Details of the Target

General Information of Target

Target ID LDTP03615
Target Name Heterogeneous nuclear ribonucleoprotein H (HNRNPH1)
Gene Name HNRNPH1
Gene ID 3187
Synonyms
HNRPH; HNRPH1; Heterogeneous nuclear ribonucleoprotein H; hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVE
LESEDEVKLALKKDRETMGHRYVEVFKSNNVEMDWVLKHTGPNSPDTANDGFVRLRGLPF
GCSKEEIVQFFSGLEIVPNGITLPVDFQGRSTGEAFVQFASQEIAEKALKKHKERIGHRY
IEIFKSSRAEVRTHYDPPRKLMAMQRPGPYDRPGAGRGYNSIGRGAGFERMRRGAYGGGY
GGYDDYNGYNDGYGFGSDRFGRDLNYCFSGMSDHRYGDGGSTFQSTTGHCVHMRGLPYRA
TENDIYNFFSPLNPVRVHIEIGPDGRVTGEADVEFATHEDAVAAMSKDKANMQHRYVELF
LNSTAGASGGAYEHRYVELFLNSTAGASGGAYGSQMMGGMGLSNQSSYGGPASQQLSGGY
GGGYGGQSSMSGYDQVLQENSSDFQSNIA
Target Bioclass
Other
Subcellular location
Nucleus, nucleoplasm
Function
This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).
Uniprot ID
P31943
Ensemble ID
ENST00000356731.9
HGNC ID
HGNC:5041
ChEMBL ID
CHEMBL3797013

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 56 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.74  LDD0402  [1]
P1
 Probe Info  		10.00  LDD0448  [2]
P3
 Probe Info  		10.00  LDD0450  [2]
P8
 Probe Info  		10.00  LDD0455  [2]
CY4
 Probe Info  		2.36  LDD0244  [3]
N1
 Probe Info  		3.18  LDD0242  [3]
W1
 Probe Info  		10.62  LDD0235  [4]
TH211
 Probe Info  		Y180(20.00); Y249(20.00); Y266(20.00); Y276(20.00)  LDD0257  [5]
TH214
 Probe Info  		Y266(20.00); Y276(20.00); Y82(20.00); Y180(11.54)  LDD0258  [5]
TH216
 Probe Info  		Y240(20.00); Y243(20.00); Y249(20.00); Y253(20.00)  LDD0259  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
YN-4
 Probe Info  		100.00  LDD0445  [6]
BTD
 Probe Info  		C34(4.80)  LDD1699  [7]
AZ-9
 Probe Info  		E26(10.00)  LDD2209  [8]
ONAyne
 Probe Info  		N.A.  LDD0273  [9]
Probe 1
 Probe Info  		Y82(61.61); Y195(74.25); Y210(10.60); Y219(118.78)  LDD3495  [10]
AHL-Pu-1
 Probe Info  		C290(2.06)  LDD0169  [11]
HPAP
 Probe Info  		3.56  LDD0063  [12]
HHS-482
 Probe Info  		Y180(0.96); Y195(1.00); Y266(0.65); Y82(0.94)  LDD0285  [13]
HHS-475
 Probe Info  		Y306(0.57); Y240(0.65); Y356(0.70); Y236(0.70)  LDD0264  [14]
HHS-465
 Probe Info  		Y180(10.00); Y195(10.00); Y236(10.00); Y240(10.00)  LDD2237  [15]
DBIA
 Probe Info  		C22(1.53); C290(1.14)  LDD0080  [16]
5E-2FA
 Probe Info  		H274(0.00); H99(0.00); H318(0.00); H289(0.00)  LDD2235  [17]
ATP probe
 Probe Info  		K98(0.00); K349(0.00); K35(0.00); K167(0.00)  LDD0199  [18]
4-Iodoacetamidophenylacetylene
 Probe Info  		C267(0.00); C122(0.00); C22(0.00); C290(0.00)  LDD0038  [19]
IA-alkyne
 Probe Info  		C122(0.00); C290(0.00); C22(0.00)  LDD0032  [20]
IPIAA_H
 Probe Info  		C267(0.00); C22(0.00); C290(0.00)  LDD0030  [21]
IPIAA_L
 Probe Info  		C267(0.00); C22(0.00); C34(0.00); C122(0.00)  LDD0031  [21]
Lodoacetamide azide
 Probe Info  		C267(0.00); C122(0.00); C22(0.00); C290(0.00)  LDD0037  [19]
ATP probe
 Probe Info  		K98(0.00); K167(0.00)  LDD0035  [22]
JW-RF-010
 Probe Info  		C22(0.00); C290(0.00); C34(0.00); C267(0.00)  LDD0026  [23]
NAIA_4
 Probe Info  		C34(0.00); C122(0.00); C267(0.00)  LDD2226  [24]
TFBX
 Probe Info  		C122(0.00); C22(0.00); C267(0.00); C290(0.00)  LDD0027  [23]
WYneC
 Probe Info  		N.A.  LDD0014  [25]
WYneN
 Probe Info  		C22(0.00); C34(0.00); C267(0.00)  LDD0021  [25]
WYneO
 Probe Info  		C267(0.00); C22(0.00); C122(0.00)  LDD0022  [25]
aHNE
 Probe Info  		N.A.  LDD0001  [25]
Compound 10
 Probe Info  		C122(0.00); C22(0.00); C267(0.00); C290(0.00)  LDD2216  [26]
Compound 11
 Probe Info  		C22(0.00); C267(0.00); C290(0.00)  LDD2213  [26]
ENE
 Probe Info  		C122(0.00); C22(0.00); C34(0.00); C267(0.00)  LDD0006  [25]
IPM
 Probe Info  		C290(0.00); C122(0.00); C22(0.00); C267(0.00)  LDD0005  [25]
NHS
 Probe Info  		K98(0.00); K185(0.00); K14(0.00)  LDD0010  [25]
OSF
 Probe Info  		H99(0.00); H194(0.00)  LDD0029  [27]
PF-06672131
 Probe Info  		C22(0.00); C34(0.00); C267(0.00)  LDD0017  [28]
SF
 Probe Info  		K167(0.00); Y276(0.00); Y195(0.00); Y356(0.00)  LDD0028  [27]
STPyne
 Probe Info  		K98(0.00); K167(0.00)  LDD0009  [25]
VSF
 Probe Info  		C267(0.00); C122(0.00)  LDD0007  [25]
Phosphinate-6
 Probe Info  		C267(0.00); C22(0.00); C290(0.00)  LDD0018  [29]
Ox-W18
 Probe Info  		N.A.  LDD2175  [30]
1c-yne
 Probe Info  		K98(0.00); K87(0.00); K167(0.00); K35(0.00)  LDD0228  [31]
Acrolein
 Probe Info  		H374(0.00); H338(0.00); C22(0.00)  LDD0217  [32]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [32]
Crotonaldehyde
 Probe Info  		C290(0.00); H374(0.00); C22(0.00); H289(0.00)  LDD0219  [32]
Methacrolein
 Probe Info  		C290(0.00); C22(0.00)  LDD0218  [32]
AOyne
 Probe Info  		5.00  LDD0443  [33]
NAIA_5
 Probe Info  		C267(0.00); C34(0.00); C122(0.00); C22(0.00)  LDD2223  [24]
PAL-AfBPP Probe
Click To Hide/Show 44 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		6.59  LDD1714  [34]
C139
 Probe Info  		10.78  LDD1821  [34]
C145
 Probe Info  		8.75  LDD1827  [34]
C161
 Probe Info  		10.48  LDD1841  [34]
C165
 Probe Info  		17.39  LDD1845  [34]
C166
 Probe Info  		8.00  LDD1846  [34]
C169
 Probe Info  		23.43  LDD1849  [34]
C174
 Probe Info  		5.06  LDD1854  [34]
C196
 Probe Info  		10.20  LDD1872  [34]
C206
 Probe Info  		15.56  LDD1881  [34]
C210
 Probe Info  		41.36  LDD1884  [34]
C213
 Probe Info  		25.11  LDD1887  [34]
C218
 Probe Info  		11.47  LDD1892  [34]
C232
 Probe Info  		52.35  LDD1905  [34]
C235
 Probe Info  		16.80  LDD1908  [34]
C249
 Probe Info  		12.30  LDD1922  [34]
C284
 Probe Info  		40.50  LDD1954  [34]
C313
 Probe Info  		14.22  LDD1980  [34]
C314
 Probe Info  		11.16  LDD1981  [34]
C322
 Probe Info  		5.82  LDD1988  [34]
C338
 Probe Info  		19.70  LDD2001  [34]
C346
 Probe Info  		11.47  LDD2007  [34]
C347
 Probe Info  		5.03  LDD2008  [34]
C361
 Probe Info  		19.97  LDD2022  [34]
C382
 Probe Info  		8.75  LDD2041  [34]
C383
 Probe Info  		11.31  LDD2042  [34]
C407
 Probe Info  		11.63  LDD2064  [34]
C420
 Probe Info  		10.06  LDD2075  [34]
C431
 Probe Info  		15.78  LDD2086  [34]
FFF probe11
 Probe Info  		10.31  LDD0471  [35]
FFF probe12
 Probe Info  		5.61  LDD0473  [35]
FFF probe13
 Probe Info  		14.29  LDD0475  [35]
FFF probe14
 Probe Info  		12.25  LDD0477  [35]
FFF probe2
 Probe Info  		15.76  LDD0463  [35]
FFF probe3
 Probe Info  		14.38  LDD0464  [35]
FFF probe6
 Probe Info  		5.20  LDD0467  [35]
FFF probe9
 Probe Info  		5.10  LDD0470  [35]
JN0003
 Probe Info  		12.77  LDD0469  [35]
VE-P
 Probe Info  		N.A.  LDD0396  [36]
BD-F
 Probe Info  		G238(0.00); D244(0.00); P53(0.00); G241(0.00)  LDD0024  [37]
LD-F
 Probe Info  		C267(0.00); Y266(0.00); D245(0.00); Y240(0.00)  LDD0015  [37]
DA-2
 Probe Info  		N.A.  LDD0070  [38]
OEA-DA
 Probe Info  		4.17  LDD0046  [39]
STS-1
 Probe Info  		N.A.  LDD0068  [40]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C267(0.75); C22(0.64); C290(0.47)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C267(1.07); C34(0.54); C22(0.96); C290(0.73)  LDD2112  [7]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C267(0.86); C34(0.72); C22(0.69); C290(0.57)  LDD2095  [7]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C267(0.74); C34(1.05); C22(1.18); C290(1.04)  LDD2130  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C22(1.29); C290(1.32)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C267(1.33); C22(1.76); C290(1.76); C122(1.30)  LDD2152  [7]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C290(1.08)  LDD2103  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C290(0.51); C122(0.43)  LDD2132  [7]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C267(0.83); C34(0.94); C22(1.74); C290(0.74)  LDD2131  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C290(2.06)  LDD0169  [11]
 LDCM0214  AC1 HCT 116 C22(1.52)  LDD0531  [16]
 LDCM0215  AC10 HCT 116 C22(1.27)  LDD0532  [16]
 LDCM0216  AC100 HCT 116 C22(1.38); C290(1.09)  LDD0533  [16]
 LDCM0217  AC101 HCT 116 C22(1.19); C290(0.92)  LDD0534  [16]
 LDCM0218  AC102 HCT 116 C22(0.98); C290(0.80)  LDD0535  [16]
 LDCM0219  AC103 HCT 116 C22(0.82); C290(0.87)  LDD0536  [16]
 LDCM0220  AC104 HCT 116 C22(1.10); C290(1.09)  LDD0537  [16]
 LDCM0221  AC105 HCT 116 C22(1.08); C290(0.81)  LDD0538  [16]
 LDCM0222  AC106 HCT 116 C22(0.85); C290(0.77)  LDD0539  [16]
 LDCM0223  AC107 HCT 116 C22(0.94); C290(0.97)  LDD0540  [16]
 LDCM0224  AC108 HCT 116 C22(1.05); C290(0.89)  LDD0541  [16]
 LDCM0225  AC109 HCT 116 C22(0.97); C290(0.66)  LDD0542  [16]
 LDCM0226  AC11 HCT 116 C22(1.67)  LDD0543  [16]
 LDCM0227  AC110 HCT 116 C22(0.83); C290(0.74)  LDD0544  [16]
 LDCM0228  AC111 HCT 116 C22(0.58); C290(1.12)  LDD0545  [16]
 LDCM0229  AC112 HCT 116 C22(0.77); C290(1.00)  LDD0546  [16]
 LDCM0230  AC113 HCT 116 C22(1.07); C290(0.98)  LDD0547  [16]
 LDCM0231  AC114 HCT 116 C22(0.75); C290(1.12)  LDD0548  [16]
 LDCM0232  AC115 HCT 116 C22(0.61); C290(1.01)  LDD0549  [16]
 LDCM0233  AC116 HCT 116 C22(0.59); C290(1.38)  LDD0550  [16]
 LDCM0234  AC117 HCT 116 C22(0.82); C290(1.13)  LDD0551  [16]
 LDCM0235  AC118 HCT 116 C22(0.93); C290(0.99)  LDD0552  [16]
 LDCM0236  AC119 HCT 116 C22(0.74); C290(1.08)  LDD0553  [16]
 LDCM0237  AC12 HCT 116 C22(1.80)  LDD0554  [16]
 LDCM0238  AC120 HCT 116 C22(0.76); C290(2.06)  LDD0555  [16]
 LDCM0239  AC121 HCT 116 C22(0.98); C290(0.75)  LDD0556  [16]
 LDCM0240  AC122 HCT 116 C22(0.91); C290(0.80)  LDD0557  [16]
 LDCM0241  AC123 HCT 116 C22(1.08); C290(1.06)  LDD0558  [16]
 LDCM0242  AC124 HCT 116 C22(0.97); C290(1.06)  LDD0559  [16]
 LDCM0243  AC125 HCT 116 C22(0.90); C290(0.81)  LDD0560  [16]
 LDCM0244  AC126 HCT 116 C22(0.66); C290(0.88)  LDD0561  [16]
 LDCM0245  AC127 HCT 116 C22(0.79); C290(0.76)  LDD0562  [16]
 LDCM0246  AC128 HCT 116 C22(0.91); C290(0.98)  LDD0563  [16]
 LDCM0247  AC129 HCT 116 C22(1.35); C290(0.71)  LDD0564  [16]
 LDCM0249  AC130 HCT 116 C22(0.94); C290(1.12)  LDD0566  [16]
 LDCM0250  AC131 HCT 116 C22(1.22); C290(0.76)  LDD0567  [16]
 LDCM0251  AC132 HCT 116 C22(1.09); C290(0.71)  LDD0568  [16]
 LDCM0252  AC133 HCT 116 C22(0.90); C290(0.91)  LDD0569  [16]
 LDCM0253  AC134 HCT 116 C22(0.85); C290(1.26)  LDD0570  [16]
 LDCM0254  AC135 HCT 116 C22(0.87); C290(0.96)  LDD0571  [16]
 LDCM0255  AC136 HCT 116 C22(1.07); C290(1.05)  LDD0572  [16]
 LDCM0256  AC137 HCT 116 C22(1.14); C290(0.86)  LDD0573  [16]
 LDCM0257  AC138 HCT 116 C22(0.72); C290(0.94)  LDD0574  [16]
 LDCM0258  AC139 HCT 116 C22(0.97); C290(0.73)  LDD0575  [16]
 LDCM0259  AC14 HCT 116 C22(2.06)  LDD0576  [16]
 LDCM0260  AC140 HCT 116 C22(0.84); C290(0.84)  LDD0577  [16]
 LDCM0261  AC141 HCT 116 C22(0.86); C290(0.96)  LDD0578  [16]
 LDCM0262  AC142 HCT 116 C22(2.03); C290(0.70)  LDD0579  [16]
 LDCM0263  AC143 HCT 116 C22(0.86); C290(0.98)  LDD0580  [16]
 LDCM0264  AC144 HCT 116 C22(0.55); C290(1.26)  LDD0581  [16]
 LDCM0265  AC145 HCT 116 C22(0.68); C290(1.04)  LDD0582  [16]
 LDCM0266  AC146 HCT 116 C22(0.51); C290(1.20)  LDD0583  [16]
 LDCM0267  AC147 HCT 116 C22(0.58); C290(1.18)  LDD0584  [16]
 LDCM0268  AC148 HCT 116 C22(0.42); C290(1.28)  LDD0585  [16]
 LDCM0269  AC149 HCT 116 C22(0.48); C290(1.23)  LDD0586  [16]
 LDCM0270  AC15 HCT 116 C22(1.31)  LDD0587  [16]
 LDCM0271  AC150 HCT 116 C22(0.87); C290(1.11)  LDD0588  [16]
 LDCM0272  AC151 HCT 116 C22(0.68); C290(1.20)  LDD0589  [16]
 LDCM0273  AC152 HCT 116 C22(0.51); C290(1.49)  LDD0590  [16]
 LDCM0274  AC153 HCT 116 C22(0.33); C290(1.00)  LDD0591  [16]
 LDCM0621  AC154 HCT 116 C22(0.58); C290(1.47)  LDD2158  [16]
 LDCM0622  AC155 HCT 116 C22(0.56); C290(1.19)  LDD2159  [16]
 LDCM0623  AC156 HCT 116 C22(0.68); C290(0.86)  LDD2160  [16]
 LDCM0624  AC157 HCT 116 C22(0.66); C290(0.85)  LDD2161  [16]
 LDCM0276  AC17 HCT 116 C22(1.06)  LDD0593  [16]
 LDCM0277  AC18 HCT 116 C22(0.67)  LDD0594  [16]
 LDCM0278  AC19 HCT 116 C22(1.01)  LDD0595  [16]
 LDCM0279  AC2 HCT 116 C22(1.04)  LDD0596  [16]
 LDCM0280  AC20 HCT 116 C22(0.94)  LDD0597  [16]
 LDCM0281  AC21 HCT 116 C22(0.80)  LDD0598  [16]
 LDCM0282  AC22 HCT 116 C22(0.97)  LDD0599  [16]
 LDCM0283  AC23 HCT 116 C22(0.99)  LDD0600  [16]
 LDCM0284  AC24 HCT 116 C22(1.22)  LDD0601  [16]
 LDCM0285  AC25 HCT 116 C290(1.02); C22(1.30)  LDD0602  [16]
 LDCM0286  AC26 HCT 116 C22(0.83); C290(1.05)  LDD0603  [16]
 LDCM0287  AC27 HCT 116 C22(0.79); C290(1.17)  LDD0604  [16]
 LDCM0288  AC28 HCT 116 C22(0.84); C290(1.41)  LDD0605  [16]
 LDCM0289  AC29 HCT 116 C22(0.75); C290(1.76)  LDD0606  [16]
 LDCM0290  AC3 HCT 116 C22(1.28)  LDD0607  [16]
 LDCM0291  AC30 HCT 116 C22(0.67); C290(1.69)  LDD0608  [16]
 LDCM0292  AC31 HCT 116 C22(0.94); C290(1.17)  LDD0609  [16]
 LDCM0293  AC32 HCT 116 C22(0.67); C290(1.46)  LDD0610  [16]
 LDCM0294  AC33 HCT 116 C22(0.67); C290(1.05)  LDD0611  [16]
 LDCM0295  AC34 HCT 116 C22(0.60); C290(0.95)  LDD0612  [16]
 LDCM0296  AC35 HCT 116 C290(1.07); C22(1.42)  LDD0613  [16]
 LDCM0297  AC36 HCT 116 C22(1.21); C290(1.24)  LDD0614  [16]
 LDCM0298  AC37 HCT 116 C290(1.15); C22(1.88)  LDD0615  [16]
 LDCM0299  AC38 HCT 116 C290(0.87); C22(1.40)  LDD0616  [16]
 LDCM0300  AC39 HCT 116 C290(1.11); C22(1.33)  LDD0617  [16]
 LDCM0301  AC4 HCT 116 C22(1.10)  LDD0618  [16]
 LDCM0302  AC40 HCT 116 C22(0.95); C290(1.22)  LDD0619  [16]
 LDCM0303  AC41 HCT 116 C22(0.98); C290(1.19)  LDD0620  [16]
 LDCM0304  AC42 HCT 116 C22(0.92); C290(1.36)  LDD0621  [16]
 LDCM0305  AC43 HCT 116 C22(1.05); C290(1.23)  LDD0622  [16]
 LDCM0306  AC44 HCT 116 C22(0.75); C290(1.08)  LDD0623  [16]
 LDCM0307  AC45 HCT 116 C22(0.70); C290(1.20)  LDD0624  [16]
 LDCM0308  AC46 HCT 116 C22(0.95)  LDD0625  [16]
 LDCM0309  AC47 HCT 116 C22(0.94)  LDD0626  [16]
 LDCM0310  AC48 HCT 116 C22(1.11)  LDD0627  [16]
 LDCM0311  AC49 HCT 116 C22(0.43)  LDD0628  [16]
 LDCM0312  AC5 HCT 116 C22(1.19)  LDD0629  [16]
 LDCM0313  AC50 HCT 116 C22(0.53)  LDD0630  [16]
 LDCM0314  AC51 HCT 116 C22(2.75)  LDD0631  [16]
 LDCM0315  AC52 HCT 116 C22(0.99)  LDD0632  [16]
 LDCM0316  AC53 HCT 116 C22(0.69)  LDD0633  [16]
 LDCM0317  AC54 HCT 116 C22(0.79)  LDD0634  [16]
 LDCM0318  AC55 HCT 116 C22(0.54)  LDD0635  [16]
 LDCM0319  AC56 HCT 116 C22(0.39)  LDD0636  [16]
 LDCM0320  AC57 HCT 116 C22(0.52)  LDD0637  [16]
 LDCM0321  AC58 HCT 116 C22(0.58)  LDD0638  [16]
 LDCM0322  AC59 HCT 116 C22(0.49)  LDD0639  [16]
 LDCM0323  AC6 HCT 116 C22(0.96)  LDD0640  [16]
 LDCM0324  AC60 HCT 116 C22(0.42)  LDD0641  [16]
 LDCM0325  AC61 HCT 116 C22(0.65)  LDD0642  [16]
 LDCM0326  AC62 HCT 116 C22(0.45)  LDD0643  [16]
 LDCM0327  AC63 HCT 116 C22(0.57)  LDD0644  [16]
 LDCM0328  AC64 HCT 116 C22(0.41)  LDD0645  [16]
 LDCM0329  AC65 HCT 116 C22(0.45)  LDD0646  [16]
 LDCM0330  AC66 HCT 116 C22(0.57)  LDD0647  [16]
 LDCM0331  AC67 HCT 116 C22(0.33)  LDD0648  [16]
 LDCM0332  AC68 HCT 116 C290(0.78); C22(1.03)  LDD0649  [16]
 LDCM0333  AC69 HCT 116 C290(0.62); C22(1.10)  LDD0650  [16]
 LDCM0334  AC7 HCT 116 C22(1.16)  LDD0651  [16]
 LDCM0335  AC70 HCT 116 C290(0.56); C22(0.93)  LDD0652  [16]
 LDCM0336  AC71 HCT 116 C290(0.71); C22(1.25)  LDD0653  [16]
 LDCM0337  AC72 HCT 116 C290(0.73); C22(0.87)  LDD0654  [16]
 LDCM0338  AC73 HCT 116 C22(0.90); C290(0.93)  LDD0655  [16]
 LDCM0339  AC74 HCT 116 C290(1.01); C22(1.16)  LDD0656  [16]
 LDCM0340  AC75 HCT 116 C290(0.72); C22(0.88)  LDD0657  [16]
 LDCM0341  AC76 HCT 116 C22(1.11); C290(1.12)  LDD0658  [16]
 LDCM0342  AC77 HCT 116 C290(0.76); C22(0.95)  LDD0659  [16]
 LDCM0343  AC78 HCT 116 C290(0.72); C22(1.05)  LDD0660  [16]
 LDCM0344  AC79 HCT 116 C290(0.85); C22(1.00)  LDD0661  [16]
 LDCM0345  AC8 HCT 116 C22(1.07)  LDD0662  [16]
 LDCM0346  AC80 HCT 116 C290(1.13); C22(1.46)  LDD0663  [16]
 LDCM0347  AC81 HCT 116 C22(0.94); C290(0.96)  LDD0664  [16]
 LDCM0348  AC82 HCT 116 C290(0.86); C22(0.96)  LDD0665  [16]
 LDCM0349  AC83 HCT 116 C22(0.40); C290(1.32)  LDD0666  [16]
 LDCM0350  AC84 HCT 116 C22(0.45); C290(1.09)  LDD0667  [16]
 LDCM0351  AC85 HCT 116 C22(0.64); C290(0.92)  LDD0668  [16]
 LDCM0352  AC86 HCT 116 C22(0.56); C290(1.06)  LDD0669  [16]
 LDCM0353  AC87 HCT 116 C22(0.97); C290(1.03)  LDD0670  [16]
 LDCM0354  AC88 HCT 116 C22(0.73); C290(1.06)  LDD0671  [16]
 LDCM0355  AC89 HCT 116 C22(0.53); C290(1.31)  LDD0672  [16]
 LDCM0357  AC90 HCT 116 C290(0.69); C22(3.55)  LDD0674  [16]
 LDCM0358  AC91 HCT 116 C22(0.44); C290(0.57)  LDD0675  [16]
 LDCM0359  AC92 HCT 116 C22(0.46); C290(0.88)  LDD0676  [16]
 LDCM0360  AC93 HCT 116 C22(0.81); C290(0.87)  LDD0677  [16]
 LDCM0361  AC94 HCT 116 C22(0.62); C290(0.70)  LDD0678  [16]
 LDCM0362  AC95 HCT 116 C290(0.69); C22(0.91)  LDD0679  [16]
 LDCM0363  AC96 HCT 116 C290(0.57); C22(0.68)  LDD0680  [16]
 LDCM0364  AC97 HCT 116 C22(0.48); C290(0.74)  LDD0681  [16]
 LDCM0365  AC98 HCT 116 C22(0.75); C290(0.90)  LDD0682  [16]
 LDCM0366  AC99 HCT 116 C22(0.72); C290(0.84)  LDD0683  [16]
 LDCM0545  Acetamide MDA-MB-231 C34(0.90); C122(0.35)  LDD2138  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C267(0.93); C34(0.61); C22(0.91); C290(0.74)  LDD2113  [7]
 LDCM0248  AKOS034007472 HCT 116 C22(1.48)  LDD0565  [16]
 LDCM0356  AKOS034007680 HCT 116 C22(1.88)  LDD0673  [16]
 LDCM0275  AKOS034007705 HCT 116 C22(1.01)  LDD0592  [16]
 LDCM0156  Aniline NCI-H1299 11.68  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C290(1.26)  LDD2171  [16]
 LDCM0498  BS-3668 MDA-MB-231 C34(0.80); C22(0.97); C290(0.67)  LDD2091  [7]
 LDCM0108  Chloroacetamide HeLa C290(0.00); H338(0.00); H374(0.00); C22(0.00)  LDD0222  [32]
 LDCM0632  CL-Sc Hep-G2 C267(1.04); C267(0.88); C290(0.67)  LDD2227  [24]
 LDCM0367  CL1 HCT 116 C22(1.05)  LDD0684  [16]
 LDCM0368  CL10 HCT 116 C22(0.57)  LDD0685  [16]
 LDCM0369  CL100 HCT 116 C22(1.18)  LDD0686  [16]
 LDCM0370  CL101 HCT 116 C22(1.13)  LDD0687  [16]
 LDCM0371  CL102 HCT 116 C22(1.20)  LDD0688  [16]
 LDCM0372  CL103 HCT 116 C22(1.64)  LDD0689  [16]
 LDCM0373  CL104 HCT 116 C22(1.30)  LDD0690  [16]
 LDCM0374  CL105 HCT 116 C22(0.67)  LDD0691  [16]
 LDCM0375  CL106 HCT 116 C22(0.53)  LDD0692  [16]
 LDCM0376  CL107 HCT 116 C22(0.69)  LDD0693  [16]
 LDCM0377  CL108 HCT 116 C22(0.55)  LDD0694  [16]
 LDCM0378  CL109 HCT 116 C22(0.71)  LDD0695  [16]
 LDCM0379  CL11 HCT 116 C22(0.52)  LDD0696  [16]
 LDCM0380  CL110 HCT 116 C22(0.62)  LDD0697  [16]
 LDCM0381  CL111 HCT 116 C22(0.70)  LDD0698  [16]
 LDCM0382  CL112 HCT 116 C290(1.09); C22(1.12)  LDD0699  [16]
 LDCM0383  CL113 HCT 116 C22(0.69); C290(1.31)  LDD0700  [16]
 LDCM0384  CL114 HCT 116 C22(0.87); C290(1.52)  LDD0701  [16]
 LDCM0385  CL115 HCT 116 C22(0.70); C290(1.23)  LDD0702  [16]
 LDCM0386  CL116 HCT 116 C22(0.84); C290(1.13)  LDD0703  [16]
 LDCM0387  CL117 HCT 116 C290(1.14); C22(1.34)  LDD0704  [16]
 LDCM0388  CL118 HCT 116 C22(1.04); C290(1.14)  LDD0705  [16]
 LDCM0389  CL119 HCT 116 C22(0.86); C290(1.19)  LDD0706  [16]
 LDCM0390  CL12 HCT 116 C22(0.46)  LDD0707  [16]
 LDCM0391  CL120 HCT 116 C290(1.05); C22(1.96)  LDD0708  [16]
 LDCM0392  CL121 HCT 116 C22(0.64)  LDD0709  [16]
 LDCM0393  CL122 HCT 116 C22(0.73)  LDD0710  [16]
 LDCM0394  CL123 HCT 116 C22(0.60)  LDD0711  [16]
 LDCM0395  CL124 HCT 116 C22(0.50)  LDD0712  [16]
 LDCM0396  CL125 HCT 116 C22(0.81)  LDD0713  [16]
 LDCM0397  CL126 HCT 116 C22(0.55)  LDD0714  [16]
 LDCM0398  CL127 HCT 116 C22(0.76)  LDD0715  [16]
 LDCM0399  CL128 HCT 116 C22(0.52)  LDD0716  [16]
 LDCM0400  CL13 HCT 116 C22(0.63)  LDD0717  [16]
 LDCM0401  CL14 HCT 116 C22(0.75)  LDD0718  [16]
 LDCM0402  CL15 HCT 116 C22(0.71)  LDD0719  [16]
 LDCM0403  CL16 HCT 116 C22(0.87)  LDD0720  [16]
 LDCM0404  CL17 HCT 116 C22(1.14)  LDD0721  [16]
 LDCM0405  CL18 HCT 116 C22(1.14)  LDD0722  [16]
 LDCM0406  CL19 HCT 116 C22(0.92)  LDD0723  [16]
 LDCM0407  CL2 HCT 116 C22(0.95)  LDD0724  [16]
 LDCM0408  CL20 HCT 116 C22(0.90)  LDD0725  [16]
 LDCM0409  CL21 HCT 116 C22(0.75)  LDD0726  [16]
 LDCM0410  CL22 HCT 116 C22(0.66)  LDD0727  [16]
 LDCM0411  CL23 HCT 116 C22(0.79)  LDD0728  [16]
 LDCM0412  CL24 HCT 116 C22(0.70)  LDD0729  [16]
 LDCM0413  CL25 HCT 116 C22(0.67)  LDD0730  [16]
 LDCM0414  CL26 HCT 116 C22(0.81)  LDD0731  [16]
 LDCM0415  CL27 HCT 116 C22(0.86)  LDD0732  [16]
 LDCM0416  CL28 HCT 116 C22(0.71)  LDD0733  [16]
 LDCM0417  CL29 HCT 116 C22(0.85)  LDD0734  [16]
 LDCM0418  CL3 HCT 116 C22(1.03)  LDD0735  [16]
 LDCM0419  CL30 HCT 116 C22(1.01)  LDD0736  [16]
 LDCM0420  CL31 HCT 116 C22(0.73); C290(0.86)  LDD0737  [16]
 LDCM0421  CL32 HCT 116 C22(0.68); C290(0.83)  LDD0738  [16]
 LDCM0422  CL33 HCT 116 C22(0.57); C290(0.84)  LDD0739  [16]
 LDCM0423  CL34 HCT 116 C22(0.39); C290(1.07)  LDD0740  [16]
 LDCM0424  CL35 HCT 116 C22(0.34); C290(1.04)  LDD0741  [16]
 LDCM0425  CL36 HCT 116 C22(0.38); C290(1.17)  LDD0742  [16]
 LDCM0426  CL37 HCT 116 C22(0.37); C290(1.10)  LDD0743  [16]
 LDCM0428  CL39 HCT 116 C22(0.52); C290(0.88)  LDD0745  [16]
 LDCM0429  CL4 HCT 116 C22(0.84)  LDD0746  [16]
 LDCM0430  CL40 HCT 116 C22(0.48); C290(1.29)  LDD0747  [16]
 LDCM0431  CL41 HCT 116 C22(0.67); C290(0.87)  LDD0748  [16]
 LDCM0432  CL42 HCT 116 C22(0.35); C290(1.00)  LDD0749  [16]
 LDCM0433  CL43 HCT 116 C22(0.51); C290(0.86)  LDD0750  [16]
 LDCM0434  CL44 HCT 116 C22(0.49); C290(0.91)  LDD0751  [16]
 LDCM0435  CL45 HCT 116 C22(0.41); C290(0.74)  LDD0752  [16]
 LDCM0436  CL46 HCT 116 C22(1.87); C290(0.35)  LDD0753  [16]
 LDCM0437  CL47 HCT 116 C22(2.02); C290(0.78)  LDD0754  [16]
 LDCM0438  CL48 HCT 116 C22(1.87); C290(0.49)  LDD0755  [16]
 LDCM0439  CL49 HCT 116 C22(1.36); C290(0.50)  LDD0756  [16]
 LDCM0440  CL5 HCT 116 C22(1.02)  LDD0757  [16]
 LDCM0441  CL50 HCT 116 C22(1.75); C290(0.53)  LDD0758  [16]
 LDCM0442  CL51 HCT 116 C22(1.53); C290(0.42)  LDD0759  [16]
 LDCM0443  CL52 HCT 116 C22(1.39); C290(0.38)  LDD0760  [16]
 LDCM0444  CL53 HCT 116 C22(1.73); C290(0.68)  LDD0761  [16]
 LDCM0445  CL54 HCT 116 C22(2.00); C290(0.45)  LDD0762  [16]
 LDCM0446  CL55 HCT 116 C22(1.67); C290(0.82)  LDD0763  [16]
 LDCM0447  CL56 HCT 116 C22(1.21); C290(0.89)  LDD0764  [16]
 LDCM0448  CL57 HCT 116 C22(1.74); C290(0.61)  LDD0765  [16]
 LDCM0449  CL58 HCT 116 C22(1.62); C290(0.60)  LDD0766  [16]
 LDCM0450  CL59 HCT 116 C22(1.49); C290(0.68)  LDD0767  [16]
 LDCM0451  CL6 HCT 116 C22(0.88)  LDD0768  [16]
 LDCM0452  CL60 HCT 116 C22(1.49); C290(0.38)  LDD0769  [16]
 LDCM0453  CL61 HCT 116 C22(0.92); C290(0.96)  LDD0770  [16]
 LDCM0454  CL62 HCT 116 C22(0.91); C290(1.00)  LDD0771  [16]
 LDCM0455  CL63 HCT 116 C22(0.79); C290(0.83)  LDD0772  [16]
 LDCM0456  CL64 HCT 116 C22(0.68); C290(0.84)  LDD0773  [16]
 LDCM0457  CL65 HCT 116 C22(0.77); C290(1.00)  LDD0774  [16]
 LDCM0458  CL66 HCT 116 C22(0.68); C290(0.90)  LDD0775  [16]
 LDCM0459  CL67 HCT 116 C22(0.88); C290(0.83)  LDD0776  [16]
 LDCM0460  CL68 HCT 116 C22(0.81); C290(1.07)  LDD0777  [16]
 LDCM0461  CL69 HCT 116 C22(0.94); C290(1.05)  LDD0778  [16]
 LDCM0462  CL7 HCT 116 C22(0.56)  LDD0779  [16]
 LDCM0463  CL70 HCT 116 C22(0.81); C290(0.97)  LDD0780  [16]
 LDCM0464  CL71 HCT 116 C22(0.75); C290(1.01)  LDD0781  [16]
 LDCM0465  CL72 HCT 116 C22(1.02); C290(1.05)  LDD0782  [16]
 LDCM0466  CL73 HCT 116 C22(0.72); C290(1.11)  LDD0783  [16]
 LDCM0467  CL74 HCT 116 C22(0.79); C290(0.98)  LDD0784  [16]
 LDCM0469  CL76 HCT 116 C22(1.03)  LDD0786  [16]
 LDCM0470  CL77 HCT 116 C22(0.62)  LDD0787  [16]
 LDCM0471  CL78 HCT 116 C22(0.88)  LDD0788  [16]
 LDCM0472  CL79 HCT 116 C22(0.62)  LDD0789  [16]
 LDCM0473  CL8 HCT 116 C22(0.39)  LDD0790  [16]
 LDCM0474  CL80 HCT 116 C22(0.86)  LDD0791  [16]
 LDCM0475  CL81 HCT 116 C22(0.67)  LDD0792  [16]
 LDCM0476  CL82 HCT 116 C22(0.50)  LDD0793  [16]
 LDCM0477  CL83 HCT 116 C22(0.47)  LDD0794  [16]
 LDCM0478  CL84 HCT 116 C22(0.43)  LDD0795  [16]
 LDCM0479  CL85 HCT 116 C22(0.63)  LDD0796  [16]
 LDCM0480  CL86 HCT 116 C22(0.93)  LDD0797  [16]
 LDCM0481  CL87 HCT 116 C22(0.64)  LDD0798  [16]
 LDCM0482  CL88 HCT 116 C22(0.46)  LDD0799  [16]
 LDCM0483  CL89 HCT 116 C22(0.48)  LDD0800  [16]
 LDCM0484  CL9 HCT 116 C22(0.79)  LDD0801  [16]
 LDCM0485  CL90 HCT 116 C22(0.55)  LDD0802  [16]
 LDCM0486  CL91 HCT 116 C22(0.92)  LDD0803  [16]
 LDCM0487  CL92 HCT 116 C22(1.19)  LDD0804  [16]
 LDCM0488  CL93 HCT 116 C22(1.37)  LDD0805  [16]
 LDCM0489  CL94 HCT 116 C22(1.18)  LDD0806  [16]
 LDCM0490  CL95 HCT 116 C22(1.01)  LDD0807  [16]
 LDCM0491  CL96 HCT 116 C22(1.14)  LDD0808  [16]
 LDCM0492  CL97 HCT 116 C22(1.11)  LDD0809  [16]
 LDCM0493  CL98 HCT 116 C22(1.12)  LDD0810  [16]
 LDCM0494  CL99 HCT 116 C22(1.13)  LDD0811  [16]
 LDCM0634  CY-0357 Hep-G2 C22(0.68); C267(0.60)  LDD2228  [24]
 LDCM0495  E2913 HEK-293T C290(0.98); C267(1.08); C22(1.01); C122(0.92)  LDD1698  [41]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C22(1.13); C290(0.74)  LDD1702  [7]
 LDCM0625  F8 Ramos C122(0.72); C267(1.06); C22(0.70); C290(0.67)  LDD2187  [42]
 LDCM0572  Fragment10 MDA-MB-231 C267(4.84)  LDD1465  [43]
 LDCM0573  Fragment11 MDA-MB-231 C267(0.90)  LDD1467  [43]
 LDCM0574  Fragment12 MDA-MB-231 C267(4.95)  LDD1468  [43]
 LDCM0575  Fragment13 MDA-MB-231 C267(1.10)  LDD1469  [43]
 LDCM0576  Fragment14 MDA-MB-231 C267(1.34)  LDD1471  [43]
 LDCM0579  Fragment20 Ramos C122(0.60); C267(3.30); C22(0.50); C290(0.65)  LDD2194  [42]
 LDCM0580  Fragment21 MDA-MB-231 C267(1.54)  LDD1473  [43]
 LDCM0582  Fragment23 Ramos C122(0.77); C267(1.50); C22(0.45); C290(1.41)  LDD2196  [42]
 LDCM0578  Fragment27 MDA-MB-231 C267(1.09)  LDD1474  [43]
 LDCM0586  Fragment28 Ramos C122(0.81); C267(0.92); C22(0.90); C290(0.39)  LDD2198  [42]
 LDCM0587  Fragment29 Ramos C267(1.37)  LDD1476  [43]
 LDCM0588  Fragment30 Ramos C122(1.17); C267(1.61); C22(1.03); C290(3.04)  LDD2199  [42]
 LDCM0589  Fragment31 MDA-MB-231 C267(0.69)  LDD1477  [43]
 LDCM0590  Fragment32 Ramos C122(0.63); C267(2.69); C22(0.51); C290(1.10)  LDD2201  [42]
 LDCM0468  Fragment33 HCT 116 C22(0.85); C290(1.01)  LDD0785  [16]
 LDCM0596  Fragment38 MDA-MB-231 C267(1.17)  LDD1480  [43]
 LDCM0566  Fragment4 MDA-MB-231 C267(5.96)  LDD1461  [43]
 LDCM0599  Fragment41 MDA-MB-231 C267(1.04)  LDD1481  [43]
 LDCM0603  Fragment45 MDA-MB-231 C267(3.62)  LDD1482  [43]
 LDCM0427  Fragment51 HCT 116 C22(0.27); C290(1.40)  LDD0744  [16]
 LDCM0610  Fragment52 Ramos C122(1.77); C267(1.54); C22(1.20); C290(2.71)  LDD2204  [42]
 LDCM0614  Fragment56 MDA-MB-231 C267(0.81)  LDD1484  [43]
 LDCM0569  Fragment7 Ramos C122(0.74); C267(2.01); C22(0.50); C290(0.21)  LDD2186  [42]
 LDCM0570  Fragment8 MDA-MB-231 C267(5.28)  LDD1462  [43]
 LDCM0571  Fragment9 MDA-MB-231 C267(2.14)  LDD1463  [43]
 LDCM0116  HHS-0101 DM93 Y306(0.57); Y240(0.65); Y356(0.70); Y236(0.70)  LDD0264  [14]
 LDCM0117  HHS-0201 DM93 Y306(0.27); Y356(0.31); Y276(0.51); Y236(0.63)  LDD0265  [14]
 LDCM0118  HHS-0301 DM93 Y240(0.28); Y243(0.30); Y236(0.43); Y246(0.57)  LDD0266  [14]
 LDCM0119  HHS-0401 DM93 Y240(0.37); Y236(0.45); Y243(0.45); Y372(0.77)  LDD0267  [14]
 LDCM0120  HHS-0701 DM93 Y356(0.88); Y195(1.01); Y82(1.06); Y266(1.07)  LDD0268  [14]
 LDCM0107  IAA HeLa H338(0.00); H374(0.00); C22(0.00); C290(0.00)  LDD0221  [32]
 LDCM0123  JWB131 DM93 Y180(0.96); Y195(1.00); Y266(0.65); Y82(0.94)  LDD0285  [13]
 LDCM0124  JWB142 DM93 Y180(1.02); Y195(0.85); Y266(0.52); Y82(0.99)  LDD0286  [13]
 LDCM0125  JWB146 DM93 Y180(0.65); Y195(1.05); Y266(0.97); Y82(1.00)  LDD0287  [13]
 LDCM0126  JWB150 DM93 Y180(2.32); Y195(1.93); Y266(2.36); Y82(3.58)  LDD0288  [13]
 LDCM0127  JWB152 DM93 Y180(1.55); Y195(2.03); Y266(2.00); Y372(1.02)  LDD0289  [13]
 LDCM0128  JWB198 DM93 Y180(1.26); Y195(1.21); Y266(0.98); Y82(0.85)  LDD0290  [13]
 LDCM0129  JWB202 DM93 Y180(0.59); Y195(0.54); Y266(0.38); Y82(0.83)  LDD0291  [13]
 LDCM0130  JWB211 DM93 Y180(1.20); Y195(1.65); Y266(0.90); Y82(1.43)  LDD0292  [13]
 LDCM0022  KB02 HCT 116 C22(1.53); C290(1.14)  LDD0080  [16]
 LDCM0023  KB03 HCT 116 C22(1.68); C290(0.81)  LDD0081  [16]
 LDCM0024  KB05 HCT 116 C22(1.48); C290(1.18)  LDD0082  [16]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C267(0.92); C34(1.25); C290(1.09)  LDD2102  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C34(0.89); C22(1.46); C290(0.87); C122(0.73)  LDD2121  [7]
 LDCM0109  NEM HeLa H338(0.00); H374(0.00); H289(0.00)  LDD0223  [32]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C267(1.15); C34(0.92); C22(1.19); C290(0.83)  LDD2089  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C267(1.37); C34(1.19); C290(1.14)  LDD2090  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C267(0.89); C290(1.01)  LDD2092  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C267(1.41); C290(1.32); C122(0.96)  LDD2093  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C267(1.34); C290(1.67); C122(1.22)  LDD2094  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C267(0.07); C290(0.52)  LDD2096  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C267(1.27); C290(0.90); C122(0.86)  LDD2097  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C34(0.59); C22(0.40); C290(0.82)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C267(1.06); C34(1.26); C22(1.36); C290(1.18)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C290(0.38)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C267(1.32); C22(1.01); C290(1.03)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C267(0.83); C22(0.64); C290(0.40); C122(0.54)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C267(1.54); C34(1.53); C22(1.79); C290(1.72)  LDD2105  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C267(0.97); C22(0.84); C122(0.44)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C22(1.51); C290(1.15)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C267(0.90); C22(0.78); C290(0.59); C122(0.60)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C22(1.00); C290(0.84); C122(0.46)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C267(2.41); C290(0.51)  LDD2110  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C267(1.37); C34(1.32); C22(1.42); C290(1.32)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C267(0.69); C34(1.40); C22(0.88); C290(0.46)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C267(0.54); C290(0.56)  LDD2115  [7]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C290(0.65); C122(5.73)  LDD2116  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C122(0.63)  LDD2118  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C267(1.91); C22(1.77); C290(1.61); C122(2.64)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C267(0.57); C34(0.99); C290(0.63); C122(0.83)  LDD2120  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C290(0.47)  LDD2122  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C22(1.23); C290(1.12)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C122(0.36)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C22(1.02); C290(0.95)  LDD2125  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C290(0.68); C122(4.08)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C267(1.51); C22(1.64); C290(1.43); C122(0.88)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C267(0.61); C290(0.30)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C267(1.07); C22(1.83); C290(1.45)  LDD2129  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C290(0.61); C122(0.56)  LDD2133  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C267(0.58); C22(0.44); C290(0.69); C122(0.42)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C267(1.10); C22(2.27); C290(1.55); C122(1.65)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C22(1.45); C290(1.63)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C22(1.21); C290(1.04)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C290(3.10); C267(2.10); C122(1.80)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C267(1.25); C22(1.16); C290(0.90); C122(0.61)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C267(0.72); C290(0.50)  LDD2141  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C267(0.59); C34(0.87); C290(0.44)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C267(2.13); C22(2.14); C290(1.86); C122(3.01)  LDD2144  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C267(12.87)  LDD2145  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C267(1.19); C22(1.14); C290(1.05); C122(0.84)  LDD2146  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C267(1.01); C34(1.57); C290(0.77)  LDD2147  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C267(0.48); C22(1.26); C290(0.61)  LDD2148  [7]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C122(0.55)  LDD2149  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C267(0.87); C22(0.84); C290(0.70)  LDD2150  [7]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C290(0.46)  LDD2151  [7]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C267(2.77); C34(1.71); C122(1.85)  LDD2153  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C267(1.11)  LDD2206  [44]
 LDCM0628  OTUB2-COV-1 HEK-293T C22(0.75)  LDD2207  [44]
 LDCM0014  Panhematin K562 3.56  LDD0063  [12]
 LDCM0131  RA190 MM1.R C22(1.42)  LDD0304  [45]
 LDCM0021  THZ1 HCT 116 C290(1.26)  LDD2173  [16]
 LDCM0111  W14 Hep-G2 C267(23.99)  LDD0238  [4]
 LDCM0112  W16 Hep-G2 C267(0.63)  LDD0239  [4]
 LDCM0113  W17 Hep-G2 C267(12.55)  LDD0240  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) Archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family O15160
Probable ATP-dependent RNA helicase DDX17 (DDX17) DEAD box helicase family Q92841
Tudor-interacting repair regulator protein (NUDT16L1) Nudix hydrolase family Q9BRJ7
E3 ubiquitin-protein ligase DZIP3 (DZIP3) . Q86Y13
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
E3 ubiquitin-protein ligase RNF4 (RNF4) . P78317
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cation channel sperm-associated protein 1 (CATSPER1) Cation channel sperm-associated (TC 1.A.1.19) family Q8NEC5
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NF-kappa-B inhibitor delta (NFKBID) NF-kappa-B inhibitor family Q8NI38
Myb-related transcription factor, partner of profilin (MYPOP) . Q86VE0
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Oxoeicosanoid receptor 1 (OXER1) G-protein coupled receptor 1 family Q8TDS5
Other
Click To Hide/Show 20 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Large ribosomal subunit protein mL53 (MRPL53) Mitochondrion-specific ribosomal protein mL53 family Q96EL3
RNA-binding protein Musashi homolog 2 (MSI2) Musashi family Q96DH6
Muscleblind-like protein 1 (MBNL1) Muscleblind family Q9NR56
Keratin-associated protein 13-2 (KRTAP13-2) PMG family Q52LG2
RNA guanine-N7 methyltransferase activating subunit (RAMAC) RAM family Q9BTL3
RNA-binding protein 38 (RBM38) RBM38 family Q9H0Z9
Tektin-3 (TEKT3) Tektin family Q9BXF9
Tektin-4 (TEKT4) Tektin family Q8WW24
U1 small nuclear ribonucleoprotein C (SNRPC) U1 small nuclear ribonucleoprotein C family P09234
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) . O95872
G protein pathway suppressor 2 (GPS2) . Q13227
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) . P52597
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) . P31943
Heterogeneous nuclear ribonucleoprotein M (HNRNPM) . P52272
Melanoma-associated antigen D1 (MAGED1) . Q9Y5V3
Rho guanine nucleotide exchange factor 16 (ARHGEF16) . Q5VV41
Rhombotin-1 (LMO1) . P25800
TAR DNA-binding protein 43 (TARDBP) . Q13148

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Copper . DB09130

References

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2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
9 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
10 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
13 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
14 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
15 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
16 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
17 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
18 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
19 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
20 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
21 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
22 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
23 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
24 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
25 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
26 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
27 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
28 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
29 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
30 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
31 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
32 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
33 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
34 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
35 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
36 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
37 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
38 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
39 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
40 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
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Mass spectrometry data entry: PXD044402
42 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
43 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
44 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
45 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.