); C138(1.30); C102(1.80)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C59(0.94); C122(0.99); C138(1.11); C102(1.60)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C122(0.92); C59(1.03); C138(1.14); C102(1.55)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C138(0.82); C122(0.92); C59(0.96); C102(2.05)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C59(1.04); C138(1.19); C102(1.38); C99(1.38)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C59(0.91); C138(0.95); C122(1.14); C102(1.38)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C59(0.99); C138(1.01); C102(1.08); C99(1.08)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C138(0.98); C59(1.02); C122(1.04); C102(1.38)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C122(0.93); C59(0.99); C138(1.00); C102(1.25)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C59(0.95); C138(0.97); C102(0.98); C99(0.98)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C138(0.86); C59(0.88); C102(0.98); C99(0.98)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C138(0.91); C102(0.91); C99(0.91); C122(1.00)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C138(0.90); C102(0.90); C99(0.90); C122(0.91)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C138(0.85); C59(1.11); C102(1.13); C99(1.13)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C102(0.56); C99(0.56); C138(0.77); C122(0.81)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C102(1.08); C99(1.08); C59(1.09); C138(1.37)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C102(0.64); C99(0.64); C138(0.87); C122(0.91)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C59(0.99); C138(1.11); C122(1.34); C102(1.38)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C102(0.93); C99(0.93); C138(0.98); C59(1.05)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C102(0.74); C99(0.74); C122(0.85); C138(0.87)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C102(0.80); C99(0.80); C138(0.97); C59(1.01)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C102(0.70); C99(0.70); C138(0.82); C59(0.96)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C102(0.48); C99(0.48); C122(0.74); C138(0.79)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C102(0.79); C99(0.79); C122(0.96); C138(1.07)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C102(0.70); C99(0.70); C122(0.70); C138(0.97)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C102(0.78); C99(0.78); C122(0.89); C138(0.92)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C138(1.00); C59(1.05); C102(1.15); C99(1.15)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C102(0.74); C99(0.74); C122(0.93); C138(1.13)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C102(0.92); C99(0.92); C122(1.00); C138(1.03)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C102(0.77); C99(0.77); C122(0.78); C138(0.86)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C102(0.80); C99(0.80); C122(0.98); C138(1.04)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C102(0.75); C99(0.75); C138(0.75); C122(0.94)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C122(0.63); C138(0.63); C102(0.68); C99(0.68)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C122(0.67); C138(0.73); C102(0.81); C99(0.81)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C138(0.31); C102(0.61); C99(0.61); C122(0.62)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C102(0.79); C99(0.79); C138(0.94); C59(0.97)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C102(0.79); C99(0.79); C138(0.91); C59(0.97)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C138(1.00); C59(1.09); C122(1.12); C102(1.35)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C102(0.59); C99(0.59); C138(0.67); C59(0.80)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C102(0.96); C99(0.96); C59(1.00); C138(1.03)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C102(0.73); C99(0.73); C138(0.90); C59(0.91)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C102(0.46); C99(0.46); C138(0.64); C59(0.72)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C102(0.50); C99(0.50); C138(0.74); C122(0.79)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C102(0.44); C99(0.44); C138(0.59); C59(0.73)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C102(0.62); C99(0.62); C138(0.79); C59(0.90)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C102(0.66); C99(0.66); C138(0.85); C59(0.91)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C102(0.80); C99(0.80); C138(0.97); C59(1.05)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C102(0.78); C99(0.78); C138(0.92); C59(0.92)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C138(1.00); C102(1.13); C99(1.13); C122(1.19)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C102(0.64); C99(0.64); C138(0.90); C122(0.93)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C102(0.87); C99(0.87); C59(1.02); C138(1.11)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C102(0.45); C99(0.45); C138(0.57); C59(0.69)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C102(0.55); C99(0.55); C122(0.66); C138(0.68)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C102(0.64); C99(0.64); C122(0.64); C138(0.73)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C138(0.77); C122(0.78); C102(0.81); C99(0.81)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C122(0.72); C102(0.74); C99(0.74); C138(0.81)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C122(0.82); C102(0.87); C99(0.87); C138(0.92)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C102(0.75); C99(0.75); C122(0.76); C138(0.81)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C102(0.67); C99(0.67); C122(0.68); C138(0.73)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C138(0.70); C122(0.78); C59(0.95); C102(1.02)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C102(0.61); C99(0.61); C138(0.62); C122(0.77)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C138(0.62); C102(0.62); C99(0.62); C122(0.70)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C122(0.73); C102(0.77); C99(0.77); C138(0.82)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C122(0.80); C138(0.89); C102(1.00); C99(1.00)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C138(0.88); C102(0.92); C99(0.92); C122(0.97)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C138(0.74); C122(0.78); C102(0.87); C99(0.87)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C102(0.60); C99(0.60); C138(0.67); C122(0.76)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C102(0.32); C99(0.32); C138(0.50); C122(0.54)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C102(0.65); C99(0.65); C138(0.74); C122(0.79)  LDD0683  [12]
 LDCM0545  Acetamide MDA-MB-231 C122(0.36)  LDD2138  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C122(0.91)  LDD2113  [9]
 LDCM0248  AKOS034007472 HCT 116 C102(1.49); C122(1.35); C138(0.97); C59(1.06)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C138(0.96); C122(1.10); C59(1.15); C102(1.31)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C138(0.91); C122(1.12); C59(1.17); C102(1.32)  LDD0592  [12]
 LDCM0156  Aniline NCI-H1299 12.28  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C320(0.99); C122(0.89)  LDD0078  [12]
 LDCM0498  BS-3668 MDA-MB-231 C304(0.89); C122(0.48); C138(1.05)  LDD2091  [9]
 LDCM0108  Chloroacetamide HeLa C320(0.00); C122(0.00); H222(0.00); C102(0.00)  LDD0222  [22]
 LDCM0632  CL-Sc Hep-G2 C320(0.66)  LDD2227  [25]
 LDCM0367  CL1 HCT 116 C59(0.91); C138(0.95); C102(1.02); C99(1.02)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C102(0.70); C99(0.70); C138(0.77); C59(1.12)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C59(0.99); C138(1.01); C122(1.12); C102(1.26)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C59(1.10); C138(1.12); C122(1.18); C102(1.29)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C59(1.01); C122(1.05); C138(1.07); C102(1.37)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C59(1.00); C138(1.16); C122(1.30); C102(1.57)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C59(1.02); C138(1.16); C122(1.38); C102(1.67)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C102(0.88); C99(0.88); C59(0.98); C138(1.20)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C102(0.87); C99(0.87); C59(0.95); C138(1.28)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C102(0.84); C99(0.84); C59(1.05); C138(1.30)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C102(0.75); C99(0.75); C59(1.01); C138(1.09)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C59(0.84); C102(0.86); C99(0.86); C138(1.08)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C102(0.69); C99(0.69); C138(0.87); C122(1.02)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C102(0.68); C99(0.68); C138(0.82); C59(0.90)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C102(0.80); C99(0.80); C138(0.80); C122(0.87)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C122(0.50); C138(0.80); C102(0.92); C99(0.92)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C122(0.41); C102(0.70); C99(0.70); C138(0.80)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C122(0.31); C102(0.70); C99(0.70); C138(0.76)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C122(0.52); C138(0.72); C102(0.73); C99(0.73)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C122(0.72); C102(0.78); C99(0.78); C138(0.96)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C138(0.72); C122(0.79); C59(0.87); C102(1.41)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C138(0.99); C122(1.00); C59(1.00); C102(1.19)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C59(0.86); C138(0.99); C102(1.09); C99(1.09)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C102(0.65); C99(0.65); C138(0.74); C122(1.00)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C59(0.90); C138(0.92); C122(0.94); C102(1.22)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C122(0.97); C138(1.02); C59(1.03); C102(1.34)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C102(0.82); C99(0.82); C59(0.99); C122(1.00)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C102(0.68); C99(0.68); C122(0.76); C138(0.77)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C102(0.65); C99(0.65); C138(0.83); C122(0.92)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C122(0.82); C102(1.00); C99(1.00); C59(1.09)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C102(0.81); C99(0.81); C122(0.82); C59(1.16)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C102(0.88); C99(0.88); C122(1.00); C138(1.07)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C102(0.73); C99(0.73); C122(0.81); C138(0.86)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C102(0.84); C99(0.84); C59(1.12); C138(1.13)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C102(0.94); C99(0.94); C59(1.01); C138(1.02)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C102(0.94); C99(0.94); C138(1.15); C59(1.15)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C122(0.72); C102(0.79); C99(0.79); C138(0.97)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C102(0.80); C99(0.80); C122(0.82); C59(1.00)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C59(1.04); C122(1.06); C102(1.09); C99(1.09)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C102(0.89); C99(0.89); C59(0.89); C122(0.96)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C138(0.96); C122(1.01); C59(1.02); C102(1.05)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C102(0.68); C99(0.68); C122(0.83); C138(1.03)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C122(0.74); C102(0.75); C99(0.75); C138(0.81)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C102(0.70); C99(0.70); C122(0.79); C59(0.98)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C122(0.79); C138(0.98); C102(1.01); C99(1.01)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C122(0.67); C102(0.86); C99(0.86); C138(0.86)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C102(0.67); C122(0.71); C138(0.82); C59(1.10)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C102(1.06); C122(0.72); C138(0.90); C59(1.02)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C102(1.04); C122(0.96); C138(0.87); C59(1.00)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C102(0.72); C122(0.87); C138(0.80); C59(0.95)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C102(0.70); C122(0.90); C138(0.94); C59(1.12)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C102(1.03); C122(1.29); C138(0.95); C59(1.09)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C102(1.31); C122(1.01); C138(1.11); C59(0.95)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C102(0.81); C122(0.93); C138(0.93); C59(0.87)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C102(0.81); C122(0.72); C138(1.16); C59(1.07)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C102(0.66); C122(0.64); C138(1.01); C59(0.92)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C102(0.59); C122(0.58); C138(0.92); C59(0.87)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C102(0.59); C122(0.84); C138(0.98); C59(0.97)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C102(0.66); C122(0.98); C138(1.13); C59(0.88)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C102(0.60); C122(1.08); C138(0.89); C59(0.91)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C102(0.58); C122(0.91); C138(0.91); C59(0.91)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C102(0.95); C122(1.39); C138(1.00); C59(0.96)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C102(0.60); C122(0.80); C138(1.01); C59(0.97)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C102(0.60); C122(1.00); C138(1.15); C59(0.96)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C102(0.56); C122(0.78); C138(1.05); C59(0.79)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C102(0.55); C122(0.91); C138(0.96); C59(0.87)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C102(0.70); C122(1.12); C138(1.04); C59(0.93)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C102(0.67); C122(1.05); C138(0.83); C59(0.94)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C102(1.24); C122(0.93); C138(0.78); C59(0.93)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C102(1.16); C122(0.82); C138(0.96); C59(1.08)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C102(1.23); C122(1.26); C138(1.00); C59(0.86)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C102(1.02); C122(1.17); C138(1.03); C59(0.89)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C102(1.04); C122(1.65); C138(1.10); C59(1.06)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C102(1.12); C122(1.37); C138(1.11); C59(0.89)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C102(1.17); C122(1.38); C138(1.01); C59(1.03)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C102(1.16); C122(1.00); C138(1.01); C59(1.04)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C102(1.10); C122(1.00); C138(1.00); C59(0.87)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C102(1.25); C122(1.15); C138(1.07); C59(0.81)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C102(1.26); C122(1.14); C138(1.09); C59(0.96)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C102(1.09); C122(1.30); C138(1.15); C59(1.12)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C102(1.15); C122(1.23); C138(1.22); C59(0.97)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C102(1.22); C122(1.20); C138(0.90); C59(1.01)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C102(1.12); C122(1.14); C138(1.12); C59(0.97)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C102(1.02); C122(1.55); C138(0.92); C59(1.07)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C102(1.14); C122(1.42); C138(1.16); C59(1.05)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C102(0.89); C122(1.69); C138(0.99); C59(1.09)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C102(0.92); C122(1.38); C138(0.89); C59(1.04)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C102(0.97); C122(1.49); C138(0.90); C59(1.11)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C102(0.83); C122(1.91); C138(0.90); C59(1.08)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C102(0.94); C122(1.63); C138(0.95); C59(1.12)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C102(0.78); C122(1.47); C138(0.86); C59(1.21)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C102(0.97); C122(1.62); C138(1.15); C59(1.11)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C102(0.85); C122(2.79); C138(1.17); C59(1.05)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C102(0.95); C122(1.50); C138(1.16); C59(1.06)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C102(0.77); C122(1.38); C138(0.84); C59(1.12)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C102(0.90); C122(1.07); C138(1.03); C59(1.22)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C102(0.81); C122(1.29); C138(0.93); C59(1.00)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C102(0.81); C122(1.39); C138(1.01); C59(1.08)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C102(0.81); C122(1.55); C138(1.04); C59(1.13)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C102(0.85); C122(1.15); C138(1.04); C59(1.11)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C102(0.96); C122(1.19); C59(1.06); C99(0.96)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C102(0.87); C122(0.84); C59(0.99); C99(0.87)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C102(0.82); C122(0.98); C59(1.16); C99(0.82)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C102(0.82); C122(1.02); C59(1.06); C99(0.82)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C102(0.54); C122(0.62); C138(0.80); C59(1.01)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C102(1.04); C122(1.24); C59(1.10); C99(1.04)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C102(0.93); C122(1.00); C59(1.05); C99(0.93)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C102(0.73); C122(0.90); C59(1.08); C99(0.73)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C102(0.71); C122(0.79); C59(1.08); C99(0.71)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C102(0.59); C122(0.56); C59(0.99); C99(0.59)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C102(0.83); C122(0.97); C59(1.12); C99(0.83)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C102(0.92); C122(1.01); C59(1.09); C99(0.92)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C102(0.95); C122(0.87); C59(1.07); C99(0.95)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C102(0.89); C122(0.78); C59(1.10); C99(0.89)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C102(0.65); C122(0.65); C59(0.96); C99(0.65)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C102(0.82); C122(1.18); C138(0.87); C59(1.07)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C102(0.87); C122(1.78); C59(0.88); C99(0.87)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C102(0.91); C122(1.10); C138(1.43); C59(0.96)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C102(0.82); C122(1.22); C138(1.46); C59(0.84)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C102(0.95); C122(1.51); C138(1.25); C59(0.87)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C102(1.11); C122(1.33); C138(1.18); C59(0.87)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C102(0.80); C122(1.28); C138(1.29); C59(0.86)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C102(1.04); C122(1.29); C138(1.39); C59(0.94)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C102(1.02); C122(1.21); C138(1.23); C59(1.02)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C102(1.09); C122(0.92); C138(0.94); C59(1.06)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C102(1.13); C122(1.03); C138(1.07); C59(1.04)  LDD0811  [12]
 LDCM0495  E2913 HEK-293T C122(0.94); C59(0.93); C320(1.13); C138(0.83)  LDD1698  [32]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C304(1.52); C138(0.42); C122(0.21)  LDD1702  [9]
 LDCM0625  F8 Ramos C138(0.83); C122(1.75); C304(2.49)  LDD2187  [33]
 LDCM0572  Fragment10 Ramos C138(0.71); C122(0.48); C304(0.93)  LDD2189  [33]
 LDCM0573  Fragment11 Ramos C138(2.78); C122(5.44); C304(20.00); C59(0.52)  LDD2190  [33]
 LDCM0574  Fragment12 Ramos C138(0.42); C122(0.35); C304(0.81)  LDD2191  [33]
 LDCM0575  Fragment13 Ramos C138(1.02); C122(0.78); C304(0.68)  LDD2192  [33]
 LDCM0576  Fragment14 Ramos C138(0.77); C122(0.94); C304(0.76); C59(0.50)  LDD2193  [33]
 LDCM0579  Fragment20 Ramos C138(0.59); C122(0.42); C304(0.82)  LDD2194  [33]
 LDCM0580  Fragment21 Ramos C138(0.91); C122(0.72); C304(0.54)  LDD2195  [33]
 LDCM0582  Fragment23 Ramos C138(0.56); C122(0.19)  LDD2196  [33]
 LDCM0578  Fragment27 Ramos C138(0.95); C122(0.95)  LDD2197  [33]
 LDCM0586  Fragment28 Ramos C138(1.09); C122(0.55); C304(0.55)  LDD2198  [33]
 LDCM0588  Fragment30 Ramos C138(1.04); C122(0.82); C304(0.56)  LDD2199  [33]
 LDCM0589  Fragment31 Ramos C138(0.97); C122(0.67); C304(2.18)  LDD2200  [33]
 LDCM0590  Fragment32 Ramos C138(0.54); C122(0.57); C304(0.99)  LDD2201  [33]
 LDCM0468  Fragment33 HCT 116 C102(0.91); C122(2.13); C138(1.06); C59(1.13)  LDD0785  [12]
 LDCM0596  Fragment38 Ramos C138(0.76); C122(0.83)  LDD2203  [33]
 LDCM0566  Fragment4 Ramos C138(0.77); C122(0.85); C304(0.83); C59(0.99)  LDD2184  [33]
 LDCM0427  Fragment51 HCT 116 C102(0.49); C122(0.82); C138(0.93); C59(0.80)  LDD0744  [12]
 LDCM0610  Fragment52 Ramos C138(1.18); C122(0.65); C304(0.71)  LDD2204  [33]
 LDCM0614  Fragment56 Ramos C138(1.06); C122(1.00); C304(0.34)  LDD2205  [33]
 LDCM0569  Fragment7 Ramos C138(0.59); C122(1.19); C304(0.64); C59(1.25)  LDD2186  [33]
 LDCM0571  Fragment9 Ramos C138(0.55); C122(0.31); C304(0.51)  LDD2188  [33]
 LDCM0107  IAA HeLa C102(0.00); H110(0.00)  LDD0221  [22]
 LDCM0022  KB02 HCT 116 C122(1.60); C59(1.26)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C122(1.23); C59(1.17)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C122(1.69); C59(1.24)  LDD0082  [12]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C304(1.06)  LDD2102  [9]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C304(0.90); C122(0.55)  LDD2121  [9]
 LDCM0109  NEM HeLa H80(0.00); H222(0.00)  LDD0223  [22]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C304(0.95); C122(0.63); C138(1.27)  LDD2089  [9]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C304(1.53); C122(0.88)  LDD2093  [9]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C304(1.54); C122(2.13)  LDD2094  [9]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C304(0.39); C122(0.60)  LDD2096  [9]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C304(0.90); C122(0.74)  LDD2097  [9]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C304(1.25)  LDD2098  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C304(1.35); C122(0.78); C138(1.26)  LDD2099  [9]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C304(1.02)  LDD2100  [9]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C304(0.92); C122(1.16)  LDD2101  [9]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C304(0.85); C102(0.99)  LDD2104  [9]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C304(1.58)  LDD2105  [9]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C304(1.09); C122(0.82); C138(1.02)  LDD2107  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C304(0.77); C122(0.50); C138(0.79)  LDD2109  [9]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C304(1.27); C122(0.75)  LDD2111  [9]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C304(0.62)  LDD2114  [9]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C304(0.48); C122(0.62)  LDD2115  [9]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C304(0.70); C122(1.11)  LDD2116  [9]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C122(0.75)  LDD2118  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C304(0.70); C122(2.64); C138(1.70)  LDD2119  [9]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C122(0.70)  LDD2120  [9]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C304(0.90)  LDD2122  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C304(0.99); C122(0.59)  LDD2123  [9]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C304(0.73); C122(0.89)  LDD2124  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C304(0.91); C122(0.75); C138(1.03)  LDD2125  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C304(1.19); C122(0.90); C138(1.47)  LDD2127  [9]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C122(0.74)  LDD2128  [9]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C304(1.09); C122(0.96)  LDD2129  [9]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C122(0.60)  LDD2133  [9]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C304(0.45); C122(0.44)  LDD2134  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C304(1.80); C122(1.13); C138(1.71)  LDD2135  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C304(1.50); C122(1.20); C138(1.50)  LDD2136  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C304(0.88); C122(0.73)  LDD2137  [9]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C304(2.55); C122(1.15)  LDD1700  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C304(1.01); C122(0.79); C138(1.09)  LDD2140  [9]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C304(1.02)  LDD2141  [9]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C122(0.75)  LDD2143  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C304(1.84); C122(2.52); C138(1.32)  LDD2144  [9]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C304(1.12); C122(0.68)  LDD2146  [9]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C304(0.42); C122(0.53)  LDD2148  [9]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C304(1.07); C122(1.02)  LDD2149  [9]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C304(0.78); C138(1.04)  LDD2150  [9]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C304(0.62); C122(0.90)  LDD2151  [9]
 LDCM0021  THZ1 HeLa S3 C102(1.17)  LDD0460  [8]
 LDCM0085  WA NCI-H1975 2.25  LDD0192  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dual specificity protein phosphatase 12 (DUSP12) Protein-tyrosine phosphatase family Q9UNI6
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Identification of peroxiredoxin 6 as a direct target of withangulatin A by quantitative chemical proteomics in non-small cell lung cancer. Redox Biol. 2021 Oct;46:102130. doi: 10.1016/j.redox.2021.102130. Epub 2021 Sep 9.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
17 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
22 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
23 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
24 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
25 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
26 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
27 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
28 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
29 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
30 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
31 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
32 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
33 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578