Details of the Target

General Information of Target

Target ID LDTP14491
Target Name Mannose-P-dolichol utilization defect 1 protein (MPDU1)
Gene Name MPDU1
Gene ID 9526
Synonyms
Mannose-P-dolichol utilization defect 1 protein; Suppressor of Lec15 and Lec35 glycosylation mutation homolog; SL15
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGPLQFRDVAIEFSLEEWHCLDTAQRNLYRDVMLENYRNLVFLGIVVSKPDLVTCLEQGK
KPLTMERHEMIAKPPVMSSHFAQDLWPENIQNSFQIGMLRRYEECRHDNLQLKKGCKSVG
EHKVHKGGYNGLNQCLTTTQKEIFQCDKYGKVFHKFSNSNTYKTRHTGINLFKCIICGKA
FKRSSTLTTHKKIHTGEKPYRCEECGKAFNQSANLTTHKRIHTGEKPYRCEECGKAFKQS
SNLTTHKKIHTGEKPYKCEECGKAFNRSTDLTTHKIVHTGEKPYKCEECGKAFKHPSHVT
THKKIHTRGKPYNCEECGKSFKHCSNLTIHKRIHTGEKPYKCEECGKAFHLSSHLTTHKI
LHTGEKPYRCRECGKAFNHSTTLFSHEKIHTGEKPYKCDECGKTFTWPSILSKHKRTHTG
EKPYKCEECGKSFTASSTLTTHKRIHTGEKPYKCEECGKAFNWSSDLNKHKKIHIERKPY
IVKNVTDLLNVPPLLISIR
Target Bioclass
Other
Family
MPDU1 (TC 2.A.43.3) family
Subcellular location
Membrane
Function Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors.
Uniprot ID
O75352
Ensemble ID
ENST00000250124.11
HGNC ID
HGNC:7207

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HELA SNV: p.T89I .
SKMEL2 SNV: p.M80R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HDSF-alk
 Probe Info  		1.97  LDD0197  [1]
C-Sul
 Probe Info  		4.69  LDD0066  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
DBIA
 Probe Info  		C22(1.25)  LDD1093  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [5]
NAIA_5
 Probe Info  		C37(0.00); C22(0.00)  LDD2223  [6]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C094
 Probe Info  		24.25  LDD1785  [7]
OEA-DA
 Probe Info  		7.84  LDD0046  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C22(1.25)  LDD1093  [4]
 LDCM0215  AC10 PaTu 8988t C22(1.24)  LDD1094  [4]
 LDCM0216  AC100 PaTu 8988t C37(0.92); C22(1.00)  LDD1095  [4]
 LDCM0217  AC101 PaTu 8988t C37(1.02); C22(1.05)  LDD1096  [4]
 LDCM0218  AC102 PaTu 8988t C37(1.30); C22(1.24)  LDD1097  [4]
 LDCM0219  AC103 PaTu 8988t C37(1.02); C22(0.99)  LDD1098  [4]
 LDCM0220  AC104 PaTu 8988t C37(1.00); C22(1.00)  LDD1099  [4]
 LDCM0221  AC105 PaTu 8988t C37(1.09); C22(1.01)  LDD1100  [4]
 LDCM0222  AC106 PaTu 8988t C37(0.85); C22(0.88)  LDD1101  [4]
 LDCM0223  AC107 PaTu 8988t C37(1.12); C22(1.18)  LDD1102  [4]
 LDCM0224  AC108 PaTu 8988t C37(0.93); C22(0.93)  LDD1103  [4]
 LDCM0225  AC109 PaTu 8988t C37(1.02); C22(0.93)  LDD1104  [4]
 LDCM0226  AC11 PaTu 8988t C22(1.09)  LDD1105  [4]
 LDCM0227  AC110 PaTu 8988t C37(1.16); C22(1.18)  LDD1106  [4]
 LDCM0228  AC111 PaTu 8988t C37(1.03); C22(1.03)  LDD1107  [4]
 LDCM0229  AC112 PaTu 8988t C37(1.05); C22(1.07)  LDD1108  [4]
 LDCM0230  AC113 PaTu 8988t C37(1.05); C22(1.04)  LDD1109  [4]
 LDCM0231  AC114 PaTu 8988t C37(0.91); C22(0.95)  LDD1110  [4]
 LDCM0232  AC115 PaTu 8988t C37(1.01); C22(1.05)  LDD1111  [4]
 LDCM0233  AC116 PaTu 8988t C37(1.01); C22(0.98)  LDD1112  [4]
 LDCM0234  AC117 PaTu 8988t C37(0.94); C22(0.95)  LDD1113  [4]
 LDCM0235  AC118 PaTu 8988t C37(0.93); C22(0.99)  LDD1114  [4]
 LDCM0236  AC119 PaTu 8988t C37(0.92); C22(0.95)  LDD1115  [4]
 LDCM0237  AC12 PaTu 8988t C22(1.15)  LDD1116  [4]
 LDCM0238  AC120 PaTu 8988t C37(0.96); C22(1.01)  LDD1117  [4]
 LDCM0239  AC121 PaTu 8988t C37(0.91); C22(0.98)  LDD1118  [4]
 LDCM0240  AC122 PaTu 8988t C37(0.88); C22(0.95)  LDD1119  [4]
 LDCM0241  AC123 PaTu 8988t C37(1.04); C22(0.97)  LDD1120  [4]
 LDCM0242  AC124 PaTu 8988t C37(1.04); C22(1.07)  LDD1121  [4]
 LDCM0243  AC125 PaTu 8988t C37(0.90); C22(0.90)  LDD1122  [4]
 LDCM0244  AC126 PaTu 8988t C37(0.90); C22(0.96)  LDD1123  [4]
 LDCM0245  AC127 PaTu 8988t C37(0.97); C22(1.02)  LDD1124  [4]
 LDCM0259  AC14 PaTu 8988t C22(0.95)  LDD1138  [4]
 LDCM0270  AC15 PaTu 8988t C22(1.02)  LDD1149  [4]
 LDCM0276  AC17 PaTu 8988t C37(0.94); C22(0.94)  LDD1155  [4]
 LDCM0277  AC18 PaTu 8988t C37(0.94); C22(0.94)  LDD1156  [4]
 LDCM0278  AC19 PaTu 8988t C37(0.90); C22(0.90)  LDD1157  [4]
 LDCM0279  AC2 PaTu 8988t C22(1.65)  LDD1158  [4]
 LDCM0280  AC20 PaTu 8988t C37(1.13); C22(1.13)  LDD1159  [4]
 LDCM0281  AC21 PaTu 8988t C37(1.03); C22(1.03)  LDD1160  [4]
 LDCM0282  AC22 PaTu 8988t C37(1.10); C22(1.10)  LDD1161  [4]
 LDCM0283  AC23 PaTu 8988t C37(1.06); C22(1.06)  LDD1162  [4]
 LDCM0284  AC24 PaTu 8988t C37(1.04); C22(1.04)  LDD1163  [4]
 LDCM0285  AC25 HEK-293T C37(1.11)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C37(1.29); C22(1.11); C37(1.11)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C37(1.09)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C37(1.37)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C37(1.12)  LDD1528  [9]
 LDCM0290  AC3 PaTu 8988t C22(1.21)  LDD1169  [4]
 LDCM0291  AC30 HEK-293T C37(1.00)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C37(1.11); C22(1.20); C37(1.20)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C37(1.36)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C37(1.08)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C37(1.25); C22(1.25); C37(1.25)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C37(0.99)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C37(1.35)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C37(1.18)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C37(1.02)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C37(1.26); C22(1.16); C37(1.16)  LDD1539  [9]
 LDCM0301  AC4 PaTu 8988t C22(0.99)  LDD1180  [4]
 LDCM0302  AC40 HEK-293T C37(1.28)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C37(1.14)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C37(1.24); C22(1.60); C37(1.60)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C37(1.04)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C37(1.35)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C37(1.35)  LDD1546  [9]
 LDCM0308  AC46 PaTu 8988t C37(0.92); C22(0.90)  LDD1187  [4]
 LDCM0309  AC47 PaTu 8988t C37(0.81); C22(0.85)  LDD1188  [4]
 LDCM0310  AC48 PaTu 8988t C37(0.90); C22(1.04)  LDD1189  [4]
 LDCM0311  AC49 PaTu 8988t C37(0.99); C22(1.01)  LDD1190  [4]
 LDCM0312  AC5 PaTu 8988t C22(1.33)  LDD1191  [4]
 LDCM0313  AC50 PaTu 8988t C37(1.04); C22(1.08)  LDD1192  [4]
 LDCM0314  AC51 PaTu 8988t C37(0.71); C22(0.70)  LDD1193  [4]
 LDCM0315  AC52 PaTu 8988t C37(0.93); C22(1.01)  LDD1194  [4]
 LDCM0316  AC53 PaTu 8988t C37(1.12); C22(1.14)  LDD1195  [4]
 LDCM0317  AC54 PaTu 8988t C37(1.08); C22(1.16)  LDD1196  [4]
 LDCM0318  AC55 PaTu 8988t C37(0.77); C22(0.84)  LDD1197  [4]
 LDCM0319  AC56 PaTu 8988t C37(0.76); C22(1.13)  LDD1198  [4]
 LDCM0320  AC57 HEK-293T C37(1.27)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C37(1.26); C22(1.34); C37(1.34)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C37(1.32)  LDD1561  [9]
 LDCM0323  AC6 PaTu 8988t C22(1.07)  LDD1202  [4]
 LDCM0324  AC60 HEK-293T C37(1.29)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C37(1.09)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C37(1.19)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C37(1.16); C22(1.21); C37(1.21)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C37(1.36)  LDD1567  [9]
 LDCM0334  AC7 PaTu 8988t C22(0.97)  LDD1213  [4]
 LDCM0345  AC8 PaTu 8988t C22(0.94)  LDD1224  [4]
 LDCM0365  AC98 PaTu 8988t C37(0.97); C22(0.97)  LDD1244  [4]
 LDCM0366  AC99 PaTu 8988t C37(0.82); C22(0.97)  LDD1245  [4]
 LDCM0248  AKOS034007472 PaTu 8988t C22(0.93)  LDD1127  [4]
 LDCM0356  AKOS034007680 PaTu 8988t C22(1.33)  LDD1235  [4]
 LDCM0275  AKOS034007705 PaTu 8988t C22(1.14)  LDD1154  [4]
 LDCM0367  CL1 PaTu 8988t C22(1.19)  LDD1246  [4]
 LDCM0368  CL10 PaTu 8988t C22(1.04)  LDD1247  [4]
 LDCM0369  CL100 PaTu 8988t C22(1.00)  LDD1248  [4]
 LDCM0370  CL101 PaTu 8988t C22(0.99)  LDD1249  [4]
 LDCM0371  CL102 PaTu 8988t C22(0.99)  LDD1250  [4]
 LDCM0372  CL103 PaTu 8988t C22(1.11)  LDD1251  [4]
 LDCM0373  CL104 PaTu 8988t C22(0.98)  LDD1252  [4]
 LDCM0374  CL105 PaTu 8988t C37(0.95); C22(0.95)  LDD1253  [4]
 LDCM0375  CL106 PaTu 8988t C37(0.96); C22(0.96)  LDD1254  [4]
 LDCM0376  CL107 PaTu 8988t C37(1.10); C22(1.10)  LDD1255  [4]
 LDCM0377  CL108 PaTu 8988t C37(0.99); C22(0.99)  LDD1256  [4]
 LDCM0378  CL109 PaTu 8988t C37(1.01); C22(1.01)  LDD1257  [4]
 LDCM0379  CL11 PaTu 8988t C22(0.79)  LDD1258  [4]
 LDCM0380  CL110 PaTu 8988t C37(1.03); C22(1.03)  LDD1259  [4]
 LDCM0381  CL111 PaTu 8988t C37(1.15); C22(1.15)  LDD1260  [4]
 LDCM0382  CL112 HEK-293T C37(1.34)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C22(1.28); C37(1.04)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C37(1.18)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C37(1.35)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C37(1.26)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C22(1.14); C37(1.10)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C37(1.32)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C37(1.30)  LDD1593  [9]
 LDCM0390  CL12 PaTu 8988t C22(1.13)  LDD1269  [4]
 LDCM0391  CL120 HEK-293T C37(1.34)  LDD1595  [9]
 LDCM0392  CL121 PaTu 8988t C37(1.05); C22(1.01)  LDD1271  [4]
 LDCM0393  CL122 PaTu 8988t C37(1.79); C22(1.58)  LDD1272  [4]
 LDCM0394  CL123 PaTu 8988t C37(1.05); C22(1.03)  LDD1273  [4]
 LDCM0395  CL124 PaTu 8988t C37(0.97); C22(1.07)  LDD1274  [4]
 LDCM0396  CL125 HEK-293T C22(1.33); C37(1.47)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C37(1.30)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C37(1.41)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C37(1.39)  LDD1603  [9]
 LDCM0400  CL13 PaTu 8988t C22(1.46)  LDD1279  [4]
 LDCM0401  CL14 PaTu 8988t C22(1.64)  LDD1280  [4]
 LDCM0402  CL15 PaTu 8988t C22(1.02)  LDD1281  [4]
 LDCM0403  CL16 HEK-293T C37(1.69)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C37(1.01)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C37(1.52); C22(1.59); C37(1.59)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C37(1.23)  LDD1610  [9]
 LDCM0407  CL2 PaTu 8988t C22(1.13)  LDD1286  [4]
 LDCM0408  CL20 HEK-293T C37(1.09)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C37(1.16)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C37(0.92)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C37(1.07); C22(1.14); C37(1.14)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C37(1.23)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C22(1.01); C37(1.16)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C37(1.08)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C37(1.08)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C37(1.22)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C37(0.97)  LDD1621  [9]
 LDCM0418  CL3 PaTu 8988t C22(1.01)  LDD1297  [4]
 LDCM0419  CL30 HEK-293T C37(1.19); C22(1.12); C37(1.12)  LDD1623  [9]
 LDCM0420  CL31 PaTu 8988t C37(0.92); C22(0.92)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C37(0.87); C22(0.87)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C37(0.85); C22(0.85)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C37(0.87); C22(0.87)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C22(0.96); C37(0.96)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C37(0.24); C22(0.24)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C37(0.75); C22(0.75)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C37(0.68); C22(0.68)  LDD1307  [4]
 LDCM0429  CL4 PaTu 8988t C22(1.10)  LDD1308  [4]
 LDCM0430  CL40 PaTu 8988t C37(0.84); C22(0.84)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C37(0.69); C22(0.69)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C37(0.91); C22(0.91)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C37(0.89); C22(0.89)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C37(0.70); C22(0.70)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C37(0.84); C22(0.84)  LDD1314  [4]
 LDCM0436  CL46 PaTu 8988t C22(1.12)  LDD1315  [4]
 LDCM0437  CL47 PaTu 8988t C22(1.05)  LDD1316  [4]
 LDCM0438  CL48 PaTu 8988t C22(0.92)  LDD1317  [4]
 LDCM0439  CL49 PaTu 8988t C22(1.11)  LDD1318  [4]
 LDCM0440  CL5 PaTu 8988t C22(1.41)  LDD1319  [4]
 LDCM0441  CL50 PaTu 8988t C22(1.17)  LDD1320  [4]
 LDCM0442  CL51 PaTu 8988t C22(1.02)  LDD1321  [4]
 LDCM0443  CL52 PaTu 8988t C22(1.21)  LDD1322  [4]
 LDCM0444  CL53 PaTu 8988t C22(0.92)  LDD1323  [4]
 LDCM0445  CL54 PaTu 8988t C22(1.03)  LDD1324  [4]
 LDCM0446  CL55 PaTu 8988t C22(1.00)  LDD1325  [4]
 LDCM0447  CL56 PaTu 8988t C22(0.90)  LDD1326  [4]
 LDCM0448  CL57 PaTu 8988t C22(1.16)  LDD1327  [4]
 LDCM0449  CL58 PaTu 8988t C22(1.02)  LDD1328  [4]
 LDCM0450  CL59 PaTu 8988t C22(1.08)  LDD1329  [4]
 LDCM0451  CL6 PaTu 8988t C22(1.07)  LDD1330  [4]
 LDCM0452  CL60 PaTu 8988t C22(0.93)  LDD1331  [4]
 LDCM0453  CL61 PaTu 8988t C37(0.68); C22(0.70)  LDD1332  [4]
 LDCM0454  CL62 PaTu 8988t C37(0.70); C22(0.76)  LDD1333  [4]
 LDCM0455  CL63 PaTu 8988t C37(0.72); C22(0.73)  LDD1334  [4]
 LDCM0456  CL64 PaTu 8988t C37(0.73); C22(0.76)  LDD1335  [4]
 LDCM0457  CL65 PaTu 8988t C37(0.80); C22(0.82)  LDD1336  [4]
 LDCM0458  CL66 PaTu 8988t C37(0.96); C22(0.99)  LDD1337  [4]
 LDCM0459  CL67 PaTu 8988t C37(0.88); C22(0.87)  LDD1338  [4]
 LDCM0460  CL68 PaTu 8988t C37(0.83); C22(0.86)  LDD1339  [4]
 LDCM0461  CL69 PaTu 8988t C37(0.85); C22(0.89)  LDD1340  [4]
 LDCM0462  CL7 PaTu 8988t C22(1.24)  LDD1341  [4]
 LDCM0463  CL70 PaTu 8988t C37(0.75); C22(0.76)  LDD1342  [4]
 LDCM0464  CL71 PaTu 8988t C37(0.67); C22(0.73)  LDD1343  [4]
 LDCM0465  CL72 PaTu 8988t C37(0.82); C22(0.85)  LDD1344  [4]
 LDCM0466  CL73 PaTu 8988t C37(0.80); C22(0.86)  LDD1345  [4]
 LDCM0467  CL74 PaTu 8988t C37(0.77); C22(0.78)  LDD1346  [4]
 LDCM0469  CL76 HEK-293T C37(1.19)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C37(1.00)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C37(1.06); C22(1.32); C37(1.32)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C37(1.26)  LDD1675  [9]
 LDCM0473  CL8 PaTu 8988t C22(0.99)  LDD1352  [4]
 LDCM0474  CL80 HEK-293T C37(1.14)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C37(1.56)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C37(1.27)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C37(1.20); C22(1.33); C37(1.33)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C37(1.21)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C22(1.21); C37(1.01)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C37(1.17)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C37(1.18)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C37(1.17)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C37(1.18)  LDD1686  [9]
 LDCM0484  CL9 PaTu 8988t C22(1.28)  LDD1363  [4]
 LDCM0485  CL90 HEK-293T C37(1.03); C22(0.75); C37(0.75)  LDD1688  [9]
 LDCM0486  CL91 PaTu 8988t C22(1.04)  LDD1365  [4]
 LDCM0487  CL92 PaTu 8988t C22(1.17)  LDD1366  [4]
 LDCM0488  CL93 PaTu 8988t C22(1.18)  LDD1367  [4]
 LDCM0489  CL94 PaTu 8988t C22(1.19)  LDD1368  [4]
 LDCM0490  CL95 PaTu 8988t C22(1.18)  LDD1369  [4]
 LDCM0491  CL96 PaTu 8988t C22(1.03)  LDD1370  [4]
 LDCM0492  CL97 PaTu 8988t C22(1.14)  LDD1371  [4]
 LDCM0493  CL98 PaTu 8988t C22(1.12)  LDD1372  [4]
 LDCM0494  CL99 PaTu 8988t C22(1.06)  LDD1373  [4]
 LDCM0495  E2913 HEK-293T C37(0.99)  LDD1698  [9]
 LDCM0468  Fragment33 PaTu 8988t C37(1.01); C22(0.98)  LDD1347  [4]
 LDCM0427  Fragment51 PaTu 8988t C37(0.67); C22(0.67)  LDD1306  [4]
 LDCM0022  KB02 HEK-293T C37(0.85)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C37(0.97)  LDD1497  [9]
 LDCM0024  KB05 HEK-293T C37(0.97)  LDD1502  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein MANBAL (MANBAL) UPF0239 family Q9NQG1

References

1 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402