Details of the Target

General Information of Target

Target ID LDTP15634
Target Name Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5)
Gene Name UQCC5
Gene ID 440957
Synonyms
C3orf78; SMIM4; Ubiquinol-cytochrome c reductase complex assembly factor 5; Small integral membrane protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAFMVKTMVGGQLKNLTGSLGGGEDKGDGDKSAAEAQGMSREEYEEYQKQLVEEKMERDA
QFTQRKAERATLRSHFRDKYRLPKNETDESQIQMAGGDVELPRELAKMIEEDTEEEEEKA
SVLGQLASLPGLNLGSLKDKAQATLGDLKQSAEKCHVM
Target Bioclass
Other
Family
UQCC5 family
Subcellular location
Mitochondrion inner membrane
Function
Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation. Mediates early complex III biogenesis. Participates in regulating the levels of electron transport chain proteins, and therefore energy supply, in response to changes in energy demand. Also involved in the first steps of cytochrome c oxidase complex (complex IV) assembly.
Uniprot ID
Q8WVI0
Ensemble ID
ENST00000477703.6
HGNC ID
HGNC:37257

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K17(10.00)  LDD0277  [1]
PAL-AfBPP Probe
Click To Hide/Show 39 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		14.62  LDD1725  [2]
C049
 Probe Info  		5.06  LDD1747  [2]
C051
 Probe Info  		5.82  LDD1749  [2]
C052
 Probe Info  		5.66  LDD1750  [2]
C055
 Probe Info  		92.41  LDD1752  [2]
C056
 Probe Info  		59.71  LDD1753  [2]
C063
 Probe Info  		22.47  LDD1760  [2]
C065
 Probe Info  		6.28  LDD1762  [2]
C067
 Probe Info  		7.41  LDD1763  [2]
C070
 Probe Info  		19.29  LDD1766  [2]
C071
 Probe Info  		12.82  LDD1767  [2]
C072
 Probe Info  		15.03  LDD1768  [2]
C106
 Probe Info  		34.30  LDD1793  [2]
C107
 Probe Info  		20.11  LDD1794  [2]
C108
 Probe Info  		25.11  LDD1795  [2]
C141
 Probe Info  		37.27  LDD1823  [2]
C142
 Probe Info  		5.58  LDD1824  [2]
C143
 Probe Info  		51.63  LDD1825  [2]
C145
 Probe Info  		11.79  LDD1827  [2]
C147
 Probe Info  		19.84  LDD1829  [2]
C153
 Probe Info  		32.22  LDD1834  [2]
C177
 Probe Info  		11.39  LDD1856  [2]
C178
 Probe Info  		25.28  LDD1857  [2]
C225
 Probe Info  		7.06  LDD1898  [2]
C226
 Probe Info  		6.77  LDD1899  [2]
C228
 Probe Info  		17.03  LDD1901  [2]
C286
 Probe Info  		5.24  LDD1956  [2]
C287
 Probe Info  		10.27  LDD1957  [2]
C288
 Probe Info  		8.34  LDD1958  [2]
C289
 Probe Info  		25.46  LDD1959  [2]
C290
 Probe Info  		8.57  LDD1960  [2]
C355
 Probe Info  		26.72  LDD2016  [2]
C356
 Probe Info  		10.85  LDD2017  [2]
C383
 Probe Info  		31.78  LDD2042  [2]
C386
 Probe Info  		33.59  LDD2045  [2]
C387
 Probe Info  		9.71  LDD2046  [2]
C388
 Probe Info  		86.82  LDD2047  [2]
C389
 Probe Info  		8.82  LDD2048  [2]
OEA-DA
 Probe Info  		20.00  LDD0046  [3]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
3 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570