Details of the Target

General Information of Target

Target ID LDTP11065
Target Name Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (ECSIT)
Gene Name ECSIT
Gene ID 51295
Synonyms
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; Protein SITPEC
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLRWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLP
PVKSAIRGQAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRV
SGTVPGARDGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWR
DFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRR
SHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCCCIVG
DKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDFSPSLKTLCKLAVIQYNLDQSCLPHDI
RWELNAMTTNSNISRPIVSSHG
Target Bioclass
Other
Family
ECSIT family
Subcellular location
Cytoplasm
Function
Adapter protein that plays a role in different signaling pathways including TLRs and IL-1 pathways or innate antiviral induction signaling. Plays a role in the activation of NF-kappa-B by forming a signal complex with TRAF6 and TAK1/MAP3K7 to activate TAK1/MAP3K7 leading to activation of IKKs. Once ubiquitinated, interacts with the dissociated RELA and NFKB1 proteins and translocates to the nucleus where it induces NF-kappa-B-dependent gene expression. Plays a role in innate antiviral immune response by bridging the pattern recognition receptors RIGI and MDA5/IFIT1 to the MAVS complex at the mitochondrion. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development.; As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
Uniprot ID
Q9BQ95
Ensemble ID
ENST00000252440.11
HGNC ID
HGNC:29548

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 Deletion: p.Q261SfsTer5
SNV: p.P205T		 .
KELLY SNV: p.G406E .
LNCaP clone FGC SNV: p.A227T DBIA    Probe Info 
MELHO SNV: p.A307P .
NCIH1155 SNV: p.M117I .
OVK18 SNV: p.R64M .
SUPT1 SNV: p.L219M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y154(20.00)  LDD0260  [1]
STPyne
 Probe Info  		K67(0.63)  LDD0277  [2]
DBIA
 Probe Info  		C85(2.12)  LDD3310  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [5]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		15.78  LDD1714  [6]
C158
 Probe Info  		9.38  LDD1838  [6]
C196
 Probe Info  		11.24  LDD1872  [6]
C228
 Probe Info  		16.11  LDD1901  [6]
C231
 Probe Info  		14.72  LDD1904  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C299(1.09); C160(1.18)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C299(1.06); C160(1.02)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C299(1.28); C160(1.04)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C299(0.99); C160(1.00)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C299(0.98); C160(0.94)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C299(1.00); C160(1.03); C360(0.83)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C299(1.03); C160(0.99)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C299(1.12); C160(1.15)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C299(0.96); C160(1.02)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C299(1.12); C160(1.11)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C299(1.03); C160(1.01)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C299(1.03); C160(1.33)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C299(0.89); C160(0.91)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C299(0.93); C160(1.06); C360(0.83)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C299(1.09); C160(1.02)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C299(0.98); C160(1.05)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C299(1.07); C160(1.11)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C299(1.00); C160(0.88)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C299(1.06); C160(0.96)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C299(0.96); C160(1.15)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C299(1.09); C160(0.97)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C299(0.95); C160(0.85)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C299(1.01); C160(0.97); C360(1.09)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C299(1.07); C160(0.99)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C299(1.02); C160(1.12)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C299(1.12); C160(1.14)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C299(1.14); C160(1.05)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C299(1.16); C160(1.05)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C299(1.04); C160(1.09)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C299(0.95); C160(0.95)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C299(0.98); C160(1.07); C360(0.92)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C299(1.18); C160(1.00)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C299(1.10); C160(1.08)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C299(1.10); C160(1.10)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C299(1.04); C160(1.10)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C299(1.06); C160(1.04)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C299(1.10); C160(1.00)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C299(1.05); C160(1.40)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C299(1.00); C160(1.02)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C299(1.11); C160(1.09); C360(1.16)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C299(1.06); C160(1.10)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C299(1.09); C160(1.00)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C299(1.02); C160(1.16)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C299(1.10); C160(1.15)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C299(1.05); C160(0.96)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C299(1.06); C160(1.00)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C299(1.00); C160(1.22)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C299(1.08); C160(1.10)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C299(1.06); C160(0.97); C360(0.90)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C299(1.05); C160(1.01)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C299(0.98); C160(1.01)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C299(1.20); C160(1.00)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C299(1.09); C160(0.97)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C299(1.00); C160(0.99)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C299(0.96); C160(0.98)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C299(0.98); C160(1.08)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C299(0.84); C160(0.98)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C299(0.93); C160(1.05); C360(0.95)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C299(1.09); C160(1.02)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C299(1.00); C160(1.02); C360(1.00)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C299(1.03); C160(1.08)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C299(1.01); C160(1.26)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C299(1.05); C160(1.05)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C299(1.13); C160(0.97)  LDD1514  [7]
 LDCM0367  CL1 HEK-293T C299(1.04); C160(1.05)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C299(0.78); C160(1.06)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C299(1.14); C160(0.99); C360(0.94)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C299(0.99); C160(0.98)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C299(0.97); C160(1.09); C360(1.18)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C299(1.05); C160(1.00); C360(0.79)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C299(1.06); C160(1.03); C360(0.94)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C299(0.98); C160(1.01)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C299(1.08); C160(1.06); C360(0.99)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C299(0.92); C160(1.13); C360(0.94)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C299(1.03); C160(0.98); C360(1.15)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C299(1.08); C160(0.88)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C299(0.95); C160(1.02); C360(0.83)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C299(1.00); C160(1.03); C360(1.06)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C299(0.91); C160(0.99); C360(0.95)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C299(1.07); C160(0.95); C360(1.10)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C299(1.01); C160(0.83)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C299(1.04); C160(0.98); C360(1.05)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C299(0.93); C160(0.94); C360(0.80)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C299(1.15); C160(1.02); C360(1.26)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C299(1.10); C160(0.97)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C299(1.06); C160(1.00); C360(0.90)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C299(1.03); C160(1.07); C360(0.83)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C299(0.83); C160(1.01)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C299(1.16); C160(1.02); C360(1.15)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C299(1.06); C160(0.99)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C299(1.02); C160(0.98); C360(0.87)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C299(0.92); C160(0.88); C360(0.86)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C299(1.05); C160(1.04); C360(1.01)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C299(1.10); C160(1.24)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C299(0.95); C160(1.09); C360(1.33)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C299(1.07); C160(1.16); C360(0.95)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C299(1.07); C160(1.00); C360(1.20)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C299(0.95); C160(0.97)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C299(1.00); C160(1.19); C360(1.19)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C299(0.94); C160(1.12); C360(0.76)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C299(1.24); C160(1.14); C360(1.20)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C299(0.84); C160(1.10)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C299(1.17); C160(1.12)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C299(1.11); C160(0.97)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C299(0.97); C160(1.07); C360(1.11)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C299(0.96); C160(1.06)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C299(0.85); C160(1.13)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C299(0.91); C160(0.89)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C299(1.01); C160(1.10); C360(0.87)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C299(1.00); C160(1.06)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C299(0.99); C160(1.04)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C299(1.11); C160(1.07); C360(0.84)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C299(1.03); C160(1.11); C360(0.84)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C299(1.07); C160(1.01); C360(1.08)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C299(1.04); C160(1.07)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C299(1.01); C160(1.07); C360(0.86)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C299(1.09); C160(1.22)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C299(1.00); C160(0.88)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C299(0.84); C160(1.03)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C299(0.78); C160(0.96)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C299(0.81); C160(1.02)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C299(0.96); C160(1.00); C360(0.83)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C299(0.90); C160(0.99)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C299(1.10); C160(1.15)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C299(0.97); C160(1.09); C360(0.89)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C299(1.19); C160(1.10); C360(1.08)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C299(1.02); C160(1.02); C360(1.17)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C299(1.01); C160(1.08)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C299(1.09); C160(1.35)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C299(1.03); C160(1.00)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C299(1.02); C160(0.91)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C299(0.80); C160(1.29)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C299(0.80); C160(0.79)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C299(0.90); C160(0.95); C360(0.89)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C299(0.91); C160(1.03)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C299(1.10); C160(1.56)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C299(0.97); C160(1.15)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C299(1.08); C160(1.21); C360(0.89)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C299(1.09); C160(1.10); C360(1.14)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C299(0.92); C160(1.08)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C299(1.09); C160(1.15)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C299(1.13); C160(1.01)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C299(1.03); C160(1.03)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C299(0.86); C160(1.09)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C299(0.98); C160(0.82)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C299(0.89); C160(1.03); C360(0.96)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C299(1.03); C160(1.28)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C299(1.01); C160(0.95)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C299(1.11); C160(1.28)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C299(1.11); C160(1.10); C360(1.02)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C299(1.01); C160(1.18); C360(0.99)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C299(1.09); C160(1.06); C360(0.82)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C299(1.05); C160(1.11)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C299(1.10); C160(1.14)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C299(1.12); C160(0.93)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C299(1.15); C160(1.01)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C299(0.95); C160(1.07)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C299(1.04); C160(1.10)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C299(0.91); C160(1.27)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C299(1.01); C160(1.02); C360(0.80)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C299(0.89); C160(1.02)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C299(1.10); C160(1.15)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C299(1.16); C160(1.09); C360(0.94)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C299(1.15); C160(1.05); C360(1.20)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C299(0.96); C160(1.06)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C299(1.07); C160(1.30)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C299(1.15); C160(1.05)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C299(0.86); C160(1.15)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C299(1.24); C160(1.01)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C299(0.99); C160(1.05)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C299(0.92); C160(1.04)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C299(1.08); C160(0.98); C360(0.78)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C299(1.01); C160(0.98)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C299(1.11); C160(1.12)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C299(1.13); C160(1.16); C360(0.99)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C299(1.08); C160(1.19); C360(0.75)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C299(1.17); C160(1.12); C360(1.15)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C299(1.06); C160(1.07)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C299(0.99); C160(1.26)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C299(0.97); C160(1.17)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C299(1.09); C160(1.09)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C299(1.05); C160(0.96)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C299(0.88); C160(1.14)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C299(0.88); C160(0.89)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C299(0.82); C160(1.04); C360(0.76)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C299(0.92); C160(1.06)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C299(1.00); C160(0.84)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C299(1.08); C160(0.95); C360(1.28)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C299(0.98); C160(1.26); C360(1.08)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C299(1.10); C160(1.01); C360(0.92)  LDD1698  [7]
 LDCM0625  F8 Ramos C299(1.02)  LDD2187  [8]
 LDCM0573  Fragment11 Ramos C299(4.20)  LDD2190  [8]
 LDCM0576  Fragment14 Ramos C299(0.18)  LDD2193  [8]
 LDCM0468  Fragment33 HEK-293T C299(1.05); C160(1.08); C360(0.75)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C299(1.05); C160(0.99); C360(1.16)  LDD1631  [7]
 LDCM0569  Fragment7 Ramos C299(1.05)  LDD2186  [8]
 LDCM0022  KB02 HEK-293T C299(1.13); C160(1.03)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C299(0.96); C160(1.03)  LDD1497  [7]
 LDCM0024  KB05 COLO792 C85(2.12)  LDD3310  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Threonine--tRNA ligase 2, cytoplasmic (TARS3) Class-II aminoacyl-tRNA synthetase family A2RTX5
Phenylalanine--tRNA ligase alpha subunit (FARSA) Class-II aminoacyl-tRNA synthetase family Q9Y285
Probable E3 ubiquitin-protein ligase DTX2 (DTX2) Deltex family Q86UW9
Presenilin-1 (PSEN1) Peptidase A22A family P49768
Presenilin-2 (PSEN2) Peptidase A22A family P49810
Testis-specific serine/threonine-protein kinase 3 (TSSK3) CAMK Ser/Thr protein kinase family Q96PN8
GTP-binding protein GEM (GEM) RGK family P55040
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein E (APOE) Apolipoprotein A1/A4/E family P02649
Nuclear RNA export factor 1 (NXF1) NXF family Q9UBU9
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phakinin (BFSP2) Intermediate filament family Q13515
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Melanoma-associated antigen B2 (MAGEB2) . O15479

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578