Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C177  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 82 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 78.8
 LDTP03540  Heme oxygenase 2 (HMOX2) 38.6
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 31.6
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 29.2
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 26.2
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 26.2
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 25.3
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 21.6
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 19.7
 LDTP00697  Cytochrome b5 type B (CYB5B) 18.9
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 18.8
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 18.1
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) 17.3
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 17.1
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 15.8
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 15.2
 LDTP11127  ADP-dependent glucokinase (ADPGK) 12.5
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 12.5
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 12.1
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 12.0
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 12.0
 LDTP02640  X-ray repair cross-complementing protein 6 (XRCC6) 11.9
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 11.6
 LDTP12586  Phenylalanine--tRNA ligase beta subunit (FARSB) 11.5
 LDTP02837  Beta-galactosidase (GLB1) 11.3
 LDTP05228  Calcium-transporting ATPase type 2C member 1 (ATP2C1) 11.2
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 11.1
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 11.1
 LDTP02359  Heme oxygenase 1 (HMOX1) 11.1
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 11.0
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 11.0
 LDTP00975  Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (MAN1A2) 10.9
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 10.9
 LDTP00988  Protein O-GlcNAcase (OGA) 10.8
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 10.7
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 10.5
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 10.3
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 10.2
 LDTP10182  TLC domain-containing protein 1 (TLCD1) 10.2
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 10.0
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 9.8
 LDTP13751  Exonuclease 1 (EXO1) 9.6
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) 9.4
 LDTP13678  Multiple inositol polyphosphate phosphatase 1 (MINPP1) 9.4
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 9.1
 LDTP02141  Alpha-galactosidase A (GLA) 9.0
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 8.9
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 8.9
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 8.9
 LDTP05588  RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) 8.9
 LDTP02539  Lysosomal acid phosphatase (ACP2) 8.8
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 8.8
 LDTP12959  NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) 8.8
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 8.8
 LDTP13409  Anaphase-promoting complex subunit 7 (ANAPC7) 8.7
 LDTP04327  Cytosolic purine 5'-nucleotidase (NT5C2) 8.7
 LDTP08617  Patatin-like phospholipase domain-containing protein 6 (PNPLA6) 8.6
 LDTP05408  Antigen peptide transporter 1 (TAP1) 8.6
 LDTP00836  ATPase GET3 (GET3) 8.5
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 8.3
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 8.3
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 8.3
 LDTP06295  Histone-lysine N-methyltransferase SETDB1 (SETDB1) 8.2
 LDTP00589  Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) 8.2
 LDTP03608  RAC-beta serine/threonine-protein kinase (AKT2) 8.1
 LDTP00316  Ribonuclease T2 (RNASET2) 8.1
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 8.0
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 8.0
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 7.9
 LDTP10495  Ubiquitin carboxyl-terminal hydrolase 47 (USP47) 7.9
 LDTP10329  Ceramide synthase 2 (CERS2) 7.7
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 7.7
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 7.7
 LDTP11178  Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) 7.6
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 7.5
 LDTP11187  COP9 signalosome complex subunit 4 (COPS4) 7.5
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 7.5
 LDTP03842  Squalene synthase (FDFT1) 7.5
 LDTP05905  Acid ceramidase (ASAH1) 7.4
 LDTP10887  Synaptic vesicle membrane protein VAT-1 homolog (VAT1) 7.4
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 7.3
 LDTP03680  DNA replication licensing factor MCM4 (MCM4) 7.2
Transporter and channel
Click to Show/Hide to Show 50 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01804  ATP synthase subunit a (MT-ATP6) 55.7
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 53.4
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 35.8
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 29.4
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 27.7
 LDTP07236  Protein GPR107 (GPR107) 26.5
 LDTP16813  Tetraspanin-3 (TSPAN3) 24.4
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 24.1
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 23.8
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 22.6
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 22.2
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 21.3
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 19.8
 LDTP11855  Pinin (PNN) 18.9
 LDTP11615  Protein tweety homolog 3 (TTYH3) 18.6
 LDTP08881  Transmembrane protein 199 (TMEM199) 17.3
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) 16.8
 LDTP12383  Protein GPR108 (GPR108) 16.3
 LDTP05116  CMP-sialic acid transporter (SLC35A1) 16.2
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 15.8
 LDTP15948  Transmembrane protein 126A (TMEM126A) 15.1
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 14.9
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 14.6
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 14.4
 LDTP09261  Major facilitator superfamily domain-containing protein 8 (MFSD8) 14.1
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 12.6
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 12.3
 LDTP04956  Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) 11.7
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 11.7
 LDTP05900  Metaxin-1 (MTX1) 11.6
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 11.5
 LDTP15648  BRI3-binding protein (BRI3BP) 11.4
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 10.2
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 9.3
 LDTP07531  Sideroflexin-4 (SFXN4) 9.3
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 8.9
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 8.8
 LDTP13320  Prenylated Rab acceptor protein 1 (RABAC1) 8.8
 LDTP18053  Probable mitochondrial glutathione transporter SLC25A40 (SLC25A40) 8.8
 LDTP03952  Reduced folate transporter (SLC19A1) 8.7
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 8.5
 LDTP10621  Sideroflexin-2 (SFXN2) 8.2
 LDTP02215  Prosaposin (PSAP) 8.1
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 8.0
 LDTP03380  Stomatin (STOM) 7.9
 LDTP07667  Transmembrane protein 205 (TMEM205) 7.7
 LDTP04459  H(+)/Cl(-) exchange transporter 3 (CLCN3) 7.6
 LDTP11213  Nucleoporin NDC1 (NDC1) 7.6
 LDTP11095  Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) 7.4
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 7.2
GPCR
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP14610  Golgi pH regulator B (GPR89B) 8.1
Other
Click to Show/Hide to Show 47 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 31.6
 LDTP15623  Neuferricin (CYB5D2) 29.4
 LDTP11533  Oxysterol-binding protein-related protein 6 (OSBPL6) 22.2
 LDTP01522  Reticulon-3 (RTN3) 13.7
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 13.3
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 13.0
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 13.0
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 12.6
 LDTP16006  Optic atrophy 3 protein (OPA3) 12.3
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 11.9
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 11.8
 LDTP07419  Centromere protein P (CENPP) 11.5
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 11.4
 LDTP15634  Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5) 11.4
 LDTP09920  Golgi apparatus protein 1 (GLG1) 11.3
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 11.2
 LDTP09143  Divergent protein kinase domain 2A (DIPK2A) 11.2
 LDTP05160  Nucleobindin-2 (NUCB2) 11.2
 LDTP07031  Collectin-12 (COLEC12) 10.9
 LDTP04979  U6 snRNA-associated Sm-like protein LSm3 (LSM3) 10.7
 LDTP13630  Neudesin (NENF) 10.6
 LDTP12476  Translation initiation factor eIF2B subunit gamma (EIF2B3) 10.6
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 10.4
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 10.3
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 10.3
 LDTP15714  Mdm2-binding protein (MTBP) 9.8
 LDTP06097  Reticulocalbin-2 (RCN2) 9.1
 LDTP06868  Angiomotin (AMOT) 9.1
 LDTP13086  Syntaxin-18 (STX18) 9.1
 LDTP18467  LYR motif-containing protein 2 (LYRM2) 9.0
 LDTP00105  Protein unc-119 homolog B (UNC119B) 8.5
 LDTP13507  BAG family molecular chaperone regulator 5 (BAG5) 8.2
 LDTP10056  Protein FAM162A (FAM162A) 8.2
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 8.1
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 7.9
 LDTP16080  Protein FAM114A2 (FAM114A2) 7.9
 LDTP10357  RUS family member 1 (RUSF1) 7.9
 LDTP05960  Trophoblast glycoprotein (TPBG) 7.8
 LDTP00859  Synaptogyrin-2 (SYNGR2) 7.8
 LDTP01466  HAUS augmin-like complex subunit 5 (HAUS5) 7.7
 LDTP06948  Protein YIF1B (YIF1B) 7.7
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 7.5
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 7.5
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 7.4
 LDTP19963  TraB domain-containing protein (TRABD) 7.4
 LDTP00417  Programmed cell death protein 5 (PDCD5) 7.4
 LDTP17730  UPF0690 protein C1orf52 (C1orf52) 7.3

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587