Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C067  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 46 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10182  TLC domain-containing protein 1 (TLCD1) 32.7
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 24.6
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 17.8
 LDTP01389  Delta(14)-sterol reductase TM7SF2 (TM7SF2) 16.0
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 16.0
 LDTP03540  Heme oxygenase 2 (HMOX2) 13.9
 LDTP00697  Cytochrome b5 type B (CYB5B) 13.0
 LDTP01983  NADH-ubiquinone oxidoreductase chain 2 (MT-ND2) 13.0
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 12.1
 LDTP19745  ADP-ribosylation factor-like protein 10 (ARL10) 10.6
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 9.5
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 7.5
 LDTP02837  Beta-galactosidase (GLB1) 7.4
 LDTP11187  COP9 signalosome complex subunit 4 (COPS4) 7.3
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 7.3
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 7.2
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 7.1
 LDTP02896  Sphingomyelin phosphodiesterase (SMPD1) 6.9
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 6.7
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 6.6
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 6.6
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 6.6
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 6.6
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 6.5
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 6.5
 LDTP05905  Acid ceramidase (ASAH1) 6.4
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 6.4
 LDTP02359  Heme oxygenase 1 (HMOX1) 6.2
 LDTP08017  Endoplasmic reticulum metallopeptidase 1 (ERMP1) 5.9
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 5.8
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 5.6
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 5.6
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 5.6
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 5.5
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 5.4
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 5.4
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 5.3
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 5.3
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 5.2
 LDTP11127  ADP-dependent glucokinase (ADPGK) 5.2
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 5.1
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 5.0
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 5.0
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 5.0
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 5.0
 LDTP07868  Protein O-mannosyl-transferase TMTC3 (TMTC3) 5.0
Transporter and channel
Click to Show/Hide to Show 36 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 18.8
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 18.5
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 14.9
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 13.6
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 13.5
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 11.2
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 9.9
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 9.5
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 9.3
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 9.1
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 8.9
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 8.8
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 8.6
 LDTP16813  Tetraspanin-3 (TSPAN3) 8.6
 LDTP15948  Transmembrane protein 126A (TMEM126A) 8.2
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 8.1
 LDTP08881  Transmembrane protein 199 (TMEM199) 8.1
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 8.1
 LDTP11615  Protein tweety homolog 3 (TTYH3) 7.9
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 7.5
 LDTP02215  Prosaposin (PSAP) 6.8
 LDTP15648  BRI3-binding protein (BRI3BP) 6.6
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 6.6
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 6.4
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 6.0
 LDTP12383  Protein GPR108 (GPR108) 5.7
 LDTP08016  Proton-coupled amino acid transporter 1 (SLC36A1) 5.4
 LDTP07236  Protein GPR107 (GPR107) 5.3
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 5.3
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 5.2
 LDTP11213  Nucleoporin NDC1 (NDC1) 5.1
 LDTP05900  Metaxin-1 (MTX1) 5.1
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 5.1
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 5.1
 LDTP15481  Transmembrane protein 87A (TMEM87A) 5.1
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 4.9
GPCR
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15303  Membrane progestin receptor alpha (PAQR7) 10.0
Other
Click to Show/Hide to Show 22 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11076  Apolipoprotein L2 (APOL2) 21.3
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 15.7
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 14.8
 LDTP18883  Protein CEBPZOS (CEBPZOS) 12.6
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 11.8
 LDTP05160  Nucleobindin-2 (NUCB2) 11.5
 LDTP03926  Centrin-2 (CETN2) 9.7
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 9.0
 LDTP01522  Reticulon-3 (RTN3) 8.3
 LDTP15623  Neuferricin (CYB5D2) 7.6
 LDTP15634  Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5) 7.4
 LDTP11134  DNA replication complex GINS protein SLD5 (GINS4) 7.1
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 6.7
 LDTP13086  Syntaxin-18 (STX18) 6.1
 LDTP03175  Galanin peptides (GAL) 5.9
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 5.7
 LDTP04382  Kinetochore-associated protein 1 (KNTC1) 5.6
 LDTP07906  Mediator of RNA polymerase II transcription subunit 25 (MED25) 5.5
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 5.5
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 5.5
 LDTP12412  Reticulon-4 (RTN4) 5.5
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 5.1

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587