Details of the Target

General Information of Target

Target ID LDTP06069
Target Name DNA polymerase alpha subunit B (POLA2)
Gene Name POLA2
Gene ID 23649
Synonyms
DNA polymerase alpha subunit B; DNA polymerase alpha 70 kDa subunit
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSASAQQLAEELQIFGLDCEEALIEKLVELCVQYGQNEEGMVGELIAFCTSTHKVGLTSE
ILNSFEHEFLSKRLSKARHSTCKDSGHAGARDIVSIQELIEVEEEEEILLNSYTTPSKGS
QKRAISTPETPLTKRSVSTRSPHQLLSPSSFSPSATPSQKYNSRSNRGEVVTSFGLAQGV
SWSGRGGAGNISLKVLGCPEALTGSYKSMFQKLPDIREVLTCKIEELGSELKEHYKIEAF
TPLLAPAQEPVTLLGQIGCDSNGKLNNKSVILEGDREHSSGAQIPVDLSELKEYSLFPGQ
VVIMEGINTTGRKLVATKLYEGVPLPFYQPTEEDADFEQSMVLVACGPYTTSDSITYDPL
LDLIAVINHDRPDVCILFGPFLDAKHEQVENCLLTSPFEDIFKQCLRTIIEGTRSSGSHL
VFVPSLRDVHHEPVYPQPPFSYSDLSREDKKQVQFVSEPCSLSINGVIFGLTSTDLLFHL
GAEEISSSSGTSDRFSRILKHILTQRSYYPLYPPQEDMAIDYESFYVYAQLPVTPDVLII
PSELRYFVKDVLGCVCVNPGRLTKGQVGGTFARLYLRRPAADGAERQSPCIAVQVVRI
Target Bioclass
Enzyme
Family
DNA polymerase alpha subunit B family
Subcellular location
Nucleus
Function
Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively.
Uniprot ID
Q14181
Ensemble ID
ENST00000265465.8
HGNC ID
HGNC:30073
ChEMBL ID
CHEMBL2363042

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO27 SNV: p.L145I DBIA    Probe Info 
HEC1B SNV: p.K385N .
LN18 SNV: p.C590R DBIA    Probe Info 
MDST8 SNV: p.T570I DBIA    Probe Info 
MOLT4 SNV: p.S295F IA-alkyne    Probe Info 
NOMO1 Deletion: p.I540del DBIA    Probe Info 
TOV21G SNV: p.S2Y DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AHL-Pu-1
 Probe Info  		C82(20.00)  LDD0169  [2]
HHS-475
 Probe Info  		Y235(0.54)  LDD0264  [3]
DBIA
 Probe Info  		C198(1.01)  LDD0078  [4]
ATP probe
 Probe Info  		K564(0.00); K134(0.00)  LDD0199  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C392(0.00); C259(0.00); C590(0.00); C198(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [7]
Lodoacetamide azide
 Probe Info  		C392(0.00); C590(0.00); C198(0.00)  LDD0037  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [10]
Compound 10
 Probe Info  		N.A.  LDD2216  [11]
Compound 11
 Probe Info  		N.A.  LDD2213  [11]
IPM
 Probe Info  		C198(0.00); C590(0.00)  LDD0147  [8]
PF-06672131
 Probe Info  		N.A.  LDD0017  [12]
Phosphinate-6
 Probe Info  		C82(0.00); C198(0.00)  LDD0018  [13]
Acrolein
 Probe Info  		C392(0.00); C198(0.00); C222(0.00)  LDD0217  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [14]
W1
 Probe Info  		C198(0.00); C590(0.00)  LDD0236  [15]
AOyne
 Probe Info  		15.00  LDD0443  [16]
NAIA_5
 Probe Info  		C82(0.00); C19(0.00)  LDD2223  [9]
HHS-465
 Probe Info  		K232(0.00); Y235(0.00)  LDD2240  [17]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C346
 Probe Info  		10.27  LDD2007  [18]
C347
 Probe Info  		5.46  LDD2008  [18]
FFF probe2
 Probe Info  		12.27  LDD0463  [19]
VE-P
 Probe Info  		N.A.  LDD0396  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C82(20.00)  LDD0169  [2]
 LDCM0214  AC1 HCT 116 C198(1.60); C554(1.57); C556(1.57); C590(1.23)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C554(0.99); C556(0.99); C590(1.06)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C554(1.54); C556(1.54); C590(1.31)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C554(0.53); C556(0.53); C590(1.06)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C554(0.53); C556(0.53); C590(1.04)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C554(0.52); C556(0.52); C590(1.06)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C554(0.65); C556(0.65); C590(1.00)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C554(0.51); C556(0.51); C590(1.52)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C554(0.48); C556(0.48); C590(1.19)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C554(0.54); C556(0.39); C590(0.75)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C554(0.44); C556(0.60); C590(1.38)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C554(0.48); C556(0.76); C590(1.12)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C554(0.72); C556(0.72); C590(1.05)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C554(0.42); C556(0.75); C590(1.23)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C554(0.56); C556(0.62); C590(1.32)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C554(0.68); C556(0.46); C590(1.08)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C198(0.85); C554(1.07); C556(1.07); C590(1.12)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C198(1.01); C554(1.08); C556(1.09); C590(0.90)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C198(1.04); C554(1.14); C556(0.98); C590(1.13)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C198(1.10); C554(1.09); C556(1.13); C590(1.40)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C198(0.95); C554(1.15); C556(0.91); C590(0.97)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C198(0.90); C554(1.07); C556(1.15); C590(0.95)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C198(1.00); C554(0.97); C556(0.94); C590(1.12)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C554(1.07); C556(1.07); C590(1.18)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C198(1.06); C554(1.03); C556(1.07); C590(1.08)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C198(0.98); C554(1.08); C556(0.85); C590(0.95)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C198(1.06); C554(1.06); C556(1.17); C590(1.14)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C198(1.01); C554(1.14); C556(0.90); C590(0.87)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C198(0.98); C554(1.11); C556(0.96); C590(0.88)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C198(0.90); C554(1.12); C556(1.23); C590(1.13)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C198(0.93); C554(1.16); C556(1.14); C590(1.17)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C198(1.02); C554(1.13); C556(1.06); C590(1.01)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C554(1.50); C556(1.50); C590(1.26)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C554(1.49); C556(1.49); C590(1.28)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C554(1.26); C556(1.26); C590(1.34)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C554(1.09); C556(1.09); C590(1.23)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C554(0.87); C556(0.87); C590(1.19)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C554(1.07); C556(1.07); C590(1.25)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C554(0.78); C556(0.78); C590(1.23)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C554(0.87); C556(0.87); C590(1.19)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C554(0.76); C556(0.76); C590(1.23)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C554(0.78); C556(0.78); C590(1.19)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C554(0.67); C556(0.67); C590(1.21)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C554(0.65); C556(0.65); C590(1.16)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C554(0.89); C556(0.89); C590(1.12)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C554(0.67); C556(0.67); C590(1.16)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C554(0.64); C556(0.64); C590(1.27)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C554(0.81); C556(0.81); C590(1.27)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C590(1.07)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C590(1.21)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C590(1.22)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C590(1.18)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C590(1.06)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C590(1.09)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C590(1.10)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C554(1.00); C556(1.00); C590(1.16)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C590(1.19)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C590(1.23)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C590(1.12)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C590(1.21)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C590(1.21)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C590(1.31)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C590(1.15)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C590(1.22)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C198(0.79); C590(0.96)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C198(0.98); C590(1.06)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C198(0.82); C590(1.14)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C198(1.12); C554(1.16); C556(1.16); C590(1.16)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C198(0.82); C590(1.18)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C198(0.82); C590(1.01)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C198(0.74); C590(1.05)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C590(0.90); C198(1.15)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C590(1.01); C198(1.02)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C590(0.54); C198(0.96); C554(1.18); C556(1.18)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C554(0.66); C556(0.66); C590(0.69); C198(1.07)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C554(0.62); C556(0.62); C590(0.77); C198(1.81)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C590(0.65); C554(0.65); C556(0.65); C198(1.46)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C554(0.41); C556(0.41); C590(0.66); C198(0.93)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C198(1.08); C590(1.29); C554(1.40); C556(1.40)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C554(0.41); C556(0.41); C590(0.58); C198(1.08)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C554(0.58); C556(0.58); C590(0.92); C198(1.22)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C554(0.42); C556(0.42); C590(0.74); C198(1.06)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C554(0.68); C556(0.68); C590(0.77); C198(1.27)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C554(0.67); C556(0.67); C590(0.79); C198(1.51)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C554(1.10); C556(1.10); C590(1.15); C198(1.20)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C198(0.78); C590(0.86); C554(0.91); C556(0.91)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C198(0.56); C590(0.96); C554(1.12); C556(1.12)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C554(1.01); C556(1.01); C590(1.08); C198(1.70)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C554(0.88); C556(0.88); C198(0.89); C590(1.01)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C590(1.48); C554(1.49); C556(1.49); C198(1.52)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C554(0.83); C556(0.83); C198(0.91); C590(0.93)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C198(0.70); C554(0.91); C556(0.91); C590(1.05)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C198(0.81); C554(0.88); C556(0.88); C590(1.08)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C198(0.81); C554(0.85); C556(0.85); C590(1.06)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C198(0.96); C554(0.97); C556(0.97); C590(1.01)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C554(0.87); C556(0.87); C590(1.02); C198(1.24)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C554(0.71); C556(0.71); C590(0.82); C198(0.97)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C554(0.78); C556(0.78); C590(0.94); C198(1.02)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C554(0.45); C556(0.45); C590(0.82); C198(1.00)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C554(0.52); C556(0.52); C590(0.87); C198(1.14)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C198(1.35); C590(1.39); C554(1.60); C556(1.60)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C554(0.50); C556(0.50); C590(0.84); C198(1.30)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C554(0.86); C556(0.86); C198(0.88); C590(0.96)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C198(0.86); C590(0.93); C554(0.93); C556(0.93)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C554(0.61); C556(0.61); C590(0.87); C198(1.10)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C554(0.70); C556(0.70); C590(0.89); C198(1.15)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C554(0.52); C556(0.52); C590(0.87); C198(1.32)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C554(0.39); C556(0.39); C590(0.79); C198(1.45)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C554(0.69); C556(0.69); C590(1.06)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C554(0.49); C556(0.49); C590(0.94)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C554(0.61); C556(0.61); C590(1.16)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C590(0.97); C554(0.97); C556(0.97)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C554(0.39); C556(0.39); C590(1.18)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C554(0.38); C556(0.38); C590(0.93)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C554(0.58); C556(0.58); C590(1.11)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C554(0.56); C556(0.56); C590(1.32)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C554(0.59); C556(0.59); C590(1.03)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C554(0.89); C556(0.89); C590(1.22)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C554(0.73); C556(0.73); C590(1.49)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C554(0.38); C556(0.38); C590(1.00)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C554(1.18); C556(1.18); C198(1.29)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C198(0.81); C554(1.08); C556(1.08)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C554(0.94); C556(0.94); C590(1.03)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C554(1.14); C556(1.14); C198(1.17)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C554(0.87); C556(0.87); C198(1.39)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C554(1.25); C556(1.25); C198(1.50)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C554(0.80); C556(0.80); C198(1.04)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C554(0.86); C556(0.86); C198(1.17)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C554(0.78); C556(0.78); C198(1.18)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C198(0.93); C554(1.14); C556(1.14)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C198(1.09); C554(1.11); C556(1.11)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C554(0.86); C556(0.86); C198(1.39)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C554(1.10); C556(1.10); C198(1.40)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C554(0.86); C556(0.86); C590(1.20)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C198(0.97); C554(0.98); C556(0.98)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C554(1.25); C556(1.25); C198(1.27)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C554(0.72); C556(0.72); C198(1.18)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C554(0.82); C556(0.82); C590(0.97)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C554(0.73); C556(0.73); C590(0.98)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C554(0.65); C556(0.65); C590(0.97)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C590(1.02); C554(1.05); C556(1.05)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C590(1.03); C554(1.16); C556(1.16)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C554(0.93); C556(0.93); C590(0.99)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C554(0.82); C556(0.82); C590(0.97)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C590(0.94); C554(1.07); C556(1.07)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C554(0.83); C556(0.83); C590(1.04)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C554(0.86); C556(0.86); C590(0.96)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C554(0.87); C556(0.87); C590(1.00)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C554(0.80); C556(0.80); C590(1.10)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C554(0.76); C556(0.76); C590(1.02)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C554(0.78); C556(0.78); C590(1.08)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C554(0.83); C556(0.83); C590(0.96)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C554(0.27); C556(0.27); C590(1.12)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C590(1.36); C554(1.40); C556(1.40)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C554(0.93); C556(0.93); C590(1.23)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C554(0.98); C556(0.98); C590(1.07)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C554(1.03); C556(1.03); C590(1.12)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 13.78  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C198(1.01)  LDD0078  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [14]
 LDCM0632  CL-Sc Hep-G2 C198(0.69); C82(0.45)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C590(0.81); C554(1.11); C556(1.11)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C554(0.55); C556(0.55); C590(0.90)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C590(1.17); C198(1.24); C554(1.46); C556(1.46)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C590(1.05); C554(1.11); C556(1.11)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C554(1.02); C556(1.02); C590(1.04)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C590(0.97); C554(1.09); C556(1.09)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C554(1.02); C556(1.02); C590(1.09)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C590(0.97); C198(1.02)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C590(0.95); C198(1.01)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C590(0.98); C198(1.16)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C590(1.07); C198(1.08)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C198(0.83); C590(1.04)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C554(0.57); C556(0.57); C590(0.93)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C590(0.87); C198(0.92)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C590(0.93); C198(0.97)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C590(0.61); C554(0.66); C556(0.66); C198(1.77)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C554(0.39); C556(0.39); C590(0.63); C198(1.20)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C554(0.37); C556(0.37); C590(0.67); C198(1.45)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C554(0.51); C556(0.51); C590(0.74); C198(1.38)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C554(0.66); C556(0.66); C590(0.74); C198(1.00)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C554(0.78); C556(0.78); C590(0.95); C198(1.08)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C554(0.91); C556(0.91); C198(0.97); C590(1.08)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C554(0.79); C556(0.79); C198(0.86); C590(0.98)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C554(0.72); C556(0.72); C590(1.02)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C198(0.57); C554(0.90); C556(0.90); C590(1.13)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C198(0.91); C590(1.18); C554(1.22); C556(1.22)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C554(0.56); C556(0.56); C590(0.95); C198(0.97)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C554(0.67); C556(0.67); C590(0.88); C198(1.18)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C554(0.53); C556(0.53); C590(0.86); C198(1.10)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C590(0.97); C554(1.10); C556(1.10)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C554(0.94); C556(0.94); C590(0.98)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C554(0.90); C556(0.90); C590(0.94)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C554(0.82); C556(0.82); C590(1.15)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C554(0.49); C556(0.49); C590(0.91)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C590(0.97); C554(1.02); C556(1.02)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C554(0.56); C556(0.56); C590(0.95)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C554(0.76); C556(0.76); C590(1.14)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C590(0.86); C554(1.08); C556(1.08)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C554(1.00); C556(1.00); C590(1.01)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C554(1.05); C556(1.05); C590(1.17)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C590(0.91); C554(1.20); C556(1.20)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C554(0.93); C556(0.93); C590(1.20)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C554(1.13); C556(1.13); C590(1.32)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C554(0.96); C556(0.96); C590(1.21)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C554(0.88); C556(0.88); C590(0.99)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C554(1.01); C556(1.01); C590(1.16)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C554(0.97); C556(0.97); C590(1.22)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C554(0.86); C556(0.86); C590(1.13)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C554(1.05); C556(1.05); C590(1.31)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C554(0.84); C556(0.84); C590(1.22)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C554(1.01); C556(1.01); C590(1.33)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C554(1.30); C556(1.30); C590(0.93)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C554(0.95); C556(0.95); C590(1.31)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C198(1.29); C554(0.97); C556(0.97); C590(0.92)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C198(1.08); C554(0.71); C556(0.71); C590(0.87)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C198(1.00); C554(0.95); C556(0.95); C590(0.92)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C198(0.91); C554(1.10); C556(1.10); C590(0.96)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C198(0.93); C554(0.96); C556(0.96); C590(1.24)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C198(0.92); C554(1.05); C556(1.05); C590(0.99)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C198(0.97); C554(1.15); C556(1.15); C590(0.99)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C198(1.01); C554(1.23); C556(1.23); C590(1.01)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C554(1.05); C556(1.05); C590(0.91)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C198(1.27); C554(0.94); C556(0.94); C590(0.97)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C198(0.91); C554(0.94); C556(0.94); C590(0.89)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C198(0.97); C554(1.12); C556(1.12); C590(0.87)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C198(1.06); C554(0.84); C556(0.84); C590(0.86)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C198(1.11); C554(1.08); C556(1.08); C590(0.98)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C198(1.09); C554(1.19); C556(1.19); C590(1.05)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C554(0.96); C556(0.96); C590(1.17)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C554(0.99); C556(0.99); C590(1.28)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C554(0.98); C556(0.98); C590(0.99)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C554(1.03); C556(1.03); C590(1.18)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C554(0.96); C556(0.96); C590(0.91)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C554(0.97); C556(0.97); C590(1.12)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C554(1.04); C556(1.04); C590(1.39)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C554(0.80); C556(0.80); C590(1.17)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C554(0.85); C556(0.85); C590(1.43)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C554(0.99); C556(0.99); C590(0.99)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C554(1.01); C556(1.01); C590(0.99)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C554(0.98); C556(0.98); C590(1.31)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C554(1.18); C556(1.18); C590(1.09)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C554(0.88); C556(0.88); C590(1.50)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C554(1.03); C556(1.03); C590(1.00)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C554(0.45); C556(0.45); C590(0.91)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C554(0.82); C556(0.82); C590(1.20)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C198(1.03); C554(1.21); C556(1.21); C590(1.04)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C198(1.05); C554(1.00); C556(1.00); C590(0.93)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C198(1.12); C554(0.86); C556(0.86); C590(1.20)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C198(1.27); C554(1.26); C556(1.26); C590(1.12)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C198(1.16); C554(1.08); C556(1.08); C590(1.25)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C198(1.31); C554(0.97); C556(0.97); C590(1.21)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C198(1.18); C554(1.09); C556(1.09); C590(1.17)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C198(1.25); C554(1.82); C556(1.82); C590(1.23)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C198(1.21); C554(0.87); C556(0.87); C590(1.06)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C554(0.81); C556(0.81); C590(1.01)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C198(1.07); C554(1.15); C556(1.15); C590(0.91)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C198(1.11); C554(1.14); C556(1.14); C590(1.15)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C198(1.13); C554(1.37); C556(1.37); C590(0.96)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C198(1.04); C554(1.45); C556(1.45); C590(0.99)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C198(1.10); C554(1.06); C556(1.06); C590(0.93)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C554(0.96); C556(0.96)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C554(0.99); C556(0.99)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C554(1.40); C556(1.40)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C554(1.30); C556(1.30)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C554(0.94); C556(0.94); C590(0.99)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C554(0.95); C556(0.95)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C554(1.17); C556(1.17)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C554(1.11); C556(1.11)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C554(1.00); C556(1.00)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C554(0.90); C556(0.90)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C554(0.91); C556(0.91)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C554(1.18); C556(1.18)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C554(1.26); C556(1.26)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C554(1.01); C556(1.01)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C554(0.84); C556(0.84)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C554(0.92); C556(0.92); C590(0.88)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C554(0.94); C556(0.94)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C198(1.28); C554(0.91); C556(0.91); C590(1.05)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C198(2.27); C554(0.87); C556(0.87); C590(0.88)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C198(1.75); C554(1.39); C556(1.39); C590(0.89)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C198(1.59); C554(1.65); C556(1.65); C590(0.81)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C198(1.26); C554(0.98); C556(0.98); C590(0.87)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C198(1.22); C554(0.97); C556(0.97); C590(1.05)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C198(1.10); C554(0.94); C556(0.94); C590(1.04)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C198(1.21); C554(1.09); C556(1.09); C590(1.22)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C198(1.19); C554(1.41); C556(1.41); C590(1.39)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C198(1.05); C392(0.96)  LDD1698  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C198(1.42); C590(0.86)  LDD1702  [22]
 LDCM0625  F8 Ramos C198(0.72)  LDD2187  [23]
 LDCM0572  Fragment10 Ramos C198(0.78)  LDD2189  [23]
 LDCM0573  Fragment11 Ramos C198(0.13); C82(20.00)  LDD2190  [23]
 LDCM0574  Fragment12 Ramos C198(1.99)  LDD2191  [23]
 LDCM0575  Fragment13 Ramos C198(0.89)  LDD2192  [23]
 LDCM0576  Fragment14 Ramos C198(0.49); C82(0.22)  LDD2193  [23]
 LDCM0579  Fragment20 Ramos C198(0.49)  LDD2194  [23]
 LDCM0580  Fragment21 Ramos C198(0.73)  LDD2195  [23]
 LDCM0582  Fragment23 Ramos C198(0.95)  LDD2196  [23]
 LDCM0578  Fragment27 Ramos C198(0.75)  LDD2197  [23]
 LDCM0586  Fragment28 Ramos C198(0.97); C82(0.88)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos C198(0.87)  LDD2199  [23]
 LDCM0589  Fragment31 Ramos C198(0.78)  LDD2200  [23]
 LDCM0590  Fragment32 Ramos C198(2.50)  LDD2201  [23]
 LDCM0468  Fragment33 HCT 116 C198(1.17); C554(1.83); C556(1.83); C590(1.04)  LDD0785  [4]
 LDCM0596  Fragment38 Ramos C198(0.71)  LDD2203  [23]
 LDCM0566  Fragment4 Ramos C198(0.95); C82(0.66)  LDD2184  [23]
 LDCM0427  Fragment51 HCT 116 C198(1.06); C554(1.22); C556(1.22); C590(0.75)  LDD0744  [4]
 LDCM0610  Fragment52 Ramos C198(1.33)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos C198(0.97)  LDD2205  [23]
 LDCM0569  Fragment7 Ramos C198(1.09); C82(0.41)  LDD2186  [23]
 LDCM0571  Fragment9 Ramos C198(0.76)  LDD2188  [23]
 LDCM0116  HHS-0101 DM93 Y235(0.54)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y235(1.15)  LDD0265  [3]
 LDCM0119  HHS-0401 DM93 Y235(0.93)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y235(1.53)  LDD0268  [3]
 LDCM0022  KB02 HCT 116 C198(2.28)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C198(5.77)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C198(1.22)  LDD0082  [4]
 LDCM0109  NEM HeLa H431(0.00); H430(0.00)  LDD0223  [14]
 LDCM0627  NUDT7-COV-1 HEK-293T C198(0.22)  LDD2206  [24]
 LDCM0628  OTUB2-COV-1 HEK-293T C198(0.88)  LDD2207  [24]
 LDCM0131  RA190 MM1.R C198(1.59)  LDD0304  [25]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine--tRNA ligase, cytoplasmic (SARS1) Class-II aminoacyl-tRNA synthetase family P49591
Caspase-6 (CASP6) Peptidase C14A family P55212
GTP-binding nuclear protein Ran (RAN) Ran family P62826
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock-related 70 kDa protein 2 (HSPA2) Heat shock protein 70 family P54652
Stress-induced-phosphoprotein 1 (STIP1) . P31948

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dacarbazine Small molecular drug DB00851

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD022279
12 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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17 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
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25 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.