Details of the Probe

General Information of Probe

Probe ID
LDPC0567
Probe Name
C346
Synonyms
Z4225960289
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 338.4
Lipid-water partition coefficient (xlogp) 3.3
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C18H22N6O
IUPAC Name
N-[2-(3-but-3-ynyldiazirin-3-yl)ethyl]-3-(2-methylpropyl)-[1,2,4]triazolo[4,3-a]pyridine-8-carboxamide
Canonical SMILES
CC(C)CC1=NN=C2N1C=CC=C2C(=O)NCCC3(N=N3)CCC#C
InChI
InChI=1S/C18H22N6O/c1-4-5-8-18(22-23-18)9-10-19-17(25)14-7-6-11-24-15(12-13(2)3)20-21-16(14)24/h1,6-7,11,13H,5,8-10,12H2,2-3H3,(H,19,25)
InChIKey
FSCULFOSMDGCGH-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

84 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
3-ketodihydrosphingosine reductase (KDSR) LDTP05476 13.64  LDD2007 
5'-3' exonuclease PLD3 (PLD3) LDTP08476 30.27  LDD2007 
7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) LDTP10032 11.24  LDD2007 
Abasic site processing protein HMCES (HMCES) LDTP10322 17.51  LDD2007 
Acid ceramidase (ASAH1) LDTP05905 14.42  LDD2007 
Adenosine 5'-monophosphoramidase HINT3 (HINT3) LDTP12415 34.30  LDD2007 
Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) LDTP00186 15.03  LDD2007 
Alpha-galactosidase A (GLA) LDTP02141 14.83  LDD2007 
Alpha-N-acetylglucosaminidase (NAGLU) LDTP04634 18.25  LDD2007 
Apoptosis-inducing factor 1, mitochondrial (AIFM1) LDTP01687 50.56  LDD2007 
ATP-dependent translocase ABCB1 (ABCB1) LDTP02254 15.67  LDD2007 
Beta-galactosidase (GLB1) LDTP02837 13.74  LDD2007 
Beta-hexosaminidase subunit alpha (HEXA) LDTP02169 17.39  LDD2007 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 29.86  LDD2007 
Carbohydrate sulfotransferase 14 (CHST14) LDTP09096 13.83  LDD2007 
Carboxymethylenebutenolidase homolog (CMBL) LDTP10215 11.31  LDD2007 
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) LDTP03257 11.71  LDD2007 
Cartilage-associated protein (CRTAP) LDTP01300 10.85  LDD2007 
Cathepsin B (CTSB) LDTP02223 27.10  LDD2007 
Ceramide synthase 2 (CERS2) LDTP10329 15.78  LDD2007 
Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) LDTP03189 13.27  LDD2007 
Cytochrome b-c1 complex subunit 8 (UQCRQ) LDTP00486 11.47  LDD2007 
Cytochrome b5 type B (CYB5B) LDTP00697 11.00  LDD2007 
dCTP pyrophosphatase 1 (DCTPP1) LDTP12013 23.59  LDD2007 
Dehydrogenase/reductase SDR family member 1 (DHRS1) LDTP10550 12.64  LDD2007 
Delta(24)-sterol reductase (DHCR24) LDTP06375 11.08  LDD2007 
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) LDTP05724 10.70  LDD2007 
Dipeptidyl peptidase 1 (CTSC) LDTP04572 15.03  LDD2007 
DNA polymerase alpha subunit B (POLA2) LDTP06069 10.27  LDD2007 
E3 ubiquitin-protein ligase UBR1 (UBR1) LDTP08564 13.64  LDD2007 
Endoplasmic reticulum protein SC65 (P3H4) LDTP09874 11.24  LDD2007 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 15.35  LDD2007 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 10.93  LDD2007 
Enoyl-CoA delta isomerase 2 (ECI2) LDTP01245 11.47  LDD2007 
Ferrochelatase, mitochondrial (FECH) LDTP03198 20.97  LDD2007 
Heme oxygenase 1 (HMOX1) LDTP02359 13.36  LDD2007 
Heme oxygenase 2 (HMOX2) LDTP03540 20.53  LDD2007 
Histone-lysine N-methyltransferase NSD2 (NSD2) LDTP01759 18.13  LDD2007 
Holocytochrome c-type synthase (HCCS) LDTP04581 10.78  LDD2007 
Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) LDTP04211 16.00  LDD2007 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 11.88  LDD2007 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 19.70  LDD2007 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 11.16  LDD2007 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 14.12  LDD2007 
Lysosomal acid phosphatase (ACP2) LDTP02539 18.00  LDD2007 
Lysosomal alpha-glucosidase (GAA) LDTP02486 12.91  LDD2007 
Lysosomal alpha-mannosidase (MAN2B1) LDTP00338 11.16  LDD2007 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 18.90  LDD2007 
Lysosomal protective protein (CTSA) LDTP02505 21.26  LDD2007 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 36.76  LDD2007 
Macrophage migration inhibitory factor (MIF) LDTP02713 30.70  LDD2007 
N-acetylglucosamine-6-sulfatase (GNS) LDTP02799 21.56  LDD2007 
N-alpha-acetyltransferase 40 (NAA40) LDTP08265 12.30  LDD2007 
N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) LDTP11273 17.15  LDD2007 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 21.71  LDD2007 
Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) LDTP12628 14.93  LDD2007 
Peptidyl-prolyl cis-trans isomerase-like 3 (PPIL3) LDTP11823 10.41  LDD2007 
Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) LDTP06307 18.64  LDD2007 
Phospholipase A2 group XV (PLA2G15) LDTP09088 16.22  LDD2007 
Plasma alpha-L-fucosidase (FUCA2) LDTP11215 13.09  LDD2007 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 10.93  LDD2007 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 15.45  LDD2007 
Prostaglandin reductase 1 (PTGR1) LDTP06227 24.76  LDD2007 
Prostaglandin reductase 2 (PTGR2) LDTP08979 10.48  LDD2007 
Prostaglandin reductase 3 (PTGR3) LDTP15422 39.12  LDD2007 
Proteasome subunit beta type-4 (PSMB4) LDTP03417 44.02  LDD2007 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 16.68  LDD2007 
Pseudouridylate synthase 7 homolog (PUS7) LDTP10709 12.73  LDD2007 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 14.72  LDD2007 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 25.11  LDD2007 
Ribonuclease T2 (RNASET2) LDTP00316 15.89  LDD2007 
Ribosomal oxygenase 1 (RIOX1) LDTP12003 15.78  LDD2007 
RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) LDTP05588 24.42  LDD2007 
S-methyl-5'-thioadenosine phosphorylase (MTAP) LDTP05758 14.72  LDD2007 
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) LDTP15484 20.25  LDD2007 
Serum paraoxonase/arylesterase 2 (PON2) LDTP06333 14.93  LDD2007 
Signal peptide peptidase-like 2A (SPPL2A) LDTP09395 17.27  LDD2007 
Sphingosine kinase 2 (SPHK2) LDTP12490 16.68  LDD2007 
Tissue alpha-L-fucosidase (FUCA1) LDTP02006 18.38  LDD2007 
Trimethylguanosine synthase (TGS1) LDTP10780 13.27  LDD2007 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 12.04  LDD2007 
Ubiquitin carboxyl-terminal hydrolase 28 (USP28) LDTP10785 11.39  LDD2007 
Unconventional myosin-XVIIIa (MYO18A) LDTP09819 13.18  LDD2007 
V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) LDTP14030 10.70  LDD2007 
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⏷ Show the Full List of 84 Enzyme
38 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
ATP synthase subunit a (MT-ATP6) LDTP01804 15.24  LDD2007 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 12.82  LDD2007 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 10.56  LDD2007 
Lysosome membrane protein 2 (SCARB2) LDTP06034 24.42  LDD2007 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 12.21  LDD2007 
Metaxin-1 (MTX1) LDTP05900 19.70  LDD2007 
MFS-type transporter SLC18B1 (SLC18B1) LDTP07462 15.67  LDD2007 
Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) LDTP00865 10.48  LDD2007 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 52.71  LDD2007 
Mitochondrial ornithine transporter 1 (SLC25A15) LDTP14200 14.72  LDD2007 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 17.51  LDD2007 
Monocarboxylate transporter 1 (SLC16A1) LDTP04592 13.18  LDD2007 
Mpv17-like protein 2 (MPV17L2) LDTP14952 31.12  LDD2007 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 10.20  LDD2007 
NPC intracellular cholesterol transporter 2 (NPC2) LDTP04940 11.31  LDD2007 
Peroxisomal membrane protein 2 (PXMP2) LDTP16069 12.64  LDD2007 
Prosaposin (PSAP) LDTP02215 19.03  LDD2007 
Protein GPR107 (GPR107) LDTP07236 12.82  LDD2007 
Protein GPR108 (GPR108) LDTP12383 24.08  LDD2007 
Protein tweety homolog 3 (TTYH3) LDTP11615 16.22  LDD2007 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 14.12  LDD2007 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 24.59  LDD2007 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 12.91  LDD2007 
Solute carrier family 25 member 33 (SLC25A33) LDTP11162 13.27  LDD2007 
Sortilin (SORT1) LDTP10885 17.63  LDD2007 
Stomatin (STOM) LDTP03380 16.56  LDD2007 
Syntaxin-6 (STX6) LDTP00857 13.09  LDD2007 
Tetraspanin-10 (TSPAN10) LDTP15967 13.36  LDD2007 
Translocator protein (TSPO) LDTP03546 14.12  LDD2007 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 11.16  LDD2007 
Transmembrane protein 126A (TMEM126A) LDTP15948 10.85  LDD2007 
Transmembrane protein 160 (TMEM160) LDTP20002 11.39  LDD2007 
Transmembrane protein 205 (TMEM205) LDTP07667 17.03  LDD2007 
Transmembrane protein 59 (TMEM59) LDTP11406 14.62  LDD2007 
Transmembrane protein 87A (TMEM87A) LDTP15481 10.20  LDD2007 
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) LDTP09968 12.30  LDD2007 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 26.17  LDD2007 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 19.97  LDD2007 
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⏷ Show the Full List of 38 Transporter and channel
1 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Y-box-binding protein 3 (YBX3) LDTP02870 11.24  LDD2007 
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64 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) LDTP06291 10.41  LDD2007 
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 10.48  LDD2007 
Borealin (CDCA8) LDTP06915 13.36  LDD2007 
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) LDTP13755 11.55  LDD2007 
Calumenin (CALU) LDTP00887 11.16  LDD2007 
Clustered mitochondria protein homolog (CLUH) LDTP14486 12.91  LDD2007 
Coiled-coil domain-containing protein 6 (CCDC6) LDTP06515 11.55  LDD2007 
Cold-inducible RNA-binding protein (CIRBP) LDTP06022 12.21  LDD2007 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 10.34  LDD2007 
DBIRD complex subunit ZNF326 (ZNF326) LDTP06952 10.27  LDD2007 
Diablo IAP-binding mitochondrial protein (DIABLO) LDTP12468 13.00  LDD2007 
Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) LDTP08689 11.88  LDD2007 
EF-hand calcium-binding domain-containing protein 14 (EFCAB14) LDTP19021 13.18  LDD2007 
Enhancer of mRNA-decapping protein 3 (EDC3) LDTP10299 24.59  LDD2007 
ER lumen protein-retaining receptor 3 (KDELR3) LDTP00850 15.67  LDD2007 
Eukaryotic translation initiation factor 5 (EIF5) LDTP04652 11.00  LDD2007 
Exocyst complex component 6B (EXOC6B) LDTP13851 11.31  LDD2007 
Galectin-3-binding protein (LGALS3BP) LDTP05558 13.09  LDD2007 
Ganglioside GM2 activator (GM2A) LDTP02927 16.45  LDD2007 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 12.13  LDD2007 
Golgi membrane protein 1 (GOLM1) LDTP09054 10.48  LDD2007 
HAUS augmin-like complex subunit 4 (HAUS4) LDTP11978 25.99  LDD2007 
HAUS augmin-like complex subunit 5 (HAUS5) LDTP01466 11.79  LDD2007 
Heme-binding protein 1 (HEBP1) LDTP16078 34.30  LDD2007 
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) LDTP00500 10.85  LDD2007 
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) LDTP04514 10.34  LDD2007 
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) LDTP03615 11.47  LDD2007 
Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) LDTP03614 12.21  LDD2007 
Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) LDTP03182 10.63  LDD2007 
Keratin, type I cytoskeletal 18 (KRT18) LDTP02124 18.51  LDD2007 
KH domain-containing RNA-binding protein QKI (QKI) LDTP10700 11.55  LDD2007 
KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3) LDTP01246 11.39  LDD2007 
Large proline-rich protein BAG6 (BAG6) LDTP04094 13.27  LDD2007 
Large ribosomal subunit protein mL55 (MRPL55) LDTP15269 87.43  LDD2007 
MAGUK p55 subfamily member 2 (MPP2) LDTP06068 10.20  LDD2007 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 42.22  LDD2007 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 31.34  LDD2007 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 10.85  LDD2007 
Neudesin (NENF) LDTP13630 16.22  LDD2007 
Neuferricin (CYB5D2) LDTP15623 21.26  LDD2007 
Neurofilament light polypeptide (NEFL) LDTP02180 11.79  LDD2007 
Nucleobindin-1 (NUCB1) LDTP05375 14.03  LDD2007 
Nucleobindin-2 (NUCB2) LDTP05160 21.86  LDD2007 
Nucleolar protein 9 (NOP9) LDTP15283 14.42  LDD2007 
Pre-mRNA-splicing factor SLU7 (SLU7) LDTP01582 10.27  LDD2007 
Protein bicaudal D homolog 2 (BICD2) LDTP09410 10.34  LDD2007 
Protein CutA (CUTA) LDTP01075 11.88  LDD2007 
Protein unc-119 homolog B (UNC119B) LDTP00105 30.48  LDD2007 
Reticulocalbin-2 (RCN2) LDTP06097 14.62  LDD2007 
RNA-binding motif protein, X chromosome (RBMX) LDTP03850 10.63  LDD2007 
RNA-binding protein 3 (RBM3) LDTP05226 16.22  LDD2007 
RNA-binding protein FUS (FUS) LDTP03775 13.64  LDD2007 
Splicing factor 3B subunit 5 (SF3B5) LDTP11328 12.91  LDD2007 
T-complex protein 1 subunit beta (CCT2) LDTP05113 11.08  LDD2007 
T-complex protein 11-like protein 1 (TCP11L1) LDTP12629 11.79  LDD2007 
TATA-binding protein-associated factor 2N (TAF15) LDTP09881 15.56  LDD2007 
Tetraspanin-6 (TSPAN6) LDTP14458 11.24  LDD2007 
Torsin-1A-interacting protein 2 (TOR1AIP2) LDTP09215 12.30  LDD2007 
Tropomyosin alpha-1 chain (TPM1) LDTP02351 12.38  LDD2007 
Tropomyosin alpha-4 chain (TPM4) LDTP05068 11.31  LDD2007 
Tudor and KH domain-containing protein (TDRKH) LDTP13922 18.38  LDD2007 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 13.64  LDD2007 
Vimentin (VIM) LDTP02297 16.45  LDD2007 
Zinc finger CCHC domain-containing protein 3 (ZCCHC3) LDTP12623 10.34  LDD2007 
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⏷ Show the Full List of 64 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD2007 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587