Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C056  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 164 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01803  Adenosine deaminase (ADA) 99.7
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 99.7
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 99.7
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 98.4
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 96.3
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 86.8
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 74.5
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 72.0
 LDTP00697  Cytochrome b5 type B (CYB5B) 71.5
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 69.6
 LDTP11127  ADP-dependent glucokinase (ADPGK) 67.6
 LDTP19745  ADP-ribosylation factor-like protein 10 (ARL10) 61.0
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 60.1
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 59.3
 LDTP08532  Inositol 1,4,5-trisphosphate receptor-interacting protein (ITPRIP) 54.2
 LDTP08385  NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) 54.2
 LDTP03540  Heme oxygenase 2 (HMOX2) 53.8
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 52.0
 LDTP10329  Ceramide synthase 2 (CERS2) 51.3
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 50.6
 LDTP01065  E3 ubiquitin-protein ligase TRIM13 (TRIM13) 49.5
 LDTP01502  NADH dehydrogenase 1 beta subcomplex subunit 6 (NDUFB6) 47.2
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 46.9
 LDTP07990  Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) 45.9
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 45.3
 LDTP10322  Abasic site processing protein HMCES (HMCES) 42.8
 LDTP10020  Ras-related protein Rab-24 (RAB24) 42.5
 LDTP02359  Heme oxygenase 1 (HMOX1) 41.6
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 41.4
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 39.9
 LDTP01513  NADH dehydrogenase 1 alpha subcomplex subunit 3 (NDUFA3) 38.1
 LDTP12639  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5) 37.8
 LDTP03394  Ceramide synthase 1 (CERS1) 37.8
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 36.8
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 36.5
 LDTP13486  Long-chain-fatty-acid--CoA ligase 6 (ACSL6) 36.3
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 35.5
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 35.0
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 33.4
 LDTP11178  Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) 32.9
 LDTP01219  NADH dehydrogenase 1 beta subcomplex subunit 1 (NDUFB1) 32.9
 LDTP11852  Presenilin-associated rhomboid-like protein, mitochondrial (PARL) 32.2
 LDTP06617  Ceramide glucosyltransferase (UGCG) 31.1
 LDTP14264  Choline/ethanolaminephosphotransferase 1 (CEPT1) 31.1
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 30.7
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 30.7
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 30.1
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 29.7
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 29.4
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 29.2
 LDTP03189  Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) 28.6
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 28.6
 LDTP07931  Heme A synthase COX15 (COX15) 28.2
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 28.1
 LDTP11259  Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (ALG12) 27.9
 LDTP13491  E3 ubiquitin-protein ligase AMFR (AMFR) 27.7
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 27.3
 LDTP01743  NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) 27.3
 LDTP10930  Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) 27.1
 LDTP12681  ATPase family AAA domain-containing protein 3A (ATAD3A) 26.7
 LDTP03145  Catechol O-methyltransferase (COMT) 26.5
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 26.5
 LDTP05246  Cyclin-dependent kinase 16 (CDK16) 26.4
 LDTP12490  Sphingosine kinase 2 (SPHK2) 26.4
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 26.2
 LDTP14189  UbiA prenyltransferase domain-containing protein 1 (UBIAD1) 26.0
 LDTP17305  Glycosyltransferase 8 domain-containing protein 1 (GLT8D1) 25.8
 LDTP06501  Ras-related protein Rab-11B (RAB11B) 25.6
 LDTP18087  Dephospho-CoA kinase domain-containing protein (DCAKD) 25.1
 LDTP06270  Signal peptidase complex subunit 2 (SPCS2) 24.9
 LDTP14276  NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) 24.8
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 24.6
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 24.3
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 24.1
 LDTP02713  Macrophage migration inhibitory factor (MIF) 23.9
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 23.9
 LDTP06142  Squalene monooxygenase (SQLE) 23.8
 LDTP09251  Atlastin-2 (ATL2) 23.6
 LDTP13352  GTP:AMP phosphotransferase AK3, mitochondrial (AK3) 23.6
 LDTP09031  Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGNT2) 23.4
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 23.4
 LDTP14278  Sulfide:quinone oxidoreductase, mitochondrial (SQOR) 23.4
 LDTP04358  Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) 22.5
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 22.2
 LDTP12586  Phenylalanine--tRNA ligase beta subunit (FARSB) 22.2
 LDTP07756  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 (HACD2) 22.2
 LDTP12470  GTP-binding protein SAR1a (SAR1A) 22.0
 LDTP09666  Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) 22.0
 LDTP11874  Thioredoxin-related transmembrane protein 1 (TMX1) 21.9
 LDTP14427  Cytochrome c oxidase subunit 7A-related protein, mitochondrial (COX7A2L) 21.7
 LDTP16258  N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase (PIGL) 21.7
 LDTP04689  Adenosine kinase (ADK) 21.6
 LDTP09188  Lysophosphatidylcholine acyltransferase 1 (LPCAT1) 21.6
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 21.6
 LDTP04120  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) 21.4
 LDTP05624  Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) 21.4
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 21.3
 LDTP01335  Protein SCO1 homolog, mitochondrial (SCO1) 21.3
 LDTP12763  Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (BPNT2) 21.1
 LDTP03842  Squalene synthase (FDFT1) 21.1
 LDTP00877  Protein SCO2 homolog, mitochondrial (SCO2) 20.5
 LDTP00950  Dynamin-like 120 kDa protein, mitochondrial (OPA1) 20.4
 LDTP06977  GPI ethanolamine phosphate transferase 2 (PIGG) 20.3
 LDTP11535  Ras-related protein Rab-34 (RAB34) 20.1
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 19.6
 LDTP08859  Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4) 19.6
 LDTP00497  Cyclin-G-associated kinase (GAK) 19.4
 LDTP12886  Glycerophosphodiester phosphodiesterase 1 (GDE1) 19.4
 LDTP13220  Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD) 19.4
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 19.4
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 19.3
 LDTP09285  Atypical kinase COQ8A, mitochondrial (COQ8A) 19.3
 LDTP15132  2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 (OGFOD3) 19.0
 LDTP10144  Phosphatidate cytidylyltransferase, mitochondrial (TAMM41) 19.0
 LDTP12757  E3 ubiquitin-protein ligase MARCHF5 (MARCHF5) 18.9
 LDTP02150  ATP synthase subunit beta, mitochondrial (ATP5F1B) 18.6
 LDTP10182  TLC domain-containing protein 1 (TLCD1) 18.6
 LDTP07154  ATPase family AAA domain-containing protein 3B (ATAD3B) 18.5
 LDTP00994  Beta-1,4-galactosyltransferase 3 (B4GALT3) 18.4
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 18.3
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 18.3
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 18.3
 LDTP12954  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) 18.3
 LDTP09814  Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (LPGAT1) 18.1
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 18.1
 LDTP15480  Prenylcysteine oxidase-like (PCYOX1L) 18.1
 LDTP00400  Torsin-1B (TOR1B) 18.0
 LDTP10530  Beta-1,3-galactosyltransferase 6 (B3GALT6) 17.8
 LDTP16070  Epimerase family protein SDR39U1 (SDR39U1) 17.8
 LDTP10966  Microsomal glutathione S-transferase 2 (MGST2) 17.8
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 17.6
 LDTP04565  Methionine aminopeptidase 1 (METAP1) 17.6
 LDTP11690  RNA cytidine acetyltransferase (NAT10) 17.6
 LDTP09799  DCN1-like protein 4 (DCUN1D4) 17.5
 LDTP12109  Ribitol 5-phosphate transferase FKRP (FKRP) 17.5
 LDTP06023  Calcium/calmodulin-dependent protein kinase type 1 (CAMK1) 17.4
 LDTP13959  Dehydrogenase/reductase SDR family member 7 (DHRS7) 17.4
 LDTP04531  Hexokinase-2 (HK2) 17.4
 LDTP07591  Neutral cholesterol ester hydrolase 1 (NCEH1) 17.4
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 17.4
 LDTP05228  Calcium-transporting ATPase type 2C member 1 (ATP2C1) 17.3
 LDTP04581  Holocytochrome c-type synthase (HCCS) 17.3
 LDTP06810  Mitochondrial import inner membrane translocase subunit TIM50 (TIMM50) 17.1
 LDTP06986  Rab-like protein 3 (RABL3) 17.1
 LDTP04895  Ras-related protein Rab-10 (RAB10) 17.1
 LDTP05905  Acid ceramidase (ASAH1) 16.9
 LDTP02777  Beta-1,4-galactosyltransferase 1 (B4GALT1) 16.9
 LDTP02367  Cytochrome c oxidase subunit 6C (COX6C) 16.9
 LDTP12959  NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) 16.9
 LDTP01515  NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial (NDUFB8) 16.9
 LDTP09061  Retinol dehydrogenase 13 (RDH13) 16.9
 LDTP05137  Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) 16.7
 LDTP09578  Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (PTPMT1) 16.7
 LDTP10471  Protein disulfide-isomerase TMX3 (TMX3) 16.7
 LDTP01769  Dihydrofolate reductase (DHFR) 16.6
 LDTP10809  SRSF protein kinase 1 (SRPK1) 16.6
 LDTP12415  Adenosine 5'-monophosphoramidase HINT3 (HINT3) 16.3
 LDTP06147  ATP-dependent RNA helicase DHX8 (DHX8) 16.3
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 16.2
 LDTP13986  Vesicle transport protein GOT1B (GOLT1B) 16.2
 LDTP07435  Acyl-CoA dehydrogenase family member 10 (ACAD10) 16.1
 LDTP05920  Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMK2G) 16.1
 LDTP04263  Cysteine--tRNA ligase, cytoplasmic (CARS1) 16.1
 LDTP10951  Methionine synthase (MTR) 16.1
Transporter and channel
Click to Show/Hide to Show 129 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11927  Essential MCU regulator, mitochondrial (SMDT1) 99.7
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 99.7
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 99.7
 LDTP03546  Translocator protein (TSPO) 99.7
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 99.7
 LDTP15648  BRI3-binding protein (BRI3BP) 88.6
 LDTP20002  Transmembrane protein 160 (TMEM160) 84.4
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 79.9
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 74.0
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 73.5
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 72.0
 LDTP05900  Metaxin-1 (MTX1) 71.0
 LDTP03284  ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) 66.3
 LDTP01804  ATP synthase subunit a (MT-ATP6) 64.9
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 64.9
 LDTP08279  Mitochondrial coenzyme A transporter SLC25A42 (SLC25A42) 64.0
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 63.6
 LDTP15733  Solute carrier family 25 member 44 (SLC25A44) 56.5
 LDTP10065  Transmembrane protein 230 (TMEM230) 55.7
 LDTP04789  Synaptojanin-2-binding protein (SYNJ2BP) 49.9
 LDTP11245  Derlin-1 (DERL1) 49.5
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 48.8
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 48.2
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 45.6
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 44.9
 LDTP08881  Transmembrane protein 199 (TMEM199) 44.9
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 43.7
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 43.7
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 43.4
 LDTP15948  Transmembrane protein 126A (TMEM126A) 43.1
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 41.9
 LDTP16813  Tetraspanin-3 (TSPAN3) 41.4
 LDTP01601  Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1) 41.1
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 39.4
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 38.9
 LDTP11095  Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) 36.5
 LDTP09180  Zinc transporter 7 (SLC30A7) 36.3
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 35.0
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 34.8
 LDTP09288  Vang-like protein 1 (VANGL1) 33.8
 LDTP09278  Multiple coagulation factor deficiency protein 2 (MCFD2) 33.6
 LDTP07236  Protein GPR107 (GPR107) 33.6
 LDTP01060  PRA1 family protein 2 (PRAF2) 33.4
 LDTP10769  Intermembrane lipid transfer protein VPS13A (VPS13A) 33.1
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 32.9
 LDTP01016  Exocyst complex component 3 (EXOC3) 32.7
 LDTP01542  Golgi SNAP receptor complex member 1 (GOSR1) 32.7
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 32.7
 LDTP12383  Protein GPR108 (GPR108) 32.4
 LDTP15481  Transmembrane protein 87A (TMEM87A) 32.4
 LDTP11869  Growth hormone-inducible transmembrane protein (GHITM) 32.2
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 32.0
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 31.8
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 31.6
 LDTP10343  Vacuole membrane protein 1 (VMP1) 30.9
 LDTP12636  Lysosomal cobalamin transport escort protein LMBD1 (LMBRD1) 30.3
 LDTP07439  Mitochondrial adenyl nucleotide antiporter SLC25A25 (SLC25A25) 30.3
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 29.9
 LDTP08469  Complex I assembly factor TMEM126B, mitochondrial (TMEM126B) 29.4
 LDTP01217  Metaxin-2 (MTX2) 29.2
 LDTP12909  Mitochondrial carrier homolog 1 (MTCH1) 29.2
 LDTP00872  Peroxisomal membrane protein PMP34 (SLC25A17) 28.8
 LDTP11406  Transmembrane protein 59 (TMEM59) 28.8
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 28.6
 LDTP08981  Cytochrome c oxidase assembly protein COX18, mitochondrial (COX18) 27.9
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 27.9
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 27.9
 LDTP11844  Protein spinster homolog 1 (SPNS1) 27.3
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 26.7
 LDTP10059  PAT complex subunit CCDC47 (CCDC47) 26.5
 LDTP01100  Iron-sulfur clusters transporter ABCB7, mitochondrial (ABCB7) 26.4
 LDTP16190  Protein FAM8A1 (FAM8A1) 26.2
 LDTP02215  Prosaposin (PSAP) 25.8
 LDTP11250  MICOS complex subunit MIC26 (APOO) 25.6
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 25.5
 LDTP06275  Lysosomal-associated transmembrane protein 4A (LAPTM4A) 25.3
 LDTP13943  Thioredoxin-related transmembrane protein 2 (TMX2) 25.3
 LDTP12207  Putative divalent cation/proton antiporter TMEM165 (TMEM165) 24.9
 LDTP03405  Calnexin (CANX) 24.4
 LDTP12738  Ceroid-lipofuscinosis neuronal protein 6 (CLN6) 23.8
 LDTP10081  Leucine-rich repeat-containing protein 59 (LRRC59) 22.9
 LDTP00592  Surfeit locus protein 4 (SURF4) 22.9
 LDTP14682  Translocon-associated protein subunit beta (SSR2) 22.9
 LDTP15979  Transmembrane protein 245 (TMEM245) 22.9
 LDTP17682  Zinc transporter ZIP11 (SLC39A11) 22.9
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 22.8
 LDTP12331  Endoplasmic reticulum membrane protein complex subunit 7 (EMC7) 22.3
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 22.3
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 22.0
 LDTP04293  Transmembrane emp24 domain-containing protein 10 (TMED10) 22.0
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 21.7
 LDTP07531  Sideroflexin-4 (SFXN4) 21.4
 LDTP00405  Etoposide-induced protein 2.4 homolog (EI24) 21.3
 LDTP07156  Protein wntless homolog (WLS) 21.0
 LDTP04787  Transmembrane protein 33 (TMEM33) 21.0
 LDTP10073  Protein RFT1 homolog (RFT1) 20.8
 LDTP12979  Transmembrane protein 14C (TMEM14C) 20.8
 LDTP16811  Ran-binding protein 6 (RANBP6) 20.7
 LDTP12210  Mitochondrial thiamine pyrophosphate carrier (SLC25A19) 20.3
 LDTP03905  Peroxisomal biogenesis factor 19 (PEX19) 20.1
 LDTP00547  Secretory carrier-associated membrane protein 2 (SCAMP2) 20.0
 LDTP00821  Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) 19.8
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) 19.6
 LDTP06198  Major facilitator superfamily domain-containing protein 10 (MFSD10) 19.6
 LDTP11213  Nucleoporin NDC1 (NDC1) 19.4
 LDTP05305  Large neutral amino acids transporter small subunit 1 (SLC7A5) 19.2
 LDTP07472  Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24) 19.2
 LDTP01200  Peroxisomal membrane protein PEX14 (PEX14) 18.8
 LDTP13164  Protein sel-1 homolog 1 (SEL1L) 18.8
 LDTP04426  B-cell receptor-associated protein 31 (BCAP31) 18.3
 LDTP02609  ADP/ATP translocase 3 (SLC25A6) 18.0
 LDTP01309  Renin receptor (ATP6AP2) 18.0
 LDTP10804  Chloride channel CLIC-like protein 1 (CLCC1) 17.8
 LDTP01380  Wolframin (WFS1) 17.8
 LDTP11116  45 kDa calcium-binding protein (SDF4) 17.6
 LDTP06660  MICOS complex subunit MIC60 (IMMT) 17.6
 LDTP03064  Cytochrome c oxidase subunit 5A, mitochondrial (COX5A) 17.5
 LDTP11812  Protein ARV1 (ARV1) 17.5
 LDTP07667  Transmembrane protein 205 (TMEM205) 17.5
 LDTP14717  ATP synthase subunit e, mitochondrial (ATP5ME) 17.4
 LDTP13599  Calcium load-activated calcium channel (TMCO1) 17.3
 LDTP00262  Acetyl-coenzyme A transporter 1 (SLC33A1) 17.0
 LDTP03869  Protein Mpv17 (MPV17) 17.0
 LDTP15838  Translocation protein SEC62 (SEC62) 17.0
 LDTP10766  Bardet-Biedl syndrome 4 protein (BBS4) 16.7
 LDTP09333  Golgin subfamily A member 5 (GOLGA5) 16.7
 LDTP11281  Voltage-gated monoatomic cation channel TMEM109 (TMEM109) 16.2
 LDTP12451  Integral membrane protein 2C (ITM2C) 16.1
 LDTP10754  Pannexin-1 (PANX1) 16.1
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 41.1
 LDTP19380  Zinc finger MYM-type protein 1 (ZMYM1) 16.8
GPCR
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15303  Membrane progestin receptor alpha (PAQR7) 31.1
 LDTP14610  Golgi pH regulator B (GPR89B) 16.1
Immunoglobulin
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03538  HLA class I histocompatibility antigen, alpha chain F (HLA-F) 36.0
 LDTP14205  Neuroplastin (NPTN) 31.3
 LDTP05572  Leukocyte surface antigen CD47 (CD47) 29.0
 LDTP03772  Basigin (BSG) 26.0
Other
Click to Show/Hide to Show 139 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 99.7
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 99.7
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 96.3
 LDTP03926  Centrin-2 (CETN2) 86.2
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 86.2
 LDTP10056  Protein FAM162A (FAM162A) 80.4
 LDTP12891  Glycolipid transfer protein (GLTP) 73.0
 LDTP11076  Apolipoprotein L2 (APOL2) 70.5
 LDTP13086  Syntaxin-18 (STX18) 68.6
 LDTP16080  Protein FAM114A2 (FAM114A2) 66.3
 LDTP18883  Protein CEBPZOS (CEBPZOS) 63.1
 LDTP01522  Reticulon-3 (RTN3) 62.2
 LDTP15110  Protein C3orf33 (C3orf33) 60.5
 LDTP14458  Tetraspanin-6 (TSPAN6) 60.1
 LDTP15634  Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5) 59.7
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 57.3
 LDTP06948  Protein YIF1B (YIF1B) 57.3
 LDTP03175  Galanin peptides (GAL) 56.5
 LDTP14939  Membralin (TMEM259) 56.1
 LDTP18467  LYR motif-containing protein 2 (LYRM2) 54.2
 LDTP05375  Nucleobindin-1 (NUCB1) 50.9
 LDTP08154  Large ribosomal subunit protein uL10m (MRPL10) 48.2
 LDTP08904  Protein jagunal homolog 1 (JAGN1) 47.2
 LDTP00986  Syntaxin-10 (STX10) 46.9
 LDTP08796  Protein SYS1 homolog (SYS1) 45.9
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 45.3
 LDTP07274  MICOS complex subunit MIC13 (MICOS13) 44.6
 LDTP17003  Matrix-remodeling-associated protein 7 (MXRA7) 44.0
 LDTP12412  Reticulon-4 (RTN4) 44.0
 LDTP01494  Protein YIF1A (YIF1A) 43.7
 LDTP05178  Small ribosomal subunit protein bS6m (MRPS6) 43.7
 LDTP11670  Mitochondrial fission factor (MFF) 42.8
 LDTP19785  Transmembrane protein 35B (TMEM35B) 42.8
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 42.5
 LDTP14618  Protein PET100 homolog, mitochondrial (PET100) 42.2
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 42.2
 LDTP16006  Optic atrophy 3 protein (OPA3) 41.6
 LDTP13797  HIG1 domain family member 1A, mitochondrial (HIGD1A) 41.1
 LDTP05160  Nucleobindin-2 (NUCB2) 39.7
 LDTP00859  Synaptogyrin-2 (SYNGR2) 39.4
 LDTP09773  Protein FAM3C (FAM3C) 38.1
 LDTP05715  Vesicle transport protein SEC20 (BNIP1) 38.1
 LDTP14126  Mitochondrial import inner membrane translocase subunit Tim9 (TIMM9) 37.8
 LDTP01167  Reticulon-2 (RTN2) 37.5
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 35.5
 LDTP14259  Testis-expressed protein 264 (TEX264) 34.5
 LDTP19963  TraB domain-containing protein (TRABD) 34.5
 LDTP01938  Apolipoprotein C-I (APOC1) 34.1
 LDTP10442  Thioredoxin domain-containing protein 15 (TXNDC15) 33.8
 LDTP14716  ATP synthase subunit ATP5MJ, mitochondrial (ATP5MJ) 33.6
 LDTP15240  LysM and putative peptidoglycan-binding domain-containing protein 3 (LYSMD3) 33.1
 LDTP08224  Protein LYRIC (MTDH) 33.1
 LDTP06291  ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) 30.9
 LDTP15095  Receptor expression-enhancing protein 3 (REEP3) 30.9
 LDTP19021  EF-hand calcium-binding domain-containing protein 14 (EFCAB14) 30.7
 LDTP08594  Negative elongation factor C/D (NELFCD) 30.5
 LDTP08606  Nurim (NRM) 30.5
 LDTP19859  Small integral membrane protein 12 (SMIM12) 30.5
 LDTP11113  Receptor expression-enhancing protein 2 (REEP2) 30.3
 LDTP20361  Coiled-coil domain-containing protein 127 (CCDC127) 30.1
 LDTP19472  Protein NCBP2AS2 (NCBP2AS2) 30.1
 LDTP10567  Regulator of microtubule dynamics protein 2 (RMDN2) 30.1
 LDTP15398  Protein FAM177A1 (FAM177A1) 29.7
 LDTP19005  SLC35A4 upstream open reading frame protein (SLC35A4) 29.7
 LDTP01577  Tumor necrosis factor alpha-induced protein 8 (TNFAIP8) 29.7
 LDTP12982  Mitochondrial import receptor subunit TOM7 homolog (TOMM7) 29.0
 LDTP09143  Divergent protein kinase domain 2A (DIPK2A) 28.8
 LDTP10775  Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2) 28.6
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 27.9
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 27.7
 LDTP01359  Dynactin subunit 3 (DCTN3) 27.3
 LDTP07192  Intermembrane lipid transfer protein VPS13D (VPS13D) 26.7
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 26.4
 LDTP05530  Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) 26.4
 LDTP18569  PRELI domain containing protein 3B (PRELID3B) 26.2
 LDTP18272  Transmembrane protein 209 (TMEM209) 26.0
 LDTP06072  Dedicator of cytokinesis protein 1 (DOCK1) 25.8
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) 25.8
 LDTP11326  FUN14 domain-containing protein 2 (FUNDC2) 25.6
 LDTP11389  Bcl-2-like protein 13 (BCL2L13) 25.5
 LDTP00779  Trans-Golgi network integral membrane protein 2 (TGOLN2) 25.5
 LDTP04703  Tumor protein D52 (TPD52) 25.5
 LDTP15741  Cytochrome c oxidase assembly protein COX14 (COX14) 25.1
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 25.1
 LDTP15434  ADP-ribosylation factor-like protein 6-interacting protein 6 (ARL6IP6) 24.8
 LDTP16322  Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B) 24.6
 LDTP06808  Vacuolar ATPase assembly integral membrane protein VMA21 (VMA21) 24.6
 LDTP11825  Phosducin-like protein 3 (PDCL3) 24.3
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) 24.1
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 23.9
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 23.8
 LDTP02297  Vimentin (VIM) 23.6
 LDTP02443  Calmodulin-3 (CALM3) 23.3
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 22.3
 LDTP10357  RUS family member 1 (RUSF1) 21.9
 LDTP16285  Transducin beta-like protein 2 (TBL2) 21.9
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) 21.7
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 21.6
 LDTP02180  Neurofilament light polypeptide (NEFL) 20.8
 LDTP12091  Spermatogenesis-defective protein 39 homolog (VIPAS39) 20.7
 LDTP08509  FUN14 domain-containing protein 1 (FUNDC1) 20.5
 LDTP10116  Lipid droplet assembly factor 1 (LDAF1) 20.5
 LDTP04207  Heat shock 70 kDa protein 13 (HSPA13) 20.4
 LDTP06527  Alpha-internexin (INA) 20.1
 LDTP07718  MICOS complex subunit MIC27 (APOOL) 20.0
 LDTP02365  U2 small nuclear ribonucleoprotein A' (SNRPA1) 19.8
 LDTP10184  HAUS augmin-like complex subunit 1 (HAUS1) 19.7
 LDTP10924  Prohibitin-2 (PHB2) 19.7
 LDTP16250  Translocon-associated protein subunit gamma (SSR3) 19.6
 LDTP05960  Trophoblast glycoprotein (TPBG) 19.3
 LDTP11911  Golgi phosphoprotein 3 (GOLPH3) 19.2
 LDTP00397  Golgi SNAP receptor complex member 2 (GOSR2) 18.9
 LDTP13802  DNA replication complex GINS protein PSF2 (GINS2) 18.8
 LDTP13967  Transmembrane emp24 domain-containing protein 5 (TMED5) 18.8
 LDTP12948  Charged multivesicular body protein 5 (CHMP5) 18.6
 LDTP00573  Prefoldin subunit 6 (PFDN6) 18.6
 LDTP05277  Protein SET (SET) 18.5
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 18.5
 LDTP16078  Heme-binding protein 1 (HEBP1) 18.4
 LDTP04425  Translocon-associated protein subunit delta (SSR4) 18.3
 LDTP11044  Polyadenylate-binding protein-interacting protein 2 (PAIP2) 18.0
 LDTP11981  Receptor expression-enhancing protein 4 (REEP4) 18.0
 LDTP16116  BSD domain-containing protein 1 (BSDC1) 17.8
 LDTP08000  Dymeclin (DYM) 17.4
 LDTP13982  Mitochondrial fission 1 protein (FIS1) 17.4
 LDTP19860  Coiled-coil domain-containing protein 97 (CCDC97) 17.3
 LDTP12468  Diablo IAP-binding mitochondrial protein (DIABLO) 17.3
 LDTP06097  Reticulocalbin-2 (RCN2) 17.3
 LDTP12379  Complex I assembly factor TIMMDC1, mitochondrial (TIMMDC1) 17.1
 LDTP00199  HCLS1-associated protein X-1 (HAX1) 17.1
 LDTP04356  Emerin (EMD) 16.8
 LDTP00759  Tumor protein D54 (TPD52L2) 16.7
 LDTP15623  Neuferricin (CYB5D2) 16.4
 LDTP02181  Neurofilament medium polypeptide (NEFM) 16.4
 LDTP17652  Uncharacterized protein KIAA2013 (KIAA2013) 16.3
 LDTP05198  Histone H3.3 (H3-3A; H3-3B) 16.2
 LDTP01075  Protein CutA (CUTA) 16.2
 LDTP11167  Protein YIPF4 (YIPF4) 16.2
 LDTP00632  Syntaxin-7 (STX7) 16.1

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587