Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name HDSF-alk  Probe Info 
Probe concentration 1 uM
Criteria Quantification: Probe vs DMSO
Quantitative Method
SILAC
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 60 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 5.3
 LDTP00186  Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) 4.6
 LDTP12697  Androgen-induced gene 1 protein (AIG1) 4.5
 LDTP01704  Phosphatidylserine lipase ABHD16A (ABHD16A) 4.4
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 4.3
 LDTP08799  Lysophosphatidylserine lipase ABHD12 (ABHD12) 3.8
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 3.8
 LDTP11178  Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) 3.6
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 3.6
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 3.6
 LDTP09063  Estradiol 17-beta-dehydrogenase 11 (HSD17B11) 3.5
 LDTP00577  Dihydroxyacetone phosphate acyltransferase (GNPAT) 3.5
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 3.4
 LDTP07208  Alpha/beta hydrolase domain-containing protein 17B (ABHD17B) 3.3
 LDTP03945  Patatin-like phospholipase domain-containing protein 4 (PNPLA4) 3.2
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 3.0
 LDTP11261  Monoacylglycerol lipase ABHD6 (ABHD6) 3.0
 LDTP12293  Adipocyte plasma membrane-associated protein (APMAP) 2.9
 LDTP11012  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (AGPAT1) 2.8
 LDTP08617  Patatin-like phospholipase domain-containing protein 6 (PNPLA6) 2.8
 LDTP07913  GPI inositol-deacylase (PGAP1) 2.6
 LDTP17516  Protein ABHD13 (ABHD13) 2.6
 LDTP01273  Acyl-protein thioesterase 1 (LYPLA1) 2.6
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 2.6
 LDTP09495  Probable glutathione peroxidase 8 (GPX8) 2.5
 LDTP10432  ATP synthase membrane subunit K, mitochondrial (ATP5MK) 2.4
 LDTP09578  Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (PTPMT1) 2.4
 LDTP04120  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) 2.4
 LDTP04358  Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) 2.4
 LDTP09388  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (STT3B) 2.3
 LDTP01634  Fatty acid CoA ligase Acsl3 (ACSL3) 2.3
 LDTP03769  Sterol O-acyltransferase 1 (SOAT1) 2.3
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 2.2
 LDTP14213  Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (ALG6) 2.2
 LDTP08232  Glycerol-3-phosphate acyltransferase 4 (GPAT4) 2.1
 LDTP03145  Catechol O-methyltransferase (COMT) 2.1
 LDTP07591  Neutral cholesterol ester hydrolase 1 (NCEH1) 2.1
 LDTP07511  Long-chain fatty acid transport protein 4 (SLC27A4) 2.0
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 2.0
 LDTP02067  Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) 2.0
 LDTP02935  Tyrosine-protein phosphatase non-receptor type 1 (PTPN1) 2.0
 LDTP13131  7-dehydrocholesterol reductase (DHCR7) 2.0
 LDTP07831  Transmembrane protein with metallophosphoesterase domain (TMPPE) 2.0
 LDTP06270  Signal peptidase complex subunit 2 (SPCS2) 1.9
 LDTP06905  Acylglycerol kinase, mitochondrial (AGK) 1.8
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 1.8
 LDTP12954  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) 1.8
 LDTP00464  Glutathione S-transferase 3, mitochondrial (MGST3) 1.7
 LDTP00697  Cytochrome b5 type B (CYB5B) 1.7
 LDTP10966  Microsomal glutathione S-transferase 2 (MGST2) 1.7
 LDTP07227  Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) 1.7
 LDTP04253  Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) 1.7
 LDTP11127  ADP-dependent glucokinase (ADPGK) 1.7
 LDTP12105  L-2-hydroxyglutarate dehydrogenase, mitochondrial (L2HGDH) 1.7
 LDTP11284  Phosphatidylserine synthase 2 (PTDSS2) 1.7
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 1.7
 LDTP05228  Calcium-transporting ATPase type 2C member 1 (ATP2C1) 1.7
 LDTP06992  Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase (ALG10B) 1.6
 LDTP09628  Fatty acyl-CoA reductase 1 (FAR1) 1.5
 LDTP09188  Lysophosphatidylcholine acyltransferase 1 (LPCAT1) 1.5
Transporter and channel
Click to Show/Hide to Show 45 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05292  Fatty acid-binding protein 5 (FABP5) 4.5
 LDTP01060  PRA1 family protein 2 (PRAF2) 4.1
 LDTP03284  ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) 3.3
 LDTP07058  Transmembrane protein 201 (TMEM201) 3.3
 LDTP04849  CD81 antigen (CD81) 3.2
 LDTP15979  Transmembrane protein 245 (TMEM245) 3.2
 LDTP06490  Vesicle-associated membrane protein 3 (VAMP3) 3.1
 LDTP01454  SUN domain-containing protein 1 (SUN1) 3.1
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 3.0
 LDTP00361  Nuclear envelope integral membrane protein 1 (NEMP1) 2.9
 LDTP00014  Extended synaptotagmin-2 (ESYT2) 2.8
 LDTP10073  Protein RFT1 homolog (RFT1) 2.8
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 2.8
 LDTP04187  CD151 antigen (CD151) 2.7
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 2.7
 LDTP02320  CD63 antigen (CD63) 2.6
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 2.6
 LDTP11250  MICOS complex subunit MIC26 (APOO) 2.5
 LDTP02058  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (RPN2) 2.5
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 2.5
 LDTP04148  Sodium- and chloride-dependent creatine transporter 1 (SLC6A8) 2.5
 LDTP07477  Transmembrane protein 214 (TMEM214) 2.4
 LDTP00127  Nuclear envelope pore membrane protein POM 121C (POM121C) 2.4
 LDTP15845  Transmembrane 9 superfamily member 2 (TM9SF2) 2.4
 LDTP01969  Transferrin receptor protein 1 (TFRC) 2.3
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 2.2
 LDTP14084  Sorting and assembly machinery component 50 homolog (SAMM50) 2.2
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 2.2
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 2.1
 LDTP12738  Ceroid-lipofuscinosis neuronal protein 6 (CLN6) 2.0
 LDTP04426  B-cell receptor-associated protein 31 (BCAP31) 2.0
 LDTP00592  Surfeit locus protein 4 (SURF4) 1.9
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 1.9
 LDTP05305  Large neutral amino acids transporter small subunit 1 (SLC7A5) 1.8
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 1.8
 LDTP11213  Nucleoporin NDC1 (NDC1) 1.8
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 1.8
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 1.7
 LDTP00451  Secretory carrier-associated membrane protein 3 (SCAMP3) 1.7
 LDTP00590  Protein RER1 (RER1) 1.7
 LDTP14212  Solute carrier family 12 member 7 (SLC12A7) 1.7
 LDTP04592  Monocarboxylate transporter 1 (SLC16A1) 1.6
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 1.5
 LDTP06462  Neutral amino acid transporter B(0) (SLC1A5) 1.5
 LDTP04653  Solute carrier family 12 member 2 (SLC12A2) 1.5
GPCR
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05933  Melatonin-related receptor (GPR50) 2.1
Immunoglobulin
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03772  Basigin (BSG) 1.9
 LDTP13034  Prostaglandin F2 receptor negative regulator (PTGFRN) 1.9
Other
Click to Show/Hide to Show 17 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05556  Golgin subfamily A member 3 (GOLGA3) 3.5
 LDTP03482  Cellular retinoic acid-binding protein 2 (CRABP2) 3.4
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) 3.3
 LDTP14217  Lipid droplet-regulating VLDL assembly factor AUP1 (AUP1) 3.2
 LDTP12412  Reticulon-4 (RTN4) 2.9
 LDTP11906  Phosphatidylinositol glycan anchor biosynthesis class U protein (PIGU) 2.9
 LDTP15887  Lipase maturation factor 2 (LMF2) 2.7
 LDTP01522  Reticulon-3 (RTN3) 2.6
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 2.4
 LDTP10357  RUS family member 1 (RUSF1) 2.4
 LDTP19963  TraB domain-containing protein (TRABD) 2.4
 LDTP14491  Mannose-P-dolichol utilization defect 1 protein (MPDU1) 2.0
 LDTP08902  CDGSH iron-sulfur domain-containing protein 2 (CISD2) 2.0
 LDTP10924  Prohibitin-2 (PHB2) 1.9
 LDTP11981  Receptor expression-enhancing protein 4 (REEP4) 1.8
 LDTP12677  DnaJ homolog subfamily C member 11 (DNAJC11) 1.6
 LDTP14458  Tetraspanin-6 (TSPAN6) 1.6

References

1 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.