Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C147  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 88 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05029  Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) 91.8
 LDTP01562  Peptidyl-prolyl cis-trans isomerase FKBP9 (FKBP9) 44.6
 LDTP01769  Dihydrofolate reductase (DHFR) 30.9
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) 30.1
 LDTP02359  Heme oxygenase 1 (HMOX1) 25.6
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 21.4
 LDTP03540  Heme oxygenase 2 (HMOX2) 19.4
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 17.4
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 17.0
 LDTP04333  GMP synthase [glutamine-hydrolyzing] (GMPS) 16.9
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 16.8
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 16.2
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 14.8
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 14.6
 LDTP04737  DNA polymerase epsilon subunit 2 (POLE2) 14.3
 LDTP10101  Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10) 13.8
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 13.8
 LDTP12509  N-lysine methyltransferase SMYD2 (SMYD2) 13.7
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 13.3
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 13.2
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 12.9
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 12.9
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 12.8
 LDTP06307  Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) 12.8
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 12.4
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 12.3
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 12.2
 LDTP10329  Ceramide synthase 2 (CERS2) 11.9
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 11.8
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 11.4
 LDTP01419  Retinal dehydrogenase 2 (ALDH1A2) 11.2
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 11.2
 LDTP03560  Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) 11.2
 LDTP08947  eEF1A lysine and N-terminal methyltransferase (METTL13) 11.2
 LDTP00957  Lysine-specific histone demethylase 1A (KDM1A) 11.0
 LDTP00697  Cytochrome b5 type B (CYB5B) 10.9
 LDTP00988  Protein O-GlcNAcase (OGA) 10.5
 LDTP02539  Lysosomal acid phosphatase (ACP2) 10.3
 LDTP05372  Peptidyl-prolyl cis-trans isomerase FKBP4 (FKBP4) 10.3
 LDTP02505  Lysosomal protective protein (CTSA) 10.2
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 10.1
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 10.1
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 9.9
 LDTP02837  Beta-galactosidase (GLB1) 9.8
 LDTP04384  Cyclin-dependent kinase 9 (CDK9) 9.7
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 9.4
 LDTP06849  Prolyl endopeptidase-like (PREPL) 9.3
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 9.1
 LDTP10182  TLC domain-containing protein 1 (TLCD1) 9.0
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 8.8
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 8.8
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 8.7
 LDTP04289  Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL) 8.6
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 8.6
 LDTP16040  Glyoxalase domain-containing protein 4 (GLOD4) 8.5
 LDTP07620  Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (PAOX) 8.5
 LDTP02896  Sphingomyelin phosphodiesterase (SMPD1) 8.4
 LDTP08265  N-alpha-acetyltransferase 40 (NAA40) 8.3
 LDTP06617  Ceramide glucosyltransferase (UGCG) 8.2
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 8.2
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 8.1
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 8.1
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 7.9
 LDTP01983  NADH-ubiquinone oxidoreductase chain 2 (MT-ND2) 7.9
 LDTP07504  Lysophospholipid acyltransferase 5 (LPCAT3) 7.8
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 7.8
 LDTP11187  COP9 signalosome complex subunit 4 (COPS4) 7.7
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 7.7
 LDTP01444  E3 UFM1-protein ligase 1 (UFL1) 7.5
 LDTP00783  Beta-1,4-glucuronyltransferase 1 (B4GAT1) 7.5
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 7.5
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 7.4
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 7.4
 LDTP03417  Proteasome subunit beta type-4 (PSMB4) 7.4
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 7.3
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 7.2
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 7.1
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 7.1
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 7.0
 LDTP13814  Phospholipase A-2-activating protein (PLAA) 7.0
 LDTP12020  Histone-lysine N-methyltransferase SMYD3 (SMYD3) 6.8
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 6.7
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) 6.7
 LDTP04247  Protein farnesyltransferase subunit beta (FNTB) 6.7
 LDTP02141  Alpha-galactosidase A (GLA) 6.6
 LDTP03374  Peptidyl-prolyl cis-trans isomerase FKBP2 (FKBP2) 6.6
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 6.5
 LDTP02006  Tissue alpha-L-fucosidase (FUCA1) 6.5
Transporter and channel
Click to Show/Hide to Show 47 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 28.6
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 24.1
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 22.6
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 21.6
 LDTP16813  Tetraspanin-3 (TSPAN3) 19.6
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 17.5
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 17.1
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 16.9
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 16.3
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 16.0
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 15.0
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 13.2
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 12.8
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 12.7
 LDTP08881  Transmembrane protein 199 (TMEM199) 12.6
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 12.3
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 11.6
 LDTP18459  StAR-related lipid transfer protein 7, mitochondrial (STARD7) 11.4
 LDTP07236  Protein GPR107 (GPR107) 10.9
 LDTP15481  Transmembrane protein 87A (TMEM87A) 10.8
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 10.3
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 9.3
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 9.2
 LDTP04462  H(+)/Cl(-) exchange transporter 6 (CLCN6) 8.9
 LDTP12451  Integral membrane protein 2C (ITM2C) 8.9
 LDTP11615  Protein tweety homolog 3 (TTYH3) 8.9
 LDTP12636  Lysosomal cobalamin transport escort protein LMBD1 (LMBRD1) 8.6
 LDTP02215  Prosaposin (PSAP) 8.6
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 8.2
 LDTP07156  Protein wntless homolog (WLS) 8.2
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 8.2
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 8.0
 LDTP15948  Transmembrane protein 126A (TMEM126A) 7.9
 LDTP11844  Protein spinster homolog 1 (SPNS1) 7.8
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 7.8
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 7.6
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 7.6
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 7.2
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 7.2
 LDTP11213  Nucleoporin NDC1 (NDC1) 7.2
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 7.1
 LDTP12207  Putative divalent cation/proton antiporter TMEM165 (TMEM165) 7.1
 LDTP20002  Transmembrane protein 160 (TMEM160) 7.1
 LDTP01969  Transferrin receptor protein 1 (TFRC) 6.9
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 6.8
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 6.7
 LDTP11116  45 kDa calcium-binding protein (SDF4) 6.6
Other
Click to Show/Hide to Show 53 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11076  Apolipoprotein L2 (APOL2) 29.4
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 22.6
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 22.6
 LDTP05160  Nucleobindin-2 (NUCB2) 20.1
 LDTP15634  Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5) 19.8
 LDTP00105  Protein unc-119 homolog B (UNC119B) 16.9
 LDTP12476  Translation initiation factor eIF2B subunit gamma (EIF2B3) 15.0
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 14.9
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 14.7
 LDTP13656  Protein kinase C and casein kinase substrate in neurons protein 2 (PACSIN2) 14.6
 LDTP01075  Protein CutA (CUTA) 14.0
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 13.4
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 12.3
 LDTP05375  Nucleobindin-1 (NUCB1) 12.1
 LDTP14458  Tetraspanin-6 (TSPAN6) 12.0
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 11.0
 LDTP13402  Dynactin subunit 4 (DCTN4) 10.5
 LDTP01652  Centrosomal protein 43 (CEP43) 10.4
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 10.1
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 10.0
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 9.9
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 9.8
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 9.6
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 9.6
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 9.3
 LDTP01522  Reticulon-3 (RTN3) 9.3
 LDTP16080  Protein FAM114A2 (FAM114A2) 9.1
 LDTP00376  Coatomer subunit epsilon (COPE) 8.6
 LDTP14259  Testis-expressed protein 264 (TEX264) 8.5
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 8.3
 LDTP05277  Protein SET (SET) 8.2
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 8.1
 LDTP06097  Reticulocalbin-2 (RCN2) 7.8
 LDTP05226  RNA-binding protein 3 (RBM3) 7.8
 LDTP07496  Zinc finger CCHC domain-containing protein 8 (ZCCHC8) 7.8
 LDTP09920  Golgi apparatus protein 1 (GLG1) 7.5
 LDTP04853  Eukaryotic translation initiation factor 3 subunit E (EIF3E) 7.4
 LDTP10056  Protein FAM162A (FAM162A) 7.3
 LDTP15283  Nucleolar protein 9 (NOP9) 7.2
 LDTP18883  Protein CEBPZOS (CEBPZOS) 7.1
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 7.1
 LDTP06060  Ubiquitin-associated protein 2-like (UBAP2L) 7.1
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 7.0
 LDTP01358  Pre-mRNA-splicing factor SPF27 (BCAS2) 7.0
 LDTP00779  Trans-Golgi network integral membrane protein 2 (TGOLN2) 7.0
 LDTP13802  DNA replication complex GINS protein PSF2 (GINS2) 6.9
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) 6.8
 LDTP07934  Synaptic vesicle glycoprotein 2A (SV2A) 6.8
 LDTP07916  Protein MTSS 2 (MTSS2) 6.7
 LDTP10263  KIF-binding protein (KIFBP) 6.7
 LDTP12377  Mediator of RNA polymerase II transcription subunit 4 (MED4) 6.7
 LDTP06302  Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (ACAP2) 6.5
 LDTP06022  Cold-inducible RNA-binding protein (CIRBP) 6.5

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587