Details of the Target

General Information of Target

Target ID LDTP08617
Target Name Patatin-like phospholipase domain-containing protein 6 (PNPLA6)
Gene Name PNPLA6
Gene ID 10908
Synonyms
NTE; Patatin-like phospholipase domain-containing protein 6; EC 3.1.1.5; Neuropathy target esterase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEAPLQTGMMGTSSHGLATNSSGAKVAERDGFQDVLAPGEGSAGRICGAQPVPFVPQVLG
VMIGAGVAVVVTAVLILLVVRRLRVPKTPAPDGPRYRFRKRDKVLFYGRKIMRKVSQSTS
SLVDTSVSATSRPRMRKKLKMLNIAKKILRIQKETPTLQRKEPPPAVLEADLTEGDLANS
HLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQPDASIYVVQDGLL
ELCLPGPDGKECVVKEVVPGDSVNSLLSILDVITGHQHPQRTVSARAARDSTVLRLPVEA
FSAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLGLTNELFSHEIQPLRLFPSPGLPTR
TSPVRGSKRMVSTSATDEPRETPGRPPDPTGAPLPGPTGDPVKPTSLETPSAPLLSRCVS
MPGDISGLQGGPRSDFDMAYERGRISVSLQEEASGGSLAAPARTPTQEPREQPAGACEYS
YCEDESATGGCPFGPYQGRQTSSIFEAAKQELAKLMRIEDPSLLNSRVLLHHAKAGTIIA
RQGDQDVSLHFVLWGCLHVYQRMIDKAEDVCLFVAQPGELVGQLAVLTGEPLIFTLRAQR
DCTFLRISKSDFYEIMRAQPSVVLSAAHTVAARMSPFVRQMDFAIDWTAVEAGRALYRQG
DRSDCTYIVLNGRLRSVIQRGSGKKELVGEYGRGDLIGVVEALTRQPRATTVHAVRDTEL
AKLPEGTLGHIKRRYPQVVTRLIHLLSQKILGNLQQLQGPFPAGSGLGVPPHSELTNPAS
NLATVAILPVCAEVPMVAFTLELQHALQAIGPTLLLNSDIIRARLGASALDSIQEFRLSG
WLAQQEDAHRIVLYQTDASLTPWTVRCLRQADCILIVGLGDQEPTLGQLEQMLENTAVRA
LKQLVLLHREEGAGPTRTVEWLNMRSWCSGHLHLRCPRRLFSRRSPAKLHELYEKVFSRR
ADRHSDFSRLARVLTGNTIALVLGGGGARGCSHIGVLKALEEAGVPVDLVGGTSIGSFIG
ALYAEERSASRTKQRAREWAKSMTSVLEPVLDLTYPVTSMFTGSAFNRSIHRVFQDKQIE
DLWLPYFNVTTDITASAMRVHKDGSLWRYVRASMTLSGYLPPLCDPKDGHLLMDGGYINN
LPADIARSMGAKTVIAIDVGSQDETDLSTYGDSLSGWWLLWKRLNPWADKVKVPDMAEIQ
SRLAYVSCVRQLEVVKSSSYCEYLRPPIDCFKTMDFGKFDQIYDVGYQYGKAVFGGWSRG
NVIEKMLTDRRSTDLNESRRADVLAFPSSGFTDLAEIVSRIEPPTSYVSDGCADGEESDC
LTEYEEDAGPDCSRDEGGSPEGASPSTASEMEEEKSILRQRRCLPQEPPGSATDA
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
NTE family
Subcellular location
Endoplasmic reticulum membrane
Function
Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Catalyzes the hydrolysis of several naturally occurring membrane-associated lipids. Hydrolyzes lysophospholipids and monoacylglycerols, preferring the 1-acyl to the 2-acyl isomer. Does not catalyze hydrolysis of di- or triacylglycerols or fatty acid amides.
TTD ID
T38166
Uniprot ID
Q8IY17
DrugMap ID
TTWAQU2
Ensemble ID
ENST00000221249.10
HGNC ID
HGNC:16268
ChEMBL ID
CHEMBL2189129

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.77  LDD0402  [1]
HDSF-alk
 Probe Info  		2.76  LDD0197  [2]
STPyne
 Probe Info  		K103(3.63); K1190(0.63); K1192(5.88); K146(10.00)  LDD0277  [3]
DBIA
 Probe Info  		C418(2.69); C1208(3.56)  LDD3310  [4]
BTD
 Probe Info  		C991(0.38)  LDD2104  [5]
Sulforaphane-probe2
 Probe Info  		0.94  LDD0160  [6]
DA-P3
 Probe Info  		8.85  LDD0182  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C991(0.00); C208(0.00)  LDD0037  [8]
IPM
 Probe Info  		N.A.  LDD0005  [9]
SF
 Probe Info  		N.A.  LDD0028  [10]
TFBX
 Probe Info  		C208(0.00); C1208(0.00); C1230(0.00); C418(0.00)  LDD0148  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
NAIA_5
 Probe Info  		N.A.  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C027
 Probe Info  		5.98  LDD1733  [14]
C158
 Probe Info  		11.88  LDD1838  [14]
C177
 Probe Info  		8.63  LDD1856  [14]
C178
 Probe Info  		14.62  LDD1857  [14]
C218
 Probe Info  		13.36  LDD1892  [14]
C220
 Probe Info  		13.18  LDD1894  [14]
C226
 Probe Info  		6.06  LDD1899  [14]
C361
 Probe Info  		20.97  LDD2022  [14]
STS-1
 Probe Info  		4.50  LDD0137  [15]
STS-2
 Probe Info  		N.A.  LDD0138  [15]
A-DA
 Probe Info  		20.00  LDD0145  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C991(0.81)  LDD2112  [5]
 LDCM0214  AC1 HEK-293T C1208(1.02); C208(0.87); C1363(0.88); C243(1.03)  LDD1507  [17]
 LDCM0215  AC10 HEK-293T C1208(0.98); C208(0.95); C1363(0.84); C991(1.11)  LDD1508  [17]
 LDCM0226  AC11 HEK-293T C1208(0.95); C208(1.00); C418(1.06); C1363(1.67)  LDD1509  [17]
 LDCM0237  AC12 HEK-293T C1208(1.00); C208(0.95); C1124(0.93); C1363(0.99)  LDD1510  [17]
 LDCM0259  AC14 HEK-293T C1208(0.98); C208(0.89); C1124(1.01); C1363(1.01)  LDD1512  [17]
 LDCM0270  AC15 HEK-293T C1208(0.94); C208(0.96); C1363(1.24); C1230(0.97)  LDD1513  [17]
 LDCM0276  AC17 HEK-293T C1208(0.99); C208(0.86); C1363(0.91); C243(0.71)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C1208(0.96); C208(1.00); C1363(1.10); C991(1.04)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C1208(0.95); C208(0.92); C418(1.02); C1363(1.30)  LDD1517  [17]
 LDCM0279  AC2 HEK-293T C1208(0.98); C208(0.94); C1363(1.13); C991(1.09)  LDD1518  [17]
 LDCM0280  AC20 HEK-293T C1208(0.95); C208(0.87); C1124(0.96); C1363(0.92)  LDD1519  [17]
 LDCM0281  AC21 HEK-293T C1208(1.08); C208(0.99)  LDD1520  [17]
 LDCM0282  AC22 HEK-293T C1208(1.02); C208(0.86); C1124(0.89); C1363(0.89)  LDD1521  [17]
 LDCM0283  AC23 HEK-293T C1208(0.97); C208(0.80); C1363(1.25); C1230(0.97)  LDD1522  [17]
 LDCM0284  AC24 HEK-293T C1208(0.95); C208(1.09); C418(1.08); C1124(0.95)  LDD1523  [17]
 LDCM0285  AC25 HEK-293T C1208(0.98); C208(0.81); C1363(1.03); C243(1.11)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C1208(0.93); C208(1.03); C1363(1.02); C991(0.99)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C1208(0.99); C208(0.94); C418(0.84); C1363(1.23)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C1208(0.99); C208(0.87); C1124(0.97); C1363(0.77)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C1208(1.04); C208(0.93)  LDD1528  [17]
 LDCM0290  AC3 HEK-293T C1208(0.94); C208(0.99); C418(0.81); C1363(1.01)  LDD1529  [17]
 LDCM0291  AC30 HEK-293T C1208(0.96); C208(0.93); C1124(1.07); C1363(0.84)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C1208(0.89); C208(0.79); C1363(1.10); C1230(1.03)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C1208(0.98); C208(0.95); C418(1.05); C1124(1.03)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C1208(0.97); C208(0.84); C1363(0.79); C243(0.90)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C1208(0.93); C208(1.20); C1363(0.67); C991(1.01)  LDD1534  [17]
 LDCM0296  AC35 HEK-293T C1208(1.02); C208(0.97); C418(0.92); C1363(1.62)  LDD1535  [17]
 LDCM0297  AC36 HEK-293T C1208(1.00); C208(0.93); C1124(0.98); C1363(0.83)  LDD1536  [17]
 LDCM0298  AC37 HEK-293T C1208(1.06); C208(0.92)  LDD1537  [17]
 LDCM0299  AC38 HEK-293T C1208(1.02); C208(0.91); C1124(0.96); C1363(1.05)  LDD1538  [17]
 LDCM0300  AC39 HEK-293T C1208(1.03); C208(0.92); C1363(0.85); C1230(0.96)  LDD1539  [17]
 LDCM0301  AC4 HEK-293T C1208(1.03); C208(0.87); C1124(0.91); C1363(0.99)  LDD1540  [17]
 LDCM0302  AC40 HEK-293T C1208(0.99); C208(1.06); C418(1.07); C1124(1.18)  LDD1541  [17]
 LDCM0303  AC41 HEK-293T C1208(1.02); C208(0.83); C1363(0.95); C243(0.75)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C1208(0.99); C208(0.95); C1363(1.20); C991(1.11)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C1208(0.96); C208(0.94); C418(0.91); C1363(1.18)  LDD1544  [17]
 LDCM0306  AC44 HEK-293T C1208(0.99); C208(0.92); C1124(0.97); C1363(1.54)  LDD1545  [17]
 LDCM0307  AC45 HEK-293T C1208(1.10); C208(0.93)  LDD1546  [17]
 LDCM0308  AC46 HEK-293T C1208(1.03); C208(0.90); C1124(0.89); C1363(1.05)  LDD1547  [17]
 LDCM0309  AC47 HEK-293T C1208(0.96); C208(0.94); C1363(0.93); C1230(0.99)  LDD1548  [17]
 LDCM0310  AC48 HEK-293T C1208(0.96); C208(0.98); C418(1.14); C1124(1.05)  LDD1549  [17]
 LDCM0311  AC49 HEK-293T C1208(0.95); C208(0.87); C1363(0.79); C243(1.12)  LDD1550  [17]
 LDCM0312  AC5 HEK-293T C1208(1.07); C208(0.98)  LDD1551  [17]
 LDCM0313  AC50 HEK-293T C1208(1.03); C208(1.11); C1363(0.78); C991(1.02)  LDD1552  [17]
 LDCM0314  AC51 HEK-293T C1208(0.97); C208(0.97); C418(1.06); C1363(1.31)  LDD1553  [17]
 LDCM0315  AC52 HEK-293T C1208(0.99); C208(1.01); C1124(0.97); C1363(0.95)  LDD1554  [17]
 LDCM0316  AC53 HEK-293T C1208(1.06); C208(0.92)  LDD1555  [17]
 LDCM0317  AC54 HEK-293T C1208(0.95); C208(1.05); C1124(0.91); C1363(1.04)  LDD1556  [17]
 LDCM0318  AC55 HEK-293T C1208(0.93); C208(0.90); C1363(1.04); C1230(0.99)  LDD1557  [17]
 LDCM0319  AC56 HEK-293T C1208(1.23); C208(0.99); C418(1.02); C1124(1.09)  LDD1558  [17]
 LDCM0320  AC57 HEK-293T C1208(0.95); C208(0.82); C1363(0.95); C243(0.96)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C1208(1.02); C208(0.99); C1363(0.68); C991(1.10)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C1208(0.96); C208(0.96); C418(0.91); C1363(0.91)  LDD1561  [17]
 LDCM0323  AC6 HEK-293T C1208(1.03); C208(0.98); C1124(0.91); C1363(0.88)  LDD1562  [17]
 LDCM0324  AC60 HEK-293T C1208(0.97); C208(0.91); C1124(0.92); C1363(0.93)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C1208(1.03); C208(0.88)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C1208(1.01); C208(0.83); C1124(1.00); C1363(0.95)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C1208(1.08); C208(0.90); C1363(0.89); C1230(1.09)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C1208(1.02); C208(1.16); C418(1.02); C1124(1.08)  LDD1567  [17]
 LDCM0334  AC7 HEK-293T C1208(0.95); C208(0.86); C1363(1.11); C1230(1.03)  LDD1568  [17]
 LDCM0345  AC8 HEK-293T C1208(0.92); C208(1.05); C418(1.21); C1124(1.06)  LDD1569  [17]
 LDCM0248  AKOS034007472 HEK-293T C1208(1.07); C208(0.91)  LDD1511  [17]
 LDCM0356  AKOS034007680 HEK-293T C1208(1.00); C208(0.90); C1363(0.93); C243(0.86)  LDD1570  [17]
 LDCM0275  AKOS034007705 HEK-293T C1208(0.96); C208(0.94); C418(1.02); C1124(1.05)  LDD1514  [17]
 LDCM0087  Capsaicin HEK-293T 24.10  LDD0185  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [12]
 LDCM0367  CL1 HEK-293T C1208(1.06); C208(0.99); C418(1.06); C1124(0.96)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C1208(1.49); C208(1.07); C1124(1.00); C1363(0.77)  LDD1572  [17]
 LDCM0369  CL100 HEK-293T C1208(1.01); C418(0.78); C1363(1.27); C991(1.12)  LDD1573  [17]
 LDCM0370  CL101 HEK-293T C1208(1.05); C208(0.93); C418(1.04); C1124(0.97)  LDD1574  [17]
 LDCM0371  CL102 HEK-293T C1208(1.08); C208(1.07); C1363(1.01); C1230(0.99)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C1208(1.04); C1124(1.02); C1363(1.06)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C1208(1.01); C418(0.77); C1363(1.12); C991(1.05)  LDD1577  [17]
 LDCM0374  CL105 HEK-293T C1208(1.02); C208(0.81); C418(1.14); C1124(0.87)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C1208(0.99); C208(1.08); C1363(1.06); C1230(0.93)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C1208(0.96); C1124(0.92); C1363(1.11)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C1208(1.00); C418(1.02); C1363(1.37); C991(0.97)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C1208(0.98); C208(0.98); C418(1.28); C1124(0.95)  LDD1582  [17]
 LDCM0379  CL11 HEK-293T C1208(1.00); C208(1.00); C1363(1.23); C1230(0.83)  LDD1583  [17]
 LDCM0380  CL110 HEK-293T C1208(1.05); C208(0.94); C1363(1.11); C1230(0.88)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C1208(1.12); C1124(0.91); C1363(1.06)  LDD1585  [17]
 LDCM0382  CL112 HEK-293T C1208(1.04); C418(0.72); C1363(1.29); C991(1.08)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C1208(0.98); C208(0.85); C418(1.10); C1124(0.89)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C1208(1.10); C208(1.11); C1363(0.96); C1230(1.01)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C1208(0.99); C1124(0.99); C1363(0.98)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C1208(1.02); C418(0.78); C1363(1.34); C991(1.03)  LDD1590  [17]
 LDCM0387  CL117 HEK-293T C1208(1.03); C208(0.83); C418(1.07); C1124(0.91)  LDD1591  [17]
 LDCM0388  CL118 HEK-293T C1208(1.00); C208(1.00); C1363(1.06); C1230(1.06)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C1208(1.03); C1124(1.14); C1363(1.00)  LDD1593  [17]
 LDCM0390  CL12 HEK-293T C1208(1.04); C208(1.04); C418(1.02); C1124(1.18)  LDD1594  [17]
 LDCM0391  CL120 HEK-293T C1208(1.02); C418(0.92); C1363(1.37); C991(1.06)  LDD1595  [17]
 LDCM0392  CL121 HEK-293T C1208(1.01); C208(0.84); C418(1.08); C1124(0.85)  LDD1596  [17]
 LDCM0393  CL122 HEK-293T C1208(1.04); C208(1.06); C1363(0.96); C1230(0.93)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C1208(1.30); C1124(1.00); C1363(1.03)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C1208(1.04); C418(1.09); C1363(1.54); C991(1.02)  LDD1599  [17]
 LDCM0396  CL125 HEK-293T C1208(1.02); C208(0.78); C418(0.85); C1124(1.11)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C1208(1.17); C208(1.00); C1363(0.97); C1230(1.01)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C1208(1.03); C1124(0.97); C1363(1.13)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C1208(1.05); C418(1.03); C1363(1.34); C991(0.99)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C1208(1.12); C208(0.90); C418(1.17); C1124(1.02)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C1208(1.02); C208(1.06); C1363(1.09); C1230(1.02)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C1208(1.14); C1124(0.99); C1363(1.04)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C1208(1.02); C418(1.01); C1363(0.97); C991(1.01)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C1208(1.11); C208(0.89); C1363(0.95); C243(0.77)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C1208(1.00); C208(1.15); C1363(0.81); C991(1.08)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C1208(1.00); C208(1.09); C418(1.06); C1363(1.27)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C1208(1.04); C208(1.03); C1363(1.05); C1230(0.98)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C1208(1.05); C208(1.10); C1124(1.09); C1363(1.04)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C1208(1.14); C208(0.90)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C1208(1.01); C208(1.07); C1124(1.02); C1363(0.94)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C1208(1.02); C208(1.07); C1363(0.92); C1230(0.93)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C1208(0.99); C208(1.09); C418(1.09); C1124(1.05)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C1208(1.07); C208(0.85); C418(1.02); C1124(1.03)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C1208(0.98); C208(1.02); C1363(1.02); C1230(0.92)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C1208(1.03); C1124(1.06); C1363(0.95)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C1208(1.00); C418(1.05); C1363(1.02); C991(1.00)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C1208(0.93); C208(0.87); C1363(1.01); C243(0.88)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C1208(1.06); C1124(0.97); C1363(1.06)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C1208(0.96); C208(0.97); C1363(0.50); C991(1.01)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C1208(1.06); C208(0.96); C418(0.93); C1363(1.48)  LDD1624  [17]
 LDCM0421  CL32 HEK-293T C1208(0.96); C208(1.05); C1124(0.98); C1363(1.00)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C1208(1.26); C208(1.08)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C1208(1.03); C208(0.97); C1124(1.02); C1363(1.12)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C1208(1.01); C208(0.97); C1363(1.00); C1230(0.84)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C1208(1.03); C208(1.19); C418(1.02); C1124(1.10)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C1208(1.04); C208(0.82); C418(0.85); C1124(0.99)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C1208(1.14); C1124(0.99); C1363(1.01)  LDD1632  [17]
 LDCM0429  CL4 HEK-293T C1208(1.08); C418(1.06); C1363(1.17); C991(1.09)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C1208(1.14); C418(0.73); C1363(0.94); C991(1.03)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C1208(1.09); C208(0.79); C1363(0.89); C243(0.96)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C1208(0.94); C208(1.03); C1363(0.68); C991(1.02)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C1208(0.92); C208(0.95); C418(0.87); C1363(1.58)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C1208(1.01); C208(0.92); C1124(0.96); C1363(1.05)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C1208(1.21); C208(1.06)  LDD1639  [17]
 LDCM0436  CL46 HEK-293T C1208(1.01); C208(0.99); C1124(1.05); C1363(0.92)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C1208(1.11); C208(1.03); C1363(1.17); C1230(0.91)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C1208(0.97); C208(1.13); C418(1.12); C1124(1.14)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C1208(1.12); C208(0.90); C418(1.03); C1124(0.89)  LDD1643  [17]
 LDCM0440  CL5 HEK-293T C1208(0.98); C208(0.86); C1363(0.89); C243(0.88)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C1208(1.06); C208(1.15); C1363(1.00); C1230(1.07)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C1208(1.11); C418(1.02); C1363(1.60); C991(1.09)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C1208(1.04); C208(0.82); C1363(0.88); C243(0.93)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C1208(1.19); C208(1.03); C1363(0.82); C991(1.06)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C1208(0.96); C208(1.02); C418(1.04); C1363(1.16)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C1208(1.14); C208(1.01); C1124(1.06); C1363(1.03)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C1208(1.21); C208(1.10)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C1208(1.07); C208(1.11); C1124(0.89); C1363(1.00)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C1208(1.03); C208(0.85); C1363(0.76); C1230(1.01)  LDD1653  [17]
 LDCM0451  CL6 HEK-293T C1208(1.01); C208(1.07); C1363(1.10); C991(1.08)  LDD1654  [17]
 LDCM0452  CL60 HEK-293T C1208(1.01); C208(1.10); C418(1.11); C1124(1.11)  LDD1655  [17]
 LDCM0453  CL61 HEK-293T C1208(0.98); C208(0.95); C418(1.00); C1124(0.89)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C1208(1.07); C208(1.10); C1363(1.11); C1230(0.85)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C1208(1.03); C1124(0.96); C1363(1.02)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C1208(1.11); C418(1.08); C1363(1.04); C991(1.04)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C1208(1.05); C208(0.95); C1363(0.97); C243(0.90)  LDD1660  [17]
 LDCM0458  CL66 HEK-293T C1208(1.90); C208(1.15); C1363(1.04); C991(1.40)  LDD1661  [17]
 LDCM0459  CL67 HEK-293T C1208(0.99); C208(0.98); C418(1.12); C1363(1.24)  LDD1662  [17]
 LDCM0460  CL68 HEK-293T C1208(1.06); C208(0.97); C1124(1.05); C1363(1.06)  LDD1663  [17]
 LDCM0461  CL69 HEK-293T C1208(1.09); C208(0.94)  LDD1664  [17]
 LDCM0462  CL7 HEK-293T C1208(1.00); C208(0.98); C418(0.94); C1363(1.39)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C1208(1.05); C208(0.96); C1124(0.91); C1363(1.24)  LDD1666  [17]
 LDCM0464  CL71 HEK-293T C1208(0.98); C208(0.96); C1363(0.94); C1230(0.87)  LDD1667  [17]
 LDCM0465  CL72 HEK-293T C1208(0.99); C208(1.21); C418(0.97); C1124(1.03)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C1208(1.15); C208(0.85); C418(1.21); C1124(0.95)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C1208(1.01); C208(1.06); C1363(1.01); C1230(1.07)  LDD1670  [17]
 LDCM0469  CL76 HEK-293T C1208(1.04); C418(0.99); C1363(1.25); C991(1.02)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C1208(1.04); C208(0.84); C1363(0.85); C243(0.80)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C1208(0.96); C208(1.02); C1363(0.85); C991(1.01)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C1208(0.93); C208(1.02); C418(1.04); C1363(1.31)  LDD1675  [17]
 LDCM0473  CL8 HEK-293T C1208(1.32); C208(0.84); C1124(0.99); C1363(0.99)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C1208(0.98); C208(0.98); C1124(1.00); C1363(0.88)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C1208(1.05); C208(1.05)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C1208(1.01); C208(1.06); C1124(1.11); C1363(1.09)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C1208(1.07); C208(0.88); C1363(1.27); C1230(1.00)  LDD1680  [17]
 LDCM0478  CL84 HEK-293T C1208(0.95); C208(1.14); C418(1.07); C1124(1.21)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C1208(1.04); C208(0.83); C418(0.98); C1124(1.09)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C1208(1.14); C208(1.01); C1363(0.90); C1230(0.95)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C1208(0.92); C1124(1.08); C1363(1.05)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C1208(1.04); C418(1.25); C1363(1.05); C991(1.11)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C1208(1.02); C208(0.82); C1363(1.02); C243(1.07)  LDD1686  [17]
 LDCM0484  CL9 HEK-293T C1208(1.07); C208(0.95)  LDD1687  [17]
 LDCM0485  CL90 HEK-293T C1208(1.23); C208(1.07); C1363(1.12); C991(1.26)  LDD1688  [17]
 LDCM0486  CL91 HEK-293T C1208(0.99); C208(1.06); C418(0.87); C1363(0.90)  LDD1689  [17]
 LDCM0487  CL92 HEK-293T C1208(1.08); C208(1.06); C1124(1.03); C1363(1.02)  LDD1690  [17]
 LDCM0488  CL93 HEK-293T C1208(1.09); C208(0.91)  LDD1691  [17]
 LDCM0489  CL94 HEK-293T C1208(1.05); C208(1.01); C1124(0.87); C1363(0.97)  LDD1692  [17]
 LDCM0490  CL95 HEK-293T C1208(1.09); C208(0.83); C1363(1.23); C1230(0.97)  LDD1693  [17]
 LDCM0491  CL96 HEK-293T C1208(0.97); C208(1.03); C418(1.09); C1124(1.49)  LDD1694  [17]
 LDCM0492  CL97 HEK-293T C1208(1.11); C208(0.91); C418(0.99); C1124(1.04)  LDD1695  [17]
 LDCM0493  CL98 HEK-293T C1208(1.06); C208(1.11); C1363(0.93); C1230(1.00)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C1208(1.10); C1124(1.04); C1363(0.89)  LDD1697  [17]
 LDCM0495  E2913 HEK-293T C1208(1.08); C1124(1.13); C1363(1.26)  LDD1698  [17]
 LDCM0468  Fragment33 HEK-293T C1208(1.03); C1124(1.05); C1363(1.12)  LDD1671  [17]
 LDCM0427  Fragment51 HEK-293T C1208(0.94); C208(1.00); C1363(1.09); C1230(0.89)  LDD1631  [17]
 LDCM0022  KB02 HEK-293T C1363(1.11); C1208(0.99); C418(0.90); C1124(1.01)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C1363(0.74); C1208(0.98); C418(1.03); C1124(0.94)  LDD1497  [17]
 LDCM0024  KB05 COLO792 C418(2.69); C1208(3.56)  LDD3310  [4]
 LDCM0030  Luteolin HEK-293T 8.85  LDD0182  [7]
 LDCM0109  NEM HeLa N.A.  LDD0227  [12]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C991(0.38)  LDD2104  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C991(0.28)  LDD2106  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C991(0.87)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C991(0.63)  LDD2109  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C991(0.45)  LDD2114  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C991(0.98)  LDD2123  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C991(1.13)  LDD2127  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C991(1.25)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C991(1.13)  LDD2137  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C991(0.74)  LDD2141  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C991(2.44)  LDD2144  [5]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C991(1.50)  LDD2145  [5]
 LDCM0084  Ro 48-8071 A-549 20.00  LDD0145  [16]
 LDCM0003  Sulforaphane MDA-MB-231 0.94  LDD0160  [6]

References

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Mass spectrometry data entry: PXD028270
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
7 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
16 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402