Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C196  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 65 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 64.9
 LDTP02359  Heme oxygenase 1 (HMOX1) 40.2
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 36.8
 LDTP00697  Cytochrome b5 type B (CYB5B) 36.3
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 36.3
 LDTP03540  Heme oxygenase 2 (HMOX2) 31.6
 LDTP03189  Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) 29.9
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 28.1
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 26.2
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 24.3
 LDTP03331  Proteasome subunit alpha type-2 (PSMA2) 23.9
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 23.8
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 23.6
 LDTP06617  Ceramide glucosyltransferase (UGCG) 22.5
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 21.7
 LDTP01769  Dihydrofolate reductase (DHFR) 21.6
 LDTP04247  Protein farnesyltransferase subunit beta (FNTB) 21.1
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 20.8
 LDTP11127  ADP-dependent glucokinase (ADPGK) 19.6
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 17.8
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 17.4
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 17.3
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 17.1
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 16.7
 LDTP01513  NADH dehydrogenase 1 alpha subcomplex subunit 3 (NDUFA3) 16.6
 LDTP11874  Thioredoxin-related transmembrane protein 1 (TMX1) 16.6
 LDTP14108  Nucleoside diphosphate kinase homolog 7 (NME7) 16.2
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 15.9
 LDTP10329  Ceramide synthase 2 (CERS2) 15.5
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 14.7
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 14.5
 LDTP05652  Aspartyl/asparaginyl beta-hydroxylase (ASPH) 14.3
 LDTP03145  Catechol O-methyltransferase (COMT) 14.2
 LDTP01168  NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) 13.7
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 13.6
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 13.6
 LDTP16040  Glyoxalase domain-containing protein 4 (GLOD4) 13.1
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 12.7
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 12.6
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 12.5
 LDTP03787  Choline kinase alpha (CHKA) 12.4
 LDTP03139  Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) 12.4
 LDTP11016  Dual specificity protein phosphatase 9 (DUSP9) 12.1
 LDTP00758  Thioredoxin-like protein 1 (TXNL1) 12.0
 LDTP10020  Ras-related protein Rab-24 (RAB24) 11.9
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 11.9
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 11.8
 LDTP09188  Lysophosphatidylcholine acyltransferase 1 (LPCAT1) 11.6
 LDTP04203  Phosphatidylserine synthase 1 (PTDSS1) 11.5
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 11.1
 LDTP03900  ADP-ribosylation factor-like protein 1 (ARL1) 11.0
 LDTP07813  Sulfhydryl oxidase 2 (QSOX2) 11.0
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 10.9
 LDTP02721  Farnesyl pyrophosphate synthase (FDPS) 10.9
 LDTP13408  Cell division cycle protein 23 homolog (CDC23) 10.8
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 10.7
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 10.7
 LDTP06262  N-alpha-acetyltransferase 25, NatB auxiliary subunit (NAA25) 10.7
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 10.6
 LDTP06384  Ribosomal protein S6 kinase alpha-1 (RPS6KA1) 10.4
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 10.0
 LDTP11437  Peroxisomal trans-2-enoyl-CoA reductase (PECR) 9.8
 LDTP04581  Holocytochrome c-type synthase (HCCS) 9.7
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 9.7
 LDTP02385  Leukotriene A-4 hydrolase (LTA4H) 9.7
Transporter and channel
Click to Show/Hide to Show 55 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01804  ATP synthase subunit a (MT-ATP6) 99.7
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 72.0
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 65.3
 LDTP15948  Transmembrane protein 126A (TMEM126A) 36.8
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 35.0
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 31.8
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 31.6
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 29.2
 LDTP11812  Protein ARV1 (ARV1) 26.2
 LDTP20002  Transmembrane protein 160 (TMEM160) 26.2
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 26.0
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 21.0
 LDTP08881  Transmembrane protein 199 (TMEM199) 20.1
 LDTP11245  Derlin-1 (DERL1) 19.3
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 18.8
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 18.0
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 17.6
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 17.4
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 17.1
 LDTP05900  Metaxin-1 (MTX1) 16.8
 LDTP11250  MICOS complex subunit MIC26 (APOO) 16.8
 LDTP12383  Protein GPR108 (GPR108) 16.7
 LDTP07236  Protein GPR107 (GPR107) 16.0
 LDTP10065  Transmembrane protein 230 (TMEM230) 16.0
 LDTP01217  Metaxin-2 (MTX2) 15.2
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 13.9
 LDTP10059  PAT complex subunit CCDC47 (CCDC47) 13.8
 LDTP00383  AP-3 complex subunit delta-1 (AP3D1) 13.5
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 13.4
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 13.3
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 13.2
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 13.0
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 13.0
 LDTP16190  Protein FAM8A1 (FAM8A1) 12.7
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 12.6
 LDTP11213  Nucleoporin NDC1 (NDC1) 12.2
 LDTP02609  ADP/ATP translocase 3 (SLC25A6) 12.0
 LDTP13163  Nuclear RNA export factor 1 (NXF1) 12.0
 LDTP01200  Peroxisomal membrane protein PEX14 (PEX14) 12.0
 LDTP01601  Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1) 11.9
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 11.7
 LDTP01060  PRA1 family protein 2 (PRAF2) 11.6
 LDTP09294  Proton-coupled zinc antiporter SLC30A5 (SLC30A5) 11.6
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 11.6
 LDTP10036  BOS complex subunit NCLN (NCLN) 11.5
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 11.4
 LDTP11869  Growth hormone-inducible transmembrane protein (GHITM) 11.1
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 11.1
 LDTP05238  Solute carrier family 25 member 3 (SLC25A3) 11.1
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 11.0
 LDTP04787  Transmembrane protein 33 (TMEM33) 11.0
 LDTP15733  Solute carrier family 25 member 44 (SLC25A44) 10.9
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 10.6
 LDTP10663  Importin-9 (IPO9) 10.1
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 9.8
Other
Click to Show/Hide to Show 61 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05277  Protein SET (SET) 99.7
 LDTP11076  Apolipoprotein L2 (APOL2) 81.0
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 43.7
 LDTP01522  Reticulon-3 (RTN3) 36.3
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 34.8
 LDTP08154  Large ribosomal subunit protein uL10m (MRPL10) 33.6
 LDTP08796  Protein SYS1 homolog (SYS1) 30.3
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 24.9
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 24.6
 LDTP03926  Centrin-2 (CETN2) 24.3
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 24.3
 LDTP07574  Superkiller complex protein 3 (SKIC3) 24.1
 LDTP13086  Syntaxin-18 (STX18) 21.7
 LDTP08594  Negative elongation factor C/D (NELFCD) 21.6
 LDTP05375  Nucleobindin-1 (NUCB1) 19.4
 LDTP16099  p53 and DNA damage-regulated protein 1 (PDRG1) 18.8
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 18.8
 LDTP05160  Nucleobindin-2 (NUCB2) 17.9
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 17.3
 LDTP08224  Protein LYRIC (MTDH) 17.3
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 16.4
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 16.4
 LDTP12025  UPF0488 protein C8orf33 (C8orf33) 16.3
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 15.3
 LDTP16080  Protein FAM114A2 (FAM114A2) 15.0
 LDTP12476  Translation initiation factor eIF2B subunit gamma (EIF2B3) 14.1
 LDTP09297  Large ribosomal subunit protein mL64 (GADD45GIP1) 13.9
 LDTP00859  Synaptogyrin-2 (SYNGR2) 13.9
 LDTP02443  Calmodulin-3 (CALM3) 13.8
 LDTP19963  TraB domain-containing protein (TRABD) 13.7
 LDTP14217  Lipid droplet-regulating VLDL assembly factor AUP1 (AUP1) 13.6
 LDTP18561  Small ribosomal subunit protein mS33 (MRPS33) 13.2
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 13.0
 LDTP03775  RNA-binding protein FUS (FUS) 12.4
 LDTP07274  MICOS complex subunit MIC13 (MICOS13) 12.2
 LDTP06097  Reticulocalbin-2 (RCN2) 12.1
 LDTP11981  Receptor expression-enhancing protein 4 (REEP4) 11.8
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) 11.7
 LDTP10056  Protein FAM162A (FAM162A) 11.5
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 11.3
 LDTP11065  Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (ECSIT) 11.2
 LDTP01359  Dynactin subunit 3 (DCTN3) 11.2
 LDTP00991  Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) 11.2
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 11.2
 LDTP16285  Transducin beta-like protein 2 (TBL2) 11.2
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 11.0
 LDTP00500  Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) 10.9
 LDTP05318  RNA-binding protein EWS (EWSR1) 10.9
 LDTP13967  Transmembrane emp24 domain-containing protein 5 (TMED5) 10.7
 LDTP04356  Emerin (EMD) 10.5
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) 10.4
 LDTP06587  Survival motor neuron protein (SMN1; SMN2) 10.4
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) 10.2
 LDTP07297  Microtubule-associated protein 1S (MAP1S) 10.2
 LDTP11239  Protein misato homolog 1 (MSTO1) 10.2
 LDTP13922  Tudor and KH domain-containing protein (TDRKH) 10.2
 LDTP02180  Neurofilament light polypeptide (NEFL) 10.0
 LDTP12412  Reticulon-4 (RTN4) 10.0
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 10.0
 LDTP04714  Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) 9.8
 LDTP08707  Proline-, glutamic acid- and leucine-rich protein 1 (PELP1) 9.8

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587