Details of the Target

General Information of Target

Target ID LDTP01983
Target Name NADH-ubiquinone oxidoreductase chain 2 (MT-ND2)
Gene Name MT-ND2
Gene ID 4536
Synonyms
MTND2; NADH2; ND2; NADH-ubiquinone oxidoreductase chain 2; EC 7.1.1.2; NADH dehydrogenase subunit 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYF
LTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMMAMAMKLGMAPFHFWVPEVTQ
GTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSILSIMAGSWGGLNQTQLRKILA
YSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLLLNLNSSTTTLLLSRTWNKLTWL
TPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYFYLRLIYST
SITLLPMSNNVKMKWQFEHTKPTPFLPTLIALTTLLLPISPFMLMIL
Target Bioclass
Enzyme
Family
Complex I subunit 2 family
Subcellular location
Mitochondrion inner membrane
Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Uniprot ID
P03891
Ensemble ID
ENST00000361453.3
HGNC ID
HGNC:7456
ChEMBL ID
CHEMBL2363065

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C067
 Probe Info  		13.00  LDD1763  [1]
C070
 Probe Info  		18.13  LDD1766  [1]
C072
 Probe Info  		16.80  LDD1768  [1]
C141
 Probe Info  		45.25  LDD1823  [1]
C143
 Probe Info  		46.53  LDD1825  [1]
C147
 Probe Info  		7.89  LDD1829  [1]
C218
 Probe Info  		16.80  LDD1892  [1]
C219
 Probe Info  		13.83  LDD1893  [1]
C220
 Probe Info  		28.84  LDD1894  [1]
C419
 Probe Info  		35.51  LDD2074  [1]
C420
 Probe Info  		34.78  LDD2075  [1]
C422
 Probe Info  		19.70  LDD2077  [1]
FFF probe11
 Probe Info  		20.00  LDD0471  [2]
FFF probe14
 Probe Info  		20.00  LDD0477  [2]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
2 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.