Details of the Probe

General Information of Probe

Probe ID
LDPC0024
Probe Name
BD-F
Probe Type
PAL-AfBPP Probe
Structure
2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 386.499
Lipid-water partition coefficient (xlogp) 3.7417
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C24H26N4O
Canonical SMILES
C#CCN(CCC1(C)N=N1)C(=O)C1CN(C(c2ccccc2)c2ccccc2)C1
InChI
InChI=1S/C24H26N4O/c1-3-15-27(16-14-24(2)25-26-24)23(29)21-17-28(18-21)22(19-10-6-4-7-11-19)20-12-8-5-9-13-20/h1,4-13,21-22H,14-18H2,2H3
InChIKey
RQYRZRPMFZQXCX-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

60 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
60 kDa heat shock protein, mitochondrial (HSPD1) LDTP02522 N104; N106  LDD0024 
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) LDTP11321 T245; T247; L239; V246  LDD0024 
Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) LDTP03291 A333; V330; S334  LDD0024 
Actin, cytoplasmic 1 (ACTB) LDTP04876 V163; E99; A97; P164  LDD0024 
ADP-dependent glucokinase (ADPGK) LDTP11127 C40; W36  LDD0024 
ADP-ribosylation factor 1 (ARF1) LDTP05192 L177; D164  LDD0024 
ADP-ribosylation factor 3 (ARF3) LDTP04907 I46; Y58; T55; K59  LDD0024 
ADP-ribosylation factor-like protein 1 (ARL1) LDTP03900 T57; F51; Y58; G50  LDD0024 
ATP synthase subunit beta, mitochondrial (ATP5F1B) LDTP02150 E391; L392  LDD0024 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 P78; I83; S81; T79  LDD0024 
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) LDTP03257 Y202; Y486; A204; A209  LDD0024 
Cathepsin D (CTSD) LDTP02198 G323; Y325; E324  LDD0024 
CDGSH iron-sulfur domain-containing protein 1 (CISD1) LDTP12873 V17; A20; E12  LDD0024 
Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1) LDTP03610 G405; A457; P454; E411  LDD0024 
Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) LDTP03189 Y55; P57; V58  LDD0024 
Cytochrome b-c1 complex subunit 8 (UQCRQ) LDTP00486 L58; T61; I59; F56  LDD0024 
Cytochrome b-c1 complex subunit 9 (UQCR10) LDTP13189 Y44; H46  LDD0024 
Delta(24)-sterol reductase (DHCR24) LDTP06375 W337; D341; L339  LDD0024 
DNA replication licensing factor MCM6 (MCM6) LDTP06150 Q80; T77; L68; Y84  LDD0024 
E3 ubiquitin-protein ligase TRIP12 (TRIP12) LDTP06173 Q531; I536; C535; Q541  LDD0024 
Elongation factor 2 (EEF2) LDTP02672 V458  LDD0024 
Glucose-6-phosphatase 3 (G6PC3) LDTP11243 Q272; P268; S267; V273  LDD0024 
Glutathione S-transferase 3, mitochondrial (MGST3) LDTP00464 S132; V130  LDD0024 
Glutathione S-transferase LANCL1 (LANCL1) LDTP00874 Y214; Q211; Y207  LDD0024 
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (BPNT2) LDTP12763 E44; G40; S37; L41  LDD0024 
Heat shock cognate 71 kDa protein (HSPA8) LDTP02541 E446; L439; G437  LDD0024 
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH) LDTP06645 G257; P258; Y264; M256  LDD0024 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 V251; Y250; A252  LDD0024 
Inositol polyphosphate 5-phosphatase K (INPP5K) LDTP11182 Y376; V377  LDD0024 
L-lactate dehydrogenase A chain (LDHA) LDTP01766 I9; Y10; L12; N11  LDD0024 
Lactoylglutathione lyase (GLO1) LDTP05434 D168; G169; I172; I174  LDD0024 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 L247; G238; G239  LDD0024 
Leukotriene A-4 hydrolase (LTA4H) LDTP02385 Y384; A378  LDD0024 
Methylsterol monooxygenase 1 (MSMO1) LDTP06477 D232; H228; I225  LDD0024 
Mitochondrial import inner membrane translocase subunit TIM50 (TIMM50) LDTP06810 P60; G59; S57  LDD0024 
NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial (NDUFA10) LDTP01561 S340  LDD0024 
Nicotinamide phosphoribosyltransferase (NAMPT) LDTP04051 E187; Y188  LDD0024 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 K74; L86; N87; N89  LDD0024 
Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) LDTP12628 S122; G120; D119  LDD0024 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 I231; S241  LDD0024 
Presequence protease, mitochondrial (PITRM1) LDTP07003 Y380; D377; V378; G382  LDD0024 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 E192; P191  LDD0024 
Procathepsin L (CTSL) LDTP02217 P244; S255; D250; A251  LDD0024 
Proteasome subunit alpha type-2 (PSMA2) LDTP03331 Q96; Y101; Y97; L99  LDD0024 
Proteasome subunit alpha type-4 (PSMA4) LDTP03333 G78; T80; N88; D82  LDD0024 
Proteasome subunit beta type-1 (PSMB1) LDTP03060 Y132; Y133; Y135  LDD0024 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 G133; Y134  LDD0024 
Proteasome subunit beta type-6 (PSMB6) LDTP03418 V89; D91; Y95; Q96  LDD0024 
Protein disulfide-isomerase (P4HB) LDTP02188 V157; A145; A156  LDD0024 
Ras-related protein Rap-2a (RAP2A) LDTP02474 S49; D57; E54; L56  LDD0024 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 N263; T264; M258; I260  LDD0024 
Retinol dehydrogenase 14 (RDH14) LDTP12180 D199  LDD0024 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 P147; Y148; I149; D158  LDD0024 
Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3) LDTP03515 C229; G226; E223; T224  LDD0024 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 E524; D543; S525  LDD0024 
Tubulin alpha-1A chain (TUBA1A) LDTP07907 E77; E71; I75; R79  LDD0024 
Tubulin alpha-3D chain (TUBA3D) LDTP02453 N356; I355; F255; Q256  LDD0024 
Very long chain fatty acid elongase 2 (ELOVL2) LDTP12773 D8; N12  LDD0024 
Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) LDTP06901 L49; V45; E42; G50  LDD0024 
X-ray repair cross-complementing protein 6 (XRCC6) LDTP02640 E499; L497; M498; D496  LDD0024 
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⏷ Show the Full List of 60 Enzyme
39 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
14-3-3 protein epsilon (YWHAE) LDTP04969 Y214; E211; L206; T208  LDD0024 
14-3-3 protein theta (YWHAQ) LDTP03385 D209; L216; K212; S210  LDD0024 
14-3-3 protein zeta/delta (YWHAZ) LDTP05043 E209; E208  LDD0024 
ADP/ATP translocase 2 (SLC25A5) LDTP02087 L13; D292; F12; E293  LDD0024 
ADP/ATP translocase 3 (SLC25A6) LDTP02609 D292; K295; L294; E293  LDD0024 
Annexin A1 (ANXA1) LDTP02010 E17; N16  LDD0024 
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) LDTP03284 Y77; G75; Y86; G117  LDD0024 
ATP synthase subunit alpha, mitochondrial (ATP5F1A) LDTP03327 D452; V443; Q448; A444  LDD0024 
BRI3-binding protein (BRI3BP) LDTP15648 D100; L99; D105  LDD0024 
Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) LDTP05510 E196; V193; G194; E208  LDD0024 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 Y68; E72; L73; G65  LDD0024 
Cytoskeleton-associated protein 4 (CKAP4) LDTP05511 A92; A90; A94  LDD0024 
Derlin-2 (DERL2) LDTP11634 Y10; E9; L8  LDD0024 
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13) LDTP13393 I650  LDD0024 
Heat shock protein HSP 90-beta (HSP90AB1) LDTP02262 P700; D518; Y520; A697  LDD0024 
Importin subunit alpha-1 (KPNA2) LDTP04501 F138; D132  LDD0024 
Major facilitator superfamily domain-containing protein 12 (MFSD12) LDTP07480 V214; S206  LDD0024 
Major facilitator superfamily domain-containing protein 3 (MFSD3) LDTP18153 L30; P18  LDD0024 
Membrane-associated progesterone receptor component 1 (PGRMC1) LDTP00235 Q50; A52; D49; G48  LDD0024 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 C159; D163  LDD0024 
Mitochondrial carrier homolog 1 (MTCH1) LDTP12909 E82; A83; G67  LDD0024 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 I126; G120  LDD0024 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 D16; D15; G19  LDD0024 
Multiple coagulation factor deficiency protein 2 (MCFD2) LDTP09278 S113; E104; E103; A109  LDD0024 
Peroxisomal membrane protein PEX16 (PEX16) LDTP14181 A41; S43  LDD0024 
Protein Mpv17 (MPV17) LDTP03869 A144; Y147; N145  LDD0024 
Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1) LDTP04932 L283; Y285; I289; S287  LDD0024 
Putative lipid scramblase CLPTM1 (CLPTM1) LDTP01745 S338; Q337; Y335; E333  LDD0024 
Sideroflexin-1 (SFXN1) LDTP12090 R136; A129; N132; T134  LDD0024 
Sideroflexin-4 (SFXN4) LDTP07531 E48; T47; D51  LDD0024 
Solute carrier family 25 member 3 (SLC25A3) LDTP05238 T162; E173; I332; S171  LDD0024 
Succinate dehydrogenase cytochrome b small subunit, mitochondrial (SDHD) LDTP00358 Y144  LDD0024 
Sugar transporter SWEET1 (SLC50A1) LDTP11136 K64; Y60  LDD0024 
T-complex protein 1 subunit delta (CCT4) LDTP04391 A466; A469; P462; N468  LDD0024 
Transmembrane protein 126A (TMEM126A) LDTP15948 Q177; G174  LDD0024 
Transportin-1 (TNPO1) LDTP09949 N55; Q50; N49  LDD0024 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 G38; I227; G152; D228  LDD0024 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 E211; T215; C47; T88  LDD0024 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 G38; C36; V39; S35  LDD0024 
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⏷ Show the Full List of 39 Transporter and channel
3 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Nascent polypeptide-associated complex subunit alpha-2 (NACA2) LDTP15946 L131; Q129  LDD0024 
Non-POU domain-containing octamer-binding protein (NONO) LDTP06341 S160; E165; L164; E162  LDD0024 
Splicing factor, proline- and glutamine-rich (SFPQ) LDTP03212 E389; E385  LDD0024 
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38 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Diablo IAP-binding mitochondrial protein (DIABLO) LDTP12468 M158; E154; T159; T155  LDD0024 
Emerin (EMD) LDTP04356 D93  LDD0024 
Endoplasmin (HSP90B1) LDTP02734 Y575; E570; P571; V572  LDD0024 
Eukaryotic translation initiation factor 3 subunit L (EIF3L) LDTP13813 E245; T248; Y247  LDD0024 
Far upstream element-binding protein 2 (KHSRP) LDTP09938 P668; D643; Y674; S670  LDD0024 
FUN14 domain-containing protein 1 (FUNDC1) LDTP08509 E130; N125  LDD0024 
Heat shock 70 kDa protein 1A (HSPA1A) LDTP02434 G609; S608; Y371; Q612  LDD0024 
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) LDTP02364 T169; H168  LDD0024 
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) LDTP04514 E245; G241; Y243; L249  LDD0024 
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) LDTP03615 G238; D244; P53; G241  LDD0024 
Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) LDTP04714 G238; Y240  LDD0024 
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) LDTP04952 T438; Q445; I444  LDD0024 
Heterogeneous nuclear ribonucleoprotein L (HNRNPL) LDTP02750 H365; Y363; P371  LDD0024 
Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) LDTP03182 F256; G337; P251; G243  LDD0024 
Histone H2A type 2-C (H2AC20) LDTP06627 T60; L64; E62; A61  LDD0024 
Histone H2A type 3 (H2AC25) LDTP07973 T60; L56; A54; E62  LDD0024 
Histone H2A.V (H2AZ2) LDTP07908 E68; Y61; A64; I58  LDD0024 
Histone H2B type 2-E (H2BC21) LDTP06628 V67; E72  LDD0024 
Histone H3.2 (H3C15; H3C14; H3C13) LDTP07899 D107; F105  LDD0024 
Large ribosomal subunit protein mL40 (MRPL40) LDTP12395 T179; Y178; P176  LDD0024 
Large ribosomal subunit protein P1 (RPLP1) LDTP02107 A72; N62; G64; A69  LDD0024 
Large ribosomal subunit protein uL2 (RPL8) LDTP05027 Y133; N132  LDD0024 
Membralin (TMEM259) LDTP14939 D257; E258; L260  LDD0024 
MICOS complex subunit MIC13 (MICOS13) LDTP07274 Y23; P49; G64; Y26  LDD0024 
Mitochondrial import receptor subunit TOM20 homolog (TOMM20) LDTP06373 L80; V99; A98; Q105  LDD0024 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 E104; T103; L97; P98  LDD0024 
Nucleophosmin (NPM1) LDTP02164 V99; S88; T95; E93  LDD0024 
Poly(rC)-binding protein 1 (PCBP1) LDTP06366 A345; N344  LDD0024 
Poly(U)-binding-splicing factor PUF60 (PUF60) LDTP13311 V483; E480  LDD0024 
PRELI domain containing protein 3B (PRELID3B) LDTP18569 P26; N27; Y25  LDD0024 
Protein CutA (CUTA) LDTP01075 I100; E144; A146; V148  LDD0024 
Reticulocalbin-2 (RCN2) LDTP06097 A142  LDD0024 
Single-stranded DNA-binding protein, mitochondrial (SSBP1) LDTP05437 V72  LDD0024 
Small ribosomal subunit protein eS10 (RPS10) LDTP04111 L83  LDD0024 
T-complex protein 1 subunit epsilon (CCT5) LDTP04201 G103; V111; D104; L112  LDD0024 
T-complex protein 1 subunit eta (CCT7) LDTP10990 P110; Y111  LDD0024 
Transmembrane protein 256 (TMEM256) LDTP19689 Q31; A27; Y25; S24  LDD0024 
Vimentin (VIM) LDTP02297 A352; S87; N93; I92  LDD0024 
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⏷ Show the Full List of 38 Other

Full Information of The Labelling Profiles of This Probe

Qualitation: Labeling site identification
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
200 uM
Quantitative Method
Isotope tag
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Interaction Atlas ID
 LDD0024 
Download The Altas

References

1 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652