Details of the Target

General Information of Target

Target ID LDTP05238
Target Name Solute carrier family 25 member 3 (SLC25A3)
Gene Name SLC25A3
Gene ID 5250
Synonyms
PHC; Solute carrier family 25 member 3; Phosphate carrier protein, mitochondrial; Phosphate transport protein; PTP
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEEQYSCDYG
SGRFFILCGLGGIISCGTTHTALVPLDLVKCRMQVDPQKYKGIFNGFSVTLKEDGVRGLA
KGWAPTFLGYSMQGLCKFGFYEVFKVLYSNMLGEENTYLWRTSLYLAASASAEFFADIAL
APMEAAKVRIQTQPGYANTLRDAAPKMYKEEGLKAFYKGVAPLWMRQIPYTMMKFACFER
TVEALYKFVVPKPRSECSKPEQLVVTFVAGYIAGVFCAIVSHPADSVVSVLNKEKGSSAS
LVLKRLGFKGVWKGLFARIIMIGTLTALQWFIYDSVKVYFRLPRPPPPEMPESLKKKLGL
TQ
Target Bioclass
Transporter and channel
Family
Mitochondrial carrier (TC 2.A.29) family
Subcellular location
Mitochondrion inner membrane
Function
Inorganic ion transporter that transports phosphate or copper ions across the mitochondrial inner membrane into the matrix compartment. Mediates proton-coupled symport of phosphate ions necessary for mitochondrial oxidative phosphorylation of ADP to ATP. Transports copper ions probably in the form of anionic copper(I) complexes to maintain mitochondrial matrix copper pool and to supply copper for cytochrome C oxidase complex assembly. May also play a role in regulation of the mitochondrial permeability transition pore (mPTP).
Uniprot ID
Q00325
Ensemble ID
ENST00000188376.9
HGNC ID
HGNC:10989
ChEMBL ID
CHEMBL4295795

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 46 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.95  LDD0402  [2]
Alkylaryl probe 3
 Probe Info  		6.74  LDD0381  [3]
CHEMBL5175495
 Probe Info  		8.08  LDD0196  [4]
CY-1
 Probe Info  		22.66  LDD0243  [5]
CY4
 Probe Info  		8.24  LDD0244  [5]
N1
 Probe Info  		18.79  LDD0242  [5]
W1
 Probe Info  		27.57  LDD0235  [6]
TH211
 Probe Info  		Y196(20.00); Y208(10.44); Y100(5.42)  LDD0260  [7]
TH214
 Probe Info  		Y208(11.01)  LDD0258  [7]
TH216
 Probe Info  		Y208(10.83); Y100(8.39); Y196(6.72)  LDD0259  [7]
YN-1
 Probe Info  		100.00  LDD0444  [8]
YN-4
 Probe Info  		100.00  LDD0445  [8]
ONAyne
 Probe Info  		K206(1.41); K209(0.40); K252(0.28); K295(0.98)  LDD0274  [9]
BTD
 Probe Info  		C237(6.08)  LDD1699  [10]
OPA-S-S-alkyne
 Probe Info  		K218(0.82); K234(1.80); K252(3.68); K313(4.20)  LDD3494  [11]
Probe 1
 Probe Info  		Y196(188.66); Y246(37.16)  LDD3495  [12]
EA-probe
 Probe Info  		N.A.  LDD0440  [13]
DBIA
 Probe Info  		C136(1.93)  LDD0080  [14]
AMP probe
 Probe Info  		K99(0.00); K101(0.00)  LDD0200  [15]
ATP probe
 Probe Info  		K99(0.00); K101(0.00); K295(0.00); K304(0.00)  LDD0199  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [16]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [17]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [18]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [18]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [16]
Alkyne tyramide
 Probe Info  		Y196(0.00); Y208(0.00)  LDD0003  [19]
ATP probe
 Probe Info  		N.A.  LDD0035  [20]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [21]
TFBX
 Probe Info  		C237(0.00); C136(0.00)  LDD0027  [21]
WYneN
 Probe Info  		N.A.  LDD0021  [19]
Compound 10
 Probe Info  		N.A.  LDD2216  [22]
ENE
 Probe Info  		N.A.  LDD0006  [19]
IPM
 Probe Info  		C237(0.00); C136(0.00)  LDD0005  [19]
NHS
 Probe Info  		K218(0.00); K99(0.00); K214(0.00); K304(0.00)  LDD0010  [19]
SF
 Probe Info  		Y141(0.00); Y196(0.00); K355(0.00)  LDD0028  [23]
STPyne
 Probe Info  		N.A.  LDD0009  [19]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [24]
1c-yne
 Probe Info  		K247(0.00); K218(0.00); K101(0.00)  LDD0228  [25]
Acrolein
 Probe Info  		N.A.  LDD0217  [26]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [26]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [26]
Methacrolein
 Probe Info  		N.A.  LDD0218  [26]
AOyne
 Probe Info  		15.00  LDD0443  [27]
MPP-AC
 Probe Info  		N.A.  LDD0428  [28]
NAIA_5
 Probe Info  		C91(0.00); C136(0.00); C277(0.00); C257(0.00)  LDD2223  [29]
TPP-AC
 Probe Info  		N.A.  LDD0427  [28]
PAL-AfBPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IMP2070
 Probe Info  		1.53  LDD0367  [30]
C004
 Probe Info  		6.28  LDD1714  [31]
C196
 Probe Info  		11.08  LDD1872  [31]
C220
 Probe Info  		15.24  LDD1894  [31]
C362
 Probe Info  		30.70  LDD2023  [31]
FFF probe11
 Probe Info  		10.90  LDD0471  [32]
FFF probe13
 Probe Info  		19.18  LDD0475  [32]
FFF probe14
 Probe Info  		13.10  LDD0477  [32]
FFF probe2
 Probe Info  		13.50  LDD0463  [32]
FFF probe3
 Probe Info  		10.99  LDD0464  [32]
FFF probe4
 Probe Info  		12.32  LDD0466  [32]
FFF probe6
 Probe Info  		12.94  LDD0467  [32]
JN0003
 Probe Info  		15.98  LDD0469  [32]
STS-2
 Probe Info  		2.36  LDD0139  [33]
BD-F
 Probe Info  		T162(0.00); E173(0.00); I332(0.00); S171(0.00)  LDD0024  [34]
LD-F
 Probe Info  		S169(0.00); E173(0.00); M207(0.00); A168(0.00)  LDD0015  [34]
DA-2
 Probe Info  		N.A.  LDD0070  [35]
OEA-DA
 Probe Info  		3.35  LDD0046  [36]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C237(0.82)  LDD2142  [10]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C237(1.09)  LDD2112  [10]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C237(0.70)  LDD2095  [10]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C237(0.91)  LDD2130  [10]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C237(1.25)  LDD2117  [10]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C237(1.29)  LDD2152  [10]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C237(0.97)  LDD2103  [10]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C237(0.65)  LDD2132  [10]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C237(0.70)  LDD2131  [10]
 LDCM0545  Acetamide MDA-MB-231 C237(0.63)  LDD2138  [10]
 LDCM0156  Aniline NCI-H1299 12.14  LDD0403  [2]
 LDCM0498  BS-3668 MDA-MB-231 C237(1.08)  LDD2091  [10]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [26]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C237(47.55)  LDD1702  [10]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [13]
 LDCM0625  F8 Ramos C136(1.24)  LDD2187  [37]
 LDCM0572  Fragment10 Ramos C136(1.86)  LDD2189  [37]
 LDCM0573  Fragment11 Ramos C136(0.11)  LDD2190  [37]
 LDCM0574  Fragment12 Ramos C136(3.30)  LDD2191  [37]
 LDCM0575  Fragment13 Ramos C136(0.95)  LDD2192  [37]
 LDCM0579  Fragment20 Ramos C136(2.87)  LDD2194  [37]
 LDCM0580  Fragment21 Ramos C136(1.01)  LDD2195  [37]
 LDCM0582  Fragment23 Ramos C136(0.48)  LDD2196  [37]
 LDCM0578  Fragment27 Ramos C136(0.71)  LDD2197  [37]
 LDCM0586  Fragment28 Ramos C136(0.73)  LDD2198  [37]
 LDCM0588  Fragment30 Ramos C136(1.39)  LDD2199  [37]
 LDCM0589  Fragment31 Ramos C136(0.96)  LDD2200  [37]
 LDCM0590  Fragment32 Ramos C136(2.15)  LDD2201  [37]
 LDCM0468  Fragment33 Ramos C136(1.66)  LDD2202  [37]
 LDCM0596  Fragment38 Ramos C136(1.44)  LDD2203  [37]
 LDCM0566  Fragment4 Ramos C136(3.25)  LDD2184  [37]
 LDCM0610  Fragment52 Ramos C136(2.34)  LDD2204  [37]
 LDCM0614  Fragment56 Ramos C136(1.90)  LDD2205  [37]
 LDCM0569  Fragment7 Ramos C136(3.00)  LDD2186  [37]
 LDCM0571  Fragment9 Ramos C136(4.20)  LDD2188  [37]
 LDCM0015  HNE MDA-MB-231 C136(1.14)  LDD0346  [37]
 LDCM0107  IAA HeLa N.A.  LDD0221  [26]
 LDCM0022  KB02 HCT 116 C136(1.93)  LDD0080  [14]
 LDCM0023  KB03 HCT 116 C136(2.95)  LDD0081  [14]
 LDCM0024  KB05 HCT 116 C136(2.92)  LDD0082  [14]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C237(1.41)  LDD2102  [10]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C237(0.75)  LDD2121  [10]
 LDCM0109  NEM HeLa N.A.  LDD0223  [26]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C237(0.96)  LDD2089  [10]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C237(1.59)  LDD2090  [10]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C237(1.10)  LDD2092  [10]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C237(1.00)  LDD2093  [10]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C237(1.48)  LDD2094  [10]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C237(0.85)  LDD2097  [10]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C237(1.64)  LDD2098  [10]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C237(0.97)  LDD2099  [10]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C237(1.90)  LDD2100  [10]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C237(0.77)  LDD2101  [10]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C237(0.87)  LDD2104  [10]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C237(1.14)  LDD2105  [10]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C237(1.17)  LDD2106  [10]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C237(1.07)  LDD2107  [10]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C237(0.75)  LDD2108  [10]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C237(0.92)  LDD2109  [10]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C237(4.02)  LDD2110  [10]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C237(1.19)  LDD2111  [10]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C237(1.02)  LDD2114  [10]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C237(0.57)  LDD2115  [10]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C237(0.22)  LDD2118  [10]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C237(1.62)  LDD2119  [10]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C237(0.95)  LDD2120  [10]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C237(0.05)  LDD2122  [10]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C237(1.03)  LDD2123  [10]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C237(1.04)  LDD2125  [10]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C237(1.65)  LDD2127  [10]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C237(1.01)  LDD2128  [10]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C237(1.06)  LDD2129  [10]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C237(0.69)  LDD2133  [10]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C237(0.58)  LDD2134  [10]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C237(1.25)  LDD2135  [10]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C237(0.97)  LDD2136  [10]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C237(0.86)  LDD2137  [10]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C237(2.14)  LDD1700  [10]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C237(0.99)  LDD2140  [10]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C237(0.66)  LDD2141  [10]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C237(0.79)  LDD2143  [10]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C237(1.71)  LDD2144  [10]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C237(8.90)  LDD2145  [10]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C237(1.12)  LDD2146  [10]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C237(1.20)  LDD2147  [10]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C237(0.60)  LDD2148  [10]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C237(0.66)  LDD2150  [10]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C237(0.06)  LDD2151  [10]
 LDCM0627  NUDT7-COV-1 HEK-293T C136(1.04); C237(0.89)  LDD2206  [38]
 LDCM0628  OTUB2-COV-1 HEK-293T C237(0.81); C136(0.76)  LDD2207  [38]
 LDCM0131  RA190 MM1.R C136(1.64); C237(1.54)  LDD0304  [39]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
4 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
9 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
12 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
13 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
14 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
15 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
18 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
21 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
22 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
23 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
24 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
25 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
26 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
27 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
28 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
29 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
30 A Probe for NLRP3 Inflammasome Inhibitor MCC950 Identifies Carbonic Anhydrase 2 as a Novel Target. ACS Chem Biol. 2021 Jun 18;16(6):982-990. doi: 10.1021/acschembio.1c00218. Epub 2021 May 18.
Mass spectrometry data entry: PXD024915 , PXD024913
31 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
32 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
33 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
34 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
35 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
36 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
37 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
38 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
39 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.