Details of the Probe

General Information of Probe

Probe ID
LDPC0133
Probe Name
HDSF-alk
Probe Type
ABPP Probe
Structure
2D MOL
Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 332.525
Lipid-water partition coefficient (xlogp) 5.7704
Rotatable Bond Count (rotbonds) 16
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 2
Chemical Identifiers
Formula
C18H33FO2S
Canonical SMILES
C#CCCCCCCCCCCCCCCCCS(=O)(=O)F
InChI
InChI=1S/C18H33FO2S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-22(19,20)21/h1H,3-18H2
InChIKey
PEYZUNFGXUVQEV-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

60 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (AGPAT1) LDTP11012 2.80  LDD0197 
7-dehydrocholesterol reductase (DHCR7) LDTP13131 1.96  LDD0197 
Acyl-protein thioesterase 1 (LYPLA1) LDTP01273 2.58  LDD0197 
Acylglycerol kinase, mitochondrial (AGK) LDTP06905 1.78  LDD0197 
Adipocyte plasma membrane-associated protein (APMAP) LDTP12293 2.87  LDD0197 
ADP-dependent glucokinase (ADPGK) LDTP11127 1.68  LDD0197 
Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) LDTP00186 4.65  LDD0197 
Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) LDTP04253 1.70  LDD0197 
Alpha/beta hydrolase domain-containing protein 17B (ABHD17B) LDTP07208 3.26  LDD0197 
Androgen-induced gene 1 protein (AIG1) LDTP12697 4.53  LDD0197 
ATP synthase membrane subunit K, mitochondrial (ATP5MK) LDTP10432 2.44  LDD0197 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 2.56  LDD0197 
Calcium-transporting ATPase type 2C member 1 (ATP2C1) LDTP05228 1.66  LDD0197 
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) LDTP04358 2.38  LDD0197 
Catechol O-methyltransferase (COMT) LDTP03145 2.10  LDD0197 
CDGSH iron-sulfur domain-containing protein 1 (CISD1) LDTP12873 1.77  LDD0197 
Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) LDTP11178 3.58  LDD0197 
Cytochrome b5 type B (CYB5B) LDTP00697 1.75  LDD0197 
Dihydroxyacetone phosphate acyltransferase (GNPAT) LDTP00577 3.51  LDD0197 
Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (ALG6) LDTP14213 2.18  LDD0197 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) LDTP04120 2.41  LDD0197 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (STT3B) LDTP09388 2.32  LDD0197 
Endonuclease domain-containing 1 protein (ENDOD1) LDTP01462 1.67  LDD0197 
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) LDTP09063 3.55  LDD0197 
Fatty acid CoA ligase Acsl3 (ACSL3) LDTP01634 2.29  LDD0197 
Fatty acyl-CoA reductase 1 (FAR1) LDTP09628 1.53  LDD0197 
Glutathione S-transferase 3, mitochondrial (MGST3) LDTP00464 1.75  LDD0197 
Glycerol-3-phosphate acyltransferase 4 (GPAT4) LDTP08232 2.14  LDD0197 
GPI inositol-deacylase (PGAP1) LDTP07913 2.64  LDD0197 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 3.80  LDD0197 
L-2-hydroxyglutarate dehydrogenase, mitochondrial (L2HGDH) LDTP12105 1.68  LDD0197 
Lipid droplet-associated hydrolase (LDAH) LDTP16007 3.57  LDD0197 
Long-chain fatty acid transport protein 4 (SLC27A4) LDTP07511 2.03  LDD0197 
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) LDTP09188 1.52  LDD0197 
Lysophosphatidylserine lipase ABHD12 (ABHD12) LDTP08799 3.83  LDD0197 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 3.57  LDD0197 
Microsomal glutathione S-transferase 2 (MGST2) LDTP10966 1.74  LDD0197 
Minor histocompatibility antigen H13 (HM13) LDTP09396 3.05  LDD0197 
Monoacylglycerol lipase ABHD6 (ABHD6) LDTP11261 2.99  LDD0197 
Neutral cholesterol ester hydrolase 1 (NCEH1) LDTP07591 2.07  LDD0197 
Patatin-like phospholipase domain-containing protein 4 (PNPLA4) LDTP03945 3.22  LDD0197 
Patatin-like phospholipase domain-containing protein 6 (PNPLA6) LDTP08617 2.76  LDD0197 
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (PTPMT1) LDTP09578 2.44  LDD0197 
Phosphatidylserine lipase ABHD16A (ABHD16A) LDTP01704 4.42  LDD0197 
Phosphatidylserine synthase 2 (PTDSS2) LDTP11284 1.68  LDD0197 
Phospholipase A2 group XV (PLA2G15) LDTP09088 5.32  LDD0197 
Probable glutathione peroxidase 8 (GPX8) LDTP09495 2.51  LDD0197 
Protein ABHD13 (ABHD13) LDTP17516 2.64  LDD0197 
Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase (ALG10B) LDTP06992 1.64  LDD0197 
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) LDTP02860 3.36  LDD0197 
Signal peptidase complex subunit 2 (SPCS2) LDTP06270 1.88  LDD0197 
Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) LDTP02067 2.02  LDD0197 
Sphingosine-1-phosphate lyase 1 (SGPL1) LDTP01613 2.23  LDD0197 
Sterol O-acyltransferase 1 (SOAT1) LDTP03769 2.25  LDD0197 
Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) LDTP07227 1.73  LDD0197 
Transmembrane protein with metallophosphoesterase domain (TMPPE) LDTP07831 1.95  LDD0197 
Tyrosine-protein phosphatase non-receptor type 1 (PTPN1) LDTP02935 1.98  LDD0197 
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) LDTP12954 1.76  LDD0197 
Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) LDTP06901 4.34  LDD0197 
Very-long-chain enoyl-CoA reductase (TECR) LDTP12867 2.03  LDD0197 
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⏷ Show the Full List of 60 Enzyme
45 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 2.48  LDD0197 
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) LDTP03284 3.29  LDD0197 
B-cell receptor-associated protein 31 (BCAP31) LDTP04426 2.02  LDD0197 
CD151 antigen (CD151) LDTP04187 2.74  LDD0197 
CD63 antigen (CD63) LDTP02320 2.61  LDD0197 
CD81 antigen (CD81) LDTP04849 3.24  LDD0197 
Ceroid-lipofuscinosis neuronal protein 6 (CLN6) LDTP12738 2.02  LDD0197 
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) LDTP02645 2.18  LDD0197 
Cytoskeleton-associated protein 4 (CKAP4) LDTP05511 2.11  LDD0197 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (RPN2) LDTP02058 2.50  LDD0197 
ER membrane protein complex subunit 5 (MMGT1) LDTP08878 2.18  LDD0197 
Extended synaptotagmin-2 (ESYT2) LDTP00014 2.84  LDD0197 
Fatty acid-binding protein 5 (FABP5) LDTP05292 4.49  LDD0197 
High affinity cationic amino acid transporter 1 (SLC7A1) LDTP03559 1.54  LDD0197 
Large neutral amino acids transporter small subunit 1 (SLC7A5) LDTP05305 1.83  LDD0197 
Lipid scramblase CLPTM1L (CLPTM1L) LDTP10499 1.87  LDD0197 
MICOS complex subunit MIC26 (APOO) LDTP11250 2.55  LDD0197 
Mitochondrial carrier homolog 2 (MTCH2) LDTP14235 3.04  LDD0197 
Mitochondrial proton/calcium exchanger protein (LETM1) LDTP01525 1.73  LDD0197 
Monocarboxylate transporter 1 (SLC16A1) LDTP04592 1.58  LDD0197 
Neutral amino acid transporter B(0) (SLC1A5) LDTP06462 1.54  LDD0197 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 2.68  LDD0197 
Nuclear envelope integral membrane protein 1 (NEMP1) LDTP00361 2.95  LDD0197 
Nuclear envelope pore membrane protein POM 121C (POM121C) LDTP00127 2.39  LDD0197 
Nucleoporin NDC1 (NDC1) LDTP11213 1.81  LDD0197 
PRA1 family protein 2 (PRAF2) LDTP01060 4.09  LDD0197 
Protein RER1 (RER1) LDTP00590 1.71  LDD0197 
Protein RFT1 homolog (RFT1) LDTP10073 2.83  LDD0197 
Putative lipid scramblase CLPTM1 (CLPTM1) LDTP01745 2.75  LDD0197 
Secretory carrier-associated membrane protein 3 (SCAMP3) LDTP00451 1.72  LDD0197 
Sodium- and chloride-dependent creatine transporter 1 (SLC6A8) LDTP04148 2.46  LDD0197 
Solute carrier family 12 member 2 (SLC12A2) LDTP04653 1.51  LDD0197 
Solute carrier family 12 member 7 (SLC12A7) LDTP14212 1.68  LDD0197 
Sorting and assembly machinery component 50 homolog (SAMM50) LDTP14084 2.18  LDD0197 
SUN domain-containing protein 1 (SUN1) LDTP01454 3.06  LDD0197 
Surfeit locus protein 4 (SURF4) LDTP00592 1.94  LDD0197 
Transferrin receptor protein 1 (TFRC) LDTP01969 2.34  LDD0197 
Transmembrane 9 superfamily member 2 (TM9SF2) LDTP15845 2.39  LDD0197 
Transmembrane protein 201 (TMEM201) LDTP07058 3.28  LDD0197 
Transmembrane protein 214 (TMEM214) LDTP07477 2.43  LDD0197 
Transmembrane protein 245 (TMEM245) LDTP15979 3.23  LDD0197 
Vesicle-associated membrane protein 3 (VAMP3) LDTP06490 3.14  LDD0197 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 1.78  LDD0197 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 2.55  LDD0197 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 1.82  LDD0197 
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⏷ Show the Full List of 45 Transporter and channel
1 GPCR Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Melatonin-related receptor (GPR50) LDTP05933 2.05  LDD0197 
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2 Immunoglobulin Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Basigin (BSG) LDTP03772 1.87  LDD0197 
Prostaglandin F2 receptor negative regulator (PTGFRN) LDTP13034 1.85  LDD0197 
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17 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
CDGSH iron-sulfur domain-containing protein 2 (CISD2) LDTP08902 1.97  LDD0197 
Cellular retinoic acid-binding protein 2 (CRABP2) LDTP03482 3.38  LDD0197 
DnaJ homolog subfamily C member 11 (DNAJC11) LDTP12677 1.64  LDD0197 
Golgin subfamily A member 3 (GOLGA3) LDTP05556 3.52  LDD0197 
Lipase maturation factor 2 (LMF2) LDTP15887 2.72  LDD0197 
Lipid droplet-regulating VLDL assembly factor AUP1 (AUP1) LDTP14217 3.17  LDD0197 
Mannose-P-dolichol utilization defect 1 protein (MPDU1) LDTP14491 1.97  LDD0197 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 2.42  LDD0197 
Phosphatidylinositol glycan anchor biosynthesis class U protein (PIGU) LDTP11906 2.90  LDD0197 
Prohibitin-2 (PHB2) LDTP10924 1.92  LDD0197 
Receptor expression-enhancing protein 4 (REEP4) LDTP11981 1.81  LDD0197 
Receptor expression-enhancing protein 5 (REEP5) LDTP05257 3.27  LDD0197 
Reticulon-3 (RTN3) LDTP01522 2.63  LDD0197 
Reticulon-4 (RTN4) LDTP12412 2.94  LDD0197 
RUS family member 1 (RUSF1) LDTP10357 2.38  LDD0197 
Tetraspanin-6 (TSPAN6) LDTP14458 1.64  LDD0197 
TraB domain-containing protein (TRABD) LDTP19963 2.37  LDD0197 
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⏷ Show the Full List of 17 Other

Full Information of The Labelling Profiles of This Probe

Quantification: Probe vs DMSO
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
1 uM
Quantitative Method
SILAC
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Interaction Atlas ID
 LDD0197 
Download The Altas

References

1 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.