Details of the Target
General Information of Target
Target ID | LDTP12763 | |||||
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Target Name | Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (BPNT2) | |||||
Gene Name | BPNT2 | |||||
Gene ID | 54928 | |||||
Synonyms |
IMPA3; IMPAD1; Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase; Golgi-resident PAP phosphatase; gPAPP; EC 3.1.3.7; 3'(2'), 5'-bisphosphate nucleotidase 2; Inositol monophosphatase domain-containing protein 1; Myo-inositol monophosphatase A3; Phosphoadenosine phosphate 3'-nucleotidase
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3D Structure | ||||||
Sequence |
MAVLGVQLVVTLLTATLMHRLAPHCSFARWLLCNGSLFRYKHPSEEELRALAGKPRPRGR
KERWANGLSEEKPLSVPRDAPFQLETCPLTTVDALVLRFFLEYQWFVDFAVYSGGVYLFT EAYYYMLGPAKETNIAVFWCLLTVTFSIKMFLTVTRLYFSAEEGGERSVCLTFAFLFLLL AMLVQVVREETLELGLEPGLASMTQNLEPLLKKQGWDWALPVAKLAIRVGLAVVGSVLGA FLTFPGLRLAQTHRDALTMSEDRPMLQFLLHTSFLSPLFILWLWTKPIARDFLHQPPFGE TRFSLLSDSAFDSGRLWLLVVLCLLRLAVTRPHLQAYLCLAKARVEQLRREAGRIEAREI QQRVVRVYCYVTVVSLQYLTPLILTLNCTLLLKTLGGYSWGLGPAPLLSPDPSSASAAPI GSGEDEVQQTAARIAGALGGLLTPLFLRGVLAYLIWWTAACQLLASLFGLYFHQHLAGS |
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Target Bioclass |
Enzyme
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Family |
Inositol monophosphatase superfamily
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Subcellular location |
Golgi apparatus
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Function |
Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4.
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Uniprot ID | ||||||
Ensemble ID | ||||||
HGNC ID |
Probe(s) Labeling This Target
ABPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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FBPP2 Probe Info |
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2.19 | LDD0324 | [1] | |
STPyne Probe Info |
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K116(5.26) | LDD0277 | [2] | |
Acrolein Probe Info |
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N.A. | LDD0222 | [3] | |
DBIA Probe Info |
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C302(0.95) | LDD1508 | [4] | |
ATP probe Probe Info |
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K93(0.00); K95(0.00) | LDD0199 | [5] | |
m-APA Probe Info |
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N.A. | LDD2231 | [6] | |
4-Iodoacetamidophenylacetylene Probe Info |
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N.A. | LDD0038 | [7] | |
IA-alkyne Probe Info |
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N.A. | LDD0036 | [7] | |
Lodoacetamide azide Probe Info |
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N.A. | LDD0037 | [7] | |
NAIA_5 Probe Info |
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N.A. | LDD2223 | [8] |
PAL-AfBPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
---|---|---|---|---|---|
C056 Probe Info |
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21.11 | LDD1753 | [9] | |
C063 Probe Info |
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12.04 | LDD1760 | [9] | |
C091 Probe Info |
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30.48 | LDD1782 | [9] | |
C092 Probe Info |
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36.25 | LDD1783 | [9] | |
C094 Probe Info |
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52.71 | LDD1785 | [9] | |
C106 Probe Info |
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25.46 | LDD1793 | [9] | |
C107 Probe Info |
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5.70 | LDD1794 | [9] | |
C108 Probe Info |
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8.51 | LDD1795 | [9] | |
C134 Probe Info |
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25.81 | LDD1816 | [9] | |
C135 Probe Info |
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12.47 | LDD1817 | [9] | |
C170 Probe Info |
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13.18 | LDD1850 | [9] | |
C186 Probe Info |
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9.71 | LDD1864 | [9] | |
C201 Probe Info |
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44.02 | LDD1877 | [9] | |
C206 Probe Info |
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19.16 | LDD1881 | [9] | |
C210 Probe Info |
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39.95 | LDD1884 | [9] | |
C218 Probe Info |
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16.22 | LDD1892 | [9] | |
C220 Probe Info |
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15.35 | LDD1894 | [9] | |
C226 Probe Info |
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8.06 | LDD1899 | [9] | |
C246 Probe Info |
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12.30 | LDD1919 | [9] | |
C281 Probe Info |
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5.46 | LDD1951 | [9] | |
C289 Probe Info |
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36.50 | LDD1959 | [9] | |
C310 Probe Info |
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18.90 | LDD1977 | [9] | |
C313 Probe Info |
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12.30 | LDD1980 | [9] | |
C326 Probe Info |
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12.91 | LDD1990 | [9] | |
C362 Probe Info |
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42.81 | LDD2023 | [9] | |
C364 Probe Info |
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15.24 | LDD2025 | [9] | |
C388 Probe Info |
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59.71 | LDD2047 | [9] | |
C390 Probe Info |
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89.88 | LDD2049 | [9] | |
C391 Probe Info |
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14.52 | LDD2050 | [9] | |
C403 Probe Info |
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17.88 | LDD2061 | [9] | |
FFF probe11 Probe Info |
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20.00 | LDD0471 | [10] | |
FFF probe12 Probe Info |
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20.00 | LDD0473 | [10] | |
FFF probe2 Probe Info |
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20.00 | LDD0463 | [10] | |
VE-P Probe Info |
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N.A. | LDD0396 | [11] | |
BD-F Probe Info |
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E44(0.00); G40(0.00); S37(0.00); L41(0.00) | LDD0024 | [12] | |
LD-F Probe Info |
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N.A. | LDD0015 | [12] | |
OEA-DA Probe Info |
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14.49 | LDD0046 | [13] |
Competitor(s) Related to This Target
Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
---|---|---|---|---|---|
LDCM0215 | AC10 | HEK-293T | C302(0.95) | LDD1508 | [4] |
LDCM0226 | AC11 | HEK-293T | C302(0.93) | LDD1509 | [4] |
LDCM0237 | AC12 | HEK-293T | C302(0.95) | LDD1510 | [4] |
LDCM0259 | AC14 | HEK-293T | C302(0.98) | LDD1512 | [4] |
LDCM0270 | AC15 | HEK-293T | C302(0.95) | LDD1513 | [4] |
LDCM0277 | AC18 | HEK-293T | C302(1.05) | LDD1516 | [4] |
LDCM0278 | AC19 | HEK-293T | C302(1.03) | LDD1517 | [4] |
LDCM0279 | AC2 | HEK-293T | C302(0.99) | LDD1518 | [4] |
LDCM0280 | AC20 | HEK-293T | C302(1.02) | LDD1519 | [4] |
LDCM0281 | AC21 | HEK-293T | C302(0.92) | LDD1520 | [4] |
LDCM0282 | AC22 | HEK-293T | C302(1.00) | LDD1521 | [4] |
LDCM0283 | AC23 | HEK-293T | C302(1.07) | LDD1522 | [4] |
LDCM0284 | AC24 | HEK-293T | C302(0.88) | LDD1523 | [4] |
LDCM0286 | AC26 | HEK-293T | C302(0.95) | LDD1525 | [4] |
LDCM0287 | AC27 | HEK-293T | C302(0.95) | LDD1526 | [4] |
LDCM0288 | AC28 | HEK-293T | C302(0.95) | LDD1527 | [4] |
LDCM0289 | AC29 | HEK-293T | C302(0.83) | LDD1528 | [4] |
LDCM0290 | AC3 | HEK-293T | C302(0.96) | LDD1529 | [4] |
LDCM0291 | AC30 | HEK-293T | C302(1.06) | LDD1530 | [4] |
LDCM0292 | AC31 | HEK-293T | C302(0.96) | LDD1531 | [4] |
LDCM0293 | AC32 | HEK-293T | C302(0.95) | LDD1532 | [4] |
LDCM0295 | AC34 | HEK-293T | C302(1.04) | LDD1534 | [4] |
LDCM0296 | AC35 | HEK-293T | C302(0.84) | LDD1535 | [4] |
LDCM0297 | AC36 | HEK-293T | C302(0.97) | LDD1536 | [4] |
LDCM0298 | AC37 | HEK-293T | C302(0.95) | LDD1537 | [4] |
LDCM0299 | AC38 | HEK-293T | C302(0.88) | LDD1538 | [4] |
LDCM0300 | AC39 | HEK-293T | C302(0.98) | LDD1539 | [4] |
LDCM0301 | AC4 | HEK-293T | C302(1.13) | LDD1540 | [4] |
LDCM0302 | AC40 | HEK-293T | C302(0.87) | LDD1541 | [4] |
LDCM0304 | AC42 | HEK-293T | C302(1.04) | LDD1543 | [4] |
LDCM0305 | AC43 | HEK-293T | C302(0.92) | LDD1544 | [4] |
LDCM0306 | AC44 | HEK-293T | C302(1.15) | LDD1545 | [4] |
LDCM0307 | AC45 | HEK-293T | C302(0.95) | LDD1546 | [4] |
LDCM0308 | AC46 | HEK-293T | C302(0.97) | LDD1547 | [4] |
LDCM0309 | AC47 | HEK-293T | C302(1.02) | LDD1548 | [4] |
LDCM0310 | AC48 | HEK-293T | C302(0.96) | LDD1549 | [4] |
LDCM0312 | AC5 | HEK-293T | C302(0.97) | LDD1551 | [4] |
LDCM0313 | AC50 | HEK-293T | C302(1.04) | LDD1552 | [4] |
LDCM0314 | AC51 | HEK-293T | C302(0.96) | LDD1553 | [4] |
LDCM0315 | AC52 | HEK-293T | C302(0.94) | LDD1554 | [4] |
LDCM0316 | AC53 | HEK-293T | C302(0.92) | LDD1555 | [4] |
LDCM0317 | AC54 | HEK-293T | C302(0.89) | LDD1556 | [4] |
LDCM0318 | AC55 | HEK-293T | C302(0.99) | LDD1557 | [4] |
LDCM0319 | AC56 | HEK-293T | C302(0.88) | LDD1558 | [4] |
LDCM0321 | AC58 | HEK-293T | C302(1.07) | LDD1560 | [4] |
LDCM0322 | AC59 | HEK-293T | C302(1.08) | LDD1561 | [4] |
LDCM0323 | AC6 | HEK-293T | C302(1.32) | LDD1562 | [4] |
LDCM0324 | AC60 | HEK-293T | C302(1.09) | LDD1563 | [4] |
LDCM0325 | AC61 | HEK-293T | C302(1.01) | LDD1564 | [4] |
LDCM0326 | AC62 | HEK-293T | C302(1.22) | LDD1565 | [4] |
LDCM0327 | AC63 | HEK-293T | C302(1.16) | LDD1566 | [4] |
LDCM0328 | AC64 | HEK-293T | C302(1.02) | LDD1567 | [4] |
LDCM0334 | AC7 | HEK-293T | C302(0.98) | LDD1568 | [4] |
LDCM0345 | AC8 | HEK-293T | C302(0.93) | LDD1569 | [4] |
LDCM0248 | AKOS034007472 | HEK-293T | C302(0.86) | LDD1511 | [4] |
LDCM0275 | AKOS034007705 | HEK-293T | C302(1.00) | LDD1514 | [4] |
LDCM0108 | Chloroacetamide | HeLa | N.A. | LDD0222 | [3] |
LDCM0367 | CL1 | HEK-293T | C302(1.01) | LDD1571 | [4] |
LDCM0368 | CL10 | HEK-293T | C302(1.12) | LDD1572 | [4] |
LDCM0369 | CL100 | HEK-293T | C302(1.10) | LDD1573 | [4] |
LDCM0370 | CL101 | HEK-293T | C302(1.01) | LDD1574 | [4] |
LDCM0371 | CL102 | HEK-293T | C302(1.42) | LDD1575 | [4] |
LDCM0372 | CL103 | HEK-293T | C302(1.05) | LDD1576 | [4] |
LDCM0373 | CL104 | HEK-293T | C302(1.13) | LDD1577 | [4] |
LDCM0374 | CL105 | HEK-293T | C302(1.05) | LDD1578 | [4] |
LDCM0375 | CL106 | HEK-293T | C302(0.98) | LDD1579 | [4] |
LDCM0376 | CL107 | HEK-293T | C302(0.88) | LDD1580 | [4] |
LDCM0377 | CL108 | HEK-293T | C302(1.09) | LDD1581 | [4] |
LDCM0378 | CL109 | HEK-293T | C302(1.05) | LDD1582 | [4] |
LDCM0379 | CL11 | HEK-293T | C302(1.01) | LDD1583 | [4] |
LDCM0380 | CL110 | HEK-293T | C302(1.21) | LDD1584 | [4] |
LDCM0381 | CL111 | HEK-293T | C302(1.00) | LDD1585 | [4] |
LDCM0382 | CL112 | HEK-293T | C302(1.13) | LDD1586 | [4] |
LDCM0383 | CL113 | HEK-293T | C302(0.96) | LDD1587 | [4] |
LDCM0384 | CL114 | HEK-293T | C302(1.24) | LDD1588 | [4] |
LDCM0385 | CL115 | HEK-293T | C302(1.14) | LDD1589 | [4] |
LDCM0386 | CL116 | HEK-293T | C302(1.09) | LDD1590 | [4] |
LDCM0387 | CL117 | HEK-293T | C302(0.99) | LDD1591 | [4] |
LDCM0388 | CL118 | HEK-293T | C302(1.03) | LDD1592 | [4] |
LDCM0389 | CL119 | HEK-293T | C302(0.91) | LDD1593 | [4] |
LDCM0390 | CL12 | HEK-293T | C302(1.08) | LDD1594 | [4] |
LDCM0391 | CL120 | HEK-293T | C302(1.12) | LDD1595 | [4] |
LDCM0392 | CL121 | HEK-293T | C302(1.05) | LDD1596 | [4] |
LDCM0393 | CL122 | HEK-293T | C302(1.40) | LDD1597 | [4] |
LDCM0394 | CL123 | HEK-293T | C302(1.21) | LDD1598 | [4] |
LDCM0395 | CL124 | HEK-293T | C302(1.13) | LDD1599 | [4] |
LDCM0396 | CL125 | HEK-293T | C302(1.19) | LDD1600 | [4] |
LDCM0397 | CL126 | HEK-293T | C302(1.25) | LDD1601 | [4] |
LDCM0398 | CL127 | HEK-293T | C302(1.19) | LDD1602 | [4] |
LDCM0399 | CL128 | HEK-293T | C302(1.17) | LDD1603 | [4] |
LDCM0400 | CL13 | HEK-293T | C302(1.06) | LDD1604 | [4] |
LDCM0401 | CL14 | HEK-293T | C302(1.16) | LDD1605 | [4] |
LDCM0402 | CL15 | HEK-293T | C302(0.90) | LDD1606 | [4] |
LDCM0403 | CL16 | HEK-293T | C302(1.02) | LDD1607 | [4] |
LDCM0405 | CL18 | HEK-293T | C302(0.95) | LDD1609 | [4] |
LDCM0406 | CL19 | HEK-293T | C302(0.82) | LDD1610 | [4] |
LDCM0407 | CL2 | HEK-293T | C302(1.07) | LDD1611 | [4] |
LDCM0408 | CL20 | HEK-293T | C302(0.91) | LDD1612 | [4] |
LDCM0409 | CL21 | HEK-293T | C302(1.06) | LDD1613 | [4] |
LDCM0410 | CL22 | HEK-293T | C302(0.93) | LDD1614 | [4] |
LDCM0411 | CL23 | HEK-293T | C302(0.93) | LDD1615 | [4] |
LDCM0412 | CL24 | HEK-293T | C302(0.95) | LDD1616 | [4] |
LDCM0413 | CL25 | HEK-293T | C302(1.23) | LDD1617 | [4] |
LDCM0414 | CL26 | HEK-293T | C302(0.99) | LDD1618 | [4] |
LDCM0415 | CL27 | HEK-293T | C302(0.95) | LDD1619 | [4] |
LDCM0416 | CL28 | HEK-293T | C302(1.04) | LDD1620 | [4] |
LDCM0418 | CL3 | HEK-293T | C302(1.23) | LDD1622 | [4] |
LDCM0419 | CL30 | HEK-293T | C302(1.00) | LDD1623 | [4] |
LDCM0420 | CL31 | HEK-293T | C302(1.04) | LDD1624 | [4] |
LDCM0421 | CL32 | HEK-293T | C302(0.93) | LDD1625 | [4] |
LDCM0422 | CL33 | HEK-293T | C302(1.24) | LDD1626 | [4] |
LDCM0423 | CL34 | HEK-293T | C302(1.05) | LDD1627 | [4] |
LDCM0424 | CL35 | HEK-293T | C302(1.03) | LDD1628 | [4] |
LDCM0425 | CL36 | HEK-293T | C302(0.95) | LDD1629 | [4] |
LDCM0426 | CL37 | HEK-293T | C302(1.19) | LDD1630 | [4] |
LDCM0428 | CL39 | HEK-293T | C302(1.02) | LDD1632 | [4] |
LDCM0429 | CL4 | HEK-293T | C302(1.21) | LDD1633 | [4] |
LDCM0430 | CL40 | HEK-293T | C302(1.04) | LDD1634 | [4] |
LDCM0432 | CL42 | HEK-293T | C302(1.06) | LDD1636 | [4] |
LDCM0433 | CL43 | HEK-293T | C302(1.13) | LDD1637 | [4] |
LDCM0434 | CL44 | HEK-293T | C302(0.96) | LDD1638 | [4] |
LDCM0435 | CL45 | HEK-293T | C302(0.99) | LDD1639 | [4] |
LDCM0436 | CL46 | HEK-293T | C302(0.94) | LDD1640 | [4] |
LDCM0437 | CL47 | HEK-293T | C302(0.90) | LDD1641 | [4] |
LDCM0438 | CL48 | HEK-293T | C302(1.00) | LDD1642 | [4] |
LDCM0439 | CL49 | HEK-293T | C302(1.20) | LDD1643 | [4] |
LDCM0441 | CL50 | HEK-293T | C302(0.99) | LDD1645 | [4] |
LDCM0443 | CL52 | HEK-293T | C302(1.05) | LDD1646 | [4] |
LDCM0445 | CL54 | HEK-293T | C302(1.31) | LDD1648 | [4] |
LDCM0446 | CL55 | HEK-293T | C302(0.92) | LDD1649 | [4] |
LDCM0447 | CL56 | HEK-293T | C302(1.03) | LDD1650 | [4] |
LDCM0448 | CL57 | HEK-293T | C302(1.17) | LDD1651 | [4] |
LDCM0449 | CL58 | HEK-293T | C302(0.96) | LDD1652 | [4] |
LDCM0450 | CL59 | HEK-293T | C302(1.04) | LDD1653 | [4] |
LDCM0451 | CL6 | HEK-293T | C302(1.17) | LDD1654 | [4] |
LDCM0452 | CL60 | HEK-293T | C302(1.03) | LDD1655 | [4] |
LDCM0453 | CL61 | HEK-293T | C302(1.16) | LDD1656 | [4] |
LDCM0454 | CL62 | HEK-293T | C302(0.98) | LDD1657 | [4] |
LDCM0455 | CL63 | HEK-293T | C302(0.94) | LDD1658 | [4] |
LDCM0456 | CL64 | HEK-293T | C302(1.17) | LDD1659 | [4] |
LDCM0458 | CL66 | HEK-293T | C302(1.06) | LDD1661 | [4] |
LDCM0459 | CL67 | HEK-293T | C302(1.00) | LDD1662 | [4] |
LDCM0460 | CL68 | HEK-293T | C302(1.00) | LDD1663 | [4] |
LDCM0461 | CL69 | HEK-293T | C302(1.02) | LDD1664 | [4] |
LDCM0462 | CL7 | HEK-293T | C302(0.99) | LDD1665 | [4] |
LDCM0463 | CL70 | HEK-293T | C302(1.01) | LDD1666 | [4] |
LDCM0464 | CL71 | HEK-293T | C302(0.96) | LDD1667 | [4] |
LDCM0465 | CL72 | HEK-293T | C302(0.86) | LDD1668 | [4] |
LDCM0466 | CL73 | HEK-293T | C302(1.28) | LDD1669 | [4] |
LDCM0467 | CL74 | HEK-293T | C302(1.13) | LDD1670 | [4] |
LDCM0469 | CL76 | HEK-293T | C302(1.09) | LDD1672 | [4] |
LDCM0471 | CL78 | HEK-293T | C302(0.98) | LDD1674 | [4] |
LDCM0472 | CL79 | HEK-293T | C302(0.93) | LDD1675 | [4] |
LDCM0473 | CL8 | HEK-293T | C302(1.51) | LDD1676 | [4] |
LDCM0474 | CL80 | HEK-293T | C302(0.92) | LDD1677 | [4] |
LDCM0475 | CL81 | HEK-293T | C302(0.83) | LDD1678 | [4] |
LDCM0476 | CL82 | HEK-293T | C302(1.13) | LDD1679 | [4] |
LDCM0477 | CL83 | HEK-293T | C302(1.04) | LDD1680 | [4] |
LDCM0478 | CL84 | HEK-293T | C302(1.00) | LDD1681 | [4] |
LDCM0479 | CL85 | HEK-293T | C302(1.11) | LDD1682 | [4] |
LDCM0480 | CL86 | HEK-293T | C302(1.52) | LDD1683 | [4] |
LDCM0481 | CL87 | HEK-293T | C302(1.19) | LDD1684 | [4] |
LDCM0482 | CL88 | HEK-293T | C302(1.15) | LDD1685 | [4] |
LDCM0484 | CL9 | HEK-293T | C302(1.04) | LDD1687 | [4] |
LDCM0485 | CL90 | HEK-293T | C302(1.85) | LDD1688 | [4] |
LDCM0486 | CL91 | HEK-293T | C302(1.09) | LDD1689 | [4] |
LDCM0487 | CL92 | HEK-293T | C302(1.14) | LDD1690 | [4] |
LDCM0488 | CL93 | HEK-293T | C302(1.06) | LDD1691 | [4] |
LDCM0489 | CL94 | HEK-293T | C302(1.08) | LDD1692 | [4] |
LDCM0490 | CL95 | HEK-293T | C302(1.32) | LDD1693 | [4] |
LDCM0491 | CL96 | HEK-293T | C302(1.06) | LDD1694 | [4] |
LDCM0492 | CL97 | HEK-293T | C302(1.07) | LDD1695 | [4] |
LDCM0493 | CL98 | HEK-293T | C302(1.09) | LDD1696 | [4] |
LDCM0494 | CL99 | HEK-293T | C302(1.17) | LDD1697 | [4] |
LDCM0495 | E2913 | HEK-293T | C302(1.08) | LDD1698 | [4] |
LDCM0468 | Fragment33 | HEK-293T | C302(1.06) | LDD1671 | [4] |
LDCM0427 | Fragment51 | HEK-293T | C302(1.16) | LDD1631 | [4] |
References