Details of the Target

General Information of Target

Target ID LDTP05305
Target Name Large neutral amino acids transporter small subunit 1 (SLC7A5)
Gene Name SLC7A5
Gene ID 8140
Synonyms
CD98LC; LAT1; MPE16; Large neutral amino acids transporter small subunit 1; 4F2 light chain; 4F2 LC; 4F2LC; CD98 light chain; Integral membrane protein E16; E16; L-type amino acid transporter 1; hLAT1; Solute carrier family 7 member 5; y+ system cationic amino acid transporter
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGAGPKRRALAAPAAEEKEEAREKMLAAKSADGSAPAGEGEGVTLQRNITLLNGVAIIV
GTIIGSGIFVTPTGVLKEAGSPGLALVVWAACGVFSIVGALCYAELGTTISKSGGDYAYM
LEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPLFPTCPVPEEAAKLVACLCVL
LLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFVQIGKGDVSNLDPNFSFEGTKLDV
GNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTL
STEQMLSSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLP
SILSMIHPQLLTPVPSLVFTCVMTLLYAFSKDIFSVINFFSFFNWLCVALAIIGMIWLRH
RKPELERPIKVNLALPVFFILACLFLIAVSFWKTPVECGIGFTIILSGLPVYFFGVWWKN
KPKWLLQGIFSTTVLCQKLMQVVPQET
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
Amino acid-polyamine-organocation (APC) superfamily, L-type amino acid transporter (LAT) (TC 2.A.3.8) family
Subcellular location
Apical cell membrane
Function
The heterodimer with SLC3A2 functions as a sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, leucine, histidine, methionine, tryptophan, valine, isoleucine and alanine. The heterodimer with SLC3A2 mediates the uptake of L-DOPA. Functions as an amino acid exchanger. May play a role in the transport of L-DOPA across the blood-brain barrier. May act as the major transporter of tyrosine in fibroblasts (Probable). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier.Can mediate the transport of thyroid hormones diiodothyronine (T2), triiodothyronine (T3) and thyroxine (T4) across the cell membrane. When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation. Involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the membrane.; (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis.
TTD ID
T48330
Uniprot ID
Q01650
DrugMap ID
TTPH2JB
Ensemble ID
ENST00000261622.5
HGNC ID
HGNC:11063
ChEMBL ID
CHEMBL4459

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		7.75  LDD0402  [1]
HDSF-alk
 Probe Info  		1.83  LDD0197  [2]
CHEMBL5175495
 Probe Info  		8.91  LDD0196  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
CY4
 Probe Info  		100.00  LDD0244  [4]
N1
 Probe Info  		100.00  LDD0242  [4]
C-Sul
 Probe Info  		3.92  LDD0066  [5]
YN-4
 Probe Info  		100.00  LDD0445  [6]
ONAyne
 Probe Info  		K19(6.25)  LDD0274  [7]
STPyne
 Probe Info  		K25(5.76)  LDD0277  [7]
AZ-9
 Probe Info  		E42(1.22)  LDD2208  [8]
EA-probe
 Probe Info  		N.A.  LDD0440  [9]
DBIA
 Probe Info  		C496(1.06)  LDD0531  [10]
ATP probe
 Probe Info  		N.A.  LDD0199  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [12]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [12]
ATP probe
 Probe Info  		N.A.  LDD0035  [13]
IPM
 Probe Info  		N.A.  LDD2156  [14]
NHS
 Probe Info  		N.A.  LDD0010  [15]
TER-AC
 Probe Info  		N.A.  LDD0426  [16]
TPP-AC
 Probe Info  		N.A.  LDD0427  [16]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		45.89  LDD1752  [17]
C056
 Probe Info  		19.16  LDD1753  [17]
SAHA-CA-8PAP
 Probe Info  		5.50  LDD0362  [18]
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [19]
OEA-DA
 Probe Info  		8.41  LDD0046  [20]
STS-1
 Probe Info  		N.A.  LDD0068  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C496(1.06)  LDD0531  [10]
 LDCM0215  AC10 PaTu 8988t C496(0.63)  LDD1094  [10]
 LDCM0216  AC100 PaTu 8988t C496(0.73)  LDD1095  [10]
 LDCM0217  AC101 PaTu 8988t C496(0.80)  LDD1096  [10]
 LDCM0218  AC102 PaTu 8988t C496(0.61)  LDD1097  [10]
 LDCM0219  AC103 PaTu 8988t C496(0.73)  LDD1098  [10]
 LDCM0220  AC104 PaTu 8988t C496(0.77)  LDD1099  [10]
 LDCM0221  AC105 PaTu 8988t C496(0.76)  LDD1100  [10]
 LDCM0222  AC106 PaTu 8988t C496(0.73)  LDD1101  [10]
 LDCM0223  AC107 PaTu 8988t C496(0.76)  LDD1102  [10]
 LDCM0224  AC108 PaTu 8988t C496(0.70)  LDD1103  [10]
 LDCM0225  AC109 PaTu 8988t C496(0.61)  LDD1104  [10]
 LDCM0226  AC11 PaTu 8988t C496(0.94)  LDD1105  [10]
 LDCM0227  AC110 PaTu 8988t C496(0.66)  LDD1106  [10]
 LDCM0228  AC111 PaTu 8988t C496(0.68)  LDD1107  [10]
 LDCM0229  AC112 PaTu 8988t C496(0.73)  LDD1108  [10]
 LDCM0230  AC113 PaTu 8988t C496(1.10)  LDD1109  [10]
 LDCM0231  AC114 PaTu 8988t C496(0.96)  LDD1110  [10]
 LDCM0232  AC115 PaTu 8988t C496(1.25)  LDD1111  [10]
 LDCM0233  AC116 PaTu 8988t C496(1.19)  LDD1112  [10]
 LDCM0234  AC117 PaTu 8988t C496(1.22)  LDD1113  [10]
 LDCM0235  AC118 PaTu 8988t C496(1.14)  LDD1114  [10]
 LDCM0236  AC119 PaTu 8988t C496(1.00)  LDD1115  [10]
 LDCM0237  AC12 PaTu 8988t C496(0.86)  LDD1116  [10]
 LDCM0238  AC120 PaTu 8988t C496(1.04)  LDD1117  [10]
 LDCM0239  AC121 PaTu 8988t C496(1.00)  LDD1118  [10]
 LDCM0240  AC122 PaTu 8988t C496(0.93)  LDD1119  [10]
 LDCM0241  AC123 PaTu 8988t C496(1.03)  LDD1120  [10]
 LDCM0242  AC124 PaTu 8988t C496(1.07)  LDD1121  [10]
 LDCM0243  AC125 PaTu 8988t C496(0.98)  LDD1122  [10]
 LDCM0244  AC126 PaTu 8988t C496(1.10)  LDD1123  [10]
 LDCM0245  AC127 PaTu 8988t C496(1.08)  LDD1124  [10]
 LDCM0259  AC14 PaTu 8988t C496(0.81)  LDD1138  [10]
 LDCM0263  AC143 PaTu 8988t C496(0.69)  LDD1142  [10]
 LDCM0264  AC144 PaTu 8988t C496(0.79)  LDD1143  [10]
 LDCM0265  AC145 PaTu 8988t C496(0.79)  LDD1144  [10]
 LDCM0266  AC146 PaTu 8988t C496(0.69)  LDD1145  [10]
 LDCM0267  AC147 PaTu 8988t C496(0.88)  LDD1146  [10]
 LDCM0268  AC148 PaTu 8988t C496(0.64)  LDD1147  [10]
 LDCM0269  AC149 PaTu 8988t C496(0.83)  LDD1148  [10]
 LDCM0270  AC15 PaTu 8988t C496(0.74)  LDD1149  [10]
 LDCM0271  AC150 PaTu 8988t C496(1.00)  LDD1150  [10]
 LDCM0272  AC151 PaTu 8988t C496(0.86)  LDD1151  [10]
 LDCM0273  AC152 PaTu 8988t C496(0.84)  LDD1152  [10]
 LDCM0274  AC153 PaTu 8988t C496(0.83)  LDD1153  [10]
 LDCM0621  AC154 PaTu 8988t C496(0.89)  LDD2166  [10]
 LDCM0622  AC155 PaTu 8988t C496(0.71)  LDD2167  [10]
 LDCM0623  AC156 PaTu 8988t C496(0.83)  LDD2168  [10]
 LDCM0624  AC157 PaTu 8988t C496(1.02)  LDD2169  [10]
 LDCM0276  AC17 PaTu 8988t C496(0.82)  LDD1155  [10]
 LDCM0277  AC18 PaTu 8988t C496(0.68)  LDD1156  [10]
 LDCM0278  AC19 PaTu 8988t C496(0.94)  LDD1157  [10]
 LDCM0279  AC2 HCT 116 C496(1.21)  LDD0596  [10]
 LDCM0280  AC20 PaTu 8988t C496(0.79)  LDD1159  [10]
 LDCM0281  AC21 PaTu 8988t C496(0.80)  LDD1160  [10]
 LDCM0282  AC22 PaTu 8988t C496(0.76)  LDD1161  [10]
 LDCM0283  AC23 PaTu 8988t C496(0.77)  LDD1162  [10]
 LDCM0284  AC24 PaTu 8988t C496(0.68)  LDD1163  [10]
 LDCM0285  AC25 PaTu 8988t C496(1.23)  LDD1164  [10]
 LDCM0286  AC26 PaTu 8988t C496(1.02)  LDD1165  [10]
 LDCM0287  AC27 PaTu 8988t C496(1.01)  LDD1166  [10]
 LDCM0288  AC28 PaTu 8988t C496(0.97)  LDD1167  [10]
 LDCM0289  AC29 PaTu 8988t C496(1.15)  LDD1168  [10]
 LDCM0290  AC3 HCT 116 C496(0.99)  LDD0607  [10]
 LDCM0291  AC30 PaTu 8988t C496(1.12)  LDD1170  [10]
 LDCM0292  AC31 PaTu 8988t C496(1.12)  LDD1171  [10]
 LDCM0293  AC32 PaTu 8988t C496(1.08)  LDD1172  [10]
 LDCM0294  AC33 PaTu 8988t C496(0.89)  LDD1173  [10]
 LDCM0295  AC34 PaTu 8988t C496(1.14)  LDD1174  [10]
 LDCM0296  AC35 PaTu 8988t C496(0.73)  LDD1175  [10]
 LDCM0297  AC36 PaTu 8988t C496(0.60)  LDD1176  [10]
 LDCM0298  AC37 PaTu 8988t C496(0.87)  LDD1177  [10]
 LDCM0299  AC38 PaTu 8988t C496(0.71)  LDD1178  [10]
 LDCM0300  AC39 PaTu 8988t C496(0.77)  LDD1179  [10]
 LDCM0301  AC4 HCT 116 C496(0.95)  LDD0618  [10]
 LDCM0302  AC40 PaTu 8988t C496(0.80)  LDD1181  [10]
 LDCM0303  AC41 PaTu 8988t C496(0.91)  LDD1182  [10]
 LDCM0304  AC42 PaTu 8988t C496(0.86)  LDD1183  [10]
 LDCM0305  AC43 PaTu 8988t C496(1.00)  LDD1184  [10]
 LDCM0306  AC44 PaTu 8988t C496(0.87)  LDD1185  [10]
 LDCM0307  AC45 PaTu 8988t C496(0.96)  LDD1186  [10]
 LDCM0308  AC46 PaTu 8988t C496(0.88)  LDD1187  [10]
 LDCM0309  AC47 PaTu 8988t C496(0.78)  LDD1188  [10]
 LDCM0310  AC48 PaTu 8988t C496(0.65)  LDD1189  [10]
 LDCM0311  AC49 PaTu 8988t C496(0.66)  LDD1190  [10]
 LDCM0312  AC5 HCT 116 C496(0.98)  LDD0629  [10]
 LDCM0313  AC50 PaTu 8988t C496(0.65)  LDD1192  [10]
 LDCM0314  AC51 PaTu 8988t C496(0.84)  LDD1193  [10]
 LDCM0315  AC52 PaTu 8988t C496(0.70)  LDD1194  [10]
 LDCM0316  AC53 PaTu 8988t C496(0.65)  LDD1195  [10]
 LDCM0317  AC54 PaTu 8988t C496(0.63)  LDD1196  [10]
 LDCM0318  AC55 PaTu 8988t C496(0.76)  LDD1197  [10]
 LDCM0319  AC56 PaTu 8988t C496(0.68)  LDD1198  [10]
 LDCM0320  AC57 HCT 116 C496(0.89)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C496(0.72)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C496(0.83)  LDD0639  [10]
 LDCM0323  AC6 PaTu 8988t C496(0.84)  LDD1202  [10]
 LDCM0324  AC60 HCT 116 C496(0.75)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C496(0.81)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C496(0.82)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C496(0.76)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C496(0.78)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C496(0.93)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C496(1.10)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C496(0.72)  LDD0648  [10]
 LDCM0332  AC68 PaTu 8988t C496(1.09)  LDD1211  [10]
 LDCM0333  AC69 PaTu 8988t C496(1.10)  LDD1212  [10]
 LDCM0334  AC7 PaTu 8988t C496(1.31)  LDD1213  [10]
 LDCM0335  AC70 PaTu 8988t C496(1.00)  LDD1214  [10]
 LDCM0336  AC71 PaTu 8988t C496(1.09)  LDD1215  [10]
 LDCM0337  AC72 PaTu 8988t C496(1.19)  LDD1216  [10]
 LDCM0338  AC73 PaTu 8988t C496(1.09)  LDD1217  [10]
 LDCM0339  AC74 PaTu 8988t C496(1.06)  LDD1218  [10]
 LDCM0340  AC75 PaTu 8988t C496(0.92)  LDD1219  [10]
 LDCM0341  AC76 PaTu 8988t C496(0.99)  LDD1220  [10]
 LDCM0342  AC77 PaTu 8988t C496(1.07)  LDD1221  [10]
 LDCM0343  AC78 PaTu 8988t C496(1.15)  LDD1222  [10]
 LDCM0344  AC79 PaTu 8988t C496(1.05)  LDD1223  [10]
 LDCM0345  AC8 PaTu 8988t C496(0.76)  LDD1224  [10]
 LDCM0346  AC80 PaTu 8988t C496(0.99)  LDD1225  [10]
 LDCM0347  AC81 PaTu 8988t C496(1.08)  LDD1226  [10]
 LDCM0348  AC82 PaTu 8988t C496(1.06)  LDD1227  [10]
 LDCM0365  AC98 PaTu 8988t C496(0.80)  LDD1244  [10]
 LDCM0366  AC99 PaTu 8988t C496(0.73)  LDD1245  [10]
 LDCM0248  AKOS034007472 PaTu 8988t C496(0.74)  LDD1127  [10]
 LDCM0356  AKOS034007680 PaTu 8988t C496(0.77)  LDD1235  [10]
 LDCM0275  AKOS034007705 PaTu 8988t C496(0.79)  LDD1154  [10]
 LDCM0367  CL1 HCT 116 C496(1.58)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C496(1.03)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C496(1.03)  LDD0686  [10]
 LDCM0370  CL101 PaTu 8988t C496(0.77)  LDD1249  [10]
 LDCM0371  CL102 PaTu 8988t C496(0.75)  LDD1250  [10]
 LDCM0372  CL103 PaTu 8988t C496(0.75)  LDD1251  [10]
 LDCM0373  CL104 PaTu 8988t C496(0.86)  LDD1252  [10]
 LDCM0374  CL105 PaTu 8988t C496(0.88)  LDD1253  [10]
 LDCM0375  CL106 PaTu 8988t C496(0.75)  LDD1254  [10]
 LDCM0376  CL107 PaTu 8988t C496(0.69)  LDD1255  [10]
 LDCM0377  CL108 PaTu 8988t C496(0.80)  LDD1256  [10]
 LDCM0378  CL109 PaTu 8988t C496(0.87)  LDD1257  [10]
 LDCM0379  CL11 HCT 116 C496(1.01)  LDD0696  [10]
 LDCM0380  CL110 PaTu 8988t C496(0.71)  LDD1259  [10]
 LDCM0381  CL111 PaTu 8988t C496(0.77)  LDD1260  [10]
 LDCM0382  CL112 PaTu 8988t C496(1.16)  LDD1261  [10]
 LDCM0383  CL113 PaTu 8988t C496(1.20)  LDD1262  [10]
 LDCM0384  CL114 PaTu 8988t C496(1.07)  LDD1263  [10]
 LDCM0385  CL115 PaTu 8988t C496(1.25)  LDD1264  [10]
 LDCM0386  CL116 PaTu 8988t C496(1.12)  LDD1265  [10]
 LDCM0387  CL117 PaTu 8988t C496(1.04)  LDD1266  [10]
 LDCM0388  CL118 PaTu 8988t C496(0.99)  LDD1267  [10]
 LDCM0389  CL119 PaTu 8988t C496(0.78)  LDD1268  [10]
 LDCM0390  CL12 HCT 116 C496(0.85)  LDD0707  [10]
 LDCM0391  CL120 PaTu 8988t C496(0.73)  LDD1270  [10]
 LDCM0392  CL121 PaTu 8988t C496(0.80)  LDD1271  [10]
 LDCM0393  CL122 PaTu 8988t C496(0.80)  LDD1272  [10]
 LDCM0394  CL123 PaTu 8988t C496(0.66)  LDD1273  [10]
 LDCM0395  CL124 PaTu 8988t C496(0.72)  LDD1274  [10]
 LDCM0396  CL125 HCT 116 C496(0.81)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C496(0.81)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C496(0.71)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C496(0.95)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C496(0.97)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C496(1.15)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C496(1.20)  LDD0719  [10]
 LDCM0403  CL16 PaTu 8988t C496(0.98)  LDD1282  [10]
 LDCM0404  CL17 PaTu 8988t C496(0.97)  LDD1283  [10]
 LDCM0405  CL18 PaTu 8988t C496(0.90)  LDD1284  [10]
 LDCM0406  CL19 PaTu 8988t C496(0.95)  LDD1285  [10]
 LDCM0407  CL2 HCT 116 C496(1.00)  LDD0724  [10]
 LDCM0408  CL20 PaTu 8988t C496(0.92)  LDD1287  [10]
 LDCM0409  CL21 PaTu 8988t C496(0.77)  LDD1288  [10]
 LDCM0410  CL22 PaTu 8988t C496(0.94)  LDD1289  [10]
 LDCM0411  CL23 PaTu 8988t C496(0.88)  LDD1290  [10]
 LDCM0412  CL24 PaTu 8988t C496(0.94)  LDD1291  [10]
 LDCM0413  CL25 PaTu 8988t C496(0.88)  LDD1292  [10]
 LDCM0414  CL26 PaTu 8988t C496(0.98)  LDD1293  [10]
 LDCM0415  CL27 PaTu 8988t C496(0.98)  LDD1294  [10]
 LDCM0416  CL28 PaTu 8988t C496(1.03)  LDD1295  [10]
 LDCM0417  CL29 PaTu 8988t C496(0.82)  LDD1296  [10]
 LDCM0418  CL3 HCT 116 C496(1.08)  LDD0735  [10]
 LDCM0419  CL30 PaTu 8988t C496(0.72)  LDD1298  [10]
 LDCM0420  CL31 PaTu 8988t C496(0.95)  LDD1299  [10]
 LDCM0421  CL32 PaTu 8988t C496(0.88)  LDD1300  [10]
 LDCM0422  CL33 PaTu 8988t C496(0.80)  LDD1301  [10]
 LDCM0423  CL34 PaTu 8988t C496(0.98)  LDD1302  [10]
 LDCM0424  CL35 PaTu 8988t C496(0.87)  LDD1303  [10]
 LDCM0425  CL36 PaTu 8988t C496(0.72)  LDD1304  [10]
 LDCM0426  CL37 PaTu 8988t C496(0.91)  LDD1305  [10]
 LDCM0428  CL39 PaTu 8988t C496(0.76)  LDD1307  [10]
 LDCM0429  CL4 HCT 116 C496(1.31)  LDD0746  [10]
 LDCM0430  CL40 PaTu 8988t C496(0.87)  LDD1309  [10]
 LDCM0431  CL41 PaTu 8988t C496(0.73)  LDD1310  [10]
 LDCM0432  CL42 PaTu 8988t C496(0.88)  LDD1311  [10]
 LDCM0433  CL43 PaTu 8988t C496(0.90)  LDD1312  [10]
 LDCM0434  CL44 PaTu 8988t C496(0.87)  LDD1313  [10]
 LDCM0435  CL45 PaTu 8988t C496(0.98)  LDD1314  [10]
 LDCM0436  CL46 HEK-293T C496(0.95)  LDD1640  [22]
 LDCM0437  CL47 HEK-293T C496(0.85); C164(2.22)  LDD1641  [22]
 LDCM0438  CL48 HEK-293T C496(1.00); C164(2.28)  LDD1642  [22]
 LDCM0439  CL49 HEK-293T C496(1.03)  LDD1643  [22]
 LDCM0440  CL5 HCT 116 C496(1.06)  LDD0757  [10]
 LDCM0441  CL50 HEK-293T C496(1.03); C164(1.21)  LDD1645  [22]
 LDCM0443  CL52 HEK-293T C496(0.94)  LDD1646  [22]
 LDCM0444  CL53 HEK-293T C496(1.19); C164(1.27)  LDD1647  [22]
 LDCM0445  CL54 HEK-293T C496(1.10); C164(1.53)  LDD1648  [22]
 LDCM0446  CL55 HEK-293T C496(0.85); C164(1.64)  LDD1649  [22]
 LDCM0447  CL56 HEK-293T C496(0.85)  LDD1650  [22]
 LDCM0448  CL57 HEK-293T C496(0.97)  LDD1651  [22]
 LDCM0449  CL58 HEK-293T C496(1.04)  LDD1652  [22]
 LDCM0450  CL59 HEK-293T C496(0.89); C164(2.00)  LDD1653  [22]
 LDCM0451  CL6 HCT 116 C496(0.90)  LDD0768  [10]
 LDCM0452  CL60 HEK-293T C496(0.99); C164(2.50)  LDD1655  [22]
 LDCM0453  CL61 PaTu 8988t C496(0.93)  LDD1332  [10]
 LDCM0454  CL62 PaTu 8988t C496(0.91)  LDD1333  [10]
 LDCM0455  CL63 PaTu 8988t C496(0.80)  LDD1334  [10]
 LDCM0456  CL64 PaTu 8988t C496(0.84)  LDD1335  [10]
 LDCM0457  CL65 PaTu 8988t C496(1.00)  LDD1336  [10]
 LDCM0458  CL66 PaTu 8988t C496(0.94)  LDD1337  [10]
 LDCM0459  CL67 PaTu 8988t C496(0.98)  LDD1338  [10]
 LDCM0460  CL68 PaTu 8988t C496(0.87)  LDD1339  [10]
 LDCM0461  CL69 PaTu 8988t C496(0.82)  LDD1340  [10]
 LDCM0462  CL7 HCT 116 C496(1.03)  LDD0779  [10]
 LDCM0463  CL70 PaTu 8988t C496(0.73)  LDD1342  [10]
 LDCM0464  CL71 PaTu 8988t C496(0.98)  LDD1343  [10]
 LDCM0465  CL72 PaTu 8988t C496(0.90)  LDD1344  [10]
 LDCM0466  CL73 PaTu 8988t C496(0.81)  LDD1345  [10]
 LDCM0467  CL74 PaTu 8988t C496(0.85)  LDD1346  [10]
 LDCM0469  CL76 HCT 116 C496(0.76)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C496(0.98)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C496(0.71)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C496(0.75)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C496(0.94)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C496(1.08)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C496(0.88)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C496(0.73)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C496(0.78)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C496(0.67)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C496(0.85)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C496(0.97)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C496(0.83)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C496(0.79)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C496(0.74)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C496(1.13)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C496(0.89)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C496(0.85)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C496(1.10)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C496(0.90)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C496(0.99)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C496(1.06)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C496(0.97)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C496(1.01)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C496(1.05)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C496(1.07)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C496(1.05); C164(0.99)  LDD1698  [22]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [9]
 LDCM0468  Fragment33 PaTu 8988t C496(0.80)  LDD1347  [10]
 LDCM0427  Fragment51 PaTu 8988t C496(0.58)  LDD1306  [10]
 LDCM0022  KB02 HEK-293T C164(0.74); C496(0.95)  LDD1492  [22]
 LDCM0023  KB03 HEK-293T C164(1.00); C496(0.99)  LDD1497  [22]
 LDCM0024  KB05 UACC257 C496(2.78)  LDD3325  [23]
 LDCM0096  SAHA K562 5.50  LDD0362  [18]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [19]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amino acid transporter heavy chain SLC3A2 (SLC3A2) SLC3A transporter family P08195

The Drug(s) Related To This Target

Approved
Click To Hide/Show 8 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dextrothyroxine Small molecular drug DB00509
Gabapentin Small molecular drug DB00996
L-glutamine Small molecular drug DB00130
Levodopa Small molecular drug DB01235
Levothyroxine Small molecular drug DB00451
Liothyronine Small molecular drug DB00279
Pregabalin Small molecular drug DB00230
Thyroid Porcine . DB09100
Investigative
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(+/-)-2-amino-1,2,3,4-tetrahydro-2-naphthoic Acid Small molecular drug D01BCL
(+/-)-2-aminoindane-2-carboxylic Acid Small molecular drug D0SC5V
Bch Small molecular drug D05BOD
D-phenylalanine Small molecular drug DB02556
S-(Methylmercury)-l-cysteine . DB02750

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
9 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
14 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
19 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
20 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
21 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840